DK3296299T3 - Krystalform af 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1h-pyrazol-4-yl)-1h- imidazol-1-yl)-1h-pyrazolo[3,4-b]pyridin-1-yl}benzamid - Google Patents

Krystalform af 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1h-pyrazol-4-yl)-1h- imidazol-1-yl)-1h-pyrazolo[3,4-b]pyridin-1-yl}benzamid Download PDF

Info

Publication number
DK3296299T3
DK3296299T3 DK16792715.1T DK16792715T DK3296299T3 DK 3296299 T3 DK3296299 T3 DK 3296299T3 DK 16792715 T DK16792715 T DK 16792715T DK 3296299 T3 DK3296299 T3 DK 3296299T3
Authority
DK
Denmark
Prior art keywords
pyrazolo
pyrazol
benzamide
imidazol
pyridin
Prior art date
Application number
DK16792715.1T
Other languages
English (en)
Inventor
Takao Uno
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DK3296299T3 publication Critical patent/DK3296299T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16792715.1T 2015-05-12 2016-05-11 Krystalform af 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1h-pyrazol-4-yl)-1h- imidazol-1-yl)-1h-pyrazolo[3,4-b]pyridin-1-yl}benzamid DK3296299T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015097521 2015-05-12
PCT/JP2016/063989 WO2016181990A1 (ja) 2015-05-12 2016-05-11 アザ二環式化合物の結晶

Publications (1)

Publication Number Publication Date
DK3296299T3 true DK3296299T3 (da) 2019-12-16

Family

ID=57248173

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16792715.1T DK3296299T3 (da) 2015-05-12 2016-05-11 Krystalform af 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1h-pyrazol-4-yl)-1h- imidazol-1-yl)-1h-pyrazolo[3,4-b]pyridin-1-yl}benzamid

Country Status (20)

Country Link
US (2) US10526324B2 (da)
EP (1) EP3296299B1 (da)
JP (1) JP6537601B2 (da)
KR (1) KR102089254B1 (da)
CN (1) CN107531707B (da)
AU (1) AU2016260279B2 (da)
BR (1) BR112017024367B1 (da)
CA (1) CA2985033C (da)
DK (1) DK3296299T3 (da)
ES (1) ES2760503T3 (da)
HU (1) HUE047855T2 (da)
MX (1) MX2017014438A (da)
MY (1) MY189352A (da)
PH (1) PH12017502007A1 (da)
PL (1) PL3296299T3 (da)
PT (1) PT3296299T (da)
RU (1) RU2697521C2 (da)
SG (1) SG11201708793SA (da)
TW (1) TWI659954B (da)
WO (1) WO2016181990A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020002886A (es) * 2017-09-15 2020-10-01 Taiho Pharmaceutical Co Ltd Agente profilactico y/o terapeutico para enfermedades que involucran la expresion de ido.
CN112584837A (zh) 2018-08-31 2021-03-30 细胞内治疗公司 新方法
CA3108558A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
US11753419B2 (en) 2019-12-11 2023-09-12 Intra-Cellular Therapies, Inc. 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)phenyl)butan-1-one for treating conditions of the central nervous system and cardiac disorders
CN114685492A (zh) * 2020-12-31 2022-07-01 杭州领业医药科技有限公司 Tas-116的晶型及其制备方法、药物组合物和用途
TW202404585A (zh) * 2022-06-10 2024-02-01 日商大鵬藥品工業股份有限公司 含有匹密特匹（Pimitespib）之醫藥組合物
WO2023238930A1 (ja) * 2022-06-10 2023-12-14 大鵬薬品工業株式会社 アザ二環式化合物の類縁物質
CN115960100B (zh) * 2022-12-28 2023-08-18 北京康立生医药技术开发有限公司 一种治疗胃肠道间质瘤药物皮咪特昔布的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL375993A1 (en) 2002-09-16 2005-12-12 Glaxo Group Limited Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
RU2357967C2 (ru) * 2002-09-16 2009-06-10 Глаксо Груп Лимитед ПРОИЗВОДНЫЕ ПИРАЗОЛО[3, 4-b]ПИРИДИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ (ВАРИАНТЫ), ПРИМЕНЕНИЕ (ВАРИАНТЫ), КОМПОЗИЦИЯ (ВАРИАНТЫ)
WO2011004610A1 (ja) * 2009-07-10 2011-01-13 大鵬薬品工業株式会社 アザ二環式化合物又はその塩
MX2013007938A (es) 2011-01-07 2013-11-01 Taiho Pharmaceutical Co Ltd Compuesto biciclico novedoso o sal del mismo.
AU2014325016C1 (en) * 2013-09-30 2021-10-07 Taiho Pharmaceutical Co., Ltd. Combination therapy using azabicyclo compound for cancer

