DK528075A - - Google Patents

Info

Publication number
DK528075A
DK528075A DK528075A DK528075A DK528075A DK 528075 A DK528075 A DK 528075A DK 528075 A DK528075 A DK 528075A DK 528075 A DK528075 A DK 528075A DK 528075 A DK528075 A DK 528075A
Authority
DK
Denmark
Application number
DK528075A
Other languages
Danish (da)
Other versions
DK138663B (da
DK138663C (US20020128544A1-20020912-P00008.png
Inventor
J S Kahan
F M Kahan
E O Stapley
R T Goegelman
S Hernandez
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority to DK544975A priority Critical patent/DK140344C/da
Publication of DK528075A publication Critical patent/DK528075A/da
Publication of DK138663B publication Critical patent/DK138663B/da
Application granted granted Critical
Publication of DK138663C publication Critical patent/DK138663C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK528075AA 1974-11-25 1975-11-24 Fremgangsmåde til fremstilling af et antibiotisk stof, thienamycin. DK138663B (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK544975A DK140344C (da) 1974-12-19 1975-12-03 Fremgangsmaade til fremstilling af et antibiotisk stof thienamycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/526,992 US3950357A (en) 1974-11-25 1974-11-25 Antibiotics

Publications (3)

Publication Number Publication Date
DK528075A true DK528075A (US20020128544A1-20020912-P00008.png) 1976-05-26
DK138663B DK138663B (da) 1978-10-09
DK138663C DK138663C (US20020128544A1-20020912-P00008.png) 1979-04-02

Family

ID=24099662

Family Applications (1)

Application Number Title Priority Date Filing Date
DK528075AA DK138663B (da) 1974-11-25 1975-11-24 Fremgangsmåde til fremstilling af et antibiotisk stof, thienamycin.

Country Status (35)

