MX2018016082A - Compuestos quelatos. - Google Patents
Compuestos quelatos.Info
- Publication number
- MX2018016082A MX2018016082A MX2018016082A MX2018016082A MX2018016082A MX 2018016082 A MX2018016082 A MX 2018016082A MX 2018016082 A MX2018016082 A MX 2018016082A MX 2018016082 A MX2018016082 A MX 2018016082A MX 2018016082 A MX2018016082 A MX 2018016082A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- chelate compounds
- mri
- complexes
- manganese
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000013522 chelant Substances 0.000 title 1
- WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical class [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención proporciona compuestos de Fórmula (I) adecuados para usarse como agentes de contraste en imágenes por resonancia magnética (IRM). Los compuestos de la presente invención son complejos de manganeso (II) que tienen propiedades ventajosas en comparación con compuestos conocidos similares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1610738.5A GB201610738D0 (en) | 2016-06-20 | 2016-06-20 | Chelate compounds |
| PCT/EP2017/065135 WO2017220610A1 (en) | 2016-06-20 | 2017-06-20 | Chelate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018016082A true MX2018016082A (es) | 2019-09-10 |
Family
ID=56895099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018016082A MX2018016082A (es) | 2016-06-20 | 2017-06-20 | Compuestos quelatos. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11884686B2 (es) |
| EP (1) | EP3472163B1 (es) |
| JP (2) | JP7048591B2 (es) |
| KR (2) | KR102435941B1 (es) |
| CN (2) | CN109641900B (es) |
| AU (1) | AU2017281189B2 (es) |
| BR (1) | BR112018076389A2 (es) |
| CA (1) | CA3028027A1 (es) |
| DK (1) | DK3472163T3 (es) |
| ES (1) | ES2848580T3 (es) |
| GB (1) | GB201610738D0 (es) |
| HU (1) | HUE053402T2 (es) |
| LT (1) | LT3472163T (es) |
| MX (1) | MX2018016082A (es) |
| PL (1) | PL3472163T3 (es) |
| RU (1) | RU2747310C2 (es) |
| SG (1) | SG11201811380RA (es) |
| WO (1) | WO2017220610A1 (es) |
| ZA (1) | ZA201900371B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| DK3558394T3 (da) * | 2016-12-21 | 2020-08-24 | Ge Healthcare As | Tetraazabicyklo-macrocykel-baseret mangan-chelatforbindelser egnede som mri-kontraststoffer |
| EP3728168B1 (en) | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
| CN114423761A (zh) * | 2019-09-03 | 2022-04-29 | 通用电气医疗集团股份有限公司 | 锰螯合物异构体 |
| CN113801071B (zh) * | 2021-09-14 | 2023-04-07 | 安徽普利药业有限公司 | 一种钆特酸葡甲胺的精制方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU608759B2 (en) | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| US5334371A (en) | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| DE3825040A1 (de) | 1988-07-20 | 1990-01-25 | Schering Ag | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| NZ230778A (en) | 1988-09-27 | 1993-01-27 | Salutar Inc | Diagnostic imaging contrast medium comprising biscarbamoyl derivatives |
| FR2644785B1 (fr) | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| GB9001245D0 (en) | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
| US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| WO1994026754A1 (en) | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation |
| WO1994026313A1 (en) | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
| US5428139A (en) | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| HUT67602A (en) | 1991-12-10 | 1995-04-28 | Dow Chemical Co | Process for producing bicyclo-polyaza-macrocyclo-carboxylic acid complexes, their conjugates and contrast materials containing them |
| HUT66220A (en) | 1991-12-10 | 1994-10-28 | Dow Chemical Co | Bicyclopolyazamacrocyclophosponic acids, their complexes and conjugates for use as contrast agents, and processes for their preparation |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2836916B1 (fr) | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
| WO2004112840A2 (en) | 2003-06-25 | 2004-12-29 | Guerbet | Peptide conjugate for magnetic resonance imaging |
| FR2856689A1 (fr) | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| WO2006002873A2 (en) | 2004-07-02 | 2006-01-12 | Bracco Imaging Spa | 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri ) |
