DK3636274T3 - Sammensætninger til modulering af gamma-c-cytokin-aktivitet - Google Patents
Sammensætninger til modulering af gamma-c-cytokin-aktivitet Download PDFInfo
- Publication number
- DK3636274T3 DK3636274T3 DK19206731.2T DK19206731T DK3636274T3 DK 3636274 T3 DK3636274 T3 DK 3636274T3 DK 19206731 T DK19206731 T DK 19206731T DK 3636274 T3 DK3636274 T3 DK 3636274T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- cytokine activity
- modulating gamma
- modulating
- gamma
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K38/10—Peptides having 12 to 20 amino acids
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161433890P | 2011-01-18 | 2011-01-18 | |
| US201161527049P | 2011-08-24 | 2011-08-24 | |
| EP12736203.6A EP2665486B1 (en) | 2011-01-18 | 2012-01-17 | Compositions for modulating gamma-c-cytokine activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3636274T3 true DK3636274T3 (da) | 2024-10-07 |
Family
ID=46516044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12736203.6T DK2665486T3 (da) | 2011-01-18 | 2012-01-17 | Sammensætninger til modulering af gamma-c-cytokin-aktivitet |
| DK19206731.2T DK3636274T3 (da) | 2011-01-18 | 2012-01-17 | Sammensætninger til modulering af gamma-c-cytokin-aktivitet |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12736203.6T DK2665486T3 (da) | 2011-01-18 | 2012-01-17 | Sammensætninger til modulering af gamma-c-cytokin-aktivitet |
Country Status (19)
| Country | Link |
|---|---|
| US (10) | US9133244B2 (enExample) |
| EP (3) | EP3636274B1 (enExample) |
| JP (4) | JP6395379B2 (enExample) |
| CN (2) | CN109021069A (enExample) |
| AU (3) | AU2012207456C1 (enExample) |
| BR (1) | BR112013018046B1 (enExample) |
| CA (1) | CA2824515C (enExample) |
| CY (1) | CY1122846T1 (enExample) |
| DK (2) | DK2665486T3 (enExample) |
| ES (2) | ES2989085T3 (enExample) |
| FI (1) | FI3636274T3 (enExample) |
| HR (1) | HRP20200470T1 (enExample) |
| LT (1) | LT2665486T (enExample) |
| PL (2) | PL3636274T3 (enExample) |
| PT (2) | PT2665486T (enExample) |
| RS (1) | RS60050B1 (enExample) |
| SI (1) | SI2665486T1 (enExample) |
| SM (1) | SMT202000142T1 (enExample) |
| WO (1) | WO2012099886A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6395379B2 (ja) | 2011-01-18 | 2018-09-26 | バイオニズ リミテッド ライアビリティー カンパニー | γcサイトカイン活性を調節するための組成物および方法 |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| CN104789527B (zh) * | 2015-05-15 | 2018-05-29 | 江苏杰晟生物科技有限公司 | 一种自体自然杀伤细胞鸡尾酒式培养的制备方法及其试剂盒产品 |
| US11400134B2 (en) * | 2015-10-09 | 2022-08-02 | Bioniz, Llc | Modulating gamma-c-cytokine activity |
| CN109562143A (zh) * | 2016-05-06 | 2019-04-02 | 王牧林 | 白细胞介素组合及其用途 |
| KR102707650B1 (ko) * | 2017-04-07 | 2024-09-19 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 안정한 조절자 |
| PE20211376A1 (es) * | 2018-07-19 | 2021-07-27 | Univ School St Marianna Medicine | Agente terapeutico o profilactico para la mielopatia asociada al htlv-1 (ham), y metodo de tratamiento del ham |
| US12459980B2 (en) | 2018-07-25 | 2025-11-04 | AskGene Pharma, Inc. | IL-21 prodrugs and methods of use thereof |
| KR20210055070A (ko) | 2018-08-06 | 2021-05-14 | 메디카인 인코포레이티드 | Il-2 수용체 결합 화합물 |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| US12030936B2 (en) | 2019-05-03 | 2024-07-09 | Bioniz Therapeutics, Inc. | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| CN114341189A (zh) | 2019-06-12 | 2022-04-12 | 奥美药业有限公司 | 全新il-15前药及其应用 |
| KR102265435B1 (ko) * | 2019-08-20 | 2021-06-15 | 주식회사 케어젠 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
