DK345285A - Diphosphonsyrederivater, fremgangsmaade til deres fremstilling og laegemidler, der indeholder disse forbindelser - Google Patents
Diphosphonsyrederivater, fremgangsmaade til deres fremstilling og laegemidler, der indeholder disse forbindelser Download PDFInfo
- Publication number
- DK345285A DK345285A DK345285A DK345285A DK345285A DK 345285 A DK345285 A DK 345285A DK 345285 A DK345285 A DK 345285A DK 345285 A DK345285 A DK 345285A DK 345285 A DK345285 A DK 345285A
- Authority
- DK
- Denmark
- Prior art keywords
- optionally substituted
- alkyl
- preparation
- radical
- procedures
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical class OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- -1 1,2,4-triazole radical Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Non-Portable Lighting Devices Or Systems Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3428524A DE3428524A1 (de) | 1984-08-02 | 1984-08-02 | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK345285D0 DK345285D0 (da) | 1985-07-30 |
| DK345285A true DK345285A (da) | 1986-02-03 |
Family
ID=6242211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK345285A DK345285A (da) | 1984-08-02 | 1985-07-30 | Diphosphonsyrederivater, fremgangsmaade til deres fremstilling og laegemidler, der indeholder disse forbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4687767A (https=) |
| EP (1) | EP0170228B1 (https=) |
| JP (1) | JPS6143197A (https=) |
| AT (1) | ATE39489T1 (https=) |
| AU (1) | AU553419B2 (https=) |
| CA (1) | CA1264326A (https=) |
| CS (1) | CS257277B2 (https=) |
| DD (1) | DD236533A5 (https=) |
| DE (2) | DE3428524A1 (https=) |
| DK (1) | DK345285A (https=) |
| ES (1) | ES8606876A1 (https=) |
| FI (1) | FI78915C (https=) |
| GR (1) | GR851881B (https=) |
| HU (1) | HU196419B (https=) |
| IL (1) | IL75971A (https=) |
| SU (1) | SU1475487A3 (https=) |
| ZA (1) | ZA855760B (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| PH27078A (en) * | 1984-12-21 | 1993-02-01 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonates |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US5641762A (en) * | 1985-05-02 | 1997-06-24 | Research Corporation Technologies, Inc. | Bone targeted inhibitors of carbonic anhydrase |
| DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| DE3770982D1 (de) * | 1986-04-24 | 1991-08-01 | Fujisawa Pharmaceutical Co | Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel. |
| DE3626058A1 (de) * | 1986-08-01 | 1988-02-11 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3776880D1 (de) * | 1986-11-21 | 1992-04-02 | Ciba Geigy Ag | Neue substituierte alkandiphosphonsaeuren. |
| ATE64397T1 (de) * | 1986-11-21 | 1991-06-15 | Ciba Geigy Ag | Aromatisch substituierte azacycloalkylalkandiphosphons|uren. |
| US5057505A (en) * | 1986-11-21 | 1991-10-15 | Ciba-Geigy Corporation | Substituted aminomethanediphosphonic acids and use in medicaments |
| DE3640938A1 (de) * | 1986-11-29 | 1988-06-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5071840A (en) * | 1986-12-19 | 1991-12-10 | Norwich Eaton Pharmaceuticals, Inc. | Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism |
| US4939265A (en) * | 1987-02-25 | 1990-07-03 | Bristol-Myers Company | Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds |
| HU199151B (en) * | 1987-03-10 | 1990-01-29 | Yamanouchi Pharma Co Ltd | Process for producing bis-phosphonic acid derivatives |
| EP0282309A3 (en) * | 1987-03-11 | 1990-03-14 | Yamanouchi Pharmaceutical Co. Ltd. | Azole-aminomethylene bisphosphonic acid derivatives |
| US4963681A (en) * | 1987-07-06 | 1990-10-16 | Norwich Eaton Pharmaceuticals, Inc. | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| EP0317505A1 (de) * | 1987-11-13 | 1989-05-24 | Ciba-Geigy Ag | Neue Azacycloalkylalkandiphosphonsäuren |
| US5190930A (en) * | 1987-12-11 | 1993-03-02 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| US5110807A (en) * | 1988-12-01 | 1992-05-05 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| DE3817956A1 (de) * | 1988-05-27 | 1989-12-07 | Hoechst Ag | Verfahren zur herstellung phosphorhaltiger l-aminosaeuren sowie ihrer ester und n-derivate |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4990503A (en) * | 1988-08-12 | 1991-02-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic bisphosphonic acid derivatives |
