DK82893D0 - Peptid - Google Patents

Peptid

Info

Publication number
DK82893D0
DK82893D0 DK93828A DK82893A DK82893D0 DK 82893 D0 DK82893 D0 DK 82893D0 DK 93828 A DK93828 A DK 93828A DK 82893 A DK82893 A DK 82893A DK 82893 D0 DK82893 D0 DK 82893D0
Authority
DK
Denmark
Prior art keywords
pct
sequence encoding
dna sequence
date
peptide
Prior art date
Application number
DK93828A
Other languages
Danish (da)
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK93828A priority Critical patent/DK82893D0/da
Publication of DK82893D0 publication Critical patent/DK82893D0/da
Priority to IL11023894A priority patent/IL110238A/xx
Priority to ZA944912A priority patent/ZA944912B/xx
Priority to CA002166684A priority patent/CA2166684A1/en
Priority to AT94920419T priority patent/ATE207124T1/de
Priority to AU71221/94A priority patent/AU7122194A/en
Priority to NZ268346A priority patent/NZ268346A/en
Priority to DE69428719T priority patent/DE69428719T2/de
Priority to JP50376895A priority patent/JP3542604B2/ja
Priority to UA96010072A priority patent/UA40625C2/uk
Priority to US08/446,646 priority patent/US5726038A/en
Priority to PL94312436A priority patent/PL178924B1/pl
Priority to PT94920419T priority patent/PT792367E/pt
Priority to RU96103364/13A priority patent/RU2143495C1/ru
Priority to HU9600053A priority patent/HU222406B1/hu
Priority to EP94920419A priority patent/EP0792367B1/en
Priority to ES94920419T priority patent/ES2165881T3/es
Priority to DK94920419T priority patent/DK0792367T3/da
Priority to PCT/DK1994/000281 priority patent/WO1995002059A1/en
Priority to SG1996004717A priority patent/SG52452A1/en
Priority to KR1019960700049A priority patent/KR100245173B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK93828A 1993-07-08 1993-07-08 Peptid DK82893D0 (da)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DK93828A DK82893D0 (da) 1993-07-08 1993-07-08 Peptid
IL11023894A IL110238A (en) 1993-07-08 1994-07-07 Dna construct comprising a dna sequence encoding the yeast aspartic protease 3 signal peptide
ZA944912A ZA944912B (en) 1993-07-08 1994-07-07 A DNA construct comprising the YAP3 signal peptide
SG1996004717A SG52452A1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 singal peptide
JP50376895A JP3542604B2 (ja) 1993-07-08 1994-07-08 Ｙａｐ３シグナルペプチドをコードするｄｎａ構築体
PT94920419T PT792367E (pt) 1993-07-08 1994-07-08 Constructo de adn que codifica o peptido sinal yap3
AU71221/94A AU7122194A (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
NZ268346A NZ268346A (en) 1993-07-08 1994-07-08 Improved secretion of proteins using the "signal protein" of yeast aspartic protease
DE69428719T DE69428719T2 (de) 1993-07-08 1994-07-08 Für das yap3 signalpeptid kodierendes dna-konstrukt
CA002166684A CA2166684A1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
UA96010072A UA40625C2 (uk) 1993-07-08 1994-07-08 Конструкція днк, рекомбінантний експресуючий вектор, спосіб одержання гетерологічного поліпептиду
US08/446,646 US5726038A (en) 1993-07-08 1994-07-08 DNA construct encoding the YAP3 signal peptide
PL94312436A PL178924B1 (pl) 1993-07-08 1994-07-08 Konstrukt DNA, zrekombinowany wektor ekspresji, komórka transformowana i sposób wytwarzania heterologicznego polipeptydu
AT94920419T ATE207124T1 (de) 1993-07-08 1994-07-08 Für das yap3 signalpeptid kodierendes dna- konstrukt
RU96103364/13A RU2143495C1 (ru) 1993-07-08 1994-07-08 Способ получения гетерологичного белка
HU9600053A HU222406B1 (hu) 1993-07-08 1994-07-08 YAP3 szignál peptidet kódoló DNS-szerkezet
EP94920419A EP0792367B1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
ES94920419T ES2165881T3 (es) 1993-07-08 1994-07-08 Constructo de adn que codifica el peptido señal yap3.
DK94920419T DK0792367T3 (da) 1993-07-08 1994-07-08 DNA-konstruktion, der koder YAP3-signalpeptidet
PCT/DK1994/000281 WO1995002059A1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
KR1019960700049A KR100245173B1 (en) 1993-07-08 1996-01-08 A dna construct encoding the yap3 signal peptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK93828A DK82893D0 (da) 1993-07-08 1993-07-08 Peptid

