FR2332014A1 - Derives n-alcoyles de thienamycine utiles en tant qu'antibiotiques - Google Patents

Derives n-alcoyles de thienamycine utiles en tant qu'antibiotiques

Info

Publication number
FR2332014A1
FR2332014A1 FR7634884A FR7634884A FR2332014A1 FR 2332014 A1 FR2332014 A1 FR 2332014A1 FR 7634884 A FR7634884 A FR 7634884A FR 7634884 A FR7634884 A FR 7634884A FR 2332014 A1 FR2332014 A1 FR 2332014A1
Authority
FR
France
Prior art keywords
thienamycin
antibiotics
alkyl derivatives
derivatives useful
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7634884A
Other languages
English (en)
Other versions
FR2332014B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2332014A1 publication Critical patent/FR2332014A1/fr
Application granted granted Critical
Publication of FR2332014B1 publication Critical patent/FR2332014B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR7634884A 1975-11-21 1976-11-19 Derives n-alcoyles de thienamycine utiles en tant qu'antibiotiques Granted FR2332014A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63429775A 1975-11-21 1975-11-21

Publications (2)

Publication Number Publication Date
FR2332014A1 true FR2332014A1 (fr) 1977-06-17
FR2332014B1 FR2332014B1 (fr) 1978-11-10

Family

ID=24543224

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7634884A Granted FR2332014A1 (fr) 1975-11-21 1976-11-19 Derives n-alcoyles de thienamycine utiles en tant qu'antibiotiques

Country Status (8)

Country Link
JP (1) JPS5277085A (fr)
CH (1) CH628051A5 (fr)
DE (1) DE2652676A1 (fr)
DK (1) DK523676A (fr)
FR (1) FR2332014A1 (fr)
GB (1) GB1570988A (fr)
NL (1) NL7612937A (fr)
SE (1) SE7612964L (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
EP0008888B1 (fr) * 1978-08-23 1983-09-21 Beecham Group Plc Composés bêta-lactames antibactériens, leur préparation et compositions pharmaceutiques les contenant
EP0017992A1 (fr) * 1979-04-19 1980-10-29 Merck & Co. Inc. Acides 1-carbadéthiapén-2-èm-carboxyliques substitués en position 2 et 6, procédés pour les préparer, compositions pharmaceutiques antibiotiques les contenant et procédé pour préparer des intermédiaires
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
ATE10838T1 (de) * 1980-02-28 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. 4-substituierte 2-oxoazetidin-verbindungen, verfahren zu deren herstellung und ihre verwendung zur antibiotika-herstellung.
JPS5798257A (en) * 1980-12-10 1982-06-18 Sankyo Co Ltd 3,4-disubstituted azetidine-2-one compound and its preparation
EP0062407A1 (fr) * 1981-03-10 1982-10-13 Beecham Group Plc Composés thérapeutiques à cycle bête-lactame
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
JPS5910588A (ja) * 1982-06-18 1984-01-20 ブリストル―マイヤーズ　スクイブ　カンパニー カルバペネム抗生物質
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
KR100667373B1 (ko) * 2003-12-09 2007-01-10 주식회사 중외제약 이미페넴의 신규 제조방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
JPS5277085A (en) 1977-06-29
DE2652676A1 (de) 1977-06-02
FR2332014B1 (fr) 1978-11-10
CH628051A5 (en) 1982-02-15
GB1570988A (en) 1980-07-09
DK523676A (da) 1977-05-22
SE7612964L (sv) 1977-05-22
NL7612937A (nl) 1977-05-24

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Legal Events

Date Code Title Description
ST Notification of lapse