SG11201811380RA - Chelate compounds - Google Patents
Chelate compoundsInfo
- Publication number
- SG11201811380RA SG11201811380RA SG11201811380RA SG11201811380RA SG11201811380RA SG 11201811380R A SG11201811380R A SG 11201811380RA SG 11201811380R A SG11201811380R A SG 11201811380RA SG 11201811380R A SG11201811380R A SG 11201811380RA SG 11201811380R A SG11201811380R A SG 11201811380RA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- nycoveien
- oslo
- pct
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000013522 chelant Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 241000502522 Luscinia megarhynchos Species 0.000 abstract 1
- WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical class [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 abstract 1
- 241000269319 Squalius cephalus Species 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 239000011572 manganese Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000002023 wood Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 December 2017 (28.12.2017) WIP0 I PCT °minim o H0111°1°11E111 m1111E11 ow (10) International Publication Number WO 2017/220610 Al (51) International Patent Classification: C07D 471/08 (2006.01) A61K 49/10 (2006.01) (21) International Application Number: PCT/EP2017/065135 (22) International Filing Date: 20 June 2017 (20.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1610738.5 20 June 2016 (20.06.2016) GB (71) Applicant: GE HEALTHACRE AS [NO/NO]; 4220, Ny- dalen, Nycoveien 1-2, N-0401 Oslo (NO). (72) Inventors: MEIJER, Andreas, Richard; GE Healthcare AS, P.O. Box 4220 Nydalen, Nycoveien 1-2, N-0401 Oslo (NO). THANING, Mikkel, Jacob; GE Healthcare AS, P.O. Box 4220 Nydalen, Nycoveien 1-2, N-0401 Oslo (NO). BALES, Brian, Christopher; GE Global Research, One Research Circle, Niskayuna, New York 12309-1027 (US). RISHEL, Michael, James; GE Global Research, One Re- search Circle, Niskayuna, New York 12309-1027 (US). (74) Agent: BANNAN, Sally et al.; GE Healthcare Limited, Pol- lards Wood, Nightingales Lane, Chalfont St Giles Bucking- hamshire HP8 4SP (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) (54) Title: CHELATE COMPOUNDS W O 20 17 / 2206 10 Al R 3 0 N Mn N (57) : The invention provides compounds of formula (I) suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds. ( H 2 C ( CH 2 ) 0 N-R 1 R 2 R 4 R 2 (I)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1610738.5A GB201610738D0 (en) | 2016-06-20 | 2016-06-20 | Chelate compounds |
| PCT/EP2017/065135 WO2017220610A1 (en) | 2016-06-20 | 2017-06-20 | Chelate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201811380RA true SG11201811380RA (en) | 2019-01-30 |
Family
ID=56895099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201811380RA SG11201811380RA (en) | 2016-06-20 | 2017-06-20 | Chelate compounds |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11884686B2 (en) |
| EP (1) | EP3472163B1 (en) |
| JP (2) | JP7048591B2 (en) |
| KR (2) | KR102435941B1 (en) |
| CN (2) | CN109641900B (en) |
| AU (1) | AU2017281189B2 (en) |
| BR (1) | BR112018076389A2 (en) |
| CA (1) | CA3028027A1 (en) |
| DK (1) | DK3472163T3 (en) |
| ES (1) | ES2848580T3 (en) |
| GB (1) | GB201610738D0 (en) |
| HU (1) | HUE053402T2 (en) |
| LT (1) | LT3472163T (en) |
| MX (1) | MX2018016082A (en) |
| PL (1) | PL3472163T3 (en) |
| RU (1) | RU2747310C2 (en) |
| SG (1) | SG11201811380RA (en) |
| WO (1) | WO2017220610A1 (en) |
| ZA (1) | ZA201900371B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| KR102550339B1 (en) * | 2016-12-21 | 2023-07-04 | 지이 헬스케어 에이에스 | Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as MRI imaging agents |
