DK2848681T3 - Isolering, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra børn, der udelukkende er fodret med modermælk - Google Patents
Isolering, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra børn, der udelukkende er fodret med modermælk Download PDFInfo
- Publication number
- DK2848681T3 DK2848681T3 DK14190638.8T DK14190638T DK2848681T3 DK 2848681 T3 DK2848681 T3 DK 2848681T3 DK 14190638 T DK14190638 T DK 14190638T DK 2848681 T3 DK2848681 T3 DK 2848681T3
- Authority
- DK
- Denmark
- Prior art keywords
- strain
- lactobacillus
- bacteria
- vol
- strains
- Prior art date
Links
- 210000003608 fece Anatomy 0.000 title claims description 25
- 235000020256 human milk Nutrition 0.000 title claims description 11
- 210000004251 human milk Anatomy 0.000 title claims description 11
- 230000000694 effects Effects 0.000 title description 75
- 238000012512 characterization method Methods 0.000 title description 13
- 238000002955 isolation Methods 0.000 title description 4
- 239000006041 probiotic Substances 0.000 claims description 163
- 235000018291 probiotics Nutrition 0.000 claims description 163
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims description 117
- 230000000529 probiotic effect Effects 0.000 claims description 113
- 241000186605 Lactobacillus paracasei Species 0.000 claims description 67
- 230000000968 intestinal effect Effects 0.000 claims description 57
- 235000013305 food Nutrition 0.000 claims description 55
- 244000005700 microbiome Species 0.000 claims description 54
- 239000000203 mixture Substances 0.000 claims description 52
- 206010012735 Diarrhoea Diseases 0.000 claims description 51
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 29
- 210000000936 intestine Anatomy 0.000 claims description 29
- 235000013350 formula milk Nutrition 0.000 claims description 28
- 235000013336 milk Nutrition 0.000 claims description 22
- 210000004080 milk Anatomy 0.000 claims description 22
- 239000008267 milk Substances 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 22
- 239000000047 product Substances 0.000 claims description 20
- 244000052769 pathogen Species 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 17
- 230000002265 prevention Effects 0.000 claims description 17
- 235000005911 diet Nutrition 0.000 claims description 16
- 230000037213 diet Effects 0.000 claims description 16
- 208000011231 Crohn disease Diseases 0.000 claims description 14
- 235000013406 prebiotics Nutrition 0.000 claims description 14
- 235000015140 cultured milk Nutrition 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 13
- 208000015181 infectious disease Diseases 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 235000016709 nutrition Nutrition 0.000 claims description 13
- 210000000987 immune system Anatomy 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 11
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 11
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 11
- 239000008101 lactose Substances 0.000 claims description 11
- 235000013339 cereals Nutrition 0.000 claims description 7
- 230000035764 nutrition Effects 0.000 claims description 7
- 208000004155 Malabsorption Syndromes Diseases 0.000 claims description 6
- 230000037406 food intake Effects 0.000 claims description 6
- 230000004936 stimulating effect Effects 0.000 claims description 6
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 201000009840 acute diarrhea Diseases 0.000 claims description 4
- 230000001154 acute effect Effects 0.000 claims description 4
- 235000008452 baby food Nutrition 0.000 claims description 4
- 206010009887 colitis Diseases 0.000 claims description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 235000013622 meat product Nutrition 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 235000008429 bread Nutrition 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 235000021105 fermented cheese Nutrition 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 229940127557 pharmaceutical product Drugs 0.000 claims description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 claims description 3
- 235000014347 soups Nutrition 0.000 claims description 3
- 206010010774 Constipation Diseases 0.000 claims description 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 2
- 208000004262 Food Hypersensitivity Diseases 0.000 claims description 2
- 206010017964 Gastrointestinal infection Diseases 0.000 claims description 2
- 206010025476 Malabsorption Diseases 0.000 claims description 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010049416 Short-bowel syndrome Diseases 0.000 claims description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 2
