DE3166608D1 - A process for enzymatic replacement of the b-30 amino acid in insulins - Google Patents

A process for enzymatic replacement of the b-30 amino acid in insulins

Info

Publication number
DE3166608D1
DE3166608D1 DE8181303383T DE3166608T DE3166608D1 DE 3166608 D1 DE3166608 D1 DE 3166608D1 DE 8181303383 T DE8181303383 T DE 8181303383T DE 3166608 T DE3166608 T DE 3166608T DE 3166608 D1 DE3166608 D1 DE 3166608D1
Authority
DE
Germany
Prior art keywords
ins
amino acid
insulin
ser
insulins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181303383T
Other languages
English (en)
Inventor
Klaus Breddam
Fred C O Dept Of Health Widmer
Jack Taaning Johansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carlsberg Biotechnology Ltd AS
Original Assignee
De Forenede Bryggerier AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by De Forenede Bryggerier AS filed Critical De Forenede Bryggerier AS
Application granted granted Critical
Publication of DE3166608D1 publication Critical patent/DE3166608D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8181303383T 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins Expired DE3166608D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK319780A DK319780A (da) 1980-07-24 1980-07-24 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Publications (1)

Publication Number Publication Date
DE3166608D1 true DE3166608D1 (en) 1984-11-15

Family

ID=8120166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181303383T Expired DE3166608D1 (en) 1980-07-24 1981-07-23 A process for enzymatic replacement of the b-30 amino acid in insulins

Country Status (14)

Country Link
US (1) US4645740A (de)
EP (1) EP0045187B1 (de)
JP (1) JPS642360B2 (de)
AT (1) ATE9820T1 (de)
AU (1) AU543687B2 (de)
CA (1) CA1175372A (de)
DE (1) DE3166608D1 (de)
DK (1) DK319780A (de)
ES (2) ES8300858A1 (de)
HU (1) HU185668B (de)
IE (1) IE51620B1 (de)
SU (2) SU1554766A3 (de)
WO (1) WO1982000301A1 (de)
ZA (1) ZA815066B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
WO1982004069A1 (en) * 1981-05-20 1982-11-25 Andresen Finn Hede A process for the preparation of insulin derivatives
DK353781A (da) * 1981-08-10 1983-02-11 Novo Industri As Fremgangsmaade til fremstilling af insulinderivater
EP0087238A1 (de) * 1982-02-08 1983-08-31 Biogen N.V. Methode zur Herstellung von menschlichem Insulin aus nichtmenschlichem Insulin-
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
IT1189353B (it) * 1982-06-07 1988-02-04 Nordisk Insulinlab Procedimento per la preparazione di insulina umana e suoi esteri
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
HU217684B (hu) * 1993-09-17 2000-03-28 Novo Nordisk A/S Acilezett inzulinszármazékok és azokat tartalmazó gyógyszerkészítmények és előállításuk
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
WO1998004731A1 (fr) * 1996-07-25 1998-02-05 Firma 'nika-Universal' Techniques binaires de production de peptides biologiquement actifs
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4182654A (en) * 1974-09-18 1980-01-08 Pierce Chemical Company Production of polypeptides using polynucleotides
AU545416B2 (en) * 1979-04-06 1985-07-11 Carlsberg Biotechnology Ltd. A/S A process for enzymatic production of peptides
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
DE3064479D1 (en) * 1979-04-13 1983-09-08 Shionogi & Co Process for preparing a b30-threonine insulin
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin

Also Published As

Publication number Publication date
EP0045187A1 (de) 1982-02-03
ES504462A0 (es) 1982-12-01
ES8300858A1 (es) 1982-12-01
WO1982000301A1 (en) 1982-02-04
HU185668B (en) 1985-03-28
AU543687B2 (en) 1985-04-26
IE51620B1 (en) 1987-01-21
US4645740A (en) 1987-02-24
ATE9820T1 (de) 1984-10-15
ZA815066B (en) 1983-03-30
EP0045187B1 (de) 1984-10-10
AU7450881A (en) 1982-02-16
DK319780A (da) 1982-01-25
SU1611217A3 (ru) 1990-11-30
ES514463A0 (es) 1983-06-01
SU1554766A3 (ru) 1990-03-30
JPS57501161A (de) 1982-07-08
IE811660L (en) 1982-01-24
ES8306182A1 (es) 1983-06-01
JPS642360B2 (de) 1989-01-17
CA1175372A (en) 1984-10-02

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CARLSBERG BIOTECHNOLOGY LTD. A/S, KOPENHAGEN/KOEBE

8328 Change in the person/name/address of the agent

Free format text: DELFS, K., DIPL.-ING., 2000 HAMBURG MOLL, W., DIPL.-PHYS. DR.RER.NAT., 8000 MUENCHEN MENGDEHL, U., DIPL.-CHEM. DR.RER.NAT. NIEBUHR, H., DIPL.-PHYS. DR.PHIL.HABIL., 2000 HAMBURG GLAWE, U., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee