DK3198026T3 - Fremgangsmåde til bestemmelse af pik3ca-mutationsstatus i en prøve - Google Patents
Fremgangsmåde til bestemmelse af pik3ca-mutationsstatus i en prøve Download PDFInfo
- Publication number
- DK3198026T3 DK3198026T3 DK15753745.7T DK15753745T DK3198026T3 DK 3198026 T3 DK3198026 T3 DK 3198026T3 DK 15753745 T DK15753745 T DK 15753745T DK 3198026 T3 DK3198026 T3 DK 3198026T3
- Authority
- DK
- Denmark
- Prior art keywords
- sample
- procedure
- determining
- mutation status
- pik3ca mutation
- Prior art date
Links
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 title 1
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 title 1
- 230000035772 mutation Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/186—Modifications characterised by incorporating a non-extendable or blocking moiety
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/107—Temperature of melting, i.e. Tm
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462034231P | 2014-08-07 | 2014-08-07 | |
| PCT/GR2015/000036 WO2016020710A1 (en) | 2014-08-07 | 2015-07-28 | Method of determining pik3ca mutational status in a sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3198026T3 true DK3198026T3 (da) | 2020-01-20 |
Family
ID=53938365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15753745.7T DK3198026T3 (da) | 2014-08-07 | 2015-07-28 | Fremgangsmåde til bestemmelse af pik3ca-mutationsstatus i en prøve |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11279979B2 (https=) |
| EP (1) | EP3198026B1 (https=) |
| JP (1) | JP6770957B2 (https=) |
| CN (1) | CN106715723B (https=) |
| CA (1) | CA2957396C (https=) |
| CY (1) | CY1122647T1 (https=) |
| DK (1) | DK3198026T3 (https=) |
| ES (1) | ES2764423T3 (https=) |
| HR (1) | HRP20192353T1 (https=) |
| HU (1) | HUE047958T2 (https=) |
| IL (1) | IL250392B (https=) |
| LT (1) | LT3198026T (https=) |
| PL (1) | PL3198026T3 (https=) |
| PT (1) | PT3198026T (https=) |
| RS (1) | RS59710B1 (https=) |
| SI (1) | SI3198026T1 (https=) |
| SM (1) | SMT202000005T1 (https=) |
| WO (1) | WO2016020710A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012029066A2 (pt) | 2010-05-14 | 2020-09-01 | The General Hospital Corporation | composições e processos de identificação de neoantígenos específicos de tumor. |
| WO2015039024A1 (en) | 2013-09-16 | 2015-03-19 | Oregon Health & Science University | Bioabsorbable clips and applicator for tissue closure |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| JP6532113B2 (ja) | 2014-11-03 | 2019-06-19 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 組織閉鎖のためのクリップおよびアプリケータ |
| US10993997B2 (en) * | 2014-12-19 | 2021-05-04 | The Broad Institute, Inc. | Methods for profiling the t cell repertoire |
| US10975442B2 (en) | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
| TW202523682A (zh) | 2015-05-20 | 2025-06-16 | 美商博德研究所有限公司 | 共有之gata3相關之腫瘤特異性新抗原 |
| US10870891B2 (en) | 2017-01-05 | 2020-12-22 | Biodesix, Inc. | Diagnostic test system for specific, sensitive and reproducible detection of circulating nucleic acids in whole blood |
