DK2916866T3 - Formulering til bispecifikke t-celle-engangers (bites) - Google Patents
Formulering til bispecifikke t-celle-engangers (bites) Download PDFInfo
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- DK2916866T3 DK2916866T3 DK13786255.3T DK13786255T DK2916866T3 DK 2916866 T3 DK2916866 T3 DK 2916866T3 DK 13786255 T DK13786255 T DK 13786255T DK 2916866 T3 DK2916866 T3 DK 2916866T3
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- Oil, Petroleum & Natural Gas (AREA)
Claims (12)
1. Flydende farmaceutisk sammensætning, der omfatter et polypeptid, TRIS og phosphat, hvor polypeptidet omfatter aminosyresekvensen ifølge SEQ ID NO: 8, kendetegnet ved, at sammensætningen indeholder polypeptidet i en koncentration fra 0,5 yg/mL til 3,0 mg/ml, at sammensætningen indeholder 100 mM TRIS og 50 mM phosphat, at sammensætningens pH-værdi ligger mellem 5,0 og 7,5, at sammensætningen indeholder 0,04 % (m/v) polysorbat 80 og at sammensætningen endvidere indeholder et lyobeskyttende stof.
2. Sammensætning ifølge krav 1, kendetegnet ved, at sammensætningen indeholder 2 - 10 % (m/v) af et lyobeskyttende stof.
3. Sammensætning ifølge krav 2, kendetegnet ved, at det lyobeskyttende stof er trehalose eller trehalosedihydrat.
4. Sammensætning ifølge et hvilket som helst foregående krav, kendetegnet ved, at sammensætningen indeholder polypeptidet i en koncentration på 2 mg/ml.
5. Faststofblanding, der kan fremstilles ved frysetørring af en flydende sammensætning ifølge et hvilket som helst foregående krav.
6. Flydende farmaceutisk sammensætning, kendetegnet ved, at sammensætningen rekonstitueres ved opløsning af en frysetørret faststofblanding ifølge krav 5 i et egnet flydende medium.
7. Sammensætning ifølge et hvilket som helst foregående krav, kendetegnet ved, at polypeptidets biotilgængelighed efter subkutan indgivelse af sammensætningen er >60 %.
8. Sammensætning ifølge et hvilket som helst foregående krav til anvendelse i en terapeutisk fremgangsmåde.
9. Sammensætning ifølge et hvilket som helst foregående krav til anvendelse i en terapeutisk fremgangsmåde, hvor fremgangsmåden omfatter parenteral indgivelse af sammensætningen.
10. Sammensætning ifølge et hvilket som helst foregående krav til anvendelse i en fremgangsmåde til terapeutisk behandling af hyperproliferative prostatasygdomme.
11. Sammensætning ifølge et hvilket som helst foregående krav til anvendelse i en fremgangsmåde til terapeutisk behandling af hyperproliferative prostatasygdomme, hvor fremgangsmåden omfatter subkutan indgivelse af sammensætningen.
12. Injektionssprøjte, der indeholder en sammensætning ifølge et hvilket som helst foregående krav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12191493 | 2012-11-06 | ||
| PCT/EP2013/073024 WO2014072277A1 (de) | 2012-11-06 | 2013-11-05 | Formulierung für bispecific t-cell-engangers (bites) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2916866T3 true DK2916866T3 (da) | 2018-07-23 |
Family
ID=47143702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13786255.3T DK2916866T3 (da) | 2012-11-06 | 2013-11-05 | Formulering til bispecifikke t-celle-engangers (bites) |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US11052128B2 (da) |
| EP (1) | EP2916866B1 (da) |
| JP (1) | JP6321667B2 (da) |
| KR (1) | KR20150082328A (da) |
| CN (1) | CN104780940B (da) |
| AR (1) | AR093365A1 (da) |
| AU (2) | AU2013343638B2 (da) |
| CA (1) | CA2890166C (da) |
| CY (1) | CY1120391T1 (da) |
| DK (1) | DK2916866T3 (da) |
| ES (1) | ES2676468T3 (da) |
| HK (1) | HK1211215A1 (da) |
| HR (1) | HRP20181021T1 (da) |
| HU (1) | HUE038151T2 (da) |
| IL (1) | IL238615A0 (da) |
| LT (1) | LT2916866T (da) |
| MX (1) | MX367034B (da) |
| NZ (1) | NZ707895A (da) |
| PL (1) | PL2916866T3 (da) |
| PT (1) | PT2916866T (da) |
| RS (1) | RS57394B1 (da) |
| RU (1) | RU2679124C2 (da) |
| SG (1) | SG11201502730SA (da) |
| SI (1) | SI2916866T1 (da) |
| TR (1) | TR201809507T4 (da) |
| TW (1) | TWI615158B (da) |
| WO (1) | WO2014072277A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016019969A1 (en) | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
| SG11202102995PA (en) * | 2018-10-01 | 2021-04-29 | Amgen Inc | Methods for reducing aggregation of bispecific antibodies |