| KR20220110209A (ko) | 2019-11-05 | 2022-08-05 | 메디카인 인코포레이티드 | 이중 il-2r 및 il-7r 결합 화합물 |
| CA3160133A1 (en) | 2019-11-05 | 2021-05-14 | Medikine, Inc. | Il-2rbyc binding compounds |
| TWI812918B (zh) | 2020-02-03 | 2023-08-21 | 美商麥地金公司 | IL-7Rαγc結合化合物 |
| JP2023512687A (ja) | 2020-02-03 | 2023-03-28 | メディカイン、インコーポレイテッド | IL-7Rα結合化合物 |
| CN115667523A (zh) | 2020-04-10 | 2023-01-31 | 西托姆克斯治疗公司 | 可活化细胞因子构建体和相关组合物以及方法 |
| JP2023532272A (ja) * | 2020-06-24 | 2023-07-27 | バイオニズ リミテッド ライアビリティー カンパニー | サイトカイン放出症候群およびサイトカインストーム関連障害の治療用の、il-2、il-9およびil-15のシグナル伝達を標的とするアンタゴニストペプチド |
| US20230321152A1 (en) | 2020-09-08 | 2023-10-12 | Dexon Pharmaceuticals Inc. | Cytokine storm suppressor, method for using cytokine storm suppressor and screening method |
| AU2022237504A1 (en) | 2021-03-16 | 2023-10-05 | Cytomx Therapeutics, Inc. | Masked activatable cytokine constructs and related compositions and methods |
| JP6974892B1 (ja) | 2021-05-27 | 2021-12-01 | デクソンファーマシューティカルズ株式会社 | 癌悪液質の改善剤および癌悪液質の改善方法 |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5700913A (en) | 1982-12-15 | 1997-12-23 | Ajinomoto Co., Inc. | Unglycosylated human interleukin-2 polypeptides |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| PT83761B (pt) | 1985-11-19 | 1989-06-30 | Schering Biotech Corp | Metodo para a producao de interleuquina-4 de mamifero |
| US6028186A (en) | 1991-06-10 | 2000-02-22 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands of cytokines |
| US7008624B1 (en) | 1995-02-22 | 2006-03-07 | Immunex Corporation | Antagonists of interleukin-15 |
| US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| US5908839A (en) | 1995-08-24 | 1999-06-01 | Magainin Pharmaceuticals, Inc. | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
| IL130238A0 (en) | 1999-06-01 | 2000-06-01 | Peptor Ltd | Conformationally constrained backbone cyclized interleukin-6 antagonists |
| AU2937597A (en) | 1996-05-10 | 1997-12-05 | Biogen, Inc. | Common gamma chain blocking agents |
| US6127387A (en) | 1996-12-10 | 2000-10-03 | Thomas Jefferson University | Use of CD4-binding small molecules to inhibit immune responses |
| CA2296770A1 (en) * | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| US7189400B2 (en) | 1998-03-17 | 2007-03-13 | Genetics Institute, Llc | Methods of treatment with antagonists of MU-1 |
| US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| US6861227B2 (en) | 1998-03-19 | 2005-03-01 | Human Genome Sciences, Inc. | Antibodies to cytokine receptor common gamma chain like |
| US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| US6307024B1 (en) | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| CA2408691A1 (en) | 2000-05-12 | 2001-11-22 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for achieving immune suppression |
| EP1349873B1 (en) * | 2000-09-14 | 2009-04-01 | Beth Israel Deaconess Medical Center, Inc. | Modulation of il-2- and il-15-mediated t cell responses |
| MXPA03003407A (es) * | 2000-10-18 | 2004-05-04 | Immunex Corp | Metodos para el tratamiento de artritis reumatoide usando antagonistas il-17. |
| US20040126900A1 (en) | 2001-04-13 | 2004-07-01 | Barry Stephen E | High affinity peptide- containing nanoparticles |
| US7033604B2 (en) | 2001-07-06 | 2006-04-25 | Sucampo Ag | Composition for topical administration |
| WO2003035846A2 (en) | 2001-10-24 | 2003-05-01 | National Jewish Medical And Research Center | Structure of tall-1 and its cognate receptor |
| WO2003040313A2 (en) | 2001-11-05 | 2003-05-15 | Zymogenetics, Inc | Il-21 antagonists |
| DK1576112T3 (da) | 2002-01-18 | 2012-06-25 | Zymogenetics Inc | Cytokin-receptor zcytor17-multimerer |
