IL256916B2 - Genetically modified anti-third party central memory t cells and use of same in immunotherapy - Google Patents

Genetically modified anti-third party central memory t cells and use of same in immunotherapy

Info

Publication number
IL256916B2
IL256916B2 IL256916A IL25691618A IL256916B2 IL 256916 B2 IL256916 B2 IL 256916B2 IL 256916 A IL256916 A IL 256916A IL 25691618 A IL25691618 A IL 25691618A IL 256916 B2 IL256916 B2 IL 256916B2
Authority
IL
Israel
Prior art keywords
cell
cells
antigen
tcm
party
Prior art date
Application number
IL256916A
Other languages
English (en)
Hebrew (he)
Other versions
IL256916A (en
IL256916B1 (en
Inventor
Reisner Yair
Ophir Eran
Eidelstein Yaki
Or-Geva Noga
GIDRON BUDOVSKY Rotem
Original Assignee
Yeda Res & Dev
Reisner Yair
Ophir Eran
Eidelstein Yaki
Noga Or Geva
GIDRON BUDOVSKY Rotem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Reisner Yair, Ophir Eran, Eidelstein Yaki, Noga Or Geva, GIDRON BUDOVSKY Rotem filed Critical Yeda Res & Dev
Publication of IL256916A publication Critical patent/IL256916A/en
Publication of IL256916B1 publication Critical patent/IL256916B1/en
Publication of IL256916B2 publication Critical patent/IL256916B2/en

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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/42—Cancer antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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IL256916A 2015-07-16 2016-07-14 Genetically modified anti-third party central memory t cells and use of same in immunotherapy IL256916B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562193207P 2015-07-16 2015-07-16
US201562193229P 2015-07-16 2015-07-16
PCT/IL2016/050775 WO2017009853A1 (en) 2015-07-16 2016-07-14 Genetically modified anti-third party central memory t cells and use of same in immunotherapy

Publications (3)

Publication Number Publication Date
IL256916A IL256916A (en) 2018-03-29
IL256916B1 IL256916B1 (en) 2023-12-01
IL256916B2 true IL256916B2 (en) 2024-04-01

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ID=56555512

Family Applications (1)

Application Number Title Priority Date Filing Date
IL256916A IL256916B2 (en) 2015-07-16 2016-07-14 Genetically modified anti-third party central memory t cells and use of same in immunotherapy

Country Status (10)

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US (4) US10933124B2 (enExample)
EP (2) EP3322425B1 (enExample)
JP (1) JP7057748B2 (enExample)
CN (3) CN108135938A (enExample)
AU (1) AU2016291825B2 (enExample)
DK (1) DK3322425T3 (enExample)
ES (2) ES2963038T3 (enExample)
IL (1) IL256916B2 (enExample)
PL (2) PL3322425T3 (enExample)
WO (2) WO2017009853A1 (enExample)

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WO2010049935A1 (en) 2008-10-30 2010-05-06 Yeda Research And Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
SG11201400513PA (en) 2011-09-08 2014-06-27 Yeda Res & Dev Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
KR20200029627A (ko) * 2014-03-12 2020-03-18 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
AU2016291825B2 (en) * 2015-07-16 2022-08-11 Yeda Research And Development Co. Ltd. Genetically modified anti-third party central memory T cells and use of same in immunotherapy
EP3475414B1 (en) 2016-06-27 2025-03-26 Yeda Research and Development Co. Ltd Veto cells generated from memory t cells
US10751368B2 (en) 2017-01-18 2020-08-25 Yeda Research And Development Co. Ltd. Methods of transplantation and disease treatment
ES3064681T3 (en) 2017-01-18 2026-04-28 Yeda Res & Dev Genetically modified veto cells and use of same in immunotherapy
CN107573419A (zh) * 2017-01-24 2018-01-12 深圳市体内生物医药科技有限公司 一种增强t细胞抗肿瘤活性的核酸分子
CN107254489B (zh) * 2017-06-19 2021-06-18 河南省华隆生物技术有限公司 一种检测嵌合抗原受体或基因修饰的t细胞受体表达的方法和应用
CA3089991A1 (en) * 2018-02-02 2019-08-08 The Trustees Of The University Of Pennsylvania Modified monocytes/macrophages/dendritic cells expressing chimeric antigen receptors and uses in diseases and disorders associated with protein aggregates
US20210213066A1 (en) * 2018-05-18 2021-07-15 Children's National Medical Center Improved cell therapy compositions for hematopoietic stem cell transplant patients
MX2021002702A (es) * 2018-09-10 2021-05-12 Atara Biotherapeutics Inc Metodos para expandir celulas t del receptor de antigeno quimerico especificas de antigenos, composiciones y usos relacionados con las mismas.
CN109536444B (zh) * 2018-12-11 2022-06-28 吉林省拓华生物科技有限公司 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法
EP3959305A1 (en) * 2019-04-26 2022-03-02 Allogene Therapeutics, Inc. Methods of manufacturing allogeneic car t cells
CN110358734B (zh) 2019-06-13 2020-08-25 首都医科大学宣武医院 以Tcm为主要效应成分的CAR-T制备方法及其应用
EP4009991A4 (en) * 2019-08-06 2023-09-13 Yeda Research and Development Co. Ltd ANTI-VIRAL CENTRAL MEMORY CD8+ VETO CELLS IN HAPLOIDENTIC STEM CELL TRANSPLANTATION
CN110628717B (zh) * 2019-10-28 2020-10-30 上海科医联创生物科技有限公司 一种浸润性t细胞的培养方法
AU2020379319A1 (en) * 2019-11-05 2022-06-23 Yeda Research And Development Co. Ltd. Use of veto cells in treatment of T cell mediated autoimmune diseases
BR112022008700A2 (pt) * 2019-11-05 2022-07-19 Yeda Res & Dev Método para tratar ou prevenir uma doença falciforme, e, transplante de células hematopoiéticas imaturas e uma quantidade terapeuticamente eficaz de uma população isolada de células anti-terceiros não indutoras de doença do enxerto versus hospedeiro
JP2023516300A (ja) * 2020-02-28 2023-04-19 ケーエスキュー セラピューティクス， インコーポレイテッド 腫瘍浸潤リンパ球の活性化及び増殖のための方法
EP4161536A4 (en) 2020-06-04 2024-08-14 Carisma Therapeutics Inc. Novel constructs for chimeric antigen receptors
IL300470A (en) * 2020-08-11 2023-04-01 Yeda res & development co ltd Veto type CAR-T cells
WO2022076743A1 (en) * 2020-10-07 2022-04-14 Board Of Regents, The University Of Texas System Induction by low dose radiation of cancer cell targets for cell-based or small molecule therapy

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