- 210000003484 anatomy Anatomy 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 235000020932 food allergy Nutrition 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 239000013589 supplement Substances 0.000 claims description 2
- 206010056663 Gastric infection Diseases 0.000 claims 1
- 208000019902 chronic diarrheal disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 235000013384 milk substitute Nutrition 0.000 claims 1
- 235000021395 porridge Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 241000894006 Bacteria Species 0.000 description 145
- 241000186660 Lactobacillus Species 0.000 description 107
- 229940039696 lactobacillus Drugs 0.000 description 97
- 241000186000 Bifidobacterium Species 0.000 description 83
- 241000282414 Homo sapiens Species 0.000 description 71
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 66
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 63
- 210000004027 cell Anatomy 0.000 description 60
- 239000006228 supernatant Substances 0.000 description 50
- 241000186012 Bifidobacterium breve Species 0.000 description 39
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 38
- 239000003833 bile salt Substances 0.000 description 37
- 239000002609 medium Substances 0.000 description 37
- 230000012010 growth Effects 0.000 description 35
- 239000004310 lactic acid Substances 0.000 description 33
- 235000014655 lactic acid Nutrition 0.000 description 33
- 108020004465 16S ribosomal RNA Proteins 0.000 description 32
- 230000002401 inhibitory effect Effects 0.000 description 31
- 108090000623 proteins and genes Proteins 0.000 description 30
- 229940093761 bile salts Drugs 0.000 description 29
- 239000012634 fragment Substances 0.000 description 28
- 108020004414 DNA Proteins 0.000 description 26
- 230000035899 viability Effects 0.000 description 25
- 230000036541 health Effects 0.000 description 24
- 241000588724 Escherichia coli Species 0.000 description 22
- 230000001580 bacterial effect Effects 0.000 description 22
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 22
- 244000199866 Lactobacillus casei Species 0.000 description 21
- 235000013365 dairy product Nutrition 0.000 description 21
- 238000000034 method Methods 0.000 description 21
- 235000013618 yogurt Nutrition 0.000 description 21
- 241000736262 Microbiota Species 0.000 description 19
- 239000001963 growth medium Substances 0.000 description 19
- 230000004083 survival effect Effects 0.000 description 19
- 108091034117 Oligonucleotide Proteins 0.000 description 18
- 238000003556 assay Methods 0.000 description 18
- 230000009286 beneficial effect Effects 0.000 description 18
- 241000917009 Lactobacillus rhamnosus GG Species 0.000 description 17
- 238000011161 development Methods 0.000 description 17
- 230000018109 developmental process Effects 0.000 description 17
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 16
- 230000006907 apoptotic process Effects 0.000 description 16
- 239000003613 bile acid Substances 0.000 description 16
- 244000005709 gut microbiome Species 0.000 description 16
- 210000004347 intestinal mucosa Anatomy 0.000 description 16
- 229940059406 lactobacillus rhamnosus gg Drugs 0.000 description 16
- 230000001717 pathogenic effect Effects 0.000 description 16
- 235000013958 Lactobacillus casei Nutrition 0.000 description 15
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 15
- 244000052616 bacterial pathogen Species 0.000 description 15
- 229940017800 lactobacillus casei Drugs 0.000 description 15
- 241000894007 species Species 0.000 description 15
- 240000001046 Lactobacillus acidophilus Species 0.000 description 14
- 108010005774 beta-Galactosidase Proteins 0.000 description 14
- 210000001072 colon Anatomy 0.000 description 14
- 230000005764 inhibitory process Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 206010009944 Colon cancer Diseases 0.000 description 13
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 13
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 13
- 239000007788 liquid Substances 0.000 description 13
- 230000009467 reduction Effects 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 241000700605 Viruses Species 0.000 description 12
- 239000002253 acid Substances 0.000 description 12
- 235000012000 cholesterol Nutrition 0.000 description 12
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 12
- 238000000338 in vitro Methods 0.000 description 12
- 230000000813 microbial effect Effects 0.000 description 12
- 229960002181 saccharomyces boulardii Drugs 0.000 description 12
- 241001608472 Bifidobacterium longum Species 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 11
- 239000003242 anti bacterial agent Substances 0.000 description 11
- 201000011510 cancer Diseases 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 11
