DK3103046T3 - Biomarkør-signaturfremgangsmåde og apparater og kits deraf - Google Patents
Biomarkør-signaturfremgangsmåde og apparater og kits deraf Download PDFInfo
- Publication number
- DK3103046T3 DK3103046T3 DK15746053.6T DK15746053T DK3103046T3 DK 3103046 T3 DK3103046 T3 DK 3103046T3 DK 15746053 T DK15746053 T DK 15746053T DK 3103046 T3 DK3103046 T3 DK 3103046T3
- Authority
- DK
- Denmark
- Prior art keywords
- kits
- devices
- biomarker signature
- signature procedure
- procedure
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Artificial Intelligence (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Data Mining & Analysis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014900363A AU2014900363A0 (en) | 2014-02-06 | Biomarker Signature Method, and Apparatus and Kits Therefor | |
| PCT/AU2015/050043 WO2015117204A1 (en) | 2014-02-06 | 2015-02-06 | Biomarker signature method, and apparatus and kits therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3103046T3 true DK3103046T3 (da) | 2020-06-02 |
Family
ID=53754326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15746053.6T DK3103046T3 (da) | 2014-02-06 | 2015-02-06 | Biomarkør-signaturfremgangsmåde og apparater og kits deraf |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US11047010B2 (https=) |
| EP (1) | EP3103046B1 (https=) |
| JP (1) | JP2017512304A (https=) |
| CN (1) | CN105981026A (https=) |
| AU (1) | AU2015213486B2 (https=) |
| CA (1) | CA2930925A1 (https=) |
| DK (1) | DK3103046T3 (https=) |
| WO (1) | WO2015117204A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10190169B2 (en) | 2013-06-20 | 2019-01-29 | Immunexpress Pty Ltd | Biomarker identification |
| US11047010B2 (en) | 2014-02-06 | 2021-06-29 | Immunexpress Pty Ltd | Biomarker signature method, and apparatus and kits thereof |
| AU2016267392B2 (en) * | 2015-05-28 | 2021-12-09 | Immunexpress Pty Ltd | Validating biomarker measurement |
| CN108513586A (zh) * | 2015-09-30 | 2018-09-07 | 因姆内克斯普雷斯私人有限公司 | 病原体生物标志物及其用途 |
| EP3371324B1 (en) * | 2015-11-06 | 2021-08-18 | ImmuneXpress Pty Ltd | Viral biomarkers and uses therefor |
| CN106701900B (zh) * | 2015-11-16 | 2020-03-20 | 上海市东方医院 | 长链非编码rna herc2p3基因及其在胃癌中的用途 |
| CN105256063B (zh) * | 2015-12-01 | 2019-03-01 | 北京泱深生物信息技术有限公司 | 肿瘤标志物dmbx1及其应用 |
| AU2016377391B2 (en) | 2015-12-24 | 2022-09-01 | Immunexpress Pty Ltd | Triage biomarkers and uses therefor |
| CN105506172B (zh) * | 2016-03-01 | 2019-04-09 | 北京泱深生物信息技术有限公司 | 含检测gfod2的骨质疏松血液诊断试剂及其应用 |
| US20230187067A1 (en) * | 2016-03-23 | 2023-06-15 | Peach Intellihealth, Inc. | Use of clinical parameters for the prediction of sirs |
| AU2017315328A1 (en) * | 2016-08-24 | 2019-03-21 | Immunexpress Pty Ltd | Systemic inflammatory and pathogen biomarkers and uses therefor |
| GB201616557D0 (en) * | 2016-09-29 | 2016-11-16 | Secretary Of State For Health The | Assay for distinguishing between sepsis and systemic inflammatory response syndrome |
| JP7274748B2 (ja) | 2016-11-08 | 2023-05-17 | クヴェッラ コーポレーション | 核酸の安定化及び分離を行う方法 |
| CN106755343A (zh) * | 2016-12-01 | 2017-05-31 | 北京致成生物医学科技有限公司 | 胰腺癌预后诊断分子标记物 |
