DK306584A - Anthracyclinderivater og syreadditionssalte deraf, deres fremstilling ved fermentering og deres anvendelse som laegemidler - Google Patents

Anthracyclinderivater og syreadditionssalte deraf, deres fremstilling ved fermentering og deres anvendelse som laegemidler Download PDF

Info

Publication number
DK306584A
DK306584A DK306584A DK306584A DK306584A DK 306584 A DK306584 A DK 306584A DK 306584 A DK306584 A DK 306584A DK 306584 A DK306584 A DK 306584A DK 306584 A DK306584 A DK 306584A
Authority
DK
Denmark
Prior art keywords
preparation
anthracycline derivatives
medicines
additional salts
acid additional
Prior art date
Application number
DK306584A
Other languages
Danish (da)
English (en)
Other versions
DK306584D0 (da
Inventor
Werner Aretz
Hans Gerd Berscheid
Gerhard Huber
Hans-Wolfram Fehlhaber
Hans Peter Kraemer
Hans-Harald Sedlacek
Bimal Naresh Ganguli
Ratan Sagar Sood
Julia Gandhi
Gauknapalli Chandrasekha Reddy
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK306584D0 publication Critical patent/DK306584D0/da
Publication of DK306584A publication Critical patent/DK306584A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK306584A 1983-06-25 1984-06-22 Anthracyclinderivater og syreadditionssalte deraf, deres fremstilling ved fermentering og deres anvendelse som laegemidler DK306584A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3323025A DE3323025A1 (de) 1983-06-25 1983-06-25 Anthracyclin-derivate, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika

Publications (2)

Publication Number Publication Date
DK306584D0 DK306584D0 (da) 1984-06-22
DK306584A true DK306584A (da) 1984-12-26

Family

ID=6202458

Family Applications (1)

Application Number Title Priority Date Filing Date
DK306584A DK306584A (da) 1983-06-25 1984-06-22 Anthracyclinderivater og syreadditionssalte deraf, deres fremstilling ved fermentering og deres anvendelse som laegemidler

Country Status (20)

Country Link
US (1) US4713371A (pt)
EP (1) EP0131181B1 (pt)
JP (1) JPS6036437A (pt)
KR (1) KR850000529A (pt)
AT (1) ATE50776T1 (pt)
AU (1) AU578615B2 (pt)
CA (1) CA1244364A (pt)
DE (2) DE3323025A1 (pt)
DK (1) DK306584A (pt)
ES (1) ES8601230A1 (pt)
FI (1) FI80071C (pt)
GR (1) GR81630B (pt)
HU (1) HU195979B (pt)
IL (1) IL72214A0 (pt)
MX (1) MX7303E (pt)
NO (1) NO160011C (pt)
NZ (1) NZ208622A (pt)
PH (1) PH22276A (pt)
PT (1) PT78784B (pt)
ZA (1) ZA844742B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3325957A1 (de) * 1983-07-19 1985-02-07 Hoechst Ag, 6230 Frankfurt Anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatika
JPS6117597A (ja) * 1984-07-03 1986-01-25 Microbial Chem Res Found アントラサイクリン化合物
DE3524117A1 (de) * 1985-07-05 1987-02-05 Hoechst Ag Neue anthracyclin-tetrasaccharide, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatik
DE3706175A1 (de) * 1987-02-26 1988-09-08 Behringwerke Ag Verwendung von lipophilen anthracyclinen zur behandlung "sekundaer" anthracyclin-resistenter tumoren, mittel enthaltend ein lipophiles anthracyclin und verfahren zu seiner herstellung
DE3712350A1 (de) * 1987-04-11 1988-10-20 Behringwerke Ag Semisynthetische rhodomycine, verfahren zu ihrer herstellung und ihre verwendung als zytostatika
US4918172A (en) * 1987-10-06 1990-04-17 Sanraku Incorporated Anthracycline antibiotics
DE3842836A1 (de) * 1988-12-20 1990-06-21 Behringwerke Ag Rhodomycine mit einer modifizierten kohlenhydrat-einheit
DE3920062A1 (de) * 1989-06-20 1991-01-10 Hoechst Ag Neue anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FI93860C (fi) * 1991-03-25 1995-06-12 Leiras Oy Menetelmä antibioottien tuottamiseksi, siinä käyttökelpoisia DNA-jaksoja, yhdistelmä-DNA-konstruktioita ja näitä sisältäviä mikrobikantoja
DE10029433A1 (de) * 2000-06-15 2001-12-20 Bioleads Gmbh Rhodomycinon-Derivate
ES2330326T3 (es) * 2002-05-24 2009-12-09 Angiotech International Ag Composiciones y metodos para recubrir implantes medicos.
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
TW200510719A (en) * 2003-08-06 2005-03-16 Pharmacia Italia Spa Method for detecting contaminants in pharmaceutical products
WO2005051871A2 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5323961A (en) * 1976-08-16 1978-03-06 Microbial Chem Res Found Antitumors
JPS55120786A (en) * 1979-03-14 1980-09-17 Sanraku Inc Variant capable of producing anthracycline glycoside
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
CH648327A5 (de) * 1980-10-16 1985-03-15 Hoffmann La Roche Anthracycline.
JPS57114547A (en) * 1981-01-07 1982-07-16 Sanraku Inc Anthracycline antibiotic substance and its preparation
JPS57176995A (en) * 1981-04-23 1982-10-30 Sanraku Inc Novel anthracyclinone glycoside and its preparation
JPS5826895A (ja) * 1981-08-11 1983-02-17 Sanraku Inc ２‐ヒドロキシアクラシノマイシンｂ
JPS5874694A (ja) * 1981-10-29 1983-05-06 Sanraku Inc アントラサイクリン誘導体
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
JPS59231023A (ja) * 1983-11-11 1984-12-25 Ajinomoto Co Inc 抗腫瘍剤