| EP3728168B1 (en) | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
| KR20220058574A (en) | 2019-09-03 | 2022-05-09 | 지이 헬스케어 에이에스 | Manganese Chelate Isomer |
| CN113801071B (en) * | 2021-09-14 | 2023-04-07 | 安徽普利药业有限公司 | Refining method of meglumine gadoterate |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU608759B2 (en) | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| DE3640708C2 (en) | 1986-11-28 | 1995-05-18 | Schering Ag | Improved pharmaceuticals containing metals |
| US5334371A (en) | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| DE3825040A1 (en) | 1988-07-20 | 1990-01-25 | Schering Ag | 5- OR 6-RING MACROCYCLIC POLYAZA COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
| EP0436579B1 (en) | 1988-09-27 | 1993-08-04 | Nycomed Salutar, Inc. | Chelate compositions |
| FR2644785B1 (en) | 1989-03-24 | 1991-07-05 | Guerbet Sa | NOVEL NITROGEN MACROCYCLIC LIGANDS, PROCESS FOR THEIR PREPARATION, METAL COMPLEXES FORMED BY SUCH LIGANDS AND DIAGNOSTIC COMPOSITION CONTAINING THEM |
| GB9001245D0 (en) | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
| US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| US5428139A (en) | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| ES2110593T3 (en) | 1991-12-10 | 1998-02-16 | Dow Chemical Co | BICYCLOAZAMACROCYCLOPHOSPHONIC ACID, CONJUGATES, CONTRAST AND PREPARATION AGENTS. |
| HUT67602A (en) | 1991-12-10 | 1995-04-28 | Dow Chemical Co | Process for producing bicyclo-polyaza-macrocyclo-carboxylic acid complexes, their conjugates and contrast materials containing them |
| WO1994026313A1 (en) | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
| EP0696290A1 (en) | 1993-05-06 | 1996-02-14 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation |
| FR2794744B1 (en) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | METAL COMPLEXES OF BICYCLIC POLYAMINOACIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN MEDICAL IMAGING |
| FR2836916B1 (en) | 2002-03-05 | 2004-06-11 | Guerbet Sa | GADOLINIUM CHELATE OLIGOMERS, THEIR APPLICATION AS CONTRAST PRODUCTS IN MAGNETIC RESONANCE IMAGING AND THEIR SYNTHESIS INTERMEDIARIES |
| FR2856689A1 (en) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | New targeted diagnostic agents, used especially for detecting cardiovascular, cancerous or inflammatory disorders, comprise high relaxivity signal moiety bonded via linker to biovector |
| WO2004112840A2 (en) | 2003-06-25 | 2004-12-29 | Guerbet | Peptide conjugate for magnetic resonance imaging |
| CN1993357B (en) | 2004-07-02 | 2011-10-19 | 伯拉考成像股份公司 | Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents |
| WO2006080022A2 (en) * | 2005-01-31 | 2006-08-03 | Yeda Research And Development Co. Ltd. | Mri contrast agents for diagnosis and prognosis of tumors |
| FR2891830B1 (en) | 2005-10-07 | 2011-06-24 | Guerbet Sa | SHORT AMINOALCOHOL COMPOUNDS AND METAL COMPLEXES FOR MEDICAL IMAGING |
| GB0609610D0 (en) | 2006-05-15 | 2006-06-21 | Stiftelsen Universitetsforskni | MR perfusion |
| US8192721B2 (en) | 2007-12-13 | 2012-06-05 | Verrow Pharmaceuticals, Inc. | Compositions useful for reducing toxicity associated with gadolinium-based contrast agents |
| US20090208421A1 (en) | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
| NO331773B1 (en) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Manganese chelates, compositions comprising such and their use as contrast agents for magnetic resonance imaging (MRI) |
| PL2721045T3 (en) * | 2011-06-20 | 2017-11-30 | Radiomedix Inc. | Compositions, methods of synthesis and use of carbohydrate targeted agents |