Country Link
US (1) US3950357A (US20020128544A1-20020912-P00008.png)
JP (1) JPS5839519B2 (US20020128544A1-20020912-P00008.png)
AR (1) AR211109A1 (US20020128544A1-20020912-P00008.png)
AT (1) AT341664B (US20020128544A1-20020912-P00008.png)
BE (1) BE835859A (US20020128544A1-20020912-P00008.png)
BG (1) BG27916A3 (US20020128544A1-20020912-P00008.png)
CA (1) CA1058104A (US20020128544A1-20020912-P00008.png)
CH (1) CH622825A5 (US20020128544A1-20020912-P00008.png)
CS (1) CS183829B2 (US20020128544A1-20020912-P00008.png)
CY (1) CY1092A (US20020128544A1-20020912-P00008.png)
DD (1) DD122103A5 (US20020128544A1-20020912-P00008.png)
DE (1) DE2552638C3 (US20020128544A1-20020912-P00008.png)
DK (1) DK138663B (US20020128544A1-20020912-P00008.png)
EG (1) EG11963A (US20020128544A1-20020912-P00008.png)
ES (1) ES442920A1 (US20020128544A1-20020912-P00008.png)
FI (1) FI53718C (US20020128544A1-20020912-P00008.png)
FR (1) FR2291748A1 (US20020128544A1-20020912-P00008.png)
GB (1) GB1498087A (US20020128544A1-20020912-P00008.png)
HK (1) HK60480A (US20020128544A1-20020912-P00008.png)
HU (1) HU178052B (US20020128544A1-20020912-P00008.png)
IE (1) IE42067B1 (US20020128544A1-20020912-P00008.png)
IL (1) IL48521A (US20020128544A1-20020912-P00008.png)
KE (1) KE3094A (US20020128544A1-20020912-P00008.png)
LU (1) LU73860A1 (US20020128544A1-20020912-P00008.png)
MY (1) MY8100228A (US20020128544A1-20020912-P00008.png)
NL (1) NL182008C (US20020128544A1-20020912-P00008.png)
NO (1) NO142227C (US20020128544A1-20020912-P00008.png)
NZ (1) NZ179332A (US20020128544A1-20020912-P00008.png)
PH (1) PH10809A (US20020128544A1-20020912-P00008.png)
PL (1) PL96314B1 (US20020128544A1-20020912-P00008.png)
RO (1) RO70072A (US20020128544A1-20020912-P00008.png)
SE (1) SE431348B (US20020128544A1-20020912-P00008.png)
SU (1) SU576967A3 (US20020128544A1-20020912-P00008.png)
YU (1) YU36991B (US20020128544A1-20020912-P00008.png)
ZA (1) ZA757366B (US20020128544A1-20020912-P00008.png)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467413A (en) * 1974-03-28 1977-03-16 Beecham Group Ltd Antibiotics
US4181716A (en) * 1974-03-28 1980-01-01 Beecham Group Limited Antibiotics
US4172129A (en) * 1974-03-28 1979-10-23 Beecham Group Limited Antibiotics
US4189473A (en) * 1974-03-28 1980-02-19 Beecham Group Limited Antibiotic MM 13902
US4146610A (en) * 1974-03-28 1979-03-27 Beecham Group Limited Antibiotics mm13902
US4206202A (en) * 1974-03-28 1980-06-03 Beecham Group Limited Antibiotics
US4113856A (en) * 1974-03-28 1978-09-12 Beecham Group Limited Antibiotic mm 13902
US4006060A (en) * 1974-11-25 1977-02-01 Merck & Co., Inc. Thienamycin production
US4304867A (en) * 1974-11-25 1981-12-08 Merck & Co., Inc. Culture of Streptomyces cattleya
US4000161A (en) * 1974-12-19 1976-12-28 Merck & Co., Inc. Process for purifying thienamycin
US4179498A (en) * 1975-03-15 1979-12-18 Beecham Group Limited Streptomycetal antibiotic
US4162304A (en) * 1975-03-15 1979-07-24 Beecham Group Limited Streptomycetal antibiotic
US4163051A (en) * 1975-03-15 1979-07-31 Beecham Group Limited Streptomycetal antibiotic
AU512383B2 (en) * 1975-11-21 1980-10-09 Merck & Co., Inc. Thinenamycin derivatives
US4208330A (en) * 1975-11-21 1980-06-17 Merck & Co., Inc. O-Derivatives of thienamycin
US4235920A (en) * 1975-11-21 1980-11-25 Merck & Co., Inc. N-Alkylated derivatives of thienamycin
US4181733A (en) * 1975-11-21 1980-01-01 Merck & Co., Inc. Carboxyl derivatives of thienamycin
FR2332014A1 (fr) * 1975-11-21 1977-06-17 Merck & Co Inc Derives n-alcoyles de thienamycine utiles en tant qu'antibiotiques
US4839352A (en) * 1975-11-21 1989-06-13 Merck & Co., Inc. N-acyl derivatives of thienamycin
US4162324A (en) * 1975-11-21 1979-07-24 Merck & Co., Inc. Antibiotics 890A1 and 890A3
US4165379A (en) * 1975-11-21 1979-08-21 Merck & Co., Inc. N-acetyl thienamycin
CH633554A5 (en) * 1975-11-21 1982-12-15 Merck & Co Inc Process for the preparation of novel thienamycin derivatives.
US4282322A (en) * 1975-11-24 1981-08-04 Merck & Co., Inc. Process for enzymatic deacylation of antibiotics
US4196211A (en) * 1976-03-22 1980-04-01 Merck & Co., Inc. 6-(α-Hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and derivatives thereof
DK145504C (da) * 1976-04-28 1983-04-25 Merck & Co Inc Fremgangsmaade til fremstilling af det antibiotiske stof 890a2og/eller det antibiotiske stof 890a5 og farmaceutisk acceptable salte deraf
