MX366846B - Compuestos para tratar el bloqueo de remielinizacion en enfermedades asociadas con la expresion de la proteina de envoltura herv-w. - Google Patents
Compuestos para tratar el bloqueo de remielinizacion en enfermedades asociadas con la expresion de la proteina de envoltura herv-w.Info
- Publication number
- MX366846B MX366846B MX2015003572A MX2015003572A MX366846B MX 366846 B MX366846 B MX 366846B MX 2015003572 A MX2015003572 A MX 2015003572A MX 2015003572 A MX2015003572 A MX 2015003572A MX 366846 B MX366846 B MX 366846B
- Authority
- MX
- Mexico
- Prior art keywords
- herv
- expression
- treating
- diseases associated
- envelope protein
- Prior art date
Links
- 102100021696 Syncytin-1 Human genes 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 108010037253 syncytin Proteins 0.000 title abstract 2
- 210000000653 nervous system Anatomy 0.000 abstract 2
- 101710091045 Envelope protein Proteins 0.000 abstract 1
- 241000896769 Multiple sclerosis associated retrovirus Species 0.000 abstract 1
- 102000006386 Myelin Proteins Human genes 0.000 abstract 1
- 108010083674 Myelin Proteins Proteins 0.000 abstract 1
- 101710188315 Protein X Proteins 0.000 abstract 1
- 230000001627 detrimental effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000005012 myelin Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica que comprende por lo menos un ligando anti-MSRV/HERV-W Env y por lo menos un fármaco inhibidor de radicales de óxido nítrico, en donde: dicho ligando anti.HERV-W Env es un anticuerpo, más particularmente un anticuerpo quimérico, manipulado o humanizado, e incluso más particularmente una IgG, tal como una IgGI o una IgG4, en donde dicho anticuerpo comprende cada una de las regiones determinantes de complementariedad (CDRs) establecidas en SEQ ID NO1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO.4, SEQ ID NO. 5, y SEQ ID NO. 6; dicho fármaco inhibidor de radicales de óxido nítrico se selecciona del grupo que consiste en Ng-nitro-L-arginina-metilester (L-NAME), S-metil-isotiourea (SMT) y fumarato de dimetilo (DMF).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261708779P | 2012-10-02 | 2012-10-02 | |
| US201261746792P | 2012-12-28 | 2012-12-28 | |
| PCT/EP2013/070452 WO2014053489A1 (en) | 2012-10-02 | 2013-10-01 | Compounds for treating the remyelination blockade in diseases associated with the expression of herv-w envelope protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015003572A MX2015003572A (es) | 2015-08-20 |
| MX366846B true MX366846B (es) | 2019-07-26 |
Family
ID=49274655
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015003572A MX366846B (es) | 2012-10-02 | 2013-10-01 | Compuestos para tratar el bloqueo de remielinizacion en enfermedades asociadas con la expresion de la proteina de envoltura herv-w. |
| MX2019008916A MX2019008916A (es) | 2012-10-02 | 2015-03-19 | Compuestos para tratar el bloqueo de remielinizacion en enfermedades asociadas con la expresion de la proteina de envoltura herv-w. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019008916A MX2019008916A (es) | 2012-10-02 | 2015-03-19 | Compuestos para tratar el bloqueo de remielinizacion en enfermedades asociadas con la expresion de la proteina de envoltura herv-w. |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US9840550B2 (es) |
| EP (2) | EP3447070B9 (es) |