| JP2005530716A (ja) | 2002-03-27 | 2005-10-13 | アメリカ合衆国 | ヒトにおける癌の治療方法 |
| AU2003230834A1 (en) * | 2002-04-09 | 2003-10-27 | Beth Israel Deaconess Medical Center, Inc. | Antagonists of il-21 and modulation of il-21-mediated t cell responses |
| JP2005525404A (ja) | 2002-05-01 | 2005-08-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Hiv感染およびaidsを処置するためにサイトカインアンタゴニストを使用する方法 |
| EP1531850B1 (en) | 2002-06-07 | 2012-02-22 | ZymoGenetics, Inc. | Use of IL-21 and monoclonal antibody for treating solid cancers |
| US7575742B2 (en) | 2002-06-28 | 2009-08-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist |
| AU2003251633A1 (en) | 2002-07-01 | 2004-01-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Il-21 as a regulator of immunoglobin production |
| JP4776228B2 (ja) | 2002-07-15 | 2011-09-21 | ワイス・エルエルシー | Tヘルパー(th)細胞の発生および機能を調節するための方法および組成物 |
| MXPA05003887A (es) * | 2002-10-14 | 2005-10-18 | Hoffmann La Roche | Antagonistas il - 15. |
| EP1444989A1 (en) | 2003-02-07 | 2004-08-11 | Giorgio Dr. Stassi | Sensitizing cells for apoptosis by selectively blocking cytokines |
| ZA200507235B (en) | 2003-03-21 | 2007-03-28 | Wyeth Corp | Treating immunological disorders using agonists of interleukin-21/interleukin-21 receptor |
| US7423123B2 (en) | 2003-05-14 | 2008-09-09 | Aerovance, Inc. | Interleukin-9 antagonist muteins and their pharmacological methods of use |
| US20050124044A1 (en) | 2003-06-19 | 2005-06-09 | Cunningham Mark R. | Interleukin-21 analogs |
| US7534585B2 (en) | 2003-07-21 | 2009-05-19 | Transgene S.A. | Multifunctional cytokines |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US7785580B2 (en) | 2003-08-29 | 2010-08-31 | Aerovance, Inc. | Modified IL-4 mutein receptor antagonists |
| AU2004275871A1 (en) | 2003-09-25 | 2005-04-07 | Zymogenetics, Inc. | Methods of treating autoimmune diseases using IL-21 |
| US20060228331A1 (en) | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
| WO2005067956A2 (en) | 2004-01-15 | 2005-07-28 | Novo Nordisk A/S | Use of interleukin-21 for the treatment of autoimune diseases and allograft rejection |
| EP1751175B1 (en) | 2004-05-05 | 2012-07-25 | VALORISATION-RECHERCHE, Société en Commandite | Interleukin-1 receptor antagonists, compositions, and methods of treatment |
| CA2566333A1 (en) | 2004-05-19 | 2005-12-01 | Wyeth | Modulation of immunoglobulin production and atopic disorders |
| KR20070057789A (ko) | 2004-08-05 | 2007-06-07 | 와이어쓰 | 인터루킨-21 수용체 활성의 상쇄 |
| CU23472A1 (es) * | 2004-09-17 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Péptido antagonista de la interleucina-15 |
| WO2006105538A2 (en) | 2005-03-31 | 2006-10-05 | Centocor, Inc. | Methods and compositions for treating il-21 related pathologies |
| GT200600148A (es) | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
| WO2006111524A2 (en) | 2005-04-18 | 2006-10-26 | Novo Nordisk A/S | Il-21 variants |
| EP3805245A1 (en) | 2005-05-17 | 2021-04-14 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
| WO2008036075A2 (en) * | 2005-08-10 | 2008-03-27 | Northwestern University | Composite particles |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| ES2491118T3 (es) | 2005-11-28 | 2014-09-05 | Zymogenetics, Inc. | Antagonistas de IL-21 |
| EP2066689A4 (en) | 2006-09-07 | 2010-04-28 | Univ South Florida | HYD1-PEPTIDE AS ANTICREMENT |
| CN101553501A (zh) | 2006-10-26 | 2009-10-07 | 诺沃-诺迪斯克有限公司 | Il-21变种 |
| CA2671665A1 (en) * | 2006-12-21 | 2008-06-26 | Novo-Nordisk A/S | Interleukin-21 variants with altered binding to the il-21 receptor |