Publications (1)

Publication Number Publication Date
DK82893D0 true DK82893D0 (da) 1993-07-08

Family

ID=8098010

Family Applications (2)

Application Number Title Priority Date Filing Date
DK93828A DK82893D0 (da) 1993-07-08 1993-07-08 Peptid
DK94920419T DK0792367T3 (da) 1993-07-08 1994-07-08 DNA-konstruktion, der koder YAP3-signalpeptidet

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94920419T DK0792367T3 (da) 1993-07-08 1994-07-08 DNA-konstruktion, der koder YAP3-signalpeptidet

Country Status (20)

Country Link
US (1) US5726038A (ja)
EP (1) EP0792367B1 (ja)
JP (1) JP3542604B2 (ja)
KR (1) KR100245173B1 (ja)
AT (1) ATE207124T1 (ja)
AU (1) AU7122194A (ja)
CA (1) CA2166684A1 (ja)
DE (1) DE69428719T2 (ja)
DK (2) DK82893D0 (ja)
ES (1) ES2165881T3 (ja)
HU (1) HU222406B1 (ja)
IL (1) IL110238A (ja)
NZ (1) NZ268346A (ja)
PL (1) PL178924B1 (ja)
PT (1) PT792367E (ja)
RU (1) RU2143495C1 (ja)
SG (1) SG52452A1 (ja)
UA (1) UA40625C2 (ja)
WO (1) WO1995002059A1 (ja)
ZA (1) ZA944912B (ja)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5861267A (en) * 1995-05-01 1999-01-19 Vertex Pharmaceuticals Incorporated Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
ZA9610456B (en) * 1995-12-20 1997-06-20 Novo Nordisk As N-terminally extended proteins expressed in yeast
ES2306462T3 (es) * 1996-12-13 2008-11-01 Novartis Vaccines And Diagnostics, Inc. Analisis y separacion de proteinas del factor de crecimiento derivadas de plaquetas.
EP0954589A1 (en) * 1997-01-24 1999-11-10 Novo Nordisk A/S Synthetic leader peptide sequences
US6451572B1 (en) 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
JP2003531567A (ja) * 1999-04-30 2003-10-28 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド チモーゲン活性化系
US6420157B1 (en) * 1999-04-30 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Zymogen activation system
CN1415019A (zh) 1999-12-29 2003-04-30 诺沃挪第克公司 用于生产在酵母中具有改进发酵产量的胰岛素前体和胰岛素前体类似物的方法
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
EP2267026A1 (en) * 2000-04-12 2010-12-29 Human Genome Sciences, Inc. Albumin fusion proteins
CA2446739A1 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
PT1463751E (pt) * 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
KR100496758B1 (ko) * 2002-06-29 2005-06-22 한국생명공학연구원 한세눌라 폴리모르파 앱신 유전자 결손 변이주 및 이를이용한 재조합 단백질 생산 방법
CA2925807C (en) 2002-09-13 2020-09-15 Cornell Research Foundation, Inc. Using mutations to improve aspergillus phytases
KR100470978B1 (ko) * 2003-01-02 2005-03-10 한국생명공학연구원 앱신 다중 결손 효모 변이 균주 및 이를 이용한 재조합 단백질의 생산 방법
JP2007532096A (ja) 2003-11-14 2007-11-15 ノボ　ノルディスク　アクティーゼルスカブ アシル化されたインスリンの製造方法
ATE517119T1 (de) 2003-12-03 2011-08-15 Novo Nordisk As Einzelketteninsulin
PL1729795T3 (pl) * 2004-02-09 2016-08-31 Human Genome Sciences Inc Białka fuzyjne albuminy
CN102660614A (zh) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
WO2008037735A1 (en) 2006-09-27 2008-04-03 Novo Nordisk A/S Method for making maturated insulin polypeptides
JP5404411B2 (ja) 2006-11-22 2014-01-29 ノボ・ノルデイスク・エー／エス 活性化カルボキシペプチダーゼの製造方法
CN101743252A (zh) 2007-07-16 2010-06-16 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、peg化的胰岛素类似物
PT2254906T (pt) 2008-03-18 2017-01-03 Novo Nordisk As Análogos de insulina acilados, estabilizados contra proteases
EP2258855A1 (en) 2009-05-28 2010-12-08 Universität für Bodenkultur Wien Expression sequences
CA2819552C (en) 2010-12-09 2023-09-26 Institut Pasteur Mgmt-based method for obtaining high yield of recombinant protein expression
DE102011007313A1 (de) * 2011-04-13 2012-10-18 Henkel Ag & Co. Kgaa Expressionsverfahren
DE102011118032A1 (de) * 2011-05-31 2012-12-06 Henkel Ag & Co. Kgaa Expressionsvektoren zur verbesserten Proteinsekretion
NO2788478T3 (ja) 2011-12-09 2018-01-20
ES2610990T3 (es) 2012-10-29 2017-05-04 Lonza Ltd Secuencias de expresión
JP6735561B2 (ja) 2012-12-03 2020-08-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体
WO2014195452A1 (en) 2013-06-07 2014-12-11 Novo Nordisk A/S Method for making mature insulin polypeptides
PL233560B1 (pl) 2014-12-05 2019-10-31 Mabion Spolka Akcyjna Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka
WO2016144658A1 (en) 2015-03-10 2016-09-15 Merck Sharp & Dohme Corp. Process for preparing recombinant insulin using microfiltration
EA037848B1 (ru) 2016-07-14 2021-05-27 Общество С Ограниченной Ответственностью "Биохимический Агент" Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты)
WO2019099615A1 (en) 2017-11-17 2019-05-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth
WO2022049409A1 (en) 2020-09-02 2022-03-10 Sia Terragen Express diagnosticum for sars-cov-2
CN112920280B (zh) * 2021-04-22 2022-07-05 江南大学 一种酸性蛋白酶高效表达的方法及其应用

