DK3472163T3 - Chelatforbindelser - Google Patents
Chelatforbindelser Download PDFInfo
- Publication number
- DK3472163T3 DK3472163T3 DK17731559.5T DK17731559T DK3472163T3 DK 3472163 T3 DK3472163 T3 DK 3472163T3 DK 17731559 T DK17731559 T DK 17731559T DK 3472163 T3 DK3472163 T3 DK 3472163T3
- Authority
- DK
- Denmark
- Prior art keywords
- chelate compounds
- chelate
- compounds
- Prior art date
Links
- 239000013522 chelant Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1610738.5A GB201610738D0 (en) | 2016-06-20 | 2016-06-20 | Chelate compounds |
| PCT/EP2017/065135 WO2017220610A1 (en) | 2016-06-20 | 2017-06-20 | Chelate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3472163T3 true DK3472163T3 (da) | 2021-02-01 |
Family
ID=56895099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17731559.5T DK3472163T3 (da) | 2016-06-20 | 2017-06-20 | Chelatforbindelser |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11884686B2 (da) |
| EP (1) | EP3472163B1 (da) |
| JP (2) | JP7048591B2 (da) |
| KR (2) | KR102435941B1 (da) |
| CN (2) | CN109641900B (da) |
| AU (1) | AU2017281189B2 (da) |
| BR (1) | BR112018076389A2 (da) |
| CA (1) | CA3028027A1 (da) |
| DK (1) | DK3472163T3 (da) |
| ES (1) | ES2848580T3 (da) |
| GB (1) | GB201610738D0 (da) |
| HU (1) | HUE053402T2 (da) |
| LT (1) | LT3472163T (da) |
| MX (1) | MX2018016082A (da) |
| PL (1) | PL3472163T3 (da) |
| RU (1) | RU2747310C2 (da) |
| SG (1) | SG11201811380RA (da) |
| WO (1) | WO2017220610A1 (da) |
| ZA (1) | ZA201900371B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| DK3558394T3 (da) * | 2016-12-21 | 2020-08-24 | Ge Healthcare As | Tetraazabicyklo-macrocykel-baseret mangan-chelatforbindelser egnede som mri-kontraststoffer |
| EP3728168B1 (en) | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
| CN114423761A (zh) * | 2019-09-03 | 2022-04-29 | 通用电气医疗集团股份有限公司 | 锰螯合物异构体 |
| CN113801071B (zh) * | 2021-09-14 | 2023-04-07 | 安徽普利药业有限公司 | 一种钆特酸葡甲胺的精制方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU608759B2 (en) | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| US5334371A (en) | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| DE3825040A1 (de) | 1988-07-20 | 1990-01-25 | Schering Ag | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| NZ230778A (en) | 1988-09-27 | 1993-01-27 | Salutar Inc | Diagnostic imaging contrast medium comprising biscarbamoyl derivatives |
| FR2644785B1 (fr) | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| GB9001245D0 (en) | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
| US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| WO1994026754A1 (en) | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation |
| WO1994026313A1 (en) | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
| US5428139A (en) | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| HUT67602A (en) | 1991-12-10 | 1995-04-28 | Dow Chemical Co | Process for producing bicyclo-polyaza-macrocyclo-carboxylic acid complexes, their conjugates and contrast materials containing them |
| HUT66220A (en) | 1991-12-10 | 1994-10-28 | Dow Chemical Co | Bicyclopolyazamacrocyclophosponic acids, their complexes and conjugates for use as contrast agents, and processes for their preparation |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2836916B1 (fr) | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
| WO2004112840A2 (en) | 2003-06-25 | 2004-12-29 | Guerbet | Peptide conjugate for magnetic resonance imaging |
| FR2856689A1 (fr) | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| WO2006002873A2 (en) | 2004-07-02 | 2006-01-12 | Bracco Imaging Spa | 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri ) |
| US20080305049A1 (en) | 2005-01-31 | 2008-12-11 | Hadassa Degani | Mri Contrast Agents for Diagnosis and Prognosis of Tumors |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| GB0609610D0 (en) | 2006-05-15 | 2006-06-21 | Stiftelsen Universitetsforskni | MR perfusion |
