DK2922844T3 - N-PYRROLIDINYL, N'-PYRAZOLYL-URINE, THIOURINE, GUANIDINE AND CYANOGUANIDE COMPOUNDS AS TRKA-KINASE INHIBITORS - Google Patents

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Publication number

DK2922844T3

DK2922844T3 DK13795946.6T DK13795946T DK2922844T3 DK 2922844 T3 DK2922844 T3 DK 2922844T3 DK 13795946 T DK13795946 T DK 13795946T DK 2922844 T3 DK2922844 T3 DK 2922844T3

Authority

DK

Denmark

Prior art keywords

alkyl

med

eller

forbindelse

formlen

Prior art date

2012-11-13

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• -1 N-PYRROLIDINYL Chemical class 0.000 title claims description 99
• 150000001875 compounds Chemical class 0.000 title abstract description 232
• 229940043355 kinase inhibitor Drugs 0.000 title abstract description 4
• 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract description 4
• ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title description 6
• CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title description 3
• SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title description 3
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 45
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• MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 claims description 3
• SIISYXWWQBUDOP-UHFFFAOYSA-N bis(1h-imidazol-2-yl)methanethione Chemical compound N=1C=CNC=1C(=S)C1=NC=CN1 SIISYXWWQBUDOP-UHFFFAOYSA-N 0.000 claims description 2
• PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims description 2
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