| TW198039B (https=) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
| DE3917153A1 (de) * | 1989-05-26 | 1990-11-29 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| MX21452A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| US5139786A (en) * | 1989-07-07 | 1992-08-18 | Ciba-Geigy Corporation | Topical formulations |
| JPH05507061A (ja) * | 1990-01-12 | 1993-10-14 | ローヌ―プーラン ローラー インターナショナル （ホウルディングス）インコーポレイテッド | １―アゼチジル及び１―ヘキサメチレンイミンアルキルまたはアリールビスホスホン酸及び医薬としてのその使用 |
| US5204334A (en) * | 1990-10-18 | 1993-04-20 | Ciba-Geigy Corporation | Benzoheterocyclylalkylaminoalkanediphosphonic acids, compositions thereof, and use thereof in the treatment of calcium metabolism disorders |
| US5391743A (en) * | 1992-05-29 | 1995-02-21 | Procter & Gamble Pharmaceuticals, Inc. | Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque |
| US5763611A (en) * | 1992-05-29 | 1998-06-09 | The Procter & Gamble Company | Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5753634A (en) * | 1992-05-29 | 1998-05-19 | The Procter & Gamble Company | Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism |
| FI945595A7 (fi) * | 1992-05-29 | 1994-11-28 | Procter & Gamble Pharmaceuticals Inc | Tiosubstituoituja typpipitoisia heterosyklisiä fosfonaattiyhdisteitä e pänormaalin kalsium- ja fosfaattiaineenvaihdunnan hoitamiseksi |
| EP0646119B1 (en) * | 1992-05-29 | 1998-07-15 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque |
| DK0642519T3 (da) * | 1992-05-29 | 2000-09-18 | Procter & Gamble Pharma | Svovlholdige phosphonatforbindelser til behandling af unormal calcium- og phosphatmetabolisme |
| DE69324684T2 (de) * | 1992-06-30 | 1999-11-25 | Procter & Gamble Pharmaceuticals, Inc. | Arzneimitteln zur behandlung von arthritis die phosphonate und nsaids enthalten |
| DE4228552A1 (de) * | 1992-08-27 | 1994-03-03 | Boehringer Mannheim Gmbh | Diphosphonsäuren und deren Salze enthaltende Arzneimittel |
| AU670337B2 (en) | 1992-11-30 | 1996-07-11 | Novartis Ag | Use of certain methanebisphosphonic acid derivatives in fracture healing |
| JPH06298779A (ja) * | 1993-04-15 | 1994-10-25 | Hoechst Japan Ltd | ヘテロ環イミノビスメチレンビスホスホン酸誘導体 |
| US5510517A (en) * | 1993-08-25 | 1996-04-23 | Merck & Co., Inc. | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
| GB9324143D0 (en) * | 1993-11-24 | 1994-01-12 | Schering Agrochemicals Ltd | Triazole phosphonate pesticides |
| WO1996039134A1 (en) * | 1995-06-05 | 1996-12-12 | Takeda Chemical Industries, Ltd. | Osteogenetic promoting pharmaceutical composition |
| ES2239774T3 (es) * | 1995-09-29 | 2005-10-01 | Novartis Ag | Metodo de tratamiento de la enfermedad navicular en caballos. |
| JP2003531111A (ja) | 1999-12-17 | 2003-10-21 | アライアッド・ファーマシューティカルズ・インコーポレーテッド | プロトンポンプインヒビター |
| AU2583901A (en) * | 1999-12-17 | 2001-06-25 | Ariad Pharmaceuticals, Inc. | Proton pump inhibitors |
| IL150059A0 (en) * | 1999-12-17 | 2002-12-01 | Ariad Pharma Inc | Novel heterocycles |
| US6677320B2 (en) | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| US6410520B2 (en) * | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
| CA2372450A1 (en) * | 2001-05-10 | 2001-09-19 | Pharmaceutical Partners Of Canada Inc. | Liquid injectable formulation of disodium pamidronate |
| RU2387451C2 (ru) | 2002-05-10 | 2010-04-27 | Ф.Хоффманн-Ля Рош Аг | Бисфосфоновые кислоты, предназначенные для лечения и профилактики остеопороза |
| JP4485117B2 (ja) * | 2002-06-27 | 2010-06-16 | 日東電工株式会社 | 保護剥離用フィルム |
| DE60309887T2 (de) * | 2002-07-30 | 2007-05-16 | Novartis Ag | Kombination von einem aromatasehemmer mit einem bisphosphonat |
| TW200413381A (en) | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| US20040206932A1 (en) * | 2002-12-30 | 2004-10-21 | Abuelyaman Ahmed S. | Compositions including polymerizable bisphosphonic acids and methods |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| US20050065171A1 (en) * | 2003-06-25 | 2005-03-24 | Shakespeare William C. | Substituted purine derivatives |
| DE602004030801D1 (de) * | 2003-07-30 | 2011-02-10 | Warner Chilcott Co Llc | Isedronat |
| US7632098B2 (en) * | 2003-08-12 | 2009-12-15 | 3M Innovative Properties Company | Self-adhesive dental compositions and methods |
| US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
| US8465284B2 (en) | 2004-07-08 | 2013-06-18 | 3M Innovative Properties Company | Dental methods, compositions, and kits including acid-sensitive dyes |
