DK319780A - Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner - Google Patents

Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Info

Publication number
DK319780A
DK319780A DK319780A DK319780A DK319780A DK 319780 A DK319780 A DK 319780A DK 319780 A DK319780 A DK 319780A DK 319780 A DK319780 A DK 319780A DK 319780 A DK319780 A DK 319780A
Authority
DK
Denmark
Prior art keywords
ins
amino acid
insulin
ser
formulae
Prior art date
Application number
DK319780A
Other languages
Danish (da)
English (en)
Inventor
K Breddam
F Widmer
J T Johansen
Original Assignee
Forenede Bryggerier As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forenede Bryggerier As filed Critical Forenede Bryggerier As
Priority to DK319780A priority Critical patent/DK319780A/da
Priority to ZA815066A priority patent/ZA815066B/xx
Priority to AT81303383T priority patent/ATE9820T1/de
Priority to DE8181303383T priority patent/DE3166608D1/de
Priority to PCT/DK1981/000074 priority patent/WO1982000301A1/en
Priority to AU74508/81A priority patent/AU543687B2/en
Priority to EP81303383A priority patent/EP0045187B1/de
Priority to CA000382347A priority patent/CA1175372A/en
Priority to ES504462A priority patent/ES504462A0/es
Priority to US06/364,856 priority patent/US4645740A/en
Priority to HU813205A priority patent/HU185668B/hu
Priority to IE1660/81A priority patent/IE51620B1/en
Priority to JP56502653A priority patent/JPS642360B2/ja
Publication of DK319780A publication Critical patent/DK319780A/da
Priority to SU823414346A priority patent/SU1554766A3/ru
Priority to NO820958A priority patent/NO156654C/no
Priority to DK130082A priority patent/DK148714C/da
Priority to ES514463A priority patent/ES514463A0/es
Priority to DK320483A priority patent/DK149616C/da
Priority to SU843825251A priority patent/SU1611217A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK319780A 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner DK319780A (da)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
US06/364,856 US4645740A (en) 1980-07-24 1981-07-23 Process for enzymatic replacement of the B-30 amino acid in insulins
HU813205A HU185668B (en) 1980-07-24 1981-07-23 Process for the enzymatic substitution of aminoacid in position b-30 of
DE8181303383T DE3166608D1 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins
PCT/DK1981/000074 WO1982000301A1 (en) 1980-07-24 1981-07-23 Enzymatic replacement of the b-30 amino acid in insulins
AU74508/81A AU543687B2 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid ininsulins
EP81303383A EP0045187B1 (de) 1980-07-24 1981-07-23 Verfahren zur enzymatischen Substitution der B-30-Aminosäure in den Insulinen
CA000382347A CA1175372A (en) 1980-07-24 1981-07-23 Process for enzymatic replacement of the b-30 amino acid in insulins
ES504462A ES504462A0 (es) 1980-07-24 1981-07-23 Procedimiento de tratamiento de insulinas
ZA815066A ZA815066B (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins
AT81303383T ATE9820T1 (de) 1980-07-24 1981-07-23 Verfahren zur enzymatischen substitution der b-30-aminosaeure in den insulinen.
IE1660/81A IE51620B1 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins
JP56502653A JPS642360B2 (de) 1980-07-24 1981-07-23
SU823414346A SU1554766A3 (ru) 1980-07-24 1982-03-23 Способ получени человеческого инсулина формулы I @ -Т @ -ОН или его производных
NO820958A NO156654C (no) 1980-07-24 1982-03-23 Fremgangsmaate for enzymatisk erstatning av b-30-aminosyren i insuliner.
DK130082A DK148714C (da) 1980-07-24 1982-03-23 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
ES514463A ES514463A0 (es) 1980-07-24 1982-07-28 "procedimiento de escision enzimatica de derivados de insulina".
DK320483A DK149616C (da) 1980-07-24 1983-07-12 Fremgangsmaade til fremstilling af insuliner
SU843825251A SU1611217A3 (ru) 1980-07-24 1984-12-18 Способ получени инсулина человека

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Publications (1)

Publication Number Publication Date
DK319780A true DK319780A (da) 1982-01-25

Family

ID=8120166

Family Applications (1)

Application Number Title Priority Date Filing Date
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Country Status (14)

