MX2019007595A - Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri. - Google Patents
Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri.Info
- Publication number
- MX2019007595A MX2019007595A MX2019007595A MX2019007595A MX2019007595A MX 2019007595 A MX2019007595 A MX 2019007595A MX 2019007595 A MX2019007595 A MX 2019007595A MX 2019007595 A MX2019007595 A MX 2019007595A MX 2019007595 A MX2019007595 A MX 2019007595A
- Authority
- MX
- Mexico
- Prior art keywords
- tetraazabicyclo
- imaging agents
- compounds suitable
- chelate compounds
- mri imaging
- Prior art date
Links
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229910052748 manganese Inorganic materials 0.000 title abstract 2
- 239000011572 manganese Substances 0.000 title abstract 2
- 239000013522 chelant Substances 0.000 title 1
- 239000012216 imaging agent Substances 0.000 title 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 230000000536 complexating effect Effects 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención proporciona compuestos de la fórmula (I) que representa un poli-aza-macrociclo con brazos laterales de ácido carboxílico que forman complejo con manganeso como el metal del núcleo. Los complejos son adecuados para usarse como agentes de contraste en la toma de imágenes de resonancia magnética (MRI).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662437082P | 2016-12-21 | 2016-12-21 | |
PCT/EP2017/084148 WO2018115314A1 (en) | 2016-12-21 | 2017-12-21 | Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as mri imaging agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019007595A true MX2019007595A (es) | 2019-09-09 |
Family
ID=60857088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019007595A MX2019007595A (es) | 2016-12-21 | 2017-12-21 | Compuestos de quelato de manganeso basados en tetra-azabiciclo-macrociclos adecuados como agentes de toma de imagenes mri. |
Country Status (17)
Country | Link |
---|---|
US (1) | US10730897B2 (es) |
EP (1) | EP3558394B1 (es) |
JP (1) | JP7258753B2 (es) |
KR (1) | KR102550339B1 (es) |
CN (1) | CN110290815A (es) |
AU (1) | AU2017382953B2 (es) |
BR (1) | BR112019012757A2 (es) |
CA (1) | CA3048104A1 (es) |
DK (1) | DK3558394T3 (es) |
ES (1) | ES2813077T3 (es) |
HU (1) | HUE050402T2 (es) |
LT (1) | LT3558394T (es) |
MX (1) | MX2019007595A (es) |
PL (1) | PL3558394T3 (es) |
RU (1) | RU2769699C2 (es) |
WO (1) | WO2018115314A1 (es) |
ZA (1) | ZA201904006B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
JP7332600B2 (ja) * | 2017-12-20 | 2023-08-23 | ゼネラル・エレクトリック・カンパニイ | アニオン性キレート化合物 |
WO2024097160A1 (en) * | 2022-10-31 | 2024-05-10 | Yale University | Transition metal complexes for mri applications and methods of use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU608759B2 (en) | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
DE68908185T2 (de) | 1988-09-27 | 1993-11-25 | Nycomed Salutar Inc | Chelat-zusammensetzung. |
EP0735040A3 (en) * | 1991-12-10 | 1997-02-26 | Dow Chemical Co | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, and their preparation |
FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
WO2006002875A1 (en) | 2004-07-02 | 2006-01-12 | Bracco Imaging Spa | Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents |
FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
US20090208421A1 (en) | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
DK2988756T4 (da) | 2013-04-26 | 2022-08-08 | Guerbet Sa | Formulering af kontraststof og dertil knyttet fremstillingsfremgangsmåde |
GB201610738D0 (en) * | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
-
2017
- 2017-12-21 US US16/472,579 patent/US10730897B2/en active Active
- 2017-12-21 DK DK17822298.0T patent/DK3558394T3/da active
- 2017-12-21 WO PCT/EP2017/084148 patent/WO2018115314A1/en active Application Filing
- 2017-12-21 JP JP2019533460A patent/JP7258753B2/ja active Active
- 2017-12-21 AU AU2017382953A patent/AU2017382953B2/en active Active
- 2017-12-21 CN CN201780086971.4A patent/CN110290815A/zh active Pending
- 2017-12-21 BR BR112019012757A patent/BR112019012757A2/pt unknown
- 2017-12-21 RU RU2019118365A patent/RU2769699C2/ru active
- 2017-12-21 MX MX2019007595A patent/MX2019007595A/es unknown
- 2017-12-21 HU HUE17822298A patent/HUE050402T2/hu unknown
- 2017-12-21 EP EP17822298.0A patent/EP3558394B1/en active Active
- 2017-12-21 KR KR1020197020855A patent/KR102550339B1/ko active IP Right Grant
- 2017-12-21 CA CA3048104A patent/CA3048104A1/en active Pending
- 2017-12-21 PL PL17822298T patent/PL3558394T3/pl unknown
- 2017-12-21 ES ES17822298T patent/ES2813077T3/es active Active
- 2017-12-21 LT LTEP17822298.0T patent/LT3558394T/lt unknown
-
2019
- 2019-06-20 ZA ZA2019/04006A patent/ZA201904006B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2017382953A2 (en) | 2019-09-12 |
JP7258753B2 (ja) | 2023-04-17 |
LT3558394T (lt) | 2020-09-10 |
ES2813077T3 (es) | 2021-03-22 |
HUE050402T2 (hu) | 2020-12-28 |
DK3558394T3 (da) | 2020-08-24 |
AU2017382953A1 (en) | 2019-07-04 |
US10730897B2 (en) | 2020-08-04 |
RU2019118365A (ru) | 2021-01-22 |
EP3558394B1 (en) | 2020-06-03 |
RU2019118365A3 (es) | 2021-03-09 |
US20200062791A1 (en) | 2020-02-27 |
WO2018115314A1 (en) | 2018-06-28 |
CA3048104A1 (en) | 2018-06-28 |
CN110290815A (zh) | 2019-09-27 |
AU2017382953B2 (en) | 2021-10-21 |
ZA201904006B (en) | 2022-04-28 |
JP2020503310A (ja) | 2020-01-30 |
KR102550339B1 (ko) | 2023-07-04 |
KR20190098193A (ko) | 2019-08-21 |
PL3558394T3 (pl) | 2020-11-16 |
BR112019012757A2 (pt) | 2019-11-26 |
EP3558394A1 (en) | 2019-10-30 |
RU2769699C2 (ru) | 2022-04-05 |
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