| EP1784155B1 (en) | 2004-08-11 | 2011-09-28 | 3M Innovative Properties Company | Self-adhesive compositions including a plurality of acidic compounds |
| JP5507256B2 (ja) * | 2006-12-13 | 2014-05-28 | スリーエム イノベイティブ プロパティズ カンパニー | 酸性成分及び光退色性染料を有する歯科用組成物の使用方法 |
| CA2671727C (en) * | 2006-12-20 | 2016-02-16 | Genpharm Ulc | A composition containing a bisphosphonic acid in combination with vitamin d |
| AU2007335156A1 (en) * | 2006-12-20 | 2008-06-26 | Mylan Pharmaceuticals Ulc | Pharmaceutical composition comprising a hot-melt granulated lubricant |
| EP2136814A4 (en) * | 2007-03-21 | 2012-05-30 | Univ Duke | MEDICAL KITS AND FORMULATIONS FOR PREVENTING, TREATING OR REDUCING SECONDARY FRACTURES FROM A PREVIOUS FRACTURE |
| KR20110110219A (ko) * | 2008-12-23 | 2011-10-06 | 노파르티스 아게 | 페닐알킬-이미다졸-비스포스포네이트 화합물 |
| DK2473172T3 (en) | 2009-09-01 | 2015-06-15 | Univ Duke | BISPHOSPHONATSAMMENSÆTNINGER and Methods for treating congestive heart failure |
| WO2013074587A1 (en) | 2011-11-16 | 2013-05-23 | Duke University | Bishophonate compositions and methods for treating and/or reducing cardiac dysfunction |
| PL407922A1 (pl) | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
| KR20200066690A (ko) | 2017-10-16 | 2020-06-10 | 칭화대학교 | 메발로네이트 경로 억제제 및 이의 약제학적 조성물 |
| USD958651S1 (en) | 2020-08-11 | 2022-07-26 | Bocks Inc. | Liquid soap dispenser carton |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH9776A (en) * | 1967-12-11 | 1976-03-17 | M Francis | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue and method of use |
| DE3203308A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| DE3365492D1 (en) * | 1982-01-27 | 1986-10-02 | Schering Ag | Diphosphonic acid derivatives and pharmaceutical preparations containing them |
| DE3203309A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| EP0084822B1 (de) * | 1982-01-27 | 1986-01-08 | Schering Aktiengesellschaft | Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1984
- 1984-08-02 DE DE3428524A patent/DE3428524A1/de not_active Withdrawn
-
1985
- 1985-07-24 CA CA000487443A patent/CA1264326A/en not_active Expired - Lifetime
- 1985-07-26 EP EP85109432A patent/EP0170228B1/de not_active Expired
- 1985-07-26 DE DE8585109432T patent/DE3567023D1/de not_active Expired
- 1985-07-26 AT AT85109432T patent/ATE39489T1/de active
- 1985-07-26 US US06/759,608 patent/US4687767A/en not_active Expired - Lifetime
- 1985-07-30 DD DD85279140A patent/DD236533A5/de not_active IP Right Cessation
- 1985-07-30 IL IL75971A patent/IL75971A/xx not_active IP Right Cessation
- 1985-07-30 DK DK345285A patent/DK345285A/da not_active Application Discontinuation
- 1985-07-31 ZA ZA855760A patent/ZA855760B/xx unknown
- 1985-07-31 CS CS855580A patent/CS257277B2/cs not_active IP Right Cessation
- 1985-07-31 GR GR851881A patent/GR851881B/el unknown
- 1985-08-01 HU HU852957A patent/HU196419B/hu not_active IP Right Cessation
- 1985-08-01 AU AU45686/85A patent/AU553419B2/en not_active Ceased
- 1985-08-01 FI FI852980A patent/FI78915C/fi not_active IP Right Cessation
- 1985-08-01 SU SU853935742A patent/SU1475487A3/ru active
- 1985-08-02 JP JP60169944A patent/JPS6143197A/ja active Pending
- 1985-08-02 ES ES545842A patent/ES8606876A1/es not_active Expired
-
1987
- 1987-07-23 US US07/076,706 patent/US4784993A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL75971A (en) | 1989-05-15 |
| ES8606876A1 (es) | 1986-05-16 |
| JPS6143197A (ja) | 1986-03-01 |
| AU4568685A (en) | 1986-02-06 |
| DE3428524A1 (de) | 1986-02-13 |
| DD236533A5 (de) | 1986-06-11 |
| FI852980L (fi) | 1986-02-03 |
| SU1475487A3 (ru) | 1989-04-23 |
| DK345285D0 (da) | 1985-07-30 |
| EP0170228B1 (de) | 1988-12-28 |
| CA1264326A (en) | 1990-01-09 |
| HU196419B (en) | 1988-11-28 |
| ZA855760B (en) | 1986-04-30 |
| US4784993A (en) | 1988-11-15 |
| AU553419B2 (en) | 1986-07-17 |
| FI78915C (fi) | 1989-10-10 |
| FI852980A0 (fi) | 1985-08-01 |
| FI78915B (fi) | 1989-06-30 |
| US4687767A (en) | 1987-08-18 |
| EP0170228A1 (de) | 1986-02-05 |
| GR851881B (https=) | 1985-12-02 |
| IL75971A0 (en) | 1985-12-31 |
| DE3567023D1 (en) | 1989-02-02 |
| ATE39489T1 (de) | 1989-01-15 |
| HUT38364A (en) | 1986-05-28 |
| ES545842A0 (es) | 1986-05-16 |
| CS257277B2 (en) | 1988-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |