EP1079835A4 - Pyrazinone thrombin inhibitors - Google Patents

Pyrazinone thrombin inhibitors

Info

Publication number
EP1079835A4
EP1079835A4 EP19990923087 EP99923087A EP1079835A4 EP 1079835 A4 EP1079835 A4 EP 1079835A4 EP 19990923087 EP19990923087 EP 19990923087 EP 99923087 A EP99923087 A EP 99923087A EP 1079835 A4 EP1079835 A4 EP 1079835A4
Authority
EP
European Patent Office
Prior art keywords
thrombin inhibitors
pyrazinone
pyrazinone thrombin
inhibitors
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19990923087
Other languages
German (de)
French (fr)
Other versions
EP1079835A1 (en
Inventor
Philip E Sanderson
Matthew G Stanton
Suresh K Balani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9813580.9A external-priority patent/GB9813580D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1079835A1 publication Critical patent/EP1079835A1/en
Publication of EP1079835A4 publication Critical patent/EP1079835A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
EP19990923087 1998-05-19 1999-05-14 Pyrazinone thrombin inhibitors Withdrawn EP1079835A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8598098P 1998-05-19 1998-05-19
US85980P 1998-05-19
GB9813580 1998-06-24
GBGB9813580.9A GB9813580D0 (en) 1998-06-24 1998-06-24 Pyrazinone thrombin inhibitors
PCT/US1999/010730 WO1999059591A1 (en) 1998-05-19 1999-05-14 Pyrazinone thrombin inhibitors

Publications (2)

Publication Number Publication Date
EP1079835A1 EP1079835A1 (en) 2001-03-07
EP1079835A4 true EP1079835A4 (en) 2002-10-29

Family

ID=26313923

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19990923087 Withdrawn EP1079835A4 (en) 1998-05-19 1999-05-14 Pyrazinone thrombin inhibitors

Country Status (5)

Country Link
EP (1) EP1079835A4 (en)
JP (1) JP2002515434A (en)
AU (1) AU753479B2 (en)
CA (1) CA2329914A1 (en)
WO (1) WO1999059591A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6664255B1 (en) * 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
HUP0202191A3 (en) * 1999-05-19 2003-02-28 Pharmacia Corp Chicago Substituted polycyclic aryl and heteroaryl pirazinones useful for selective inhibition of the coagulation cascade and pharmaceutical compositions containing them
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
EP1586565A1 (en) * 1999-05-19 2005-10-19 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6908919B2 (en) * 1999-05-19 2005-06-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
UA58636C2 (en) 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Pyrazinone thrombin inhibitors, pharmaceutical composition, method for treatment conditions caused by thrombus formation
AU2044401A (en) 1999-11-23 2001-06-04 Merck & Co., Inc. Pyrazinone thrombin inhibitors
US6660885B2 (en) 2000-03-13 2003-12-09 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
WO2001077097A2 (en) 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
JP2004505013A (en) 2000-04-05 2004-02-19 ファルマシア・コーポレーション Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selectively inhibiting the coagulation cascade
JP2004501077A (en) 2000-04-17 2004-01-15 ファルマシア・コーポレーション Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
KR20030015393A (en) * 2000-07-17 2003-02-20 3-디멘져널 파마슈티칼즈 인코오포레이티드 Cyclic oxyguanidine pyrazinones as protease inhibitors
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
US6624180B2 (en) 2000-11-20 2003-09-23 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
AU2002367752A1 (en) 2001-10-03 2003-11-17 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
JP2005509606A (en) * 2001-10-03 2005-04-14 ファルマシア・コーポレーション Prodrugs of substituted polycyclic compounds useful for selectively inhibiting the coagulation cascade
US6969715B2 (en) 2001-10-03 2005-11-29 Pharmacia Corporation 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
WO2007014929A1 (en) 2005-08-03 2007-02-08 Boehringer Ingelheim International Gmbh Use of flibanserin in the treatment of obesity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040024A1 (en) * 1996-04-23 1997-10-30 Merck & Co., Inc. Pyrazinone thrombin inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4127404A1 (en) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US5866573A (en) * 1997-04-21 1999-02-02 Merck & Co., Inc. Pyrazinone thrombin inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040024A1 (en) * 1996-04-23 1997-10-30 Merck & Co., Inc. Pyrazinone thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9959591A1 *

Also Published As

Publication number Publication date
CA2329914A1 (en) 1999-11-25
AU3993699A (en) 1999-12-06
AU753479B2 (en) 2002-10-17
EP1079835A1 (en) 2001-03-07
JP2002515434A (en) 2002-05-28
WO1999059591A1 (en) 1999-11-25

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