| WO2018140391A1 (en) * | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| US12303561B2 (en) | 2017-04-03 | 2025-05-20 | Biontech Us Inc. | Protein antigens and uses thereof |
| CN107287309A (zh) * | 2017-07-06 | 2017-10-24 | 罗保君 | 一种血液循环肿瘤dna点突变检测方法 |
| WO2019022132A1 (ja) * | 2017-07-26 | 2019-01-31 | 積水メディカル株式会社 | 変異遺伝子検出方法 |
| CN109295175A (zh) * | 2017-09-08 | 2019-02-01 | 广州健天基因技术有限公司 | 用于检测人胃肠道间质瘤c-kit基因v559a突变的引物、检测方法及试剂盒 |
| CN109306374A (zh) * | 2017-09-08 | 2019-02-05 | 广州健天基因技术有限公司 | 用于检测人类pik3ca基因e545k突变的引物、检测方法及试剂盒 |
| JP7306618B2 (ja) * | 2017-09-26 | 2023-07-11 | 東ソー株式会社 | がんの転移形成能に関与する因子および前記因子を用いたがん患者の予後予測方法 |
| US11793867B2 (en) | 2017-12-18 | 2023-10-24 | Biontech Us Inc. | Neoantigens and uses thereof |
| CN107937490A (zh) * | 2018-01-15 | 2018-04-20 | 福建农林大学 | 一种非对称pcr的试纸条检测植物病原菌的方法及试剂盒 |
| CA3090951C (en) * | 2018-02-12 | 2023-10-17 | F.Hoffmann-La Roche Ag | Method of predicting response to therapy by assessing tumor genetic heterogeneity |
| BR112020025764A2 (pt) | 2018-06-19 | 2021-05-11 | Biontech Us Inc. | neoantígenos e usos dos mesmos |
| CN109666747A (zh) * | 2019-02-20 | 2019-04-23 | 天津脉络医学检验有限公司 | 一种引物探针组合物及其应用 |
| US11812966B2 (en) | 2020-04-24 | 2023-11-14 | NeuraMedica Inc. | Clips, appliers, and cartridges |
| US20230220456A1 (en) * | 2020-05-01 | 2023-07-13 | William Marsh Rice University | Quantitative blocker displacement amplification (qbda) sequencing for calibration-free and multiplexed variant allele frequency quantitation |
| CN113930500B (zh) * | 2020-07-13 | 2024-11-19 | 铭炽生物科技(上海)有限公司 | 人pik3ca基因突变的数字pcr检测方法及应用 |
| CN112951325B (zh) * | 2021-02-18 | 2023-04-21 | 北京吉因加医学检验实验室有限公司 | 一种用于癌症检测的探针组合的设计方法及其应用 |
| CN113063835B (zh) * | 2021-03-19 | 2022-08-02 | 中山大学 | 一种基于元素标记-电感耦合等离子体质谱检测策略的cfDNA分析方法及其应用 |
| CN117858956A (zh) * | 2021-08-25 | 2024-04-09 | 南京金斯瑞生物科技有限公司 | 一种用于检测单碱基突变的引物组和基因芯片方法 |
| US12531162B1 (en) * | 2023-05-31 | 2026-01-20 | Northeastern University | Multi-dimensional phenotypic space for genotype to phenotype mapping and intelligent design of cancer drug therapies using a deep learning net |
| US12562256B2 (en) * | 2023-11-07 | 2026-02-24 | New York University | Systems, methods and computer-accessible medium for identifying target pairs for CAR-T therapy |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3296407T1 (sl) | 2004-03-02 | 2019-09-30 | The Johns Hopkins University | Mutacije gena PIK3CA pri rakih pri ljudeh |
| JP2010528585A (ja) * | 2007-02-26 | 2010-08-26 | ジョン ウェイン キャンサー インスティテュート | 癌の診断および治療におけるｂ−ｒａｆｄｎａ変異の有用性 |
| US8071338B2 (en) * | 2007-08-08 | 2011-12-06 | Roche Molecular Systems, Inc. | Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5′-3′ nuclease activity |
| GB2453173A (en) * | 2007-09-28 | 2009-04-01 | Dxs Ltd | Polynucleotide primers |
| US20100041048A1 (en) * | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| CN101445832B (zh) * | 2008-12-23 | 2011-09-14 | 广州益善生物技术有限公司 | Pik3ca基因突变的检测探针、液相芯片及其检测方法 |
| CN102234685B (zh) * | 2010-04-23 | 2014-08-27 | 益善生物技术股份有限公司 | 一种pik3ca基因突变检测液相芯片 |
| WO2012075231A1 (en) | 2010-12-03 | 2012-06-07 | Brandeis University | Methods and kits for detecting nucleic acid mutants in wild-type populations |
