DK535285D0 - Fremgangsmaade til rensning af proteiner og middel til brug ved fremgangsmaaden - Google Patents

Fremgangsmaade til rensning af proteiner og middel til brug ved fremgangsmaaden

Info

Publication number
DK535285D0
DK535285D0 DK535285A DK535285A DK535285D0 DK 535285 D0 DK535285 D0 DK 535285D0 DK 535285 A DK535285 A DK 535285A DK 535285 A DK535285 A DK 535285A DK 535285 D0 DK535285 D0 DK 535285D0
Authority
DK
Denmark
Prior art keywords
procedure
agents
proteins
cleaning
cleaning proteins
Prior art date
Application number
DK535285A
Other languages
English (en)
Other versions
DK171917B1 (da
DK535285A (da
Inventor
Michele Ceceil Smith
Charles Pidgeon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK535285D0 publication Critical patent/DK535285D0/da
Publication of DK535285A publication Critical patent/DK535285A/da
Application granted granted Critical
Publication of DK171917B1 publication Critical patent/DK171917B1/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/223Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material containing metals, e.g. organo-metallic compounds, coordination complexes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206Organic carriers, supports or substrates
    • B01J20/3208Polymeric carriers, supports or substrates
    • B01J20/3212Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30Processes for preparing, regenerating, or reactivating
    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244Non-macromolecular compounds
    • B01J20/3265Non-macromolecular compounds with an organic functional group containing a metal, e.g. a metal affinity ligand
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/40Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/49Materials comprising an indicator, e.g. colour indicator, pH-indicator
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/50Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54Sorbents specially adapted for analytical or investigative chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/50Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58Use in a single column
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
DK535285A 1984-12-05 1985-11-20 Forbindelser, der kan anvendes til rensning af proteiner og fremgangsmåder, der anvender disse forbindelser DK171917B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/678,602 US4569794A (en) 1984-12-05 1984-12-05 Process for purifying proteins and compounds useful in such process
US67860284 1984-12-05

Publications (3)

Publication Number Publication Date
DK535285D0 true DK535285D0 (da) 1985-11-20
DK535285A DK535285A (da) 1986-06-06
DK171917B1 DK171917B1 (da) 1997-08-11

Family

ID=24723484

Family Applications (1)

Application Number Title Priority Date Filing Date
DK535285A DK171917B1 (da) 1984-12-05 1985-11-20 Forbindelser, der kan anvendes til rensning af proteiner og fremgangsmåder, der anvender disse forbindelser

Country Status (12)