| PL2988756T5 (en) | 2013-04-26 | 2022-09-26 | Guerbet | Contrast medium formulation and related preparation method |
| US20160045623A1 (en) | 2015-04-03 | 2016-02-18 | Lipella Pharmaceuticals, Inc. | Systems and Methods to Image Intercellular and Intercompartmental Defects with Magnetic Resonance Imaging (MRI) |
| EP3380484A1 (en) | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
| CN108289970B (en) | 2015-11-30 | 2022-04-08 | 通用电气医疗集团股份有限公司 | Formulations comprising a combination of MRI contrast agents |
| AU2016368542B2 (en) | 2015-12-10 | 2020-07-16 | Bracco Imaging Spa | Contrast agents |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| KR102550339B1 (en) | 2016-12-21 | 2023-07-04 | 지이 헬스케어 에이에스 | Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as MRI imaging agents |
| EP3728168B1 (en) | 2017-12-20 | 2022-03-30 | General Electric Company | Anionic chelate compounds |
| KR20220058574A (en) | 2019-09-03 | 2022-05-09 | 지이 헬스케어 에이에스 | Manganese Chelate Isomer |
-
2016
- 2016-06-20 GB GBGB1610738.5A patent/GB201610738D0/en not_active Ceased
-
2017
- 2017-06-20 BR BR112018076389-6A patent/BR112018076389A2/en unknown
- 2017-06-20 DK DK17731559.5T patent/DK3472163T3/en active
- 2017-06-20 CN CN201780051082.4A patent/CN109641900B/en active Active
- 2017-06-20 PL PL17731559T patent/PL3472163T3/en unknown
- 2017-06-20 LT LTEP17731559.5T patent/LT3472163T/en unknown
- 2017-06-20 WO PCT/EP2017/065135 patent/WO2017220610A1/en unknown
- 2017-06-20 JP JP2019518150A patent/JP7048591B2/en active Active
- 2017-06-20 SG SG11201811380RA patent/SG11201811380RA/en unknown
- 2017-06-20 US US16/311,564 patent/US11884686B2/en active Active
- 2017-06-20 EP EP17731559.5A patent/EP3472163B1/en active Active
- 2017-06-20 KR KR1020197001479A patent/KR102435941B1/en active IP Right Grant
- 2017-06-20 RU RU2018145061A patent/RU2747310C2/en active
- 2017-06-20 CA CA3028027A patent/CA3028027A1/en active Pending
- 2017-06-20 CN CN202010082357.4A patent/CN111499633B/en active Active
- 2017-06-20 AU AU2017281189A patent/AU2017281189B2/en active Active
- 2017-06-20 ES ES17731559T patent/ES2848580T3/en active Active
- 2017-06-20 MX MX2018016082A patent/MX2018016082A/en unknown
- 2017-06-20 KR KR1020227028798A patent/KR20220123138A/en not_active Application Discontinuation
- 2017-06-20 HU HUE17731559A patent/HUE053402T2/en unknown
-
2019
- 2019-01-18 ZA ZA201900371A patent/ZA201900371B/en unknown
-
2022
- 2022-03-24 JP JP2022049034A patent/JP2022101556A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3472163A1 (en) | 2019-04-24 |
| JP2022101556A (en) | 2022-07-06 |
| PL3472163T3 (en) | 2021-05-31 |
| KR102435941B1 (en) | 2022-08-25 |
| GB201610738D0 (en) | 2016-08-03 |
| LT3472163T (en) | 2021-05-25 |
| WO2017220610A1 (en) | 2017-12-28 |
| CN111499633B (en) | 2023-02-17 |
| RU2018145061A (en) | 2020-07-21 |
| CN109641900B (en) | 2021-08-24 |
| RU2747310C2 (en) | 2021-05-04 |
| MX2018016082A (en) | 2019-09-10 |
| CN111499633A (en) | 2020-08-07 |
| US11884686B2 (en) | 2024-01-30 |
| CN109641900A (en) | 2019-04-16 |
| JP2019518082A (en) | 2019-06-27 |
| CA3028027A1 (en) | 2017-12-28 |
| US20190233450A1 (en) | 2019-08-01 |
| KR20220123138A (en) | 2022-09-05 |
| ES2848580T3 (en) | 2021-08-10 |
| AU2017281189A1 (en) | 2019-01-17 |
| EP3472163B1 (en) | 2020-11-11 |
| BR112018076389A2 (en) | 2019-03-26 |
| KR20190018710A (en) | 2019-02-25 |
| RU2018145061A3 (en) | 2020-07-28 |
| ZA201900371B (en) | 2019-10-30 |
| DK3472163T3 (en) | 2021-02-01 |
| JP7048591B2 (en) | 2022-04-05 |
| HUE053402T2 (en) | 2021-06-28 |
| AU2017281189B2 (en) | 2021-05-13 |
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