| CN102533958A (zh) | 2010-12-28 | 2012-07-04 | 苏州科贝生物技术有限公司 | 一种检测人pik3ca基因突变的方法和试剂盒 |
| WO2012095378A1 (en) | 2011-01-11 | 2012-07-19 | Roche Diagnostics Gmbh | High resolution melting analysis as a prescreening tool |
| WO2012131092A2 (en) * | 2011-03-31 | 2012-10-04 | Signature Diagnostics Ag | Method and kits for the prediction of response/nonresponse to the treatment with an anti-egfr antibody in patients with colorectal cancer of all uicc stages |
| EP2705162B1 (en) | 2011-05-04 | 2018-07-11 | Biocept, Inc. | Methods for detecting nucleic acid sequence variants |
| HK1199066A1 (en) | 2011-08-18 | 2015-06-19 | Nestec S.A. | Compositions and methods for detecting allelic variants |
| JP2013081450A (ja) | 2011-09-27 | 2013-05-09 | Arkray Inc | 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用試薬キット |
| US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| EP2711432A1 (en) | 2012-09-21 | 2014-03-26 | Genomica S.A.U. | Method for detection of BRAF and PI3K mutations |
| CN105378160B (zh) * | 2013-08-12 | 2018-04-17 | 伯乐生命医学产品有限公司 | 具有碱基配对的寡聚体的扩增报告子 |
-
2015
- 2015-07-28 RS RS20191668A patent/RS59710B1/sr unknown
- 2015-07-28 CA CA2957396A patent/CA2957396C/en active Active
- 2015-07-28 CN CN201580052321.9A patent/CN106715723B/zh active Active
- 2015-07-28 PL PL15753745T patent/PL3198026T3/pl unknown
- 2015-07-28 SI SI201531052T patent/SI3198026T1/sl unknown
- 2015-07-28 HR HRP20192353TT patent/HRP20192353T1/hr unknown
- 2015-07-28 JP JP2017526770A patent/JP6770957B2/ja active Active
- 2015-07-28 LT LTEP15753745.7T patent/LT3198026T/lt unknown
- 2015-07-28 SM SM20200005T patent/SMT202000005T1/it unknown
- 2015-07-28 PT PT157537457T patent/PT3198026T/pt unknown
- 2015-07-28 HU HUE15753745A patent/HUE047958T2/hu unknown
- 2015-07-28 EP EP15753745.7A patent/EP3198026B1/en active Active
- 2015-07-28 US US15/501,457 patent/US11279979B2/en active Active
- 2015-07-28 DK DK15753745.7T patent/DK3198026T3/da active
- 2015-07-28 ES ES15753745T patent/ES2764423T3/es active Active
- 2015-07-28 WO PCT/GR2015/000036 patent/WO2016020710A1/en not_active Ceased
-
2017
- 2017-02-01 IL IL250392A patent/IL250392B/en active IP Right Grant
-
2019
- 2019-12-30 CY CY20191101363T patent/CY1122647T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS59710B1 (sr) | 2020-01-31 |
| IL250392A0 (en) | 2017-03-30 |
| JP6770957B2 (ja) | 2020-10-21 |
| PT3198026T (pt) | 2020-01-16 |
| CN106715723B (zh) | 2021-03-30 |
| IL250392B (en) | 2020-03-31 |
| SI3198026T1 (sl) | 2020-02-28 |
| WO2016020710A1 (en) | 2016-02-11 |
| HUE047958T2 (hu) | 2020-05-28 |
| CY1122647T1 (el) | 2021-03-12 |
| CN106715723A (zh) | 2017-05-24 |
| EP3198026B1 (en) | 2019-10-09 |
| CA2957396C (en) | 2021-03-09 |
| JP2017523810A (ja) | 2017-08-24 |
| PL3198026T3 (pl) | 2020-05-18 |
| US20170233821A1 (en) | 2017-08-17 |
| EP3198026A1 (en) | 2017-08-02 |
| CA2957396A1 (en) | 2016-02-11 |
| US11279979B2 (en) | 2022-03-22 |
| ES2764423T3 (es) | 2020-06-03 |
| SMT202000005T1 (it) | 2020-03-13 |
| LT3198026T (lt) | 2020-01-27 |
| HRP20192353T1 (hr) | 2020-03-20 |
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