GB1577725A (en) * 1976-06-30 1980-10-29 Beecham Group Ltd Azetidinone derivatives
US4172144A (en) * 1976-10-18 1979-10-23 Merck & Co., Inc. Schiff's base derivatives of thienamycin
US4146633A (en) * 1976-11-19 1979-03-27 Merck & Co., Inc. Δ3 -Thienamycin
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
US5055573A (en) * 1976-11-19 1991-10-08 Merck & Co., Inc. Process for preparing 1-carba-2-penem-3-carboxylic acid
US4234596A (en) * 1976-11-19 1980-11-18 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4210661A (en) * 1977-01-27 1980-07-01 Beecham Group Limited Synthetic β-lactam compounds, a process for their preparation and compositions containing them
US4168268A (en) * 1977-03-01 1979-09-18 Merck & Co., Inc. Process for isolating thienamycin
GR62185B (en) * 1977-03-31 1979-03-02 Panlabs Inc Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
GB1584762A (en) * 1977-04-01 1981-02-18 Beecham Group Ltd Azabicycloheptenes
NL7802826A (nl) * 1977-04-08 1978-10-10 Merck & Co Inc Thienamycinederivaat, werkwijze voor het bereiden daarvan, alsmede farmaceutische preparaten.
US4162323A (en) * 1977-04-18 1979-07-24 Merck & Co., Inc. Antibiotic N-acetyl-dehydro-thienamycin
US4235917A (en) * 1977-05-05 1980-11-25 Merck & Co., Inc. N-Alkyl-N-acyl derivatives of thienamycin
SE436569B (sv) * 1977-05-05 1985-01-07 Merck & Co Inc Analogiforfarande for framstellning av tienamycinderivat
DE2724560A1 (de) * 1977-05-31 1978-12-21 Merck & Co Inc O-derivate von thienamycin
US4123547A (en) * 1977-08-04 1978-10-31 Merck & Co., Inc. Thienamycin sulfoxide and sulphone
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
US4135978A (en) * 1977-08-19 1979-01-23 Merck & Co., Inc. Production of n-acyl-thienamycins
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
US4150145A (en) * 1977-09-15 1979-04-17 Merck & Co., Inc. N-alkylated derivatives of thienamycin sulfoxide and sulfone
AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4218463A (en) * 1977-12-28 1980-08-19 Merck & Co., Inc. 3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4172895A (en) * 1977-12-28 1979-10-30 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-oxapen-2-em-3-carboxylic acid
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
US4198338A (en) * 1978-03-13 1980-04-15 Merck & Co., Inc. Process for purifying thienamycin
US4203902A (en) * 1978-04-21 1980-05-20 Merck & Co., Inc. Process for preparing 6- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
SE7805032L (sv) * 1978-05-03 1979-11-03 Merck & Co Inc Karboxylsyror och derivat derav
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
NZ190994A (en) * 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
US4212807A (en) * 1978-08-10 1980-07-15 Merck & Co., Inc. Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids
US4275207A (en) * 1978-08-14 1981-06-23 Merck & Co., Inc. Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor
US4232036A (en) * 1978-10-24 1980-11-04 Merck & Co., Inc. 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4208422A (en) * 1978-10-24 1980-06-17 Merck & Co., Inc. 1-Substituted-pen-2-em-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4218462A (en) * 1978-10-24 1980-08-19 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1-substituted-1-carbade-thiapen-2-em-3-carboxylic acids
US4206219A (en) * 1978-10-24 1980-06-03 Merck & Co., Inc. 6- and 1-Substituted-1-carbadethiapen-2-em-3-carboxylic acid
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
US4264621A (en) * 1979-07-06 1981-04-28 Merck & Co., Inc. 5-Substituted-3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4247640A (en) * 1979-07-23 1981-01-27 Merck & Co., Inc. Fermentation process for 6-hydroxymethyl-2-(2-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid
JPS5622782A (en) 1979-08-03 1981-03-03 Kyowa Hakko Kogyo Co Ltd Dc-38-v and its preparation
US4378314A (en) * 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4374065A (en) * 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
GR72296B (US20020128544A1-20020912-P00008.png) * 1979-12-03 1983-10-18 Merck & Co Inc
US4262010A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids
JPS56148297A (en) * 1980-04-17 1981-11-17 Shionogi & Co Ltd Novel preparation of thienamycin
US4357342A (en) * 1980-05-02 1982-11-02 Merck & Co., Inc. 1-Azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid
US4426390A (en) 1980-10-01 1984-01-17 Sanraku-Ocean Co., Ltd. Novel β-lactam compounds, process for producing thereof, and use thereof as medicines
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
US4508826A (en) * 1982-04-15 1985-04-02 Merck & Co., Inc. Bacteriophage DNA cloning vector TG1 and microorganisms containing TG1
US4460689A (en) * 1982-04-15 1984-07-17 Merck & Co., Inc. DNA Cloning vector TG1, derivatives, and processes of making
US4544557A (en) * 1982-07-29 1985-10-01 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-3-tetrazoly-1-carbadethiapen-2-em
CA1220215A (en) * 1983-03-07 1987-04-07 Yasutsugu Ueda Carbapenem intermediates
US5310897A (en) * 1984-12-27 1994-05-10 Sumitomo Pharmaceuticals Co., Ltd. Beta-lactams and their production
US5104984A (en) * 1985-03-29 1992-04-14 Merck & Co., Inc. Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates
CA1276156C (en) 1985-03-29 1990-11-13 Thomas N. Salzmann Enantioselective process for producing 1-beta- methylcarbapenem antibiotic intermediates
US4782051A (en) * 1985-06-10 1988-11-01 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
US4892869A (en) * 1985-06-10 1990-01-09 Merck & Co., Inc. 2-aza substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4833167A (en) * 1985-06-10 1989-05-23 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US4783453A (en) * 1985-06-10 1988-11-08 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
ATE109764T1 (de) * 1985-12-28 1994-08-15 Sumitomo Pharma Beta-lactamverbindungen und deren herstellung.
US5021566A (en) * 1989-03-06 1991-06-04 Merck & Co. Inc. 6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2-en-7-one-2-carboxylic acids
US5672701A (en) * 1990-01-16 1997-09-30 Bristol-Myers Squibb Company 4-substituted alkyl carbapenem antibiotics
IE910606A1 (en) * 1990-02-23 1991-08-28 Sankyo Co Carbapenem derivatives having antibiotic activity, their¹preparation and their use
US5241073A (en) * 1990-10-12 1993-08-31 Lederle (Japan) Process for preparing (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate and starting materials thereof
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
EP1113016A4 (en) 1998-09-10 2001-12-12 Wyeth Lederle Japan Ltd CARBAPENEM COMPOUNDS
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
EP1470241A2 (en) * 2002-01-24 2004-10-27 Ecopia Biosciences Inc. Method, system and knowledge repository for identifying a secondary metabolite from a microorganism
US7632828B2 (en) 2004-06-10 2009-12-15 Fob Synthesis, Inc. Gram-positive carbapenem antibacterials and processes for their preparation
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20070034513A1 (en) * 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US8855955B2 (en) * 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US20110046101A1 (en) * 2008-03-17 2011-02-24 Dmitrienko Gary I Bate-lactamase inhibitors
EP2376619A4 (en) 2008-12-15 2012-07-04 Greenlight Biosciences Inc METHODS FOR CONTROLLING FLOWS IN METABOLIC PATHWAYS
CN102333878B (zh) * 2008-12-22 2015-08-26 绿光生物科学公司 用于制造化合物的组合物和方法
WO2011090793A2 (en) 2010-01-20 2011-07-28 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
JP2013526277A (ja) 2010-05-07 2013-06-24 グリーンライト バイオサイエンシーズ インコーポレーテッド 酵素リロケーションにより代謝経路のフラックスを制御する方法
EP2590978B1 (en) 2010-06-18 2017-09-20 FOB Synthesis, Inc. Carbapenem antibacterials with gram-negative activity
EP3219796B1 (en) 2010-08-31 2020-10-07 GreenLight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
CA2846893A1 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
US9688977B2 (en) 2013-08-05 2017-06-27 Greenlight Biosciences, Inc. Engineered phosphoglucose isomerase proteins with a protease cleavage site
MY193444A (en) 2015-03-30 2022-10-13 Greenlight Biosciences Inc Cell-free production of ribonucleic acid
CR20180525A (es) 2016-04-06 2019-02-14 Greenlight Biosciences Inc Producción de ácido ribonucleico libre de células
JP7326164B2 (ja) 2017-06-09 2023-08-15 フオブ・シンセシス・インコーポレーテツド 細菌感染治療のためのカルバペネム化合物及び組成物
KR102571743B1 (ko) 2017-10-11 2023-08-29 그린라이트 바이오사이언시스, 아이엔씨. 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물

