ES8300858A1 - Procedimiento de tratamiento de insulinas - Google Patents
Procedimiento de tratamiento de insulinasInfo
- Publication number
- ES8300858A1 ES8300858A1 ES504462A ES504462A ES8300858A1 ES 8300858 A1 ES8300858 A1 ES 8300858A1 ES 504462 A ES504462 A ES 504462A ES 504462 A ES504462 A ES 504462A ES 8300858 A1 ES8300858 A1 ES 8300858A1
- Authority
- ES
- Spain
- Prior art keywords
- ins
- amino acid
- insulin
- ser
- insulins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO DE TRATAMIENTO DE INSULINAS. CONSISTE EN HACER REACCIONAR COMO COMPONENTE SUBSTRATO LA INSULINA INS-X EN QUE X REPRESENTA EL AMINOACIDO B-30 CON UN COMPONENTE AMINA ELEGIDO DEL GRUPO FORMADO POR: A) AMINOACIDOS; B) AMIDAS DE AMINOACIDOS OPCIONALMENTE N-SUSTITUIDAS; C) ESTERES DE AMINOACIDOS; LA REACCION TIENE LUGAR EN PRESENCIA DE UNA ENZIMA CARBOXIPESTIDASA L-ESPECIFICA DE SERINA O TIOL EN UNA DISOLUCION O DISPERSION ACUOSA QUE TIENE UN PH DE 5 A 10,5. SE EMPLEA UNA CARBOXIPEPTIDASA QUE HA SIDO PURIFICADA POR CROMATOGRAFIA DE AFINIDAD SOBRE UNA RESINA QUE COMPRENDE UNA MATRIZ DE RESINA POLIMERICA CON GRUPOS BENCILSUCCINILO ACOPLADOR. SE EMPLEA UNA DISOLUCION DE REACCION QUE CONTIENE DE 0 A 50% EN VOLUMEN DE DISOLVENTE ORGANICO, EL CUAL SE ELIGE DE ENTRE ALCANOLES, SULFOXIDO DE DIMETILO, DIMETILFORMAMIDA, DIOXANO; TETRAHIDROFURANO, DIMETOXIETANO, ETILENGLICOL, Y POLIETILENGLICOLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK319780A DK319780A (da) | 1980-07-24 | 1980-07-24 | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
Publications (2)
Publication Number | Publication Date |
---|---|
ES504462A0 ES504462A0 (es) | 1982-12-01 |
ES8300858A1 true ES8300858A1 (es) | 1982-12-01 |
Family
ID=8120166
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES504462A Expired ES8300858A1 (es) | 1980-07-24 | 1981-07-23 | Procedimiento de tratamiento de insulinas |
ES514463A Expired ES8306182A1 (es) | 1980-07-24 | 1982-07-28 | "procedimiento de escision enzimatica de derivados de insulina". |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514463A Expired ES8306182A1 (es) | 1980-07-24 | 1982-07-28 | "procedimiento de escision enzimatica de derivados de insulina". |
Country Status (14)
Country | Link |
---|---|
US (1) | US4645740A (es) |
EP (1) | EP0045187B1 (es) |
JP (1) | JPS642360B2 (es) |
AT (1) | ATE9820T1 (es) |
AU (1) | AU543687B2 (es) |
CA (1) | CA1175372A (es) |
DE (1) | DE3166608D1 (es) |
DK (1) | DK319780A (es) |
ES (2) | ES8300858A1 (es) |
HU (1) | HU185668B (es) |
IE (1) | IE51620B1 (es) |
SU (2) | SU1554766A3 (es) |
WO (1) | WO1982000301A1 (es) |
ZA (1) | ZA815066B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
EP0079362A1 (en) * | 1981-05-20 | 1983-05-25 | Nordisk Insulinlaboratorium | A process for the preparation of insulin derivatives |
DK353781A (da) * | 1981-08-10 | 1983-02-11 | Novo Industri As | Fremgangsmaade til fremstilling af insulinderivater |
CA1174623A (en) * | 1981-09-15 | 1984-09-18 | Finn H. Andresen | Process for preparing human insulin or b-30 esters thereof |
WO1983002772A1 (en) * | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
DE3209184A1 (de) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen |
NL8201650A (nl) * | 1982-04-21 | 1983-11-16 | Akzo Nv | Semisynthetische bereiding van humane insuline. |
DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
DK113585D0 (da) * | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
DK220890D0 (da) * | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
US5580751A (en) * | 1990-09-14 | 1996-12-03 | Carlsberg A/S | Process for the preparation of C-terminally amidated peptides |
US6869930B1 (en) * | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
JP3014764B2 (ja) * | 1993-09-17 | 2000-02-28 | ノボ ノルディスク アクティーゼルスカブ | アシル化インスリン |
US6011007A (en) * | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
WO1998004731A1 (fr) * | 1996-07-25 | 1998-02-05 | Firma 'nika-Universal' | Techniques binaires de production de peptides biologiquement actifs |
US6323311B1 (en) | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3276961A (en) * | 1963-04-08 | 1966-10-04 | Squibb & Sons Inc | Process for preparing human insulin |
US4182654A (en) * | 1974-09-18 | 1980-01-08 | Pierce Chemical Company | Production of polypeptides using polynucleotides |
BR8008024A (pt) * | 1979-04-06 | 1981-03-31 | Forenede Bryggerier As | Processo para a producao enzimatica de peptideos |
DE3064479D1 (en) * | 1979-04-13 | 1983-09-08 | Shionogi & Co | Process for preparing a b30-threonine insulin |
JPS55138391A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | New synthetic method of peptide derivative |
IE50892B1 (en) * | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
-
1980
- 1980-07-24 DK DK319780A patent/DK319780A/da unknown
-
1981
- 1981-07-23 DE DE8181303383T patent/DE3166608D1/de not_active Expired
- 1981-07-23 JP JP56502653A patent/JPS642360B2/ja not_active Expired
- 1981-07-23 AT AT81303383T patent/ATE9820T1/de not_active IP Right Cessation
- 1981-07-23 EP EP81303383A patent/EP0045187B1/en not_active Expired
- 1981-07-23 AU AU74508/81A patent/AU543687B2/en not_active Ceased
- 1981-07-23 ZA ZA815066A patent/ZA815066B/xx unknown
- 1981-07-23 HU HU813205A patent/HU185668B/hu not_active IP Right Cessation
- 1981-07-23 CA CA000382347A patent/CA1175372A/en not_active Expired
- 1981-07-23 IE IE1660/81A patent/IE51620B1/en unknown
- 1981-07-23 US US06/364,856 patent/US4645740A/en not_active Expired - Fee Related
- 1981-07-23 WO PCT/DK1981/000074 patent/WO1982000301A1/en unknown
- 1981-07-23 ES ES504462A patent/ES8300858A1/es not_active Expired
-
1982
- 1982-03-23 SU SU823414346A patent/SU1554766A3/ru active
- 1982-07-28 ES ES514463A patent/ES8306182A1/es not_active Expired
-
1984
- 1984-12-18 SU SU843825251A patent/SU1611217A3/ru active
Also Published As
Publication number | Publication date |
---|---|
CA1175372A (en) | 1984-10-02 |
ATE9820T1 (de) | 1984-10-15 |
JPS57501161A (es) | 1982-07-08 |
HU185668B (en) | 1985-03-28 |
ES514463A0 (es) | 1983-06-01 |
IE811660L (en) | 1982-01-24 |
AU7450881A (en) | 1982-02-16 |
EP0045187A1 (en) | 1982-02-03 |
WO1982000301A1 (en) | 1982-02-04 |
DE3166608D1 (en) | 1984-11-15 |
IE51620B1 (en) | 1987-01-21 |
JPS642360B2 (es) | 1989-01-17 |
SU1611217A3 (ru) | 1990-11-30 |
EP0045187B1 (en) | 1984-10-10 |
AU543687B2 (en) | 1985-04-26 |
SU1554766A3 (ru) | 1990-03-30 |
ZA815066B (en) | 1983-03-30 |
ES504462A0 (es) | 1982-12-01 |
US4645740A (en) | 1987-02-24 |
ES8306182A1 (es) | 1983-06-01 |
DK319780A (da) | 1982-01-25 |
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