| JP (2) | JP6379331B2 (es) |
| KR (1) | KR102098033B1 (es) |
| CN (2) | CN104684927B (es) |
| AU (2) | AU2013326552B2 (es) |
| BR (1) | BR112015007150A8 (es) |
| CA (1) | CA2882781C (es) |
| CY (2) | CY1121237T1 (es) |
| DK (2) | DK2904009T3 (es) |
| EA (2) | EA028245B1 (es) |
| EC (1) | ECSP15014925A (es) |
| ES (2) | ES2710748T3 (es) |
| HK (1) | HK1221399A1 (es) |
| HR (2) | HRP20190274T1 (es) |
| HU (2) | HUE043419T2 (es) |
| IL (3) | IL237474A0 (es) |
| IN (1) | IN2015DN02397A (es) |
| LT (2) | LT3447070T (es) |
| MX (2) | MX366846B (es) |
| MY (1) | MY172209A (es) |
| PL (2) | PL2904009T3 (es) |
| PT (2) | PT3447070T (es) |
| RS (2) | RS58320B1 (es) |
| RU (1) | RU2636355C2 (es) |
| SA (1) | SA515360207B1 (es) |
| SG (1) | SG11201501274VA (es) |
| SI (2) | SI2904009T1 (es) |
| UA (1) | UA119032C2 (es) |
| WO (1) | WO2014053489A1 (es) |
| ZA (1) | ZA201501491B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2949342A1 (en) * | 2014-05-28 | 2015-12-02 | Geneuro SA | Antiretroviral drug targeting human endogenous retrovirus |
| EP3351265A1 (en) * | 2017-01-20 | 2018-07-25 | Geneuro SA | Anti-herv-k envelope antibody and uses thereof |
| JP7122002B2 (ja) | 2017-03-01 | 2022-08-19 | 国立大学法人北海道大学 | 疾患モデル非ヒト動物の製造方法、疾患モデル非ヒト動物、該動物を用いた薬剤のスクリーニング方法及び疾患リスク判定方法 |
| WO2020045683A1 (ja) * | 2018-09-01 | 2020-03-05 | 国立大学法人北海道大学 | ストレス負荷が関与する疾患を予防及び／又は治療するための医薬 |
| EP4025303A1 (en) * | 2019-09-04 | 2022-07-13 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) | Herv inhibitors for use in treating tauopathies |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2753098B1 (fr) * | 1996-09-06 | 1998-11-27 | Sod Conseils Rech Applic | Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene |
| AU5829201A (en) * | 2000-03-21 | 2001-10-03 | Ms Research A/S | An infective endogenous retrovirus and its association with demyelinating diseases and other diseases |
| KR100927261B1 (ko) | 2001-01-17 | 2009-11-18 | 트루비온 파마슈티칼스, 인코포레이티드 | 결합 도메인-면역글로불린 융합 단백질 |
| FR2865403B1 (fr) * | 2004-01-23 | 2009-06-12 | Biomerieux Sa | Composition pour le traitement d'une pathologie associee a la msrv/herv-w |
| US20090233888A1 (en) * | 2005-03-23 | 2009-09-17 | Usc Stevens, University Of Southern California | Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth |
| WO2007100763A2 (en) * | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
| ES2599227T3 (es) * | 2007-02-08 | 2017-01-31 | Biogen Ma Inc. | Neuroprotección en enfermedades desmielinizantes |
| WO2009062926A1 (en) * | 2007-11-12 | 2009-05-22 | Ares Trading S.A. | Taci-immunoglobulin fusion proteins for treatment of relapsing multiple sclerosis |
| CN102143975B (zh) * | 2008-07-08 | 2014-12-31 | 吉纳罗公司 | 特异性配体在msrv相关疾病中的治疗用途 |
| WO2010045265A1 (en) * | 2008-10-13 | 2010-04-22 | Biovista, Inc. | Compositions and methods for treating multiple sclerosis |
| WO2010148323A2 (en) * | 2009-06-18 | 2010-12-23 | Whittemore Peterson Institute For Neuro-Immune Disease | Diagnosis and treatment of diseases or disorders associated with xenotropic murine leukemia virus |
| ES2555279T3 (es) * | 2010-02-12 | 2015-12-30 | Biogen Ma Inc. | Neuroprotección en enfermedades desmielinizantes |
-
2013
- 2013-01-10 UA UAA201504292A patent/UA119032C2/uk unknown
- 2013-10-01 MX MX2015003572A patent/MX366846B/es active IP Right Grant
- 2013-10-01 DK DK13770926.7T patent/DK2904009T3/en active