Also Published As

Publication number Publication date
NL7513686A (nl) 1976-05-28
DE2552638A1 (de) 1976-05-26
SE7513175L (sv) 1976-05-26
DD122103A5 (US20020128544A1-20020912-P00008.png) 1976-09-12
KE3094A (en) 1981-02-13
MY8100228A (en) 1981-12-31
NO142227B (no) 1980-04-08
FR2291748A1 (fr) 1976-06-18
EG11963A (en) 1978-06-30
IL48521A0 (en) 1976-01-30
PH10809A (en) 1977-09-07
CY1092A (en) 1980-12-27
FI53718C (fi) 1978-07-10
NO142227C (no) 1980-07-16
DK138663B (da) 1978-10-09
ATA891875A (de) 1977-06-15
NZ179332A (en) 1981-04-24
FI753305A (US20020128544A1-20020912-P00008.png) 1976-05-26
NL182008B (nl) 1987-07-16
AR211109A1 (es) 1977-10-31
ZA757366B (en) 1977-07-27
PL96314B1 (pl) 1977-12-31
AU8690675A (en) 1977-06-02
ES442920A1 (es) 1977-10-01
NO753944L (US20020128544A1-20020912-P00008.png) 1976-05-26
FI53718B (US20020128544A1-20020912-P00008.png) 1978-03-31
BE835859A (fr) 1976-05-24
DK138663C (US20020128544A1-20020912-P00008.png) 1979-04-02
JPS5839519B2 (ja) 1983-08-30
GB1498087A (en) 1978-01-18
RO70072A (ro) 1980-10-30
CS183829B2 (en) 1978-07-31
CH622825A5 (US20020128544A1-20020912-P00008.png) 1981-04-30
YU36991B (en) 1984-08-31
HK60480A (en) 1980-11-07
US3950357A (en) 1976-04-13
SE431348B (sv) 1984-01-30
IE42067B1 (en) 1980-05-21
IL48521A (en) 1979-01-31
DE2552638B2 (de) 1979-05-23
FR2291748B1 (US20020128544A1-20020912-P00008.png) 1980-06-20
BG27916A3 (en) 1980-01-15
AT341664B (de) 1978-02-27
HU178052B (en) 1982-02-28
DE2552638C3 (de) 1980-01-31
IE42067L (en) 1976-05-25
NL182008C (nl) 1987-12-16
CA1058104A (en) 1979-07-10
JPS5173191A (US20020128544A1-20020912-P00008.png) 1976-06-24
SU576967A3 (ru) 1977-10-15
YU297775A (en) 1982-02-25
LU73860A1 (US20020128544A1-20020912-P00008.png) 1976-09-06

Similar Documents

Publication Publication Date Title
NO753944L (US20020128544A1-20020912-P00008.png)
JPS5149174A (US20020128544A1-20020912-P00008.png)
FI752588A (US20020128544A1-20020912-P00008.png)
JPS50136368A (US20020128544A1-20020912-P00008.png)
FR2288889B1 (US20020128544A1-20020912-P00008.png)
JPS50109933U (US20020128544A1-20020912-P00008.png)
JPS50116067U (US20020128544A1-20020912-P00008.png)
JPS50106793A (US20020128544A1-20020912-P00008.png)
JPS50125049U (US20020128544A1-20020912-P00008.png)
FI740356A0 (US20020128544A1-20020912-P00008.png)
JPS50127711A (US20020128544A1-20020912-P00008.png)
JPS50106488A (US20020128544A1-20020912-P00008.png)
JPS50101140A (US20020128544A1-20020912-P00008.png)
AR198841Q (US20020128544A1-20020912-P00008.png)
NO751097L (US20020128544A1-20020912-P00008.png)
CH577817A5 (US20020128544A1-20020912-P00008.png)
CH573156A5 (US20020128544A1-20020912-P00008.png)
AU479634A (US20020128544A1-20020912-P00008.png)
AU480540A (US20020128544A1-20020912-P00008.png)
AU480977A (US20020128544A1-20020912-P00008.png)
DD109326A1 (US20020128544A1-20020912-P00008.png)
CH578234A5 (US20020128544A1-20020912-P00008.png)
CH577886A5 (US20020128544A1-20020912-P00008.png)
BG19903A1 (US20020128544A1-20020912-P00008.png)
CH576647A5 (US20020128544A1-20020912-P00008.png)

Legal Events

Date Code Title Description
PBP Patent lapsed