RS57394B1 - Formulacije bispecifičnih aktivatora t-ćelija (bite) - Google Patents
Formulacije bispecifičnih aktivatora t-ćelija (bite)Info
- Publication number
- RS57394B1 RS57394B1 RS20180777A RSP20180777A RS57394B1 RS 57394 B1 RS57394 B1 RS 57394B1 RS 20180777 A RS20180777 A RS 20180777A RS P20180777 A RSP20180777 A RS P20180777A RS 57394 B1 RS57394 B1 RS 57394B1
- Authority
- RS
- Serbia
- Prior art keywords
- bites
- bispecific
- formulation
- cell engagers
- engagers
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Pregnancy & Childbirth (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12191493 | 2012-11-06 | ||
| PCT/EP2013/073024 WO2014072277A1 (de) | 2012-11-06 | 2013-11-05 | Formulierung für bispecific t-cell-engangers (bites) |
| EP13786255.3A EP2916866B1 (de) | 2012-11-06 | 2013-11-05 | Formulierung für bispecific t-cell-engangers (bites) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS57394B1 true RS57394B1 (sr) | 2018-09-28 |
Family
ID=47143702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20180777A RS57394B1 (sr) | 2012-11-06 | 2013-11-05 | Formulacije bispecifičnih aktivatora t-ćelija (bite) |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US11052128B2 (sr) |
| EP (1) | EP2916866B1 (sr) |
| JP (1) | JP6321667B2 (sr) |
| KR (1) | KR20150082328A (sr) |
| CN (1) | CN104780940B (sr) |
| AR (1) | AR093365A1 (sr) |
| AU (2) | AU2013343638B2 (sr) |
| CA (1) | CA2890166C (sr) |
| CY (1) | CY1120391T1 (sr) |
| DK (1) | DK2916866T3 (sr) |
| ES (1) | ES2676468T3 (sr) |
| HK (1) | HK1211215A1 (sr) |
| HR (1) | HRP20181021T1 (sr) |
| HU (1) | HUE038151T2 (sr) |
| IL (1) | IL238615A0 (sr) |
| LT (1) | LT2916866T (sr) |
| MX (1) | MX367034B (sr) |
| NZ (1) | NZ707895A (sr) |
| PL (1) | PL2916866T3 (sr) |
| PT (1) | PT2916866T (sr) |
| RS (1) | RS57394B1 (sr) |
| RU (1) | RU2679124C2 (sr) |
| SG (1) | SG11201502730SA (sr) |
| SI (1) | SI2916866T1 (sr) |
| TR (1) | TR201809507T4 (sr) |
| TW (1) | TWI615158B (sr) |
| WO (1) | WO2014072277A1 (sr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016019969A1 (en) * | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
| CA3112655A1 (en) * | 2018-10-01 | 2020-04-09 | Amgen Inc. | Methods for reducing aggregation of bispecific antibodies |
| CA3123599A1 (en) * | 2018-12-19 | 2020-06-25 | City Of Hope | Baff-r bispecific t-cell engager antibody |
| TW202043253A (zh) * | 2019-01-28 | 2020-12-01 | 美商安進公司 | 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程 |
| EP4048310A4 (en) * | 2019-10-25 | 2024-03-13 | Amgen Inc. | COMPOSITIONS AND METHODS FOR MINIMIZING PROTEIN LOSS AT LOW PROTEIN CONCENTRATIONS |
| CN115968867B (zh) * | 2023-03-21 | 2023-07-14 | 天津外泌体科技有限公司 | 外泌体冻干保护剂和外泌体冻干制剂的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| EP1767225A1 (en) | 2005-09-21 | 2007-03-28 | Insense Limited | Method for stabilisation of a protein solution by addition of hydroxyl radical quenchers and its sterilisation by ionising radiation |
| GB0626021D0 (en) | 2006-12-29 | 2007-02-07 | Insense Ltd | The stabilisation of proteins |
| GB0700523D0 (en) | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
| ES2432792T5 (es) | 2007-04-03 | 2023-01-16 | Amgen Res Munich Gmbh | Dominio de unión a CD3-épsilon específico de especies cruzadas |
| WO2008119566A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
| JP5490714B2 (ja) * | 2007-11-28 | 2014-05-14 | メディミューン，エルエルシー | タンパク質製剤 |
| AR070316A1 (es) * | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| US7681537B2 (en) * | 2008-08-17 | 2010-03-23 | Cummins Intellectual Properties, Inc. | Gas extractor for an engine coolant system |
| ME02485B (me) | 2008-10-01 | 2017-02-20 | Amgen Res Munich Gmbh | Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću |
| EP2352763B2 (en) * | 2008-10-01 | 2022-09-21 | Amgen Research (Munich) GmbH | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| AU2010263058A1 (en) | 2009-06-18 | 2012-01-12 | Wyeth Llc | Lyophilized formulations for small modular immunopharmaceuticals |
| AU2010320515B2 (en) | 2009-11-20 | 2013-05-02 | Biocon Limited | Formulations of antibody |
| CN102946858B (zh) * | 2010-05-10 | 2015-09-30 | 英塔斯制药有限公司 | 含有免疫球蛋白Fc的多肽的液体制剂 |
| EP2686014A1 (en) * | 2011-03-16 | 2014-01-22 | Sanofi | Uses of a dual v region antibody-like protein |
| BR112013027229B1 (pt) * | 2011-04-22 | 2020-10-27 | Wyeth Llc | polipeptídeo imunogênico isolado e seu uso, composição imunogênica e seu uso, célula recombinante ou progênie da mesma, e método de produção de uma toxina de clostridium difficile mutante |
-
2013
- 2013-11-05 EP EP13786255.3A patent/EP2916866B1/de active Active
- 2013-11-05 RS RS20180777A patent/RS57394B1/sr unknown
- 2013-11-05 WO PCT/EP2013/073024 patent/WO2014072277A1/de active Application Filing
- 2013-11-05 DK DK13786255.3T patent/DK2916866T3/en active
- 2013-11-05 TW TW102140023A patent/TWI615158B/zh not_active IP Right Cessation
- 2013-11-05 SG SG11201502730SA patent/SG11201502730SA/en unknown
- 2013-11-05 AU AU2013343638A patent/AU2013343638B2/en active Active
- 2013-11-05 NZ NZ707895A patent/NZ707895A/en not_active IP Right Cessation
- 2013-11-05 RU RU2015121574A patent/RU2679124C2/ru not_active IP Right Cessation
- 2013-11-05 KR KR1020157013102A patent/KR20150082328A/ko not_active Application Discontinuation
- 2013-11-05 JP JP2015540157A patent/JP6321667B2/ja not_active Expired - Fee Related
- 2013-11-05 US US14/441,069 patent/US11052128B2/en active Active
- 2013-11-05 TR TR2018/09507T patent/TR201809507T4/tr unknown
- 2013-11-05 PT PT137862553T patent/PT2916866T/pt unknown
- 2013-11-05 AR ARP130104044A patent/AR093365A1/es unknown
- 2013-11-05 SI SI201331089T patent/SI2916866T1/en unknown
- 2013-11-05 CA CA2890166A patent/CA2890166C/en active Active
- 2013-11-05 CN CN201380057781.1A patent/CN104780940B/zh not_active Expired - Fee Related
- 2013-11-05 MX MX2015005700A patent/MX367034B/es active IP Right Grant
- 2013-11-05 HU HUE13786255A patent/HUE038151T2/hu unknown
- 2013-11-05 LT LTEP13786255.3T patent/LT2916866T/lt unknown
- 2013-11-05 PL PL13786255T patent/PL2916866T3/pl unknown
- 2013-11-05 ES ES13786255.3T patent/ES2676468T3/es active Active
-
2015
- 2015-05-04 IL IL238615A patent/IL238615A0/en unknown
- 2015-12-08 HK HK15112055.0A patent/HK1211215A1/xx not_active IP Right Cessation
-
2018
- 2018-07-03 HR HRP20181021TT patent/HRP20181021T1/hr unknown
- 2018-07-04 CY CY20181100711T patent/CY1120391T1/el unknown
- 2018-08-09 AU AU2018214096A patent/AU2018214096A1/en not_active Abandoned
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