HK60480A - Antibiotic azetidinopyrrole derivative - Google Patents

Antibiotic azetidinopyrrole derivative

Info

Publication number
HK60480A
HK60480A HK604/80A HK60480A HK60480A HK 60480 A HK60480 A HK 60480A HK 604/80 A HK604/80 A HK 604/80A HK 60480 A HK60480 A HK 60480A HK 60480 A HK60480 A HK 60480A
Authority
HK
Hong Kong
Prior art keywords
azetidinopyrrole
antibiotic
derivative
azetidinopyrrole derivative
antibiotic azetidinopyrrole
Prior art date
Application number
HK604/80A
Other languages
English (en)
Inventor
F M Kahan
S Hernandez
R T Goegelman
J S Kahan
E O Stapley
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK60480A publication Critical patent/HK60480A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465Streptomyces
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/886Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
HK604/80A 1974-11-25 1980-10-30 Antibiotic azetidinopyrrole derivative HK60480A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/526,992 US3950357A (en) 1974-11-25 1974-11-25 Antibiotics

Publications (1)

Publication Number Publication Date
HK60480A true HK60480A (en) 1980-11-07

Family

ID=24099662

Family Applications (1)

Application Number Title Priority Date Filing Date
HK604/80A HK60480A (en) 1974-11-25 1980-10-30 Antibiotic azetidinopyrrole derivative

Country Status (35)

