DK2904009T3 - Forbindelser til behanding af remyeliniseringsblokaden i sygdomme relateret til udtrykket af herv-w kappeprotein - Google Patents
Forbindelser til behanding af remyeliniseringsblokaden i sygdomme relateret til udtrykket af herv-w kappeprotein Download PDFInfo
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- DK2904009T3 DK2904009T3 DK13770926.7T DK13770926T DK2904009T3 DK 2904009 T3 DK2904009 T3 DK 2904009T3 DK 13770926 T DK13770926 T DK 13770926T DK 2904009 T3 DK2904009 T3 DK 2904009T3
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- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Claims (6)
1. En farmaceutisk sammensætning omfattende mindst en anti-MSRV/HERV-W Env ligand og mindst et nitrogenoxid-radikal inhibitorisk lægemiddel, hvor: - nævnte anti-HERV-W Env ligand er et antistof, mere særligt et kimært, modificeret eller humaniseret antistof, og endnu mere særligt et IgG, såsom et IgGl eller et IgG4, hvor antistoffet omfatter hver af de komplimentær bestemmende regioner (CDR'er) fremsat i SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5, og SEQ ID No. 6; - nævnte nitrogenoxid-radikal inhibitoriske lægemiddel er valgt fra gruppen bestående af Ng-nitro-L-arginin-methylester (L-NAME), S-methyl-isothiourea (SMT) og dimethyl fumarat (DMF).
2. Den farmaceutiske sammensætning ifølge krav 1 til anvendelse i forebyggelsen og/eller behandlingen af remyeliniseringsblokaden i en sygdom relateret til udtrykket af HERV-W kappeprotein (ENV), i særdeleshed af dens MSRV-undertype, hvor sygdommen relateret til udtrykket af HERV-W kappeprotein (ENV) er valgt fra gruppen bestående af multipel sklerose, mere særligt af remitterende-relapserende multipel sklerose (RRMS), progressiv multipel sklerose, såsom sekundær progressiv multipel sklerose (SPMS) eller primær progressiv multipel sklerose (PPMS), kronisk inflammatorisk demyeliniserende polyneuropati (CIDP) og psykoser, såsom skizofreni eller bipolær lidelse.
3. Et farmaceutisk produkt indeholdende: - Mindst en anti-HERV-W Env ligand; og - Mindst et nitrogenoxid-radikal inhibitorisk lægemiddel; som et kombinationsprodukt til samtidig,separat eller fordelt over tid administration til anvendelse i forebyggelsen og/eller behandingen af remyeliniseringsblokering i en sygdom relateret til udtrykket af HERV-W kappeprotein (ENV), i særdeleshed af dens MSRV-undertype, hvor: - nævnte anti-HERV-W Env ligand er et antistof, mere særligt et kimært, modificeret eller humaniseret antistof, og endnu mere særligt et IgG, såsom et IgGl eller et IgG4, hvor antistoffet omfatter hver af de komplementær bestemmende regioner (CDR'er) fremsat i SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No.
4, SEQ ID No.
5, og SEQ ID No.
6; - nævnte nitrogenoxid-radikal inhibitoriske lægemiddel er valgt fra gruppen bestående af Ng-nitro-L-arginin-methylester (L-NAME), S-methyl-isothiourea (SMT) og dimethyl fumarat (DMF), og - sygdommen relateret til udtrykket af HERV-W kappeprotein (ENV) er valgt fra gruppen bestående ad multipel sklerose, mere særligt remitterende-relapserende multipel sklerose (RRMS), progressiv multipel sklerose, såsom sekundær progressiv multipel sklerose (SPMS) eller primær progressiv multipel sklerose (PPMS), kronisk inflammatorisk demyeliniserende polyneuropati (CIDP) og psykoser, såsom skizofreni eller bipolær lidelse.
