ES8306182A1 - "procedimiento de escision enzimatica de derivados de insulina". - Google Patents

"procedimiento de escision enzimatica de derivados de insulina".

Info

Publication number
ES8306182A1
ES8306182A1 ES514463A ES514463A ES8306182A1 ES 8306182 A1 ES8306182 A1 ES 8306182A1 ES 514463 A ES514463 A ES 514463A ES 514463 A ES514463 A ES 514463A ES 8306182 A1 ES8306182 A1 ES 8306182A1
Authority
ES
Spain
Prior art keywords
ins
amino acid
insulin
ser
insulins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514463A
Other languages
English (en)
Other versions
ES514463A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
De Forenede Bryggerier AS
Original Assignee
De Forenede Bryggerier AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by De Forenede Bryggerier AS filed Critical De Forenede Bryggerier AS
Publication of ES514463A0 publication Critical patent/ES514463A0/es
Publication of ES8306182A1 publication Critical patent/ES8306182A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE ESCISION ENZIMATICA DE DERIVADOS DE INSULINA, DE FORMULA GENERALES (I), EN LAS QUE INS ES UNA DES-B-30-INSULINA; B ES UN RESIDUO DE AMINOACIDO; R Y R SE ELIGEN INDEPENDIENTEMENTE DEL GRUPO FORMADO POR HIDROGENO, AMINO, HIDROXI, ALQUILO, CICLOALQUILO, ARILO Y ARALQUILO O R Y R CONJUNTAMENTE CON EL ATOMO DE NITROGENO FORMAN UN GRUPO HETEROCICLICO QUE PUEDE CONTENER OTRO ETEROATOMO; Y R REPRESENTA ALQUILO, CICLOALQUILO, ARILO, HETEROARILO O ARALQUILO. CONSISTE EN TRATAR LOS DERIVADOS DE INSULINA CON ENZIMAS CARBOXIPEPTIDASA L-ESPECIFICA DE SERINA O TIOL PROCEDENTES DE LEVADURAS O DE ORIGEN ANIMAL, VEGETAL O MICROBIANO, EN UNA DISOLUCION O DISPERSION ACUOSA QUE TIENE UN PH COMPRENDIDO ENTRE 7 Y 10,5. DE APLICACION EN LA CONVERSION DE INSULINA PORCINA EN INSULINA HUMANA.
ES514463A 1980-07-24 1982-07-28 "procedimiento de escision enzimatica de derivados de insulina". Expired ES8306182A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Publications (2)

Publication Number Publication Date
ES514463A0 ES514463A0 (es) 1983-06-01
ES8306182A1 true ES8306182A1 (es) 1983-06-01

Family

ID=8120166

Family Applications (2)

Application Number Title Priority Date Filing Date
ES504462A Expired ES8300858A1 (es) 1980-07-24 1981-07-23 Procedimiento de tratamiento de insulinas
ES514463A Expired ES8306182A1 (es) 1980-07-24 1982-07-28 "procedimiento de escision enzimatica de derivados de insulina".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES504462A Expired ES8300858A1 (es) 1980-07-24 1981-07-23 Procedimiento de tratamiento de insulinas

Country Status (14)

Country Link
US (1) US4645740A (es)
EP (1) EP0045187B1 (es)
JP (1) JPS642360B2 (es)
AT (1) ATE9820T1 (es)
AU (1) AU543687B2 (es)
CA (1) CA1175372A (es)
DE (1) DE3166608D1 (es)
DK (1) DK319780A (es)
ES (2) ES8300858A1 (es)
HU (1) HU185668B (es)
IE (1) IE51620B1 (es)
SU (2) SU1554766A3 (es)
WO (1) WO1982000301A1 (es)
ZA (1) ZA815066B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
EP0079362A1 (en) * 1981-05-20 1983-05-25 Nordisk Insulinlaboratorium A process for the preparation of insulin derivatives
DK353781A (da) * 1981-08-10 1983-02-11 Novo Industri As Fremgangsmaade til fremstilling af insulinderivater
CA1174623A (en) * 1981-09-15 1984-09-18 Finn H. Andresen Process for preparing human insulin or b-30 esters thereof
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
JP3014764B2 (ja) * 1993-09-17 2000-02-28 ノボ ノルディスク アクティーゼルスカブ アシル化インスリン
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
WO1998004731A1 (fr) * 1996-07-25 1998-02-05 Firma 'nika-Universal' Techniques binaires de production de peptides biologiquement actifs
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4182654A (en) * 1974-09-18 1980-01-08 Pierce Chemical Company Production of polypeptides using polynucleotides
BR8008024A (pt) * 1979-04-06 1981-03-31 Forenede Bryggerier As Processo para a producao enzimatica de peptideos
DE3064479D1 (en) * 1979-04-13 1983-09-08 Shionogi & Co Process for preparing a b30-threonine insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
IE50892B1 (en) * 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters

Also Published As

Publication number Publication date
CA1175372A (en) 1984-10-02
ATE9820T1 (de) 1984-10-15
JPS57501161A (es) 1982-07-08
HU185668B (en) 1985-03-28
ES514463A0 (es) 1983-06-01
IE811660L (en) 1982-01-24
AU7450881A (en) 1982-02-16
EP0045187A1 (en) 1982-02-03
WO1982000301A1 (en) 1982-02-04
DE3166608D1 (en) 1984-11-15
IE51620B1 (en) 1987-01-21
JPS642360B2 (es) 1989-01-17
SU1611217A3 (ru) 1990-11-30
EP0045187B1 (en) 1984-10-10
AU543687B2 (en) 1985-04-26
SU1554766A3 (ru) 1990-03-30
ZA815066B (en) 1983-03-30
ES504462A0 (es) 1982-12-01
US4645740A (en) 1987-02-24
DK319780A (da) 1982-01-25
ES8300858A1 (es) 1982-12-01

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