| US20080305049A1 (en) | 2005-01-31 | 2008-12-11 | Hadassa Degani | Mri Contrast Agents for Diagnosis and Prognosis of Tumors |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| GB0609610D0 (en) | 2006-05-15 | 2006-06-21 | Stiftelsen Universitetsforskni | MR perfusion |
| US8192721B2 (en) | 2007-12-13 | 2012-06-05 | Verrow Pharmaceuticals, Inc. | Compositions useful for reducing toxicity associated with gadolinium-based contrast agents |
| US20090208421A1 (en) | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
| NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| DK2721045T3 (en) | 2011-06-20 | 2017-07-24 | Radiomedix Inc | COMPOSITIONS, METHODS OF SYNTHESIS AND USE OF CARBOHYDRATE TARGETED AGENTS |
| WO2014174120A1 (fr) | 2013-04-26 | 2014-10-30 | Guerbet | Formulation de produit de contraste et son procede de preparation associe |
| US20160045623A1 (en) | 2015-04-03 | 2016-02-18 | Lipella Pharmaceuticals, Inc. | Systems and Methods to Image Intercellular and Intercompartmental Defects with Magnetic Resonance Imaging (MRI) |
| EP3380484A1 (en) | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| EP3383441A1 (en) | 2015-11-30 | 2018-10-10 | GE Healthcare AS | Formulations comprising a combination of mri contrast agents |
| AU2016368542B2 (en) | 2015-12-10 | 2020-07-16 | Bracco Imaging Spa | Contrast agents |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| DK3558394T3 (da) | 2016-12-21 | 2020-08-24 | Ge Healthcare As | Tetraazabicyklo-macrocykel-baseret mangan-chelatforbindelser egnede som mri-kontraststoffer |
| EP3728168B1 (en) | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
| CN114423761A (zh) | 2019-09-03 | 2022-04-29 | 通用电气医疗集团股份有限公司 | 锰螯合物异构体 |
-
2016
- 2016-06-20 GB GBGB1610738.5A patent/GB201610738D0/en not_active Ceased
-
2017
- 2017-06-20 CN CN201780051082.4A patent/CN109641900B/zh active Active
- 2017-06-20 LT LTEP17731559.5T patent/LT3472163T/lt unknown
- 2017-06-20 JP JP2019518150A patent/JP7048591B2/ja active Active
- 2017-06-20 AU AU2017281189A patent/AU2017281189B2/en active Active
- 2017-06-20 KR KR1020197001479A patent/KR102435941B1/ko active IP Right Grant
- 2017-06-20 HU HUE17731559A patent/HUE053402T2/hu unknown
- 2017-06-20 EP EP17731559.5A patent/EP3472163B1/en active Active
- 2017-06-20 WO PCT/EP2017/065135 patent/WO2017220610A1/en unknown
- 2017-06-20 CA CA3028027A patent/CA3028027A1/en active Pending
- 2017-06-20 BR BR112018076389-6A patent/BR112018076389A2/pt unknown
- 2017-06-20 DK DK17731559.5T patent/DK3472163T3/da active
- 2017-06-20 SG SG11201811380RA patent/SG11201811380RA/en unknown
- 2017-06-20 MX MX2018016082A patent/MX2018016082A/es unknown
- 2017-06-20 US US16/311,564 patent/US11884686B2/en active Active
- 2017-06-20 KR KR1020227028798A patent/KR20220123138A/ko not_active Application Discontinuation
- 2017-06-20 PL PL17731559T patent/PL3472163T3/pl unknown
- 2017-06-20 RU RU2018145061A patent/RU2747310C2/ru active
- 2017-06-20 CN CN202010082357.4A patent/CN111499633B/zh active Active
- 2017-06-20 ES ES17731559T patent/ES2848580T3/es active Active
-
2019
- 2019-01-18 ZA ZA201900371A patent/ZA201900371B/en unknown
-
2022
- 2022-03-24 JP JP2022049034A patent/JP2022101556A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3472163B1 (en) | 2020-11-11 |
| CN111499633A (zh) | 2020-08-07 |
| EP3472163A1 (en) | 2019-04-24 |
| CA3028027A1 (en) | 2017-12-28 |
| BR112018076389A2 (pt) | 2019-03-26 |
| US20190233450A1 (en) | 2019-08-01 |
| US11884686B2 (en) | 2024-01-30 |
| AU2017281189A1 (en) | 2019-01-17 |
| DK3472163T3 (da) | 2021-02-01 |
| KR20220123138A (ko) | 2022-09-05 |
| CN109641900B (zh) | 2021-08-24 |
| RU2018145061A3 (es) | 2020-07-28 |
| GB201610738D0 (en) | 2016-08-03 |
| ES2848580T3 (es) | 2021-08-10 |
| RU2018145061A (ru) | 2020-07-21 |
| ZA201900371B (en) | 2019-10-30 |
| KR20190018710A (ko) | 2019-02-25 |
| SG11201811380RA (en) | 2019-01-30 |
| JP2019518082A (ja) | 2019-06-27 |
| LT3472163T (lt) | 2021-05-25 |
| CN111499633B (zh) | 2023-02-17 |
| PL3472163T3 (pl) | 2021-05-31 |
| AU2017281189B2 (en) | 2021-05-13 |
| JP7048591B2 (ja) | 2022-04-05 |
| JP2022101556A (ja) | 2022-07-06 |
| CN109641900A (zh) | 2019-04-16 |
| HUE053402T2 (hu) | 2021-06-28 |
| KR102435941B1 (ko) | 2022-08-25 |
| WO2017220610A1 (en) | 2017-12-28 |
| RU2747310C2 (ru) | 2021-05-04 |
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