Applications Claiming Priority (3)
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| US201261708779P | 2012-10-02 | 2012-10-02 | |
| US201261746792P | 2012-12-28 | 2012-12-28 | |
| PCT/EP2013/070452 WO2014053489A1 (en) | 2012-10-02 | 2013-10-01 | Compounds for treating the remyelination blockade in diseases associated with the expression of herv-w envelope protein |
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| DK2904009T3 true DK2904009T3 (da) | 2019-03-11 |
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ID=49274655
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18198309.9T DK3447070T3 (da) | 2012-10-02 | 2013-10-01 | Forbindelser til behandling af remyeliniseringsblokaden i sygdomme relateret til udtrykket af herv-w kappeprotein |
| DK13770926.7T DK2904009T3 (da) | 2012-10-02 | 2013-10-01 | Forbindelser til behanding af remyeliniseringsblokaden i sygdomme relateret til udtrykket af herv-w kappeprotein |
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| DK18198309.9T DK3447070T3 (da) | 2012-10-02 | 2013-10-01 | Forbindelser til behandling af remyeliniseringsblokaden i sygdomme relateret til udtrykket af herv-w kappeprotein |
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| EP2949342A1 (en) * | 2014-05-28 | 2015-12-02 | Geneuro SA | Antiretroviral drug targeting human endogenous retrovirus |
| EP3351265A1 (en) * | 2017-01-20 | 2018-07-25 | Geneuro SA | Anti-herv-k envelope antibody and uses thereof |
| JP7122002B2 (ja) | 2017-03-01 | 2022-08-19 | 国立大学法人北海道大学 | 疾患モデル非ヒト動物の製造方法、疾患モデル非ヒト動物、該動物を用いた薬剤のスクリーニング方法及び疾患リスク判定方法 |
| JP7317377B2 (ja) * | 2018-09-01 | 2023-07-31 | 国立大学法人北海道大学 | ストレス負荷が関与する疾患を予防及び／又は治療するための医薬 |
| US20220332799A1 (en) * | 2019-09-04 | 2022-10-20 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) | Herv inhibitors for use in treating tauopathies |
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| FR2753098B1 (fr) * | 1996-09-06 | 1998-11-27 | Sod Conseils Rech Applic | Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene |
| AU5829201A (en) * | 2000-03-21 | 2001-10-03 | Ms Research A/S | An infective endogenous retrovirus and its association with demyelinating diseases and other diseases |
| WO2002056910A1 (en) | 2001-01-17 | 2002-07-25 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| FR2865403B1 (fr) * | 2004-01-23 | 2009-06-12 | Biomerieux Sa | Composition pour le traitement d'une pathologie associee a la msrv/herv-w |
| US20090233888A1 (en) * | 2005-03-23 | 2009-09-17 | Usc Stevens, University Of Southern California | Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth |
| JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ，インコーポレイテッド | α−４阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
| EP2139467B1 (en) * | 2007-02-08 | 2016-09-21 | Biogen MA Inc. | Neuroprotection in demyelinating diseases |
| WO2009062926A1 (en) * | 2007-11-12 | 2009-05-22 | Ares Trading S.A. | Taci-immunoglobulin fusion proteins for treatment of relapsing multiple sclerosis |
| PT3211005T (pt) | 2008-07-08 | 2021-06-15 | Geneuro Sa | Utilização terapêutica de ligandos específicos nas doenças associadas a msrv |
| JP2012505257A (ja) * | 2008-10-13 | 2012-03-01 | バイオヴィスタ，インコーポレイテッド | 多発性硬化症治療のための組成物および方法 |
| WO2010148323A2 (en) * | 2009-06-18 | 2010-12-23 | Whittemore Peterson Institute For Neuro-Immune Disease | Diagnosis and treatment of diseases or disorders associated with xenotropic murine leukemia virus |
| ME02317B (me) * | 2010-02-12 | 2016-06-20 | Biogen Ma Inc | Neuroprotekcija kod demijelinizacijskih bolesti |
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