DK389089A - Pyranolderivater - Google Patents

Pyranolderivater Download PDF

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Publication number
DK389089A
DK389089A DK389089A DK389089A DK389089A DK 389089 A DK389089 A DK 389089A DK 389089 A DK389089 A DK 389089A DK 389089 A DK389089 A DK 389089A DK 389089 A DK389089 A DK 389089A
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DK
Denmark
Prior art keywords
pyranol
derivatives
pyranol derivatives
Prior art date
Application number
DK389089A
Other languages
Danish (da)
English (en)
Other versions
DK389089D0 (da
Inventor
Armin Walser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK389089D0 publication Critical patent/DK389089D0/da
Publication of DK389089A publication Critical patent/DK389089A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
DK389089A 1988-08-09 1989-08-08 Pyranolderivater DK389089A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23009488A 1988-08-09 1988-08-09
US07/367,082 US5015661A (en) 1988-08-09 1989-06-16 Chromanes and their pharmaceutical compositions and methods

Publications (2)

Publication Number Publication Date
DK389089D0 DK389089D0 (da) 1989-08-08
DK389089A true DK389089A (da) 1990-02-10

Family

ID=26923917

Family Applications (1)

Application Number Title Priority Date Filing Date
DK389089A DK389089A (da) 1988-08-09 1989-08-08 Pyranolderivater

Country Status (13)

Country Link
US (1) US5015661A (fr)
EP (1) EP0354508A3 (fr)
JP (1) JPH0283379A (fr)
KR (1) KR900003175A (fr)
AU (1) AU616039B2 (fr)
DK (1) DK389089A (fr)
HU (1) HU206204B (fr)
IL (1) IL91245A0 (fr)
MC (1) MC2050A1 (fr)
NO (1) NO172643C (fr)
NZ (1) NZ230233A (fr)
PH (1) PH27235A (fr)
PT (1) PT91400A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1305480C (fr) * 1987-03-20 1992-07-21 Roshantha A.S. Chandraratna Acetylenes disubstitues portant des groupes heteroaromatiques et heterobicycliques a activite retinoidale
FR2676056B1 (fr) * 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5149703A (en) * 1991-09-06 1992-09-22 Merck Frosst Canada, Inc. Quinoline-substituted chromans and related compounds as leukotriene antagonists
US5280040A (en) * 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
DK0682664T3 (da) * 1993-12-08 2001-07-16 Alcon Lab Inc Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler
US5747528A (en) * 1996-02-21 1998-05-05 Warner-Lambert Company Chroman derivatives as anti-oxidants
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
CA2580584C (fr) 2003-09-19 2015-07-28 Galileo Pharmaceuticals, Inc. Utilisation d'alpha-tocotrienol pour le traitement de maladies mitochondriales
CA2589363A1 (fr) 2004-12-13 2006-06-22 Eli Lilly And Company Derives spiro utilises en tant qu'inhibiteurs de lipoxygenase
CA2600004A1 (fr) 2005-02-25 2006-09-08 Eli Lilly And Company Chromans, thiochromans et dihydroquinolines heterocycliques

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
US4681890A (en) * 1984-10-30 1987-07-21 Kuraray Co., Ltd. 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same
DE3484473D1 (de) * 1984-12-06 1991-05-23 Kuraray Co Chroman-verbindungen und deren herstellung.
JPS61148173A (ja) * 1984-12-20 1986-07-05 Kuraray Co Ltd 新規なアミン及びその塩
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
JPS61204122A (ja) * 1985-03-07 1986-09-10 Kuraray Co Ltd 肝臓疾患治療剤
JPS61210030A (ja) * 1985-03-13 1986-09-18 Agency Of Ind Science & Technol 抗腫瘍剤
JPS61267570A (ja) * 1985-05-20 1986-11-27 Kuraray Co Ltd ３，４―ジヒドロ―２ｈ―ベンゾピラン誘導体及びこれを有効成分とする利胆剤
JPS61267571A (ja) * 1985-05-20 1986-11-27 Kuraray Co Ltd ２−（４−クロルフエノキシ）−２−メチルプロピオン酸エステル及びこれを有効成分とする血中脂質低下剤
JPS62132879A (ja) * 1985-12-05 1987-06-16 Kuraray Co Ltd ３，４−ジヒドロ−２ｈ−ベンゾピラン誘導体類及びこれを有効成分とする抗アレルギ−剤
US4752646A (en) * 1986-01-23 1988-06-21 Hoffmann-La Roche Inc. 2-halochromans
US4824971A (en) * 1986-01-23 1989-04-25 Hoffman-La Roche Inc. 2-allylchromans
WO1987005020A1 (fr) * 1986-02-21 1987-08-27 Kuraray Co., Ltd. Derives de 3,4-dihydro-2h-benzopyranne et leur usage medicinal
US4879395A (en) * 1987-03-27 1989-11-07 Hoffmann-La Roche Inc. Vitamin E intermediate
US4914217A (en) * 1987-12-18 1990-04-03 Hoffmann-La Roche Inc. Asymmetric synthesis of natural vitamin E
US4831185A (en) * 1987-12-18 1989-05-16 Hoffmann-La Roche Inc. Asymmetric synthesis of natural vitamin E

Also Published As

Publication number Publication date
US5015661A (en) 1991-05-14
DK389089D0 (da) 1989-08-08
AU3941889A (en) 1990-02-15
KR900003175A (ko) 1990-03-23
NO893198L (no) 1990-02-12
PT91400A (pt) 1990-03-08
EP0354508A2 (fr) 1990-02-14
NZ230233A (en) 1992-03-26
EP0354508A3 (fr) 1991-03-27
NO172643B (no) 1993-05-10
JPH0283379A (ja) 1990-03-23
MC2050A1 (fr) 1990-07-17
NO172643C (no) 1993-08-18
HUT52493A (en) 1990-07-28
AU616039B2 (en) 1991-10-17
IL91245A0 (en) 1990-03-19
JPH0579072B2 (fr) 1993-11-01
PH27235A (en) 1993-05-04
HU206204B (en) 1992-09-28
NO893198D0 (no) 1989-08-08

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AHB Application shelved due to non-payment