Country Link
US (1) US4645740A (de)
EP (1) EP0045187B1 (de)
JP (1) JPS642360B2 (de)
AT (1) ATE9820T1 (de)
AU (1) AU543687B2 (de)
CA (1) CA1175372A (de)
DE (1) DE3166608D1 (de)
DK (1) DK319780A (de)
ES (2) ES504462A0 (de)
HU (1) HU185668B (de)
IE (1) IE51620B1 (de)
SU (2) SU1554766A3 (de)
WO (1) WO1982000301A1 (de)
ZA (1) ZA815066B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
EP0079362A1 (de) * 1981-05-20 1983-05-25 Nordisk Insulinlaboratorium Verfahren zur herstellung von insulinabkömmlingen
DK353781A (da) * 1981-08-10 1983-02-11 Novo Industri As Fremgangsmaade til fremstilling af insulinderivater
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
IT1189353B (it) * 1982-06-07 1988-02-04 Nordisk Insulinlab Procedimento per la preparazione di insulina umana e suoi esteri
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
KR100310122B1 (ko) * 1993-09-17 2002-04-24 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 아실화된인슐린
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
AU1112597A (en) * 1996-07-25 1998-02-20 Firma "Nika-Universal" Binary techniques for producing biologically active peptides
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4182654A (en) * 1974-09-18 1980-01-08 Pierce Chemical Company Production of polypeptides using polynucleotides
WO1980002157A1 (en) * 1979-04-06 1980-10-16 Forenede Bryggerier As A process for enzymatic production of peptides
EP0017938B1 (de) * 1979-04-13 1983-08-03 Shionogi & Co., Ltd. Verfahren zur Herstellung von B30-Threonin-Insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin

Also Published As

Publication number Publication date
US4645740A (en) 1987-02-24
JPS57501161A (de) 1982-07-08
HU185668B (en) 1985-03-28
EP0045187A1 (de) 1982-02-03
ES8300858A1 (es) 1982-12-01
EP0045187B1 (de) 1984-10-10
CA1175372A (en) 1984-10-02
JPS642360B2 (de) 1989-01-17
ZA815066B (en) 1983-03-30
SU1611217A3 (ru) 1990-11-30
ES8306182A1 (es) 1983-06-01
IE811660L (en) 1982-01-24
DE3166608D1 (en) 1984-11-15
ES504462A0 (es) 1982-12-01
ATE9820T1 (de) 1984-10-15
ES514463A0 (es) 1983-06-01
IE51620B1 (en) 1987-01-21
SU1554766A3 (ru) 1990-03-30
AU7450881A (en) 1982-02-16
AU543687B2 (en) 1985-04-26
WO1982000301A1 (en) 1982-02-04

Similar Documents

Publication Publication Date Title
DK319780A (da) Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
BR9713136A (pt) Composto, composição inseticida, acaricida, ou nematicida, e, processos para combate e controle de pestes de inseto, acarino ou nematóide em um local e para preparação de um composto.
ATE49T1 (de) Herstellung von 1-desoxy-nojirimycin und n-substituierten derivaten.
DK309988A (da) Fremgangsmaade til fremstilling af 4-oxo-3h-phthalazin-1-yl-eddikesyre-forbindelser med benzothiazol- eller andre heterocycliske sidekaeder i 3-stillingen og forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden
DK149824C (da) Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
KR870002150A (ko) 알킬카르바모일옥시메틸 세펨화합물의 제조방법
DK103982A (da) Beta-laktam-eddikesyrederivater og deres anvendelse samt fremgangsmaade til fremstilling deraf og af 1-azabicyklo(3.2.0)-hept-2-en-antibiotika
ES481026A1 (es) Un procedimiento para la preparacion de un derivado de oxazafosforina opticamente activo.
DE68916189D1 (de) Verfahren zur Herstellung von 63-Carboxyamid-Teicoplanin-Antibiotika.
DK537179A (da) 3,4-disubstituerede 2-phenylimino-imidazolidiner og syreadditionssalte deraf og fremgangsmaade til deres fremstilling
PT99360A (pt) Processo para a preparacao de carbamatos de oxi-sulfonilo e de composicoes farmaceuticas que os contem
ATE46322T1 (de) Verfahren zur herstellung von bestatin-derivaten und deren zwischenprodukte.
DK130082A (da) Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren iinsuliner
DE69326095D1 (de) Verfahren zur Herstellung von Cephalosporinen
DK366488A (da) Fremgangsmaade til fremstilling af 2-aryloxypropionsyrer
ATE12644T1 (de) Verfahren zur herstellung von 7-acylamino-3-(thio substituierte)methyl-3-cephem-4-carboxylsaeure-1 oxyd-verbindungen.
HUT45016A (en) Herbicides containing as active substance derivatives of piridil-phenil-ether and process for production of these derivatives
ATE9152T1 (de) Verfahren zur herstellung von hydrazidinen.
DE58909308D1 (de) Verfahren zur Herstellung von Tripeptiden.
DK144684A (da) Phosphonsyreestere, fremgangsmaader til fremstilling deraf samt deres anvendelse til bekaempelse af skadelige organismer
ATE13528T1 (de) Verfahren zur herstellung von hydrazidinen.
ATE39688T1 (de) Verfahren zur herstellung von aminotriazinonderivaten.
JPS557255A (en) Thiazolidine derivative
ATE18045T1 (de) Verfahren zur herstellung von 2-(2-((5-dimethylaminomethyl)furan-2-ylmethylthio)|thylamino)-56-methylpyrid-3-yl-methyl)pyrimid-4-on.
ATE24507T1 (de) Verfahren zur herstellung von lysergsaeure-estern.