| US11435370B2 (en) * | 2017-01-16 | 2022-09-06 | Shimadzu Corporation | Data analying device and program for data analysis |
| WO2018140256A1 (en) * | 2017-01-17 | 2018-08-02 | Duke University | Gene expression signatures useful to predict or diagnose sepsis and methods of using the same |
| CN108341862B (zh) * | 2017-01-24 | 2021-04-02 | 上海交通大学医学院附属仁济医院 | 一种多肽及其应用 |
| CN106947808B (zh) * | 2017-03-10 | 2020-07-24 | 北京赛尔得生物技术有限公司 | Tmem104基因在制备治疗椎间盘退行性疾病药物中的应用 |
| CN107133475B (zh) * | 2017-05-10 | 2020-09-29 | 浙江省立同德医院 | 一种中药注射剂不良反应高危患者模式识别方法 |
| EP3879535B1 (en) | 2017-06-13 | 2024-12-11 | BostonGene Corporation | Systems and methods for identifying cancer treatments from normalized biomarker scores |
| WO2019095064A1 (en) * | 2017-11-15 | 2019-05-23 | UNIVERSITé LAVAL | Use of srsf3 agents for the treatment and/or prevention of neurological conditions, cancer, bacterial infections or viral infections |
| CN108467890A (zh) * | 2018-05-02 | 2018-08-31 | 首都医科大学附属北京天坛医院 | Vat1基因及vat1基因的干扰物的应用和应用vat1基因的产品 |
| CN108753834B (zh) * | 2018-05-28 | 2021-11-23 | 上海海洋大学 | ddx27基因缺失斑马鱼突变体的制备方法 |
| WO2020096984A1 (en) * | 2018-11-05 | 2020-05-14 | Institute For Systems Biology | Sepsis biomarker panels and methods of use |
| AU2019380342A1 (en) * | 2018-11-15 | 2021-07-01 | Ampel Biosolutions, Llc | Machine learning disease prediction and treatment prioritization |
| WO2020132327A1 (en) * | 2018-12-19 | 2020-06-25 | The Trustees Of The University Of Pennsylvania | Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias |
| CN111443065A (zh) * | 2019-01-17 | 2020-07-24 | 四川大学华西医院 | 一种肺癌的筛查试剂盒 |
| CN109762911B (zh) * | 2019-02-21 | 2020-12-01 | 华中农业大学 | Ptprj基因作为猪免疫相关性状的分子标记及其应用 |
| US12288623B2 (en) | 2019-03-19 | 2025-04-29 | Optina Diagnostics, Inc. | Method and system for identifying subjects who are potentially impacted by a medical condition |
| CN112409376A (zh) * | 2019-08-20 | 2021-02-26 | 华东师范大学 | 一种基于dcaf15的蛋白降解靶向嵌合体及其制备方法和应用 |
| CN110567861B (zh) * | 2019-09-09 | 2021-12-21 | 浙江普罗亭健康科技有限公司 | 基于质谱流式检测技术筛查具有免疫原性抗原肽的试剂盒及检测方法 |
| CN110558279B (zh) * | 2019-09-16 | 2021-11-16 | 南方科技大学 | 一种药物筛选模型、药物筛选方法及其应用 |
| CN110687285B (zh) * | 2019-10-29 | 2023-03-21 | 安徽医科大学 | 诊断试剂盒及mak16在制备系统性红斑狼疮早期诊断试剂中的应用 |
| CN110791523B (zh) * | 2019-12-13 | 2022-05-10 | 南京农业大学 | 一种棉花抗旱相关基因GhRCHY1及其应用 |
| CN111276248B (zh) * | 2020-01-20 | 2023-09-12 | 苏州帕诺米克生物医药科技有限公司 | 状态确定系统和电子设备 |
| CN114317746B (zh) * | 2020-03-30 | 2022-09-23 | 中国医学科学院肿瘤医院 | 外泌体arpc5、ypel2等在肺癌诊断中的应用 |
| CA3178405A1 (en) | 2020-05-14 | 2021-11-18 | Katherine A. OWEN | Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus |
| CN114487402A (zh) * | 2020-11-12 | 2022-05-13 | 首都医科大学附属北京世纪坛医院 | 尿液非分泌核糖核酸酶蛋白及其多肽片段在妊娠糖尿病中的应用 |
| CN112553322B (zh) * | 2020-12-25 | 2022-07-05 | 深圳市人民医院 | 一种骨质疏松诊断标志物及其应用 |
| CA3211700A1 (en) * | 2021-02-11 | 2022-08-18 | Herbert A. Fritsche | Kits and methods for detecting markers and determining the presence or risk of cancer |
| CN113125757B (zh) * | 2021-04-22 | 2022-10-28 | 石河子大学 | 一种用于母猪早期妊娠诊断的蛋白生物标志物及其用于母猪早期妊娠检测的方法 |
| WO2022226267A1 (en) * | 2021-04-23 | 2022-10-27 | Alnylam Pharmaceuticals, Inc. | iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN |
| AU2022283025A1 (en) * | 2021-05-25 | 2024-01-18 | The University Of British Columbia | Diagnostic for sepsis endotypes and/or severity |
| WO2023034111A1 (en) * | 2021-08-30 | 2023-03-09 | Inflammatix, Inc. | A baseline gene expression-based prognostic for anti-tnf alpha therapy response in patients with inflammatory bowel disease |
| AU2022375208B2 (en) * | 2021-10-29 | 2024-06-06 | GenoDx Pty Ltd | Biomarkers and uses therefor |
| CN114875144B (zh) * | 2022-04-02 | 2026-04-17 | 及智(苏州)医学技术有限公司 | 用于评估肿瘤ibc疗法的疗效的生物标志物、系统、方法及试剂盒 |
| WO2023224913A1 (en) * | 2022-05-16 | 2023-11-23 | Cz Biohub Sf, Llc | Integrated host-microbe metagenomics of cell-free nucleic acid for sepsis diagnosis |
| EP4471784A1 (fr) * | 2023-05-31 | 2024-12-04 | Biomérieux | Procede et systeme de typage probabiliste de souches microbiennes |
| EP4471785A1 (fr) * | 2023-05-31 | 2024-12-04 | Biomérieux | Procede et systeme de typage probabiliste de souches microbiennes |
| WO2025257393A1 (en) * | 2024-06-14 | 2025-12-18 | Roche Diagnostics Gmbh | Method and system for improving biomarker based disease assessments |
| CN119842884B (zh) * | 2025-01-09 | 2025-09-19 | 湖北文理学院 | Tm9sf1在制备用于监测脓毒症病程的试剂中的应用 |
| CN120405150B (zh) * | 2025-07-01 | 2025-11-18 | 南昌大学第一附属医院 | Itga6在制备脓毒症诊断及病情监测试剂或试剂盒中的应用 |
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| FI980488A7 (fi) * | 1998-03-04 | 1999-09-05 | Arctic Partners Oy Ab | Uusi diagnostinen menetelmä |
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| WO2004044556A2 (en) | 2002-11-12 | 2004-05-27 | Becton, Dickinson And Company | Diagnosis of sepsis or sirs using biomarker profiles |
| US20040096917A1 (en) | 2002-11-12 | 2004-05-20 | Becton, Dickinson And Company | Diagnosis of sepsis or SIRS using biomarker profiles |
| US20080070235A1 (en) | 2003-04-02 | 2008-03-20 | Sirs-Lab Gmbh | Method for Recognizing Acute Generalized Inflammatory Conditions (Sirs), Sepsis, Sepsis-Like Conditions and Systemic Infections |
| EP1639090A4 (en) * | 2003-06-09 | 2008-04-16 | Univ Michigan | COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER |
| JP2007518062A (ja) * | 2003-09-29 | 2007-07-05 | バイオサイト インコーポレイテッド | 敗血症を診断する方法および診断するための組成物 |
| DE102004009952B4 (de) | 2004-03-01 | 2011-06-01 | Sirs-Lab Gmbh | Verfahren zur Erkennung von Sepsis |
| US9164104B2 (en) | 2004-10-06 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
| CA2605143A1 (en) | 2005-04-15 | 2006-10-26 | Becton, Dickinson And Company | Diagnosis of sepsis |
| EP1907858A4 (en) | 2005-06-13 | 2009-04-08 | Univ Michigan | COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER |
| DE102005050933A1 (de) | 2005-10-21 | 2007-04-26 | Justus-Liebig-Universität Giessen | Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen |
| US20090297474A1 (en) * | 2005-11-25 | 2009-12-03 | Dermot Kelleher | Method for Detecting or Monitoring Sepsis by Analysing Cytokine mRNA Expression Levels |
| US8014957B2 (en) | 2005-12-15 | 2011-09-06 | Fred Hutchinson Cancer Research Center | Genes associated with progression and response in chronic myeloid leukemia and uses thereof |
| US20070255113A1 (en) | 2006-05-01 | 2007-11-01 | Grimes F R | Methods and apparatus for identifying disease status using biomarkers |