Also Published As

Publication number Publication date
AU578615B2 (en) 1988-11-03
NO160011C (no) 1989-03-01
US4713371A (en) 1987-12-15
AU2981284A (en) 1985-01-03
NO160011B (no) 1988-11-21
PH22276A (en) 1988-07-14
JPS6036437A (ja) 1985-02-25
EP0131181A3 (en) 1985-05-22
FI80071B (fi) 1989-12-29
GR81630B (pt) 1984-12-11
IL72214A0 (en) 1984-10-31
FI842523A0 (fi) 1984-06-21
MX7303E (es) 1988-04-29
HUT44803A (en) 1988-04-28
DE3481515D1 (de) 1990-04-12
FI80071C (fi) 1990-04-10
FI842523A (fi) 1984-12-26
NO842546L (no) 1984-12-27
PT78784B (de) 1986-07-22
DK306584D0 (da) 1984-06-22
ZA844742B (en) 1985-02-27
ES533631A0 (es) 1985-10-16
EP0131181A2 (de) 1985-01-16
HU195979B (en) 1988-08-29
KR850000529A (ko) 1985-02-27
DE3323025A1 (de) 1985-01-10
CA1244364A (en) 1988-11-08
ATE50776T1 (de) 1990-03-15
EP0131181B1 (de) 1990-03-07
PT78784A (de) 1984-07-01
ES8601230A1 (es) 1985-10-16
NZ208622A (en) 1988-02-29

Similar Documents

Publication Publication Date Title
DK306584A (da) Anthracyclinderivater og syreadditionssalte deraf, deres fremstilling ved fermentering og deres anvendelse som laegemidler
ES2038747T3 (es) Compuestos antineoplasicos.
HUT67039A (en) Process for preparing 2-substituted saccharin derivatives and pharmaceutical compositions containing them
JPS5615299A (en) Rhodomycin group antibiotic and its preparation
PT88306A (pt) Processo para a preparacao de nucleosidos de 2', 3'-dideoxi-3'-fluoro-pirimidina e de composicoes farmaceuticas que os contem
DE3572807D1 (en) A phenylpiperidine derivative, and its salts, their preparation, compositions containing them, and their therapeutic use
DE3060897D1 (en) Sisomicin derivatives, process for their preparation and their use as medicines
AU545885B2 (en) Oral absorption of glycosidic antibiotics
GR3001717T3 (en) A doxorubicin derivative, a process for preparing the same, pharmaceutical preparations comprising the same, and the use of the same for the manufacture of useful medicaments
ES2011462B3 (es) Un procedimiento para la produccion de un glicosido de antraciclina.
DK104481A (da) Homocitronsyre-oligoribosid-derivater fremgangsmaade til fremstilling deraf samt deres anvendelse som forebyggende middel mod caries dentalis
AU5388879A (en) Isoxazole derivatives and their use as bronchodilating agent
DK54384A (da) Antracyclinforbindelse eller syreadditionssalte deraf, dens fremstilling ved aerob fermentering og dens anvendelse som antitumor- og antimikrobemiddel
CA2022323A1 (en) Excretion of potassium ion by prostanoic acid derivatives
DE3260248D1 (en) Compounds with antibiotic activity, process for their preparation and their use as medicaments
DE3461806D1 (en) 2-desoxyoxanosine, a process for the preparation thereof and its use as a medicament
DK148184D0 (da) Plt-448-derivater,deres fremstilling ved fermentering og deres anvendelse som laegemidler
AU8241691A (en) Novel p-oxybenzoic acid derivatives, process for the preparation thereof and use thereof as drug
ES8603576A1 (es) Procedimiento para preparar derivados de antraciclina
DK400385A (da) Arphameninderivater, fremgangsmaade til deres fremstilling samt anvendelse heraf som laegemiddel
DK311284A (da) 3-(4'-aminobutylamino)-propylamino-bleomycin-derivater, deres fremstilling og deres anvendelse som laegemidler
JPS54154598A (en) Method of increasing the yield of antibiotics
HUT34158A (en) Process for preparing 2-alkyl-mercapto-1-amino-alkyl-2-pyrroline-3-carbonitriles
UA43306C2 (uk) Похідні оксаспіро[2,5]октану, що мають ангіогенезну інгібуючу активність, спосіб їх одержання (варіанти)

Legal Events

Date Code Title Description
ATS Application withdrawn