DK3490991T3 - Coelenterazine analogues - Google Patents

Coelenterazine analogues Download PDF

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Publication number
DK3490991T3
DK3490991T3 DK17749304.6T DK17749304T DK3490991T3 DK 3490991 T3 DK3490991 T3 DK 3490991T3 DK 17749304 T DK17749304 T DK 17749304T DK 3490991 T3 DK3490991 T3 DK 3490991T3
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DK
Denmark
Prior art keywords
coelenterazine analogues
coelenterazine
analogues
Prior art date
Application number
DK17749304.6T
Other languages
Danish (da)
English (en)
Inventor
Mary Hall
Thomas Kirland
Thomas Machleidt
Anton Shakhmin
Joel R Walker
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59558505&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3490991(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of DK3490991T3 publication Critical patent/DK3490991T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
    • C12Y113/12005—Renilla-luciferin 2-monooxygenase (1.13.12.5), i.e. renilla-luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
    • C12Y113/12013—Oplophorus-luciferin 2-monooxygenase (1.13.12.13)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1011—Condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK17749304.6T 2016-07-28 2017-07-27 Coelenterazine analogues DK3490991T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662367689P 2016-07-28 2016-07-28
PCT/US2017/044150 WO2018022865A1 (en) 2016-07-28 2017-07-27 Coelenterazine analogues

Publications (1)

Publication Number Publication Date
DK3490991T3 true DK3490991T3 (da) 2021-01-25

Family

ID=59558505

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17749304.6T DK3490991T3 (da) 2016-07-28 2017-07-27 Coelenterazine analogues

Country Status (5)

Country Link
US (3) US10000500B2 (enExample)
EP (1) EP3490991B1 (enExample)
JP (1) JP7212612B2 (enExample)
DK (1) DK3490991T3 (enExample)
WO (1) WO2018022865A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3548492B1 (en) * 2016-12-01 2023-07-05 Promega Corporation Cell impermeable coelenterazine analogues
JP7036343B2 (ja) * 2017-03-28 2022-03-15 国立大学法人電気通信大学 新規セレンテラジン誘導体
EP3395803A1 (en) * 2017-04-28 2018-10-31 Institut Pasteur Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins
EP3788048A1 (en) 2018-05-01 2021-03-10 Promega Corporation Coelenterazine compounds as nanoluc suicide substrates
TW202021969A (zh) * 2018-05-31 2020-06-16 南韓商Ｃ＆Ｃ新藥研究所 雜環衍生物及其用途
EP3807419A4 (en) 2018-06-12 2022-09-07 Promega Corporation MULTIPLE LUCIFERASE
JP7653351B2 (ja) * 2018-08-23 2025-03-28 プロメガ コーポレイション セレンテラジン類似体
IL318819A (en) 2018-10-03 2025-04-01 Promega Corp Compounds and methods for stabilizing cholinetyrazine and its derivatives
IL293204B1 (en) 2019-11-27 2026-08-01 Promega Corp Multipartite luciferase peptides and polypeptides
CN111072669B (zh) * 2019-12-03 2021-03-26 山东大学 一种苯基咪唑并吡嗪酮类化合物及制备方法与应用
CN111116594B (zh) * 2019-12-03 2021-05-28 山东大学 一种C-6位改造NanoLuc类型类似物及其制备方法与应用
WO2021119149A1 (en) 2019-12-10 2021-06-17 Promega Corporation Compositions and methods for bioluminescent detection using multifunctional probes
JP7677997B2 (ja) 2020-05-22 2025-05-15 プロメガ コーポレイション キナーゼターゲットエンゲージメントの増強
WO2022047186A1 (en) 2020-08-28 2022-03-03 Promega Corporation Target engagement assay for ras proteins
EP4337646A4 (en) 2021-05-13 2025-05-21 Promega Corporation BIOLUMINESCENT DETECTION OF DNA SYNTHESIS
WO2023162995A1 (ja) * 2022-02-28 2023-08-31 国立大学法人電気通信大学 新規セレンテラジン誘導体
US20240318151A1 (en) * 2023-03-20 2024-09-26 Qatar Foundation For Education, Science And Community Development Modified Luciferases
US20250206747A1 (en) * 2023-12-20 2025-06-26 Promega Corporation Coelenterazine analogues
WO2026128753A2 (en) 2024-12-12 2026-06-18 Juno Therapeutics, Inc. Methods for assessing cell proliferation of cell compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007096764A2 (en) 2006-02-27 2007-08-30 Glenmark Pharmaceuticals S.A. Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
US20090075309A1 (en) 2007-09-06 2009-03-19 Gambhir Sanjiv S Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems
JP5353279B2 (ja) 2009-02-06 2013-11-27 Ｊｎｃ株式会社 セレンテラミド又はその類縁体の製造方法
GB2479847B (en) 2009-02-09 2014-02-19 Jnc Corp Coelenterazine analogs and manufacturing method thereof
GB2479692B (en) 2009-02-09 2013-10-30 Jnc Corp Coelenteramide analogs
US8628751B2 (en) 2009-04-16 2014-01-14 Medi Beacon Development, LLC Pyrazine derivatives for optical imaging and therapy
WO2011007314A1 (en) 2009-07-13 2011-01-20 Università Degli Studi Di Siena IMIDAZO[1,2-α]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE
JP5605727B2 (ja) 2010-04-06 2014-10-15 Ｊｎｃ株式会社 セレンテラジン類縁体及びセレンテラミド類縁体
WO2012040105A2 (en) 2010-09-21 2012-03-29 Kansas State University Research Foundation Renilla/gaussia transfected cells as a light source for in-situ photodynamic therapy of cancer
CN103443121B (zh) 2010-11-02 2016-04-20 普罗梅加公司 新型腔肠素底物及其使用方法
CA2815381C (en) 2010-11-02 2019-03-19 Promega Corporation Coelenterazine derivatives and methods of using same
JP5637907B2 (ja) 2011-03-08 2014-12-10 Jnc株式会社 ｖ−セレンテラジン化合物の製造方法
EP2744521B1 (en) 2011-08-16 2017-04-05 Promega Corporation Detection of hydrogen peroxide
WO2014145512A2 (en) 2013-03-15 2014-09-18 President And Fellows Of Harvard College Potent small molecule inhibitors of autophagy, and methods of use thereof
JP6040846B2 (ja) 2013-04-08 2016-12-07 Jnc株式会社 セレンテラジン類縁体
JP7092677B2 (ja) 2016-02-15 2022-06-28 プロメガ コーポレイション セレンテラジン類似体

Also Published As

Publication number Publication date
EP3490991B1 (en) 2021-01-06
US10669280B2 (en) 2020-06-02
US10428075B2 (en) 2019-10-01
US10000500B2 (en) 2018-06-19
US20180334463A1 (en) 2018-11-22
US20180030059A1 (en) 2018-02-01
JP7212612B2 (ja) 2023-01-25
WO2018022865A1 (en) 2018-02-01
JP2019524763A (ja) 2019-09-05
US20190389869A1 (en) 2019-12-26
EP3490991A1 (en) 2019-06-05

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