AU2001289932A1 - Low molecular serine protease inhibitors comprising polyhydroxy-alkyl and polyhydroxy-cycloalkyl radicals - Google Patents

Low molecular serine protease inhibitors comprising polyhydroxy-alkyl and polyhydroxy-cycloalkyl radicals

Info

Publication number
AU2001289932A1
AU2001289932A1 AU2001289932A AU8993201A AU2001289932A1 AU 2001289932 A1 AU2001289932 A1 AU 2001289932A1 AU 2001289932 A AU2001289932 A AU 2001289932A AU 8993201 A AU8993201 A AU 8993201A AU 2001289932 A1 AU2001289932 A1 AU 2001289932A1
Authority
AU
Australia
Prior art keywords
polyhydroxy
alkyl
low molecular
protease inhibitors
serine protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001289932A
Inventor
Dieter Herr
Wilfried Hornberger
Helmut Mack
Werner Seitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Publication of AU2001289932A1 publication Critical patent/AU2001289932A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AU2001289932A 2000-10-06 2001-09-27 Low molecular serine protease inhibitors comprising polyhydroxy-alkyl and polyhydroxy-cycloalkyl radicals Abandoned AU2001289932A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10049937.6 2000-10-06
DE10049937A DE10049937A1 (en) 2000-10-06 2000-10-06 New sugar-modified amidine and guanidine compounds, useful as competitive inhibitors of serine protease, e.g. for treating thrombosis
PCT/EP2001/011207 WO2002030940A2 (en) 2000-10-06 2001-09-27 Low molecular serine protease inhibitors comprising polyhydroxy-alkyl and polyhydroxy-cycloalkyl radicals

Publications (1)

Publication Number Publication Date
AU2001289932A1 true AU2001289932A1 (en) 2002-04-22

Family

ID=7659136

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001289932A Abandoned AU2001289932A1 (en) 2000-10-06 2001-09-27 Low molecular serine protease inhibitors comprising polyhydroxy-alkyl and polyhydroxy-cycloalkyl radicals

Country Status (9)

Country Link
US (3) US20040048815A1 (en)
EP (1) EP1370573A2 (en)
JP (1) JP2004511489A (en)
AR (1) AR036326A1 (en)
AU (1) AU2001289932A1 (en)
CA (1) CA2424926A1 (en)
DE (1) DE10049937A1 (en)
MX (1) MXPA03002923A (en)
WO (1) WO2002030940A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10259382A1 (en) * 2002-12-18 2004-07-01 Abbott Gmbh & Co. Kg 3-Substituted 3,4-dihydro-thieno [2,3-d] pyrimidin-4-one derivatives, their preparation and use
CA3113691A1 (en) * 2018-09-17 2020-03-26 Board Of Regents, The University Of Texas System Compositions and methods for treating bone injury

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115468A1 (en) * 1991-05-11 1992-11-12 Behringwerke Ag AMIDINOPHENYLALANINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE USE THESE AND THE MEANS THEREOF CONTAINING ANTICOAGULANTS
DE4206858A1 (en) * 1992-03-05 1993-09-09 Behringwerke Ag GLYCOPEPTIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS
SE9301916D0 (en) * 1993-06-03 1993-06-03 Ab Astra NEW PEPTIDES DERIVATIVES
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (en) * 1994-06-17 1995-12-21 Basf Ag New thrombin inhibitors, their production and use
DE4443390A1 (en) * 1994-12-06 1996-06-13 Basf Ag New dipeptidic p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl residues
AU706834B2 (en) * 1995-02-10 1999-06-24 Abbott Gmbh & Co. Kg Thrombin inhibitors
WO1996025426A1 (en) * 1995-02-17 1996-08-22 Basf Aktiengesellschaft Novel dipeptide amidines as thrombin inhibitors
ES2185785T3 (en) * 1995-07-26 2003-05-01 Mitsubishi Chem Corp PENICILAMINAMIDE DERIVATIVES.
DE19632773A1 (en) * 1996-08-14 1998-02-19 Basf Ag New thrombin inhibitors
DE19632772A1 (en) * 1996-08-14 1998-02-19 Basf Ag New benzamidines
PL199433B1 (en) * 1998-06-17 2008-09-30 Organon Nv Antithrombotic compounds
KR20000047461A (en) * 1998-12-29 2000-07-25 성재갑 Thrombin inhibitors

Also Published As

Publication number Publication date
US20110071285A1 (en) 2011-03-24
MXPA03002923A (en) 2003-08-07
EP1370573A2 (en) 2003-12-17
DE10049937A1 (en) 2002-04-11
WO2002030940A2 (en) 2002-04-18
CA2424926A1 (en) 2003-04-04
US20040048815A1 (en) 2004-03-11
US20120190832A1 (en) 2012-07-26
WO2002030940A3 (en) 2003-10-02
AR036326A1 (en) 2004-09-01
JP2004511489A (en) 2004-04-15

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