Country Link
US (1) US3950357A (xx)
JP (1) JPS5839519B2 (xx)
AR (1) AR211109A1 (xx)
AT (1) AT341664B (xx)
BE (1) BE835859A (xx)
BG (1) BG27916A3 (xx)
CA (1) CA1058104A (xx)
CH (1) CH622825A5 (xx)
CS (1) CS183829B2 (xx)
CY (1) CY1092A (xx)
DD (1) DD122103A5 (xx)
DE (1) DE2552638C3 (xx)
DK (1) DK138663B (xx)
EG (1) EG11963A (xx)
ES (1) ES442920A1 (xx)
FI (1) FI53718C (xx)
FR (1) FR2291748A1 (xx)
GB (1) GB1498087A (xx)
HK (1) HK60480A (xx)
HU (1) HU178052B (xx)
IE (1) IE42067B1 (xx)
IL (1) IL48521A (xx)
KE (1) KE3094A (xx)
LU (1) LU73860A1 (xx)
MY (1) MY8100228A (xx)
NL (1) NL182008C (xx)
NO (1) NO142227C (xx)
NZ (1) NZ179332A (xx)
PH (1) PH10809A (xx)
PL (1) PL96314B1 (xx)
RO (1) RO70072A (xx)
SE (1) SE431348B (xx)
SU (1) SU576967A3 (xx)
YU (1) YU36991B (xx)
ZA (1) ZA757366B (xx)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467413A (en) * 1974-03-28 1977-03-16 Beecham Group Ltd Antibiotics
US4113856A (en) * 1974-03-28 1978-09-12 Beecham Group Limited Antibiotic mm 13902
US4189473A (en) * 1974-03-28 1980-02-19 Beecham Group Limited Antibiotic MM 13902
US4172129A (en) * 1974-03-28 1979-10-23 Beecham Group Limited Antibiotics
US4206202A (en) * 1974-03-28 1980-06-03 Beecham Group Limited Antibiotics
US4146610A (en) * 1974-03-28 1979-03-27 Beecham Group Limited Antibiotics mm13902
US4181716A (en) * 1974-03-28 1980-01-01 Beecham Group Limited Antibiotics
US4006060A (en) * 1974-11-25 1977-02-01 Merck & Co., Inc. Thienamycin production
US4304867A (en) * 1974-11-25 1981-12-08 Merck & Co., Inc. Culture of Streptomyces cattleya
US4000161A (en) * 1974-12-19 1976-12-28 Merck & Co., Inc. Process for purifying thienamycin
US4162304A (en) * 1975-03-15 1979-07-24 Beecham Group Limited Streptomycetal antibiotic
US4179498A (en) * 1975-03-15 1979-12-18 Beecham Group Limited Streptomycetal antibiotic
US4163051A (en) * 1975-03-15 1979-07-31 Beecham Group Limited Streptomycetal antibiotic
IL50911A (en) * 1975-11-21 1981-01-30 Merck & Co Inc Substituted n-methylene derivatives of thienamycin
US4839352A (en) * 1975-11-21 1989-06-13 Merck & Co., Inc. N-acyl derivatives of thienamycin
US4162324A (en) * 1975-11-21 1979-07-24 Merck & Co., Inc. Antibiotics 890A1 and 890A3
US4165379A (en) * 1975-11-21 1979-08-21 Merck & Co., Inc. N-acetyl thienamycin
CH633554A5 (en) * 1975-11-21 1982-12-15 Merck & Co Inc Process for the preparation of novel thienamycin derivatives.
US4208330A (en) * 1975-11-21 1980-06-17 Merck & Co., Inc. O-Derivatives of thienamycin
GB1570988A (en) * 1975-11-21 1980-07-09 Merck & Co Inc Antibiotics of the thienamycin class
US4181733A (en) * 1975-11-21 1980-01-01 Merck & Co., Inc. Carboxyl derivatives of thienamycin
US4235920A (en) * 1975-11-21 1980-11-25 Merck & Co., Inc. N-Alkylated derivatives of thienamycin
US4282322A (en) * 1975-11-24 1981-08-04 Merck & Co., Inc. Process for enzymatic deacylation of antibiotics
US4196211A (en) * 1976-03-22 1980-04-01 Merck & Co., Inc. 6-(α-Hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and derivatives thereof
NL7704040A (nl) * 1976-04-28 1977-11-01 Merck & Co Inc Werkwijze voor het bereiden van nieuwe anti- biotica.
GB1577725A (en) * 1976-06-30 1980-10-29 Beecham Group Ltd Azetidinone derivatives
US4172144A (en) * 1976-10-18 1979-10-23 Merck & Co., Inc. Schiff's base derivatives of thienamycin
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
US5055573A (en) * 1976-11-19 1991-10-08 Merck & Co., Inc. Process for preparing 1-carba-2-penem-3-carboxylic acid
US4146633A (en) * 1976-11-19 1979-03-27 Merck & Co., Inc. Δ3 -Thienamycin
US4234596A (en) * 1976-11-19 1980-11-18 Merck & Co., Inc. 3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
US4210661A (en) * 1977-01-27 1980-07-01 Beecham Group Limited Synthetic β-lactam compounds, a process for their preparation and compositions containing them
US4168268A (en) * 1977-03-01 1979-09-18 Merck & Co., Inc. Process for isolating thienamycin
GR62185B (en) * 1977-03-31 1979-03-02 Panlabs Inc Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
GB1584762A (en) * 1977-04-01 1981-02-18 Beecham Group Ltd Azabicycloheptenes
NL7802826A (nl) * 1977-04-08 1978-10-10 Merck & Co Inc Thienamycinederivaat, werkwijze voor het bereiden daarvan, alsmede farmaceutische preparaten.
US4162323A (en) * 1977-04-18 1979-07-24 Merck & Co., Inc. Antibiotic N-acetyl-dehydro-thienamycin
US4235917A (en) * 1977-05-05 1980-11-25 Merck & Co., Inc. N-Alkyl-N-acyl derivatives of thienamycin
DK170778A (da) * 1977-05-05 1979-01-15 Merck & Co Inc Fremgangsmaade til fremstilling af n-alkyl-n-iminomethyl-derivater af thienamycin
DE2724560A1 (de) * 1977-05-31 1978-12-21 Merck & Co Inc O-derivate von thienamycin
US4123547A (en) * 1977-08-04 1978-10-31 Merck & Co., Inc. Thienamycin sulfoxide and sulphone
US4135978A (en) * 1977-08-19 1979-01-23 Merck & Co., Inc. Production of n-acyl-thienamycins
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
US4150145A (en) * 1977-09-15 1979-04-17 Merck & Co., Inc. N-alkylated derivatives of thienamycin sulfoxide and sulfone
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4218463A (en) * 1977-12-28 1980-08-19 Merck & Co., Inc. 3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4172895A (en) * 1977-12-28 1979-10-30 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-oxapen-2-em-3-carboxylic acid
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
US4198338A (en) * 1978-03-13 1980-04-15 Merck & Co., Inc. Process for purifying thienamycin
US4203902A (en) * 1978-04-21 1980-05-20 Merck & Co., Inc. Process for preparing 6- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
SE7805032L (sv) * 1978-05-03 1979-11-03 Merck & Co Inc Karboxylsyror och derivat derav
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors
PH16708A (en) * 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
US4212807A (en) * 1978-08-10 1980-07-15 Merck & Co., Inc. Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids
US4275207A (en) * 1978-08-14 1981-06-23 Merck & Co., Inc. Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor
US4232036A (en) * 1978-10-24 1980-11-04 Merck & Co., Inc. 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4208422A (en) * 1978-10-24 1980-06-17 Merck & Co., Inc. 1-Substituted-pen-2-em-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4218462A (en) * 1978-10-24 1980-08-19 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1-substituted-1-carbade-thiapen-2-em-3-carboxylic acids
US4206219A (en) * 1978-10-24 1980-06-03 Merck & Co., Inc. 6- and 1-Substituted-1-carbadethiapen-2-em-3-carboxylic acid
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
US4376774A (en) * 1979-05-29 1983-03-15 Merck & Co., Inc. Antibiotic N-heterocyclyl thienamycin
US4264621A (en) * 1979-07-06 1981-04-28 Merck & Co., Inc. 5-Substituted-3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4247640A (en) * 1979-07-23 1981-01-27 Merck & Co., Inc. Fermentation process for 6-hydroxymethyl-2-(2-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid
JPS5622782A (en) * 1979-08-03 1981-03-03 Kyowa Hakko Kogyo Co Ltd Dc-38-v and its preparation
US4374065A (en) * 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) * 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
GR72296B (xx) * 1979-12-03 1983-10-18 Merck & Co Inc
US4262010A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids
JPS56148297A (en) * 1980-04-17 1981-11-17 Shionogi & Co Ltd Novel preparation of thienamycin
US4357342A (en) * 1980-05-02 1982-11-02 Merck & Co., Inc. 1-Azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid
US4426390A (en) 1980-10-01 1984-01-17 Sanraku-Ocean Co., Ltd. Novel β-lactam compounds, process for producing thereof, and use thereof as medicines
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
US4508826A (en) * 1982-04-15 1985-04-02 Merck & Co., Inc. Bacteriophage DNA cloning vector TG1 and microorganisms containing TG1
US4460689A (en) * 1982-04-15 1984-07-17 Merck & Co., Inc. DNA Cloning vector TG1, derivatives, and processes of making
US4544557A (en) * 1982-07-29 1985-10-01 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-3-tetrazoly-1-carbadethiapen-2-em
CA1220215A (en) * 1983-03-07 1987-04-07 Yasutsugu Ueda Carbapenem intermediates
US5310897A (en) * 1984-12-27 1994-05-10 Sumitomo Pharmaceuticals Co., Ltd. Beta-lactams and their production
US5104984A (en) * 1985-03-29 1992-04-14 Merck & Co., Inc. Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates
CA1276156C (en) 1985-03-29 1990-11-13 Thomas N. Salzmann Enantioselective process for producing 1-beta- methylcarbapenem antibiotic intermediates
US4833167A (en) * 1985-06-10 1989-05-23 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US4783453A (en) * 1985-06-10 1988-11-08 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids
US4782051A (en) * 1985-06-10 1988-11-01 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
US4892869A (en) * 1985-06-10 1990-01-09 Merck & Co., Inc. 2-aza substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
ES2061439T3 (es) * 1985-12-28 1994-12-16 Sumitomo Pharma Compuesto beta-lactama y su produccion.
US5021566A (en) * 1989-03-06 1991-06-04 Merck & Co. Inc. 6- and 6,6-disubstituted-3-substituted-1-azabicyclo(3.2.0)hept-2-en-7-one-2-carboxylic acids
US5672701A (en) * 1990-01-16 1997-09-30 Bristol-Myers Squibb Company 4-substituted alkyl carbapenem antibiotics
IE910606A1 (en) * 1990-02-23 1991-08-28 Sankyo Co Carbapenem derivatives having antibiotic activity, their¹preparation and their use
US5241073A (en) * 1990-10-12 1993-08-31 Lederle (Japan) Process for preparing (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate and starting materials thereof
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
EP1113016A4 (en) 1998-09-10 2001-12-12 Wyeth Lederle Japan Ltd CARBAPENEM COMPOUNDS
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
CA2414570A1 (en) * 2002-01-24 2003-04-03 Ecopia Biosciences Inc. Method, system, and knowledge repository for identifying a secondary metabolite from a microorganism
CA2569112C (en) 2004-06-10 2016-04-12 Fob Synthesis, Inc. Carbapenem antibacterials with gram-negative activity and processes for their preparation
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US8855955B2 (en) * 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
WO2009114921A1 (en) * 2008-03-17 2009-09-24 Dmitrienko Gary I INHIBITORS OF CLASS B AND CLASS D β-LACTAMASES
WO2010077806A1 (en) 2008-12-15 2010-07-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
CA2749877A1 (en) * 2008-12-22 2010-07-01 Greenlight Biosciences, Inc. Compositions and methods for the production of a compound
WO2011090793A2 (en) 2010-01-20 2011-07-28 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
KR20130071433A (ko) 2010-05-07 2013-06-28 그린라이트 바이오사이언시스, 아이엔씨. 효소의 재배치를 통한 대사 경로에서의 흐름의 제어 방법
KR101862041B1 (ko) 2010-06-18 2018-05-29 포브 신세시스 그람음성 활성을 갖는 카바페넴 항균제
JP6280367B2 (ja) 2010-08-31 2018-02-14 グリーンライト バイオサイエンシーズ インコーポレーテッドGreenlight Biosciences,Inc. プロテアーゼ操作を介した代謝経路におけるフラックスの制御のための方法
CA2846893A1 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
BR112016002494A2 (pt) 2013-08-05 2017-09-05 Greenlight Biosciences Inc Proteí-nas construídas com um sítio de clivagem de protease, ácido nucléico, vetor, célula e processo de engenharia de uma proteína recombinante e de um grande número de variantes de ácidos nucleicos que codificam proteínas recombinantes
MX2017012665A (es) 2015-03-30 2018-04-24 Greenlight Biosciences Inc Produccion de acido ribonucleico libre de celulas.
EP4293104A3 (en) 2016-04-06 2024-04-24 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
CA3066661A1 (en) 2017-06-09 2018-12-13 Fob Synthesis, Inc. Carbapenem compounds and compositions for the treatment of bacterial infections
KR20230130144A (ko) 2017-10-11 2023-09-11 그린라이트 바이오사이언시스, 아이엔씨. 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물