- 2013-10-01 EP EP18198309.9A patent/EP3447070B9/en active Active
- 2013-10-01 PL PL13770926T patent/PL2904009T3/pl unknown
- 2013-10-01 PL PL18198309T patent/PL3447070T3/pl unknown
- 2013-10-01 SI SI201331348T patent/SI2904009T1/sl unknown
- 2013-10-01 ES ES13770926T patent/ES2710748T3/es active Active
- 2013-10-01 AU AU2013326552A patent/AU2013326552B2/en active Active
- 2013-10-01 RU RU2015116149A patent/RU2636355C2/ru active
- 2013-10-01 RS RS20190185A patent/RS58320B1/sr unknown
- 2013-10-01 DK DK18198309.9T patent/DK3447070T3/da active
- 2013-10-01 EP EP13770926.7A patent/EP2904009B1/en active Active
- 2013-10-01 PT PT181983099T patent/PT3447070T/pt unknown
- 2013-10-01 JP JP2015533633A patent/JP6379331B2/ja active Active
- 2013-10-01 ES ES18198309T patent/ES2878248T3/es active Active
- 2013-10-01 LT LTEP18198309.9T patent/LT3447070T/lt unknown
- 2013-10-01 SG SG11201501274VA patent/SG11201501274VA/en unknown
- 2013-10-01 IN IN2397DEN2015 patent/IN2015DN02397A/en unknown
- 2013-10-01 BR BR112015007150A patent/BR112015007150A8/pt not_active Application Discontinuation
- 2013-10-01 SI SI201331879T patent/SI3447070T1/sl unknown
- 2013-10-01 CN CN201380051713.4A patent/CN104684927B/zh active Active
- 2013-10-01 US US14/429,199 patent/US9840550B2/en active Active
- 2013-10-01 CN CN201610152679.5A patent/CN105709224B/zh active Active
- 2013-10-01 EA EA201590678A patent/EA028245B1/ru unknown
- 2013-10-01 HU HUE13770926A patent/HUE043419T2/hu unknown
- 2013-10-01 RS RS20210555A patent/RS61794B1/sr unknown
- 2013-10-01 EA EA201791525A patent/EA037253B1/ru unknown
- 2013-10-01 KR KR1020157011152A patent/KR102098033B1/ko active IP Right Grant
- 2013-10-01 HU HUE18198309A patent/HUE054051T2/hu unknown
- 2013-10-01 CA CA2882781A patent/CA2882781C/en active Active
- 2013-10-01 LT LTEP13770926.7T patent/LT2904009T/lt unknown
- 2013-10-01 MY MYPI2015700643A patent/MY172209A/en unknown
- 2013-10-01 WO PCT/EP2013/070452 patent/WO2014053489A1/en active Application Filing
- 2013-10-01 PT PT13770926T patent/PT2904009T/pt unknown
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2015
- 2015-02-26 IL IL237474A patent/IL237474A0/en unknown
- 2015-03-04 ZA ZA2015/01491A patent/ZA201501491B/en unknown
- 2015-03-19 MX MX2019008916A patent/MX2019008916A/es unknown
- 2015-03-30 SA SA515360207A patent/SA515360207B1/ar unknown
- 2015-04-17 EC ECIEPI201514925A patent/ECSP15014925A/es unknown
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2016
- 2016-08-01 HK HK16109172.3A patent/HK1221399A1/zh unknown
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2017
- 2017-11-07 JP JP2017214696A patent/JP6538138B2/ja active Active
- 2017-11-14 US US15/812,745 patent/US10752675B2/en active Active
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2018
- 2018-08-17 AU AU2018217328A patent/AU2018217328B2/en active Active
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2019
- 2019-01-21 IL IL264382A patent/IL264382B/en active IP Right Grant
- 2019-02-07 CY CY20191100169T patent/CY1121237T1/el unknown
- 2019-02-11 HR HRP20190274TT patent/HRP20190274T1/hr unknown
-
2020
- 2020-04-19 IL IL274047A patent/IL274047B/en active IP Right Grant
-
2021
- 2021-05-11 CY CY20211100400T patent/CY1124378T1/el unknown
- 2021-05-14 HR HRP20210779TT patent/HRP20210779T1/hr unknown
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