| WO2008021115A2 (en) | 2006-08-14 | 2008-02-21 | The Brigham And Women's Hospital, Inc. | Diagnostic tests using gene expression ratios |
| EP2185728A2 (en) * | 2007-09-07 | 2010-05-19 | Université Libre de Bruxelles | Methods and tools for prognosis of cancer in er- patients |
| US20100285001A1 (en) * | 2007-10-02 | 2010-11-11 | University Of Rochester | Method and Compositions Related to Synergistic Responses to Oncogenic Mutations |
| US20120082659A1 (en) * | 2007-10-02 | 2012-04-05 | Hartmut Land | Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations |
| DE102008000715B9 (de) | 2008-03-17 | 2013-01-17 | Sirs-Lab Gmbh | Verfahren zur in vitro Erfasssung und Unterscheidung von pathophysiologischen Zuständen |
| JP2009229340A (ja) * | 2008-03-25 | 2009-10-08 | Sysmex Corp | 全身性炎症反応症候群の重症度に関する情報を生成する方法及び装置 |
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| AU2010270313B2 (en) | 2009-07-10 | 2014-05-22 | Transgene Sa | Biomarker for selecting patients and related methods |
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| US20140037649A1 (en) | 2010-11-26 | 2014-02-06 | Immunexpress Pty Ltd | Diagnostic and/or screening agents and uses therefor |
| EP2756118A4 (en) | 2011-09-16 | 2015-09-16 | Cepheid | METHOD FOR DETECTING SEPSIS |
| US20150315643A1 (en) | 2012-12-13 | 2015-11-05 | Baylor Research Institute | Blood transcriptional signatures of active pulmonary tuberculosis and sarcoidosis |
| US10190169B2 (en) | 2013-06-20 | 2019-01-29 | Immunexpress Pty Ltd | Biomarker identification |
| US11047010B2 (en) | 2014-02-06 | 2021-06-29 | Immunexpress Pty Ltd | Biomarker signature method, and apparatus and kits thereof |
-
2015
- 2015-02-06 US US15/117,137 patent/US11047010B2/en active Active
- 2015-02-06 AU AU2015213486A patent/AU2015213486B2/en active Active
- 2015-02-06 DK DK15746053.6T patent/DK3103046T3/da active
- 2015-02-06 WO PCT/AU2015/050043 patent/WO2015117204A1/en not_active Ceased
- 2015-02-06 US US14/616,565 patent/US20150218640A1/en not_active Abandoned
- 2015-02-06 CA CA2930925A patent/CA2930925A1/en not_active Abandoned
- 2015-02-06 CN CN201580007568.9A patent/CN105981026A/zh active Pending
- 2015-02-06 JP JP2016550561A patent/JP2017512304A/ja active Pending
- 2015-02-06 EP EP15746053.6A patent/EP3103046B1/en active Active
- 2015-05-15 US US14/714,188 patent/US10865447B2/en active Active
-
2022
- 2022-02-23 US US17/678,658 patent/US20220325348A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017512304A (ja) | 2017-05-18 |
| AU2015213486A1 (en) | 2016-06-02 |
| EP3103046A4 (en) | 2017-08-23 |
| EP3103046B1 (en) | 2020-03-25 |
| CA2930925A1 (en) | 2015-08-13 |
| AU2015213486B2 (en) | 2020-10-22 |
| US20220325348A1 (en) | 2022-10-13 |
| US20150259746A1 (en) | 2015-09-17 |
| US11047010B2 (en) | 2021-06-29 |
| WO2015117204A1 (en) | 2015-08-13 |
| WO2015117204A9 (en) | 2016-06-23 |
| EP3103046A1 (en) | 2016-12-14 |
| AU2015213486A9 (en) | 2016-07-07 |
| US20170191129A1 (en) | 2017-07-06 |
| CN105981026A (zh) | 2016-09-28 |
| US20150218640A1 (en) | 2015-08-06 |
| US10865447B2 (en) | 2020-12-15 |
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