| US8192721B2 (en) | 2007-12-13 | 2012-06-05 | Verrow Pharmaceuticals, Inc. | Compositions useful for reducing toxicity associated with gadolinium-based contrast agents |
| US20090208421A1 (en) | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
| NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| DK2721045T3 (da) | 2011-06-20 | 2017-07-24 | Radiomedix Inc | Compositions, methods of synthesis and use of carbohydrate targeted agents |
| WO2014174120A1 (fr) | 2013-04-26 | 2014-10-30 | Guerbet | Formulation de produit de contraste et son procede de preparation associe |
| US20160045623A1 (en) | 2015-04-03 | 2016-02-18 | Lipella Pharmaceuticals, Inc. | Systems and Methods to Image Intercellular and Intercompartmental Defects with Magnetic Resonance Imaging (MRI) |
| EP3380484A1 (en) | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| EP3383441A1 (en) | 2015-11-30 | 2018-10-10 | GE Healthcare AS | Formulations comprising a combination of mri contrast agents |
| AU2016368542B2 (en) | 2015-12-10 | 2020-07-16 | Bracco Imaging Spa | Contrast agents |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| DK3558394T3 (da) | 2016-12-21 | 2020-08-24 | Ge Healthcare As | Tetraazabicyklo-macrocykel-baseret mangan-chelatforbindelser egnede som mri-kontraststoffer |
| EP3728168B1 (en) | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
| CN114423761A (zh) | 2019-09-03 | 2022-04-29 | 通用电气医疗集团股份有限公司 | 锰螯合物异构体 |
-
2016
- 2016-06-20 GB GBGB1610738.5A patent/GB201610738D0/en not_active Ceased
-
2017
- 2017-06-20 CN CN201780051082.4A patent/CN109641900B/zh active Active
- 2017-06-20 LT LTEP17731559.5T patent/LT3472163T/lt unknown
- 2017-06-20 JP JP2019518150A patent/JP7048591B2/ja active Active
- 2017-06-20 AU AU2017281189A patent/AU2017281189B2/en active Active
- 2017-06-20 KR KR1020197001479A patent/KR102435941B1/ko active IP Right Grant
- 2017-06-20 HU HUE17731559A patent/HUE053402T2/hu unknown
- 2017-06-20 EP EP17731559.5A patent/EP3472163B1/en active Active
- 2017-06-20 WO PCT/EP2017/065135 patent/WO2017220610A1/en unknown
- 2017-06-20 CA CA3028027A patent/CA3028027A1/en active Pending
- 2017-06-20 BR BR112018076389-6A patent/BR112018076389A2/pt unknown
- 2017-06-20 DK DK17731559.5T patent/DK3472163T3/da active
- 2017-06-20 SG SG11201811380RA patent/SG11201811380RA/en unknown
- 2017-06-20 MX MX2018016082A patent/MX2018016082A/es unknown
- 2017-06-20 US US16/311,564 patent/US11884686B2/en active Active
- 2017-06-20 KR KR1020227028798A patent/KR20220123138A/ko not_active Application Discontinuation
- 2017-06-20 PL PL17731559T patent/PL3472163T3/pl unknown
- 2017-06-20 RU RU2018145061A patent/RU2747310C2/ru active
- 2017-06-20 CN CN202010082357.4A patent/CN111499633B/zh active Active
- 2017-06-20 ES ES17731559T patent/ES2848580T3/es active Active
-
2019
- 2019-01-18 ZA ZA201900371A patent/ZA201900371B/en unknown
-
2022
- 2022-03-24 JP JP2022049034A patent/JP2022101556A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3472163B1 (en) | 2020-11-11 |
| CN111499633A (zh) | 2020-08-07 |
| EP3472163A1 (en) | 2019-04-24 |
| CA3028027A1 (en) | 2017-12-28 |
| BR112018076389A2 (pt) | 2019-03-26 |
| US20190233450A1 (en) | 2019-08-01 |
| US11884686B2 (en) | 2024-01-30 |
| AU2017281189A1 (en) | 2019-01-17 |
| KR20220123138A (ko) | 2022-09-05 |
| CN109641900B (zh) | 2021-08-24 |
| RU2018145061A3 (da) | 2020-07-28 |
| GB201610738D0 (en) | 2016-08-03 |
| ES2848580T3 (es) | 2021-08-10 |
| RU2018145061A (ru) | 2020-07-21 |
| ZA201900371B (en) | 2019-10-30 |
| KR20190018710A (ko) | 2019-02-25 |
| SG11201811380RA (en) | 2019-01-30 |
| JP2019518082A (ja) | 2019-06-27 |
| LT3472163T (lt) | 2021-05-25 |
| CN111499633B (zh) | 2023-02-17 |
| PL3472163T3 (pl) | 2021-05-31 |
| AU2017281189B2 (en) | 2021-05-13 |
| JP7048591B2 (ja) | 2022-04-05 |
| JP2022101556A (ja) | 2022-07-06 |
| MX2018016082A (es) | 2019-09-10 |
| CN109641900A (zh) | 2019-04-16 |
| HUE053402T2 (hu) | 2021-06-28 |
| KR102435941B1 (ko) | 2022-08-25 |
| WO2017220610A1 (en) | 2017-12-28 |
| RU2747310C2 (ru) | 2021-05-04 |
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