Also Published As

Publication number Publication date
JP6537601B2 (ja) 2019-07-03
KR102089254B1 (ko) 2020-03-16
BR112017024367A2 (pt) 2018-07-31
HUE047855T2 (hu) 2020-05-28
WO2016181990A1 (ja) 2016-11-17
RU2017142958A3 (da) 2019-06-13
TW201704234A (zh) 2017-02-01
BR112017024367B1 (pt) 2023-05-09
ES2760503T3 (es) 2020-05-14
US20200102304A1 (en) 2020-04-02
CA2985033A1 (en) 2016-11-17
CN107531707B (zh) 2020-01-10
PT3296299T (pt) 2019-12-13
EP3296299A4 (en) 2018-10-24
US10526324B2 (en) 2020-01-07
CN107531707A (zh) 2018-01-02
MY189352A (en) 2022-02-07
AU2016260279A1 (en) 2017-11-30
KR20180003558A (ko) 2018-01-09
EP3296299B1 (en) 2019-10-02
TWI659954B (zh) 2019-05-21
US20180148443A1 (en) 2018-05-31
JPWO2016181990A1 (ja) 2018-03-01
US10947233B2 (en) 2021-03-16
PH12017502007A1 (en) 2018-03-26
PL3296299T3 (pl) 2020-04-30
SG11201708793SA (en) 2017-11-29
CA2985033C (en) 2020-02-25
RU2697521C2 (ru) 2019-08-15
EP3296299A1 (en) 2018-03-21
MX2017014438A (es) 2018-03-02
RU2017142958A (ru) 2019-06-13
AU2016260279B2 (en) 2019-03-14

Similar Documents

Publication Publication Date Title
DK3296299T3 (da) Krystalform af 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1h-pyrazol-4-yl)-1h- imidazol-1-yl)-1h-pyrazolo[3,4-b]pyridin-1-yl}benzamid
DK3303348T3 (da) Naphthyridinforbindelser som JAK-kinaseinhibitorer
DK3674302T3 (da) 1h-pyrrolo[2,3-c]pyridin-7(6h)-oner og pyrazolo[3,4-c]pyridin-7(6h)-oner som inhibitorer af bet-proteiner
DK3119397T3 (da) Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser
DK3357919T3 (da) Aromatiske heterocykliske forbindelser som antiinflammatoriske forbindelser
HK1217488A1 (zh) -二氨基- -氟苄基 -吡唑并 吡啶- -基 嘧啶- -基}甲基氨基甲酸甲酯的形式
HK1215575A1 (zh) 吡咯並吡啶或吡唑並吡啶衍生物
DK3478681T3 (da) 1h-pyrazolo[4,3-b]pyridiner som pde1-inhibitorer
IL251385A0 (en) An inhaled formulation of rapamycin for the treatment of pulmonary hypertension
FR22C1058I2 (fr) Formulation de comprimé de 2-fluoro-n-méthyl-4-[7-(quinoline -6-ylméthyl) imidazo[1,2-b][1,2,4]triazine -2-yl]benzamide
DK3380471T3 (da) Tetrahydro-8h-pyrido[1,2-a]pyrazin-8-oner som comt-inhibitorer til behandlingen af neurodegenerative lidelser
DK3021839T3 (da) Sammensætninger for behandling af fibrose
DK3297653T3 (da) Behandling af postbariatrisk hypoglykæmi med glp-1-antagonister
DK3256483T3 (da) Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav
DK3137126T3 (da) Medicinske indretninger med ikke-ensartede coatinger med henblik på forbedret ekkogenicitet
DK3265057T3 (da) Topisk formulering
DK2886108T4 (da) Optimeret farmaceutisk formulering til behandling af inflammatoriske ændringer af øsofagus
DK3194389T3 (da) Ssao inhibitorer afledt af imidazo[4,5-c]pyridin
DK3362453T3 (da) Cykliske etherderivater af pyrazolo[1,5-a]pyrimidin-3-carboxyamid
DK3218382T3 (da) 2,3-dihydro-thiazolo[3,2-a]pyridin-5-on derivativer som antibiotika til behandling af klamydiainfektioner
DK3356329T3 (da) Fremgangsmåde til fremstilling af 1-(4-methansulfonyl-2-trifluormethylbenzyl)-2-methyl-1H-pyrrolo[2,3-B]pyridin-3-yleddikesyre
PL3454674T3 (pl) Sposoby stosowania fermentowanej mieszanki mlecznej dla niemowląt
GB201720793D0 (en) Stable liquid formulations of pemetrexed
ITMI20130605A1 (it) Procedimento per la preparazione di composti benzoeterodiazolici disostituiti con gruppi benzoditiofenici
ZA201707777B (en) Pharmaceutical formulation for the treatment of inflammatory changes to the rectum