| US7910123B2 (en) | 2007-09-05 | 2011-03-22 | Warsaw Orthopedic | Methods of treating a trauma or disorder of the knee joint by local administration and sustained-delivery of a biological agent |
| WO2009100035A2 (en) | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
| US8513208B2 (en) | 2008-02-28 | 2013-08-20 | Argos Therapeutics, Inc. | Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection |
| WO2009132821A1 (en) | 2008-04-28 | 2009-11-05 | Giuliani International Limited | Interleukin (il-21) binding proteins and methods of making and using same |
| WO2009150650A2 (en) * | 2008-06-12 | 2009-12-17 | Ramot At Tel Aviv University Ltd. | Drug-eluting medical devices |
| US20110144306A1 (en) | 2008-07-23 | 2011-06-16 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| EP2344180A2 (en) | 2008-09-23 | 2011-07-20 | Wyeth LLC | Methods for predicting production of activating signals by cross-linked binding proteins |
| RU2542375C2 (ru) | 2008-11-17 | 2015-02-20 | Кёбенхаунс Университет | Пептиды-производные ил-4 для модуляции хронического воспалительного ответа и лечения аутоиммунных заболеваний |
| CA2747790A1 (en) | 2009-01-05 | 2010-07-08 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Means and method for the treatment of antibody deficiency diseases based on il-21 and il-21 variants |
| PE20160651A1 (es) | 2009-03-05 | 2016-07-24 | Abbvie Inc | Proteinas de union a il-17 |
| EP2406282A1 (en) | 2009-03-11 | 2012-01-18 | Novo Nordisk A/S | Interleukin-21 variants having antagonistic binding to the il-21 receptor |
| GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| JP2012532929A (ja) | 2009-07-13 | 2012-12-20 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二機能性のステープリングされたポリペプチドおよびそれらの使用 |
| AU2010329805B2 (en) | 2009-12-11 | 2016-07-14 | Proyecto De Biomedicina Cima S.L. | New conjugates and compositions for immunotherapy and anti-tumoral treatment |
| WO2011105520A1 (ja) * | 2010-02-26 | 2011-09-01 | 国立大学法人 長崎大学 | 抗原または薬物送達複合体 |
| WO2011133948A2 (en) | 2010-04-22 | 2011-10-27 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
| JP2013531982A (ja) | 2010-06-09 | 2013-08-15 | ザイモジェネティクス, インコーポレイテッド | 二量体vstm3融合タンパク質および関連組成物および方法 |
| WO2012006585A2 (en) * | 2010-07-09 | 2012-01-12 | The Regents Of The University Of California | Use of interleukin-15 to treat cardiovascular diseases |
| WO2012012531A2 (en) | 2010-07-20 | 2012-01-26 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods featuring il-6 and il-21 antagonists |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| JP6395379B2 (ja) | 2011-01-18 | 2018-09-26 | バイオニズ リミテッド ライアビリティー カンパニー | γcサイトカイン活性を調節するための組成物および方法 |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| US9670672B2 (en) | 2014-12-03 | 2017-06-06 | Aleksandar Stevanov | Roof panel system |
| EP3350205A1 (en) | 2015-09-16 | 2018-07-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases |
| US20170104927A1 (en) | 2015-10-07 | 2017-04-13 | Little Star Media, Inc. | Systems, methods and software programs for 360 degree video distribution platforms |
| US11400134B2 (en) | 2015-10-09 | 2022-08-02 | Bioniz, Llc | Modulating gamma-c-cytokine activity |
| US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
| KR102707650B1 (ko) | 2017-04-07 | 2024-09-19 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 안정한 조절자 |
| US12030936B2 (en) | 2019-05-03 | 2024-07-09 | Bioniz Therapeutics, Inc. | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
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