| EP3897720A4 (en) * | 2018-12-19 | 2022-12-07 | City of Hope | BAFF-R BISPECIFIC T-CELL ENGAGER ANTIBODY |
| BR112022007776A2 (pt) * | 2019-10-25 | 2022-07-05 | Amgen Inc | Composições e métodos para minimizar a perda de proteína em baixas concentrações de proteína |
| CN115968867B (zh) * | 2023-03-21 | 2023-07-14 | 天津外泌体科技有限公司 | 外泌体冻干保护剂和外泌体冻干制剂的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| EP1767225A1 (en) | 2005-09-21 | 2007-03-28 | Insense Limited | Method for stabilisation of a protein solution by addition of hydroxyl radical quenchers and its sterilisation by ionising radiation |
| GB0626021D0 (en) | 2006-12-29 | 2007-02-07 | Insense Ltd | The stabilisation of proteins |
| GB0700523D0 (en) | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
| RS53008B2 (sr) | 2007-04-03 | 2022-12-30 | Amgen Res Munich Gmbh | Interspecijski specifičan cd3-epsilon vezujući domen |
| MX2009010611A (es) | 2007-04-03 | 2010-03-26 | Micromet Ag | Enlazadores biespecificos, especificos para especies. |
| JP5490714B2 (ja) * | 2007-11-28 | 2014-05-14 | メディミューン，エルエルシー | タンパク質製剤 |
| AR070316A1 (es) * | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| US7681537B2 (en) * | 2008-08-17 | 2010-03-23 | Cummins Intellectual Properties, Inc. | Gas extractor for an engine coolant system |
| EP2352763B2 (en) * | 2008-10-01 | 2022-09-21 | Amgen Research (Munich) GmbH | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| CA2738565C (en) * | 2008-10-01 | 2023-10-10 | Micromet Ag | Cross-species-specific psmaxcd3 bispecific single chain antibody |
| CN102695499A (zh) | 2009-06-18 | 2012-09-26 | 惠氏有限责任公司 | 小模块免疫药物的冻干制剂 |
| RU2548772C2 (ru) | 2009-11-20 | 2015-04-20 | Биокон Лимитед | Составы антитела |
| EP2568960B1 (en) * | 2010-05-10 | 2018-06-06 | Intas Pharmaceuticals Ltd. | Liquid formulation of polypeptides containing an fc domain of an immunoglobulin |
| EP2686014A1 (en) * | 2011-03-16 | 2014-01-22 | Sanofi | Uses of a dual v region antibody-like protein |
| JP5917682B2 (ja) * | 2011-04-22 | 2016-05-18 | ワイス・エルエルシー | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
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- 2013-11-05 PT PT137862553T patent/PT2916866T/pt unknown
- 2013-11-05 RU RU2015121574A patent/RU2679124C2/ru not_active IP Right Cessation
- 2013-11-05 KR KR1020157013102A patent/KR20150082328A/ko not_active Application Discontinuation
- 2013-11-05 TW TW102140023A patent/TWI615158B/zh not_active IP Right Cessation
- 2013-11-05 AU AU2013343638A patent/AU2013343638B2/en active Active
- 2013-11-05 PL PL13786255T patent/PL2916866T3/pl unknown
- 2013-11-05 EP EP13786255.3A patent/EP2916866B1/de active Active
- 2013-11-05 ES ES13786255.3T patent/ES2676468T3/es active Active
- 2013-11-05 SI SI201331089T patent/SI2916866T1/en unknown
- 2013-11-05 DK DK13786255.3T patent/DK2916866T3/da active
- 2013-11-05 LT LTEP13786255.3T patent/LT2916866T/lt unknown
- 2013-11-05 HU HUE13786255A patent/HUE038151T2/hu unknown
- 2013-11-05 CA CA2890166A patent/CA2890166C/en active Active
- 2013-11-05 MX MX2015005700A patent/MX367034B/es active IP Right Grant
- 2013-11-05 US US14/441,069 patent/US11052128B2/en active Active
- 2013-11-05 AR ARP130104044A patent/AR093365A1/es unknown
- 2013-11-05 TR TR2018/09507T patent/TR201809507T4/tr unknown
- 2013-11-05 CN CN201380057781.1A patent/CN104780940B/zh not_active Expired - Fee Related
- 2013-11-05 RS RS20180777A patent/RS57394B1/sr unknown
- 2013-11-05 SG SG11201502730SA patent/SG11201502730SA/en unknown
- 2013-11-05 WO PCT/EP2013/073024 patent/WO2014072277A1/de active Application Filing
- 2013-11-05 NZ NZ707895A patent/NZ707895A/en not_active IP Right Cessation
- 2013-11-05 JP JP2015540157A patent/JP6321667B2/ja not_active Expired - Fee Related
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2015
- 2015-05-04 IL IL238615A patent/IL238615A0/en unknown
- 2015-12-08 HK HK15112055.0A patent/HK1211215A1/xx not_active IP Right Cessation
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2018
- 2018-07-03 HR HRP20181021TT patent/HRP20181021T1/hr unknown
- 2018-07-04 CY CY20181100711T patent/CY1120391T1/el unknown
- 2018-08-09 AU AU2018214096A patent/AU2018214096A1/en not_active Abandoned
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