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EP0243465A1 (en) * 1985-10-25 1987-11-04 Vivian L. Mackay Method of using bar1 for secreting foreign proteins
US5217891A (en) * 1987-07-28 1993-06-08 Chiron Corporation DNA constructs containing a kluyveromyces α factor leader sequence for directing secretion of heterologous polypeptides
US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5538863A (en) * 1993-07-01 1996-07-23 Immunex Corporation Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide

Also Published As

Publication number Publication date
PL178924B1 (pl) 2000-06-30
AU7122194A (en) 1995-02-06
ES2165881T3 (es) 2002-04-01
US5726038A (en) 1998-03-10
IL110238A0 (en) 1994-10-21
DK0792367T3 (da) 2001-12-31
PL312436A1 (en) 1996-04-29
UA40625C2 (uk) 2001-08-15
EP0792367A1 (en) 1997-09-03
NZ268346A (en) 1997-05-26
HUT74253A (en) 1996-11-28
EP0792367B1 (en) 2001-10-17
PT792367E (pt) 2002-04-29
CA2166684A1 (en) 1995-01-19
RU2143495C1 (ru) 1999-12-27
SG52452A1 (en) 1998-09-28
ATE207124T1 (de) 2001-11-15
JP3542604B2 (ja) 2004-07-14
DE69428719D1 (de) 2001-11-22
ZA944912B (en) 1995-03-27
HU222406B1 (hu) 2003-06-28
WO1995002059A1 (en) 1995-01-19
KR100245173B1 (en) 2000-02-15
DE69428719T2 (de) 2002-08-08
IL110238A (en) 2003-04-10
HU9600053D0 (en) 1996-03-28
JPH08512202A (ja) 1996-12-24

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