Country Link
US (1) US4569794A (da)
EP (1) EP0184355B1 (da)
JP (1) JPH0788400B2 (da)
AU (1) AU588840B2 (da)
CA (1) CA1252948A (da)
DE (1) DE3585147D1 (da)
DK (1) DK171917B1 (da)
HK (1) HK39192A (da)
HU (1) HU208025B (da)
IE (1) IE58501B1 (da)
IL (1) IL77104A (da)
SG (1) SG25792G (da)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279960A (en) * 1984-07-05 1994-01-18 Enzon Corp. 25 KD coccidial antigen of eimeria tenella
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US5047513A (en) * 1986-07-10 1991-09-10 Hoffmann-La Roche Inc. Metal chelate resins
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
GB8706599D0 (en) * 1987-03-19 1987-04-23 Hoffmann La Roche Plasmodium falciparum merozoite antigen peptides
EP0316695B1 (de) * 1987-11-16 1993-03-31 F. Hoffmann-La Roche Ag Rekombinante HIV-2 Polypeptide
US5780038A (en) * 1987-11-16 1998-07-14 Roche Diagnostic Systems, Inc. HIV-2 envelope polypeptides
JPH084519B2 (ja) * 1987-12-25 1996-01-24 エフ・ホフマン―ラ ロシュ アーゲー ハイブリッド形成用担体およびその調整方法
US4931498A (en) * 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
US4927879A (en) * 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US4952321A (en) * 1988-10-07 1990-08-28 Brigham Young University Process of removing and concentrating desired ions from solutions
US5169936A (en) * 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US5115102A (en) * 1989-07-21 1992-05-19 Monsanto Company Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices
US6683046B1 (en) * 1989-12-22 2004-01-27 Hoffmann-La Roche Inc. Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
US5136025A (en) * 1990-04-04 1992-08-04 California Biotechnology Inc. Method to purify basic fibroblast growth factor
US5594115A (en) * 1990-04-09 1997-01-14 Pharmacia & Upjohn Company Process of purifying recombinant proteins and compounds useful in such process
JP3346563B2 (ja) * 1990-04-09 2002-11-18 ファルマシア・アンド・アップジョン・カンパニー 組換え蛋白類を精製する改良方法および該方法で有用な化合物類
US5972337A (en) * 1990-11-01 1999-10-26 Cancer Research Fund Of Contra Costa 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein
CZ109393A3 (en) * 1990-12-13 1994-01-19 Upjohn Co Bonded proteins
AU1332992A (en) * 1991-01-25 1992-08-27 Sloan-Kettering Institute For Cancer Research Antigen recognized by patients with antibody associated cerebellar degeneration, dna encoding same and uses thereof
US5439829A (en) * 1991-01-30 1995-08-08 Eli Lilly And Company Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion
EP0875578A3 (en) * 1991-03-19 1999-05-12 Eli Lilly And Company Penicillin binding protein 2A from staphylococcus aureus strain 27R and derivatives for use in purification therefor and assay for compounds effective against methicillin resistant organisms
US6602861B1 (en) * 1992-04-16 2003-08-05 Research Corporation Technologies, Inc. Acylated phospholipid drugs
EP0583894A3 (en) * 1992-07-29 1995-09-06 Hybritech Inc Method of immobilizing and orienting molecules by use of metal chelating moieties to facilitate atomic force microscopy of proteins and molecular scale manipulation
US7105159B1 (en) 1992-11-05 2006-09-12 Sloan-Kettering Institute For Cancer Research Antibodies to prostate-specific membrane antigen
US7070782B1 (en) * 1992-11-05 2006-07-04 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
US6569432B1 (en) * 1995-02-24 2003-05-27 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
SE9303822D0 (sv) * 1993-11-18 1993-11-18 Kabi Pharmacia Ab Method for purification
US5449758A (en) * 1993-12-02 1995-09-12 Life Technologies, Inc. Protein size marker ladder
DE4433980C2 (de) * 1994-09-23 1996-08-22 Boehringer Ingelheim Int Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
US5837520A (en) * 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
US20040253246A1 (en) * 1996-02-23 2004-12-16 Israeli Ron S. Prostate-specific membrane antigen and uses thereof
ES2108652B1 (es) * 1996-04-19 1998-07-16 Antibioticos Sa Un procedimiento para modificar la enzima 7/3-(4-carboxibutanamido) cefalosporinacilasa y purificarla en un solo paso cromatografico.
DK0821006T3 (da) 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
US6071724A (en) * 1996-12-13 2000-06-06 Eli Lilly And Company Streptococcus pneumoniaegene sequence era
US6544769B1 (en) * 1996-12-13 2003-04-08 Schering Corporation Compostions comprising viruses and methods for concentrating virus preparations
US20080261289A1 (en) * 1996-12-13 2008-10-23 Schering-Plough Corporation Compositions comprising viruses and methods for concentrating virus preparations
US6261823B1 (en) 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
ATE397061T1 (de) * 1997-01-08 2008-06-15 Invitrogen Corp Verfahren zur herstellung von proteinen
US5932102A (en) * 1998-01-12 1999-08-03 Schering Corporation Immobilized metal, affinity chromatography
US7026456B1 (en) * 1998-01-23 2006-04-11 Hoffman-La Roche, Inc. Antibodies against human IL-12
US6008329A (en) * 1998-03-06 1999-12-28 The United States Of America As Represented By The Secretary Of The Army Method for purifying cholera toxin
AU4187799A (en) * 1998-05-14 1999-11-29 Clontech Laboratories, Inc. Compositions and methods for protein purification based on metal ion affinity site
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
US7176298B2 (en) 1998-09-25 2007-02-13 Clontech Laboratories, Inc. Polynucleotides encoding metal ion affinity peptides and related products
US6475743B1 (en) 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US7297544B2 (en) * 1998-10-02 2007-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20050142613A1 (en) * 1998-10-02 2005-06-30 David Bar-Or Test for the rapid evaluation of ischemic states and kits
US7449338B2 (en) * 1998-10-02 2008-11-11 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20030215359A1 (en) * 1998-10-02 2003-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US7070937B1 (en) 1998-10-02 2006-07-04 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US6479300B1 (en) 1999-03-15 2002-11-12 Millipore Corporation Metal loaded ligand bound membranes for metal ion affinity chromatography
US6379903B1 (en) * 1999-10-08 2002-04-30 Sigma-Aldrich Co. Purification of recombinant proteins fused to multiple epitopes
CA2386626A1 (en) * 1999-10-15 2001-04-26 Richard Murphy Targeted vectors
US6521111B1 (en) 2000-04-10 2003-02-18 Invitrogen Corporation Methods and articles for labeling polymer gels
US6623655B1 (en) 2000-04-24 2003-09-23 Sigma-Aldrich Co. Metal chelating compositions
ATE360035T1 (de) * 2000-08-11 2007-05-15 Univ Ruprecht Karls Heidelberg Fv-konstrukte mit beeinflussbarer affinitat zu einer zu bindenden substanz
DE10040179A1 (de) * 2000-08-17 2002-02-28 Ipk Inst Fuer Pflanzengenetik Beeinflussung der Verteilung von Metallen in transgenen Pflanzen
US20040180415A1 (en) * 2001-05-15 2004-09-16 Tchaga Grigoriy S. Methods and compositions for protein purification
AU2002315414B2 (en) 2001-06-21 2008-02-07 Clontech Laboratories, Inc. Water-soluble polymeric metal ion affinity compositions and methods for using the same
US6902914B2 (en) * 2001-09-28 2005-06-07 Sigma-Aldrich, Co. Recombinant DNA processes using a dNTP mixture containing modified nucleotides
US7799561B2 (en) * 2002-06-12 2010-09-21 Sigma-Aldrich, Co. Affinity peptides and method for purification of recombinant proteins
US8025873B2 (en) * 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8029803B2 (en) 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
SG159387A1 (en) * 2002-11-26 2010-03-30 Biocon Ltd In Modified natriuretic compounds, conjugates, and uses thereof
ITMI20030755A1 (it) * 2003-04-11 2004-10-12 Bottega Verde S R L Peptidi e loro derivati quali inibitori di fenomeni degradativi e composizioni contenenti gli stessi.
JP4078247B2 (ja) * 2003-05-02 2008-04-23 キヤノン株式会社 磁性体−生体物質複合体型構造体、磁性体に対して結合能を有するアミノ酸配列を有するペプチド断片及びその遺伝子、ならびに磁性体−生体物質複合体型構造体の製造方法
US20040259162A1 (en) * 2003-05-02 2004-12-23 Sigma-Aldrich Co. Solid phase cell lysis and capture platform
US20040224425A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Biomolecule open channel solid phase extraction systems and methods
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US7187286B2 (en) 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
WO2006026248A1 (en) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
WO2006042263A2 (en) * 2004-10-12 2006-04-20 Clontech Laboratories, Inc. Phosphoprotein affinity resins and methods for making and using the same
EP1831241A2 (en) * 2004-11-24 2007-09-12 AplaGen GmbH Method for solid-phase peptide synthesis and purification
EP2290088A1 (en) 2004-12-22 2011-03-02 Genentech, Inc. Methods for producing soluble multi-menbrane-spanning proteins
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
JP2006239661A (ja) * 2005-03-07 2006-09-14 Pentax Corp 吸着剤、吸着剤の製造方法、吸着装置および吸着装置の製造方法
US7229769B2 (en) * 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US7741053B2 (en) * 2005-05-13 2010-06-22 Sigma-Aldrich Co. Processes for purification of recombinant proteins
US7265213B2 (en) * 2005-07-28 2007-09-04 Kpl, Inc. Methodology of conjugating chelators to biomolecules
BRPI0617330A2 (pt) * 2005-10-13 2011-07-19 Virexx Medical Corp antìgeno quimérico contendo polipeptìdeo do vìrus da hepatite c e fragmento fc para despertar uma resposta imunológica
RU2008136046A (ru) * 2006-02-08 2010-03-20 Юсв Лимитед (In) Аффинный полипептид для очистки рекомбинантных белков
GB0604187D0 (en) * 2006-03-02 2006-04-12 Fusion Antibodies Ltd Peptide and uses thereof
WO2007120999A2 (en) * 2006-03-06 2007-10-25 Bio-Rad Laboratories, Inc. Chelating monomers and polymers
EP1878739A1 (en) * 2006-07-14 2008-01-16 LEK Pharmaceuticals D.D. One step IMAC (MCAC) purification of proteins
US20110053225A1 (en) * 2008-01-24 2011-03-03 Ge Healthcare Bio-Sciences Ab Multifunctional tags
JP5265762B2 (ja) 2008-05-13 2013-08-14 ユニバーシティ・オブ・カンザス 金属抽出ペプチド(map)タグおよび関連する方法
CN102482329B (zh) 2009-07-24 2017-11-14 免疫设计公司 用辛德毕斯病毒包膜糖蛋白假型化的慢病毒载体
EP2675473A1 (en) 2011-02-15 2013-12-25 Immune Design Corp. Methods for enhancing immunogen specific immune responses by vectored vaccines
MX350795B (es) 2011-04-08 2017-09-19 Inmune Design Corp Composiciones inmunogenicas y metodos para utilizar las composiciones para inducir respuestas inmunes humorales y celulares.
WO2013067448A2 (en) 2011-11-03 2013-05-10 Vca Antech Inc. Compositions and methods to detect various infectious organisms
ES2707288T3 (es) 2012-03-30 2019-04-03 Immune Design Corp Partículas de vectores lentivíricos que tienen eficiencia de transducción mejorada para células que expresan DC-SIGN
HU230585B1 (hu) 2012-05-30 2017-01-30 Budapesti Műszaki és Gazdaságtudományi Egyetem Fehérjék megkötésére és elválasztására alkalmas lantanida fémionokkal komplexált hordozók
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
AU2015218365A1 (en) 2014-02-14 2016-09-01 Immune Design Corp. Immunotherapy of cancer through combination of local and systemic immune stimulation
EP3169352A1 (en) 2014-07-15 2017-05-24 Immune Design Corp. Prime-boost regimens with a tlr4 agonist adjuvant and a lentiviral vector
AU2016354102B2 (en) 2015-11-09 2022-05-12 Immune Design Corp. A retroviral vector for the administration and expression of replicon RNA expressing heterologous nucleic acids
CN108350037A (zh) 2015-11-09 2018-07-31 免疫设计股份有限公司 包含表达il-12的慢病毒载体的组合物及其使用方法
JP7317026B2 (ja) 2018-01-30 2023-07-28 ライフ テクノロジーズ コーポレーション スマート分子分析システムのワークフローにおける使用のための機器、デバイス、および消耗品
CN114072177A (zh) * 2019-06-18 2022-02-18 马克思—普朗克科学促进协会公司 标记物和/或载体与靶分子例如带His-标签的蛋白质通过金属配合物试剂的位点特异性动力学惰性缀合
MX2022008772A (es) 2020-01-14 2022-10-07 Synthekine Inc Ortologos de il2 y metodos de uso.
JP2023536654A (ja) 2020-08-05 2023-08-28 シンセカイン インコーポレイテッド IL10Ra結合分子および使用方法
US20230272090A1 (en) 2020-08-05 2023-08-31 Sandro Vivona Il2rb binding molecules and methods of use
US20230272089A1 (en) 2020-08-05 2023-08-31 Synthekine, Inc Il2rg binding molecules and methods of use
AU2021322238A1 (en) 2020-08-05 2023-03-23 Synthekine, Inc. Compositions and methods related to IL27 receptor binding
EP4274616A2 (en) 2021-01-11 2023-11-15 Synthekine, Inc. Compositions and methods related to receptor pairing

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1048150B (it) * 1973-10-31 1980-11-20 O T I Officina Terapeutica Ita Metodo per l isolamento delle transferine da materiali biologici
US4172072A (en) * 1977-10-20 1979-10-23 Ashmead H H Buffered enzymatically produced metal proteinates
US4216143A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble non-ferrous metal proteinates
US4216144A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
JPS5562902A (en) * 1978-11-07 1980-05-12 Toray Ind Inc Separation of endotoxin
JPS55148098A (en) * 1979-05-10 1980-11-18 Toray Ind Inc Concentration and purification of interferon
JPS5835157A (ja) * 1981-08-24 1983-03-01 Otsuka Pharmaceut Co Ltd ヒトリムホブラストイドインターフェロンのn末端ペプチド
US4431546A (en) * 1981-04-27 1984-02-14 The Public Health Laboratory Services Board Affinity chromatography using metal ions
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
JPS59130254A (ja) * 1982-10-18 1984-07-26 Mitsubishi Chem Ind Ltd ポリペプチド
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
GB8308483D0 (en) * 1983-03-28 1983-05-05 Health Lab Service Board Secretion of gene products
GB8311136D0 (en) * 1983-04-25 1983-06-02 Lepetit Spa Immobilised oligopeptides
JPS59206342A (ja) * 1983-05-10 1984-11-22 Mitsubishi Chem Ind Ltd ペプチド類

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US4569794A (en) 1986-02-11
IE58501B1 (en) 1993-10-06
AU5024085A (en) 1986-06-12
IE852913L (en) 1986-06-05
EP0184355A3 (en) 1987-04-08
HUT39462A (en) 1986-09-29
JPH0788400B2 (ja) 1995-09-27
DK171917B1 (da) 1997-08-11
DE3585147D1 (de) 1992-02-20
EP0184355A2 (en) 1986-06-11
IL77104A0 (en) 1986-04-29
SG25792G (en) 1992-05-15
HK39192A (en) 1992-06-04
CA1252948A (en) 1989-04-18
IL77104A (en) 1990-03-19
HU208025B (en) 1993-07-28
DK535285A (da) 1986-06-06
AU588840B2 (en) 1989-09-28
EP0184355B1 (en) 1992-01-08
JPS61148197A (ja) 1986-07-05

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