AU2001265094A1 - Pyrazinone thrombin inhibitors - Google Patents

Pyrazinone thrombin inhibitors

Info

Publication number
AU2001265094A1
AU2001265094A1 AU2001265094A AU6509401A AU2001265094A1 AU 2001265094 A1 AU2001265094 A1 AU 2001265094A1 AU 2001265094 A AU2001265094 A AU 2001265094A AU 6509401 A AU6509401 A AU 6509401A AU 2001265094 A1 AU2001265094 A1 AU 2001265094A1
Authority
AU
Australia
Prior art keywords
thrombin inhibitors
pyrazinone
pyrazinone thrombin
inhibitors
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001265094A
Inventor
V. Brett Cooper
Cameron J. Cowden
Patricia Frech
Daniel J. Rush
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2001265094A1 publication Critical patent/AU2001265094A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001265094A 2000-06-01 2001-05-25 Pyrazinone thrombin inhibitors Abandoned AU2001265094A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20866500P 2000-06-01 2000-06-01
US60208665 2000-06-01
PCT/US2001/017268 WO2001092234A1 (en) 2000-06-01 2001-05-25 Pyrazinone thrombin inhibitors

Publications (1)

Publication Number Publication Date
AU2001265094A1 true AU2001265094A1 (en) 2001-12-11

Family

ID=22775496

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001265094A Abandoned AU2001265094A1 (en) 2000-06-01 2001-05-25 Pyrazinone thrombin inhibitors

Country Status (3)

Country Link
US (1) US6521625B2 (en)
AU (1) AU2001265094A1 (en)
WO (1) WO2001092234A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004520399A (en) * 2001-02-09 2004-07-08 メルク　エンド　カムパニー　インコーポレーテッド Thrombin inhibitor
WO2003048127A1 (en) 2001-12-04 2003-06-12 Corvas International, Inc. Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
US20040213850A1 (en) * 2003-04-25 2004-10-28 Eleni Dokou Sustained release delivery of a thrombin inhibitor
EP1621200A1 (en) * 2004-07-26 2006-02-01 Fournier Laboratories Ireland Limited Pharmaceutical combinations containing an inhibitor of platelet aggregation and a fibrate
WO2007043939A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a
JP5211540B2 (en) * 2006-08-23 2013-06-12 セントラル硝子株式会社 Pre-fogging article and anti-fogging article and coating solution for anti-fogging article
KR20140090663A (en) * 2011-11-07 2014-07-17 디아크론 파마슈티칼스, 인코포레이티드 An extended release formulation of a direct thrombin inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600226B2 (en) 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
ZA897514B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
JP2001514227A (en) * 1997-09-05 2001-09-11 メルク エンド カムパニー インコーポレーテッド Pyrazinone thrombin inhibitors
UA58636C2 (en) 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Pyrazinone thrombin inhibitors, pharmaceutical composition, method for treatment conditions caused by thrombus formation

Also Published As

Publication number Publication date
US6521625B2 (en) 2003-02-18
WO2001092234A1 (en) 2001-12-06
US20020004507A1 (en) 2002-01-10

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