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SU576967A3 (ru) 1977-10-15
DE2552638B2 (de) 1979-05-23
IL48521A (en) 1979-01-31
AT341664B (de) 1978-02-27
JPS5839519B2 (ja) 1983-08-30
NZ179332A (en) 1981-04-24
JPS5173191A (xx) 1976-06-24
NL182008B (nl) 1987-07-16
ATA891875A (de) 1977-06-15
AR211109A1 (es) 1977-10-31
US3950357A (en) 1976-04-13
DK138663B (da) 1978-10-09
CA1058104A (en) 1979-07-10
NL182008C (nl) 1987-12-16
KE3094A (en) 1981-02-13
AU8690675A (en) 1977-06-02
IE42067L (en) 1976-05-25
FR2291748B1 (xx) 1980-06-20
FI53718C (fi) 1978-07-10
SE431348B (sv) 1984-01-30
NO142227B (no) 1980-04-08
YU297775A (en) 1982-02-25
DD122103A5 (xx) 1976-09-12
FI753305A (xx) 1976-05-26
DE2552638C3 (de) 1980-01-31
NL7513686A (nl) 1976-05-28
LU73860A1 (xx) 1976-09-06
ES442920A1 (es) 1977-10-01
ZA757366B (en) 1977-07-27
BE835859A (fr) 1976-05-24
IL48521A0 (en) 1976-01-30
FI53718B (xx) 1978-03-31
FR2291748A1 (fr) 1976-06-18
SE7513175L (sv) 1976-05-26
PL96314B1 (pl) 1977-12-31
HU178052B (en) 1982-02-28
NO753944L (xx) 1976-05-26
NO142227C (no) 1980-07-16
IE42067B1 (en) 1980-05-21
YU36991B (en) 1984-08-31
MY8100228A (en) 1981-12-31
DK528075A (xx) 1976-05-26
CS183829B2 (en) 1978-07-31
DE2552638A1 (de) 1976-05-26
GB1498087A (en) 1978-01-18
RO70072A (ro) 1980-10-30
CY1092A (en) 1980-12-27
EG11963A (en) 1978-06-30
PH10809A (en) 1977-09-07
DK138663C (xx) 1979-04-02
BG27916A3 (en) 1980-01-15
CH622825A5 (xx) 1981-04-30

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