DK3322425T3 - Genmodificerede anti-tredjeparts-centralhukommelse-t-celler og brug af samme i immunterapi - Google Patents

Genmodificerede anti-tredjeparts-centralhukommelse-t-celler og brug af samme i immunterapi Download PDF

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DK3322425T3
DK3322425T3 DK16750269.9T DK16750269T DK3322425T3 DK 3322425 T3 DK3322425 T3 DK 3322425T3 DK 16750269 T DK16750269 T DK 16750269T DK 3322425 T3 DK3322425 T3 DK 3322425T3
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geneticly
cells
same
central memory
modified anti
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DK16750269.9T
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Yair Reisner
Noga Or-Geva
Eran Ophir
Yaki Eidelstein
Budovsky Rotem Gidron
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Yeda Res & Dev
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    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
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    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/41—Vertebrate antigens
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2501/20—Cytokines; Chemokines
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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DK16750269.9T 2015-07-16 2016-07-14 Genmodificerede anti-tredjeparts-centralhukommelse-t-celler og brug af samme i immunterapi DK3322425T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562193207P 2015-07-16 2015-07-16
US201562193229P 2015-07-16 2015-07-16
PCT/IL2016/050775 WO2017009853A1 (en) 2015-07-16 2016-07-14 Genetically modified anti-third party central memory t cells and use of same in immunotherapy

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DK3322425T3 true DK3322425T3 (da) 2023-06-12

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US (4) US11179448B2 (enExample)
EP (2) EP3322425B1 (enExample)
JP (1) JP7057748B2 (enExample)
CN (3) CN114457039B (enExample)
AU (1) AU2016291825B2 (enExample)
CA (1) CA2991690A1 (enExample)
DK (1) DK3322425T3 (enExample)
ES (2) ES2963038T3 (enExample)
IL (1) IL256916B2 (enExample)
PL (2) PL3322425T3 (enExample)
WO (2) WO2017009852A1 (enExample)

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WO2010049935A1 (en) 2008-10-30 2010-05-06 Yeda Research And Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
EP2753351B1 (en) 2011-09-08 2017-06-21 Yeda Research and Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
CA2942245C (en) * 2014-03-12 2021-11-02 Yeda Research And Development Co. Ltd. Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns
DK3322425T3 (da) * 2015-07-16 2023-06-12 Yeda Res & Dev Genmodificerede anti-tredjeparts-centralhukommelse-t-celler og brug af samme i immunterapi
SG11201811563RA (en) 2016-06-27 2019-01-30 Yeda Res & Dev Veto cells generated from memory t cells
US10751368B2 (en) 2017-01-18 2020-08-25 Yeda Research And Development Co. Ltd. Methods of transplantation and disease treatment
WO2018134824A1 (en) 2017-01-18 2018-07-26 Yeda Research And Development Co. Ltd. Genetically modified veto cells and use of same in immunotherapy
CN107573419A (zh) * 2017-01-24 2018-01-12 深圳市体内生物医药科技有限公司 一种增强t细胞抗肿瘤活性的核酸分子
CN107254489B (zh) * 2017-06-19 2021-06-18 河南省华隆生物技术有限公司 一种检测嵌合抗原受体或基因修饰的t细胞受体表达的方法和应用
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CN112969470A (zh) * 2018-09-10 2021-06-15 阿塔拉生物制药股份有限公司 用于扩增抗原特异性car-t细胞、组合物的方法及其相关用途
CN109536444B (zh) * 2018-12-11 2022-06-28 吉林省拓华生物科技有限公司 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法
AU2020261411B2 (en) * 2019-04-26 2025-10-02 Allogene Therapeutics, Inc. Methods of manufacturing allogeneic car T cells
CN110358734B (zh) * 2019-06-13 2020-08-25 首都医科大学宣武医院 以Tcm为主要效应成分的CAR-T制备方法及其应用
CA3149379A1 (en) * 2019-08-06 2021-02-11 Yeda Research And Development Co. Ltd. Anti-viral central memory cd8+ veto cells in haploidentical stem cell transplantation
CN110628717B (zh) * 2019-10-28 2020-10-30 上海科医联创生物科技有限公司 一种浸润性t细胞的培养方法
JP2023500277A (ja) * 2019-11-05 2023-01-05 イェダ リサーチ アンド デベロップメント カンパニー リミテッド Ｔ細胞媒介性自己免疫疾患の治療におけるベト細胞の使用
WO2021090320A1 (en) * 2019-11-05 2021-05-14 Yeda Research And Development Co. Ltd. Use of veto cells for the treatment of sickle cell disease
EP4110352A4 (en) * 2020-02-28 2024-04-24 KSQ Therapeutics, Inc. Methods for activation and expansion of tumor infiltrating lymphocytes
EP4161536A4 (en) 2020-06-04 2024-08-14 Carisma Therapeutics Inc. Novel constructs for chimeric antigen receptors
IL300470A (en) * 2020-08-11 2023-04-01 Yeda res & development co ltd Veto type CAR-T cells
US20240001142A1 (en) * 2020-10-07 2024-01-04 Board Of Regents, The University Of Texas System Induction by low dose radiation of cancer cell targets for cell-based or small molecule therapy

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