DK6691A - Isoindelinyl-alkyl-piperaziner - Google Patents

Isoindelinyl-alkyl-piperaziner Download PDF

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Publication number
DK6691A
DK6691A DK006691A DK6691A DK6691A DK 6691 A DK6691 A DK 6691A DK 006691 A DK006691 A DK 006691A DK 6691 A DK6691 A DK 6691A DK 6691 A DK6691 A DK 6691A
Authority
DK
Denmark
Prior art keywords
isoindelinyl
piperazines
alkyl
Prior art date
Application number
DK006691A
Other languages
English (en)
Other versions
DK6691D0 (da
Inventor
Terence M Dolak
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK6691D0 publication Critical patent/DK6691D0/da
Publication of DK6691A publication Critical patent/DK6691A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • C07D213/85Nitriles in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK006691A 1984-07-11 1991-01-14 Isoindelinyl-alkyl-piperaziner DK6691A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/629,649 US4585773A (en) 1984-07-11 1984-07-11 Isoindolinyl-alkyl-piperazines

Publications (2)

Publication Number Publication Date
DK6691D0 DK6691D0 (da) 1991-01-14
DK6691A true DK6691A (da) 1991-01-14

Family

ID=24523882

Family Applications (2)

Application Number Title Priority Date Filing Date
DK315085A DK163057C (da) 1984-07-11 1985-07-10 Isoindsolinyl-alkyl-piperaziner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK006691A DK6691A (da) 1984-07-11 1991-01-14 Isoindelinyl-alkyl-piperaziner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK315085A DK163057C (da) 1984-07-11 1985-07-10 Isoindsolinyl-alkyl-piperaziner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme

Country Status (25)

Country Link
US (1) US4585773A (da)
JP (2) JPS6136260A (da)
KR (1) KR870000355B1 (da)
AT (1) AT385270B (da)
AU (1) AU584104B2 (da)
BE (1) BE902847A (da)
CA (1) CA1255311A (da)
CH (1) CH664964A5 (da)
DE (1) DE3524635A1 (da)
DK (2) DK163057C (da)
ES (2) ES8705425A1 (da)
FI (1) FI79837C (da)
FR (1) FR2567519B1 (da)
GB (1) GB2161807B (da)
GR (1) GR851678B (da)
HU (1) HU195213B (da)
IE (1) IE58787B1 (da)
IT (1) IT1187756B (da)
LU (1) LU85999A1 (da)
MY (1) MY102973A (da)
NL (1) NL8501998A (da)
NO (1) NO163775C (da)
PT (1) PT80794B (da)
SE (1) SE457449B (da)
ZA (1) ZA855092B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
FR2628425B1 (fr) * 1988-03-08 1992-04-03 Rhone Poulenc Sante Derives d'isoindolinone, leurs procedes de preparation et les medicaments les contenant
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US6387909B1 (en) 1999-07-30 2002-05-14 Recordati S.A. Chemical And Pharmaceutical Company Thienopyranecarboxamide derivatives
US6306861B1 (en) 1999-07-30 2001-10-23 Recordati S.A. Chemical And Pharmaceutical Company Thienopyrancecarboxamide derivatives
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
EP2632461A4 (en) * 2010-10-29 2014-04-02 Merck Sharp & Dohme ISOINDOLINONE COMPOUNDS USEFUL AS PDE INHIBITORS 10
CN115417772A (zh) * 2022-09-26 2022-12-02 无锡双启科技有限公司 一种3-硝基-4-氟苯甲醚的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1135461B (de) * 1959-05-08 1962-08-30 Knoll Ag Verfahren zur Herstellung von basisch substituierten Phthalimidinen
FR1264070A (fr) * 1959-05-08 1961-06-19 Knoll Ag Procédé de préparation de dérivés de la phtalimidine et produits conformes à ceux obtenus
US3198798A (en) * 1962-11-02 1965-08-03 Sterling Drug Inc Phthalimido- and isoindolinyl-alkylpiperazines and their preparation
US3579524A (en) * 1968-06-05 1971-05-18 Miles Lab 2-aminoalkyl derivatives of phthalimidines
SE368009B (da) * 1971-09-16 1974-06-17 Kabi Ab
IL52413A (en) * 1977-06-29 1980-01-31 Teva Pharma Process for the preparazione of 5-chloro-6-sulfamyl-isoindolinone derivatives
SE7907121L (sv) * 1979-08-27 1981-02-28 Astra Laekemedel Ab Ftalimidinderivat
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4505911A (en) * 1983-10-13 1985-03-19 Mead Johnson & Company Isoindole diuretic derivatives, compositions and use

Also Published As

Publication number Publication date
HUT39177A (en) 1986-08-28
DK163057C (da) 1992-06-09
SE8503415D0 (sv) 1985-07-09
GB2161807B (en) 1987-12-09
FI852694A0 (fi) 1985-07-08
FI79837B (fi) 1989-11-30
FI852694L (fi) 1986-01-12
IE851734L (en) 1986-01-11
NL8501998A (nl) 1986-02-03
FI79837C (fi) 1990-03-12
BE902847A (fr) 1986-01-10
JPS61178964A (ja) 1986-08-11
CA1255311A (en) 1989-06-06
IT1187756B (it) 1987-12-23
ES8705425A1 (es) 1987-05-01
JPH0466B2 (da) 1992-01-06
DE3524635A1 (de) 1986-01-23
DK315085D0 (da) 1985-07-10
IT8521498A0 (it) 1985-07-10
KR870000355B1 (ko) 1987-03-05
DK315085A (da) 1986-01-12
GB8517418D0 (en) 1985-08-14
ES545003A0 (es) 1987-05-01
PT80794A (en) 1985-08-01
FR2567519B1 (fr) 1990-04-13
KR860001098A (ko) 1986-02-22
DK6691D0 (da) 1991-01-14
NO163775B (no) 1990-04-09
ES8707525A1 (es) 1987-08-01
AT385270B (de) 1988-03-10
SE457449B (sv) 1988-12-27
HU195213B (en) 1988-04-28
MY102973A (en) 1993-03-31
NO852779L (no) 1986-01-13
SE8503415L (sv) 1986-01-12
CH664964A5 (de) 1988-04-15
DK163057B (da) 1992-01-13
JPS6136260A (ja) 1986-02-20
PT80794B (pt) 1987-10-20
GB2161807A (en) 1986-01-22
IE58787B1 (en) 1993-11-17
NO163775C (no) 1990-07-18
ES552108A0 (es) 1987-08-01
ATA206285A (de) 1987-08-15
GR851678B (da) 1985-11-26
AU4476485A (en) 1986-01-16
ZA855092B (en) 1986-02-26
US4585773A (en) 1986-04-29
AU584104B2 (en) 1989-05-18
LU85999A1 (fr) 1986-02-12
FR2567519A1 (fr) 1986-01-17

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Legal Events

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AHB Application shelved due to non-payment