- 238000010790 dilution Methods 0.000 description 11
- 239000012895 dilution Substances 0.000 description 11
- 238000000855 fermentation Methods 0.000 description 11
- 230000004151 fermentation Effects 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 239000008186 active pharmaceutical agent Substances 0.000 description 10
- 230000000845 anti-microbial effect Effects 0.000 description 10
- 229940088710 antibiotic agent Drugs 0.000 description 10
- 210000000481 breast Anatomy 0.000 description 10
- 230000001079 digestive effect Effects 0.000 description 10
- 230000000688 enterotoxigenic effect Effects 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- 230000028993 immune response Effects 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- 102100026189 Beta-galactosidase Human genes 0.000 description 9
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 9
- 230000003321 amplification Effects 0.000 description 9
- 229940009291 bifidobacterium longum Drugs 0.000 description 9
- 230000021164 cell adhesion Effects 0.000 description 9
- 238000001727 in vivo Methods 0.000 description 9
- 230000001965 increasing effect Effects 0.000 description 9
- 238000003199 nucleic acid amplification method Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 9
- 241000186779 Listeria monocytogenes Species 0.000 description 8
- 208000029742 colonic neoplasm Diseases 0.000 description 8
- 230000002255 enzymatic effect Effects 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 230000002496 gastric effect Effects 0.000 description 8
- 230000014509 gene expression Effects 0.000 description 8
- 230000007246 mechanism Effects 0.000 description 8
- 108010062877 Bacteriocins Proteins 0.000 description 7
- 102000004127 Cytokines Human genes 0.000 description 7
- 108090000695 Cytokines Proteins 0.000 description 7
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 108010059881 Lactase Proteins 0.000 description 7
- 201000010538 Lactose Intolerance Diseases 0.000 description 7
- 241000700159 Rattus Species 0.000 description 7
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 7
- 230000009471 action Effects 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 210000000941 bile Anatomy 0.000 description 7
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 230000000112 colonic effect Effects 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 230000002550 fecal effect Effects 0.000 description 7
- 230000003993 interaction Effects 0.000 description 7
- 229940116108 lactase Drugs 0.000 description 7
- 238000012163 sequencing technique Methods 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 241000588722 Escherichia Species 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 6
- 229920001202 Inulin Polymers 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 241000607142 Salmonella Species 0.000 description 6
- 241000607760 Shigella sonnei Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000004075 alteration Effects 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 235000013351 cheese Nutrition 0.000 description 6
- 210000004443 dendritic cell Anatomy 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 6
- 229940029339 inulin Drugs 0.000 description 6
- 244000005706 microflora Species 0.000 description 6
- 210000004877 mucosa Anatomy 0.000 description 6
- 229920001542 oligosaccharide Polymers 0.000 description 6
- 235000019260 propionic acid Nutrition 0.000 description 6
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 210000003705 ribosome Anatomy 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 239000003053 toxin Substances 0.000 description 6
- 231100000765 toxin Toxicity 0.000 description 6
- 108700012359 toxins Proteins 0.000 description 6
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 5
- 241000186016 Bifidobacterium bifidum Species 0.000 description 5
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 5
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 5
- 208000005623 Carcinogenesis Diseases 0.000 description 5
- 241000193163 Clostridioides difficile Species 0.000 description 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 5
- 241000194033 Enterococcus Species 0.000 description 5
- 241000194032 Enterococcus faecalis Species 0.000 description 5
- 108010060309 Glucuronidase Proteins 0.000 description 5
- 102000053187 Glucuronidase Human genes 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 206010020751 Hypersensitivity Diseases 0.000 description 5
- 102000004890 Interleukin-8 Human genes 0.000 description 5
- 108090001007 Interleukin-8 Proteins 0.000 description 5
- 108091023242 Internal transcribed spacer Proteins 0.000 description 5
- 240000006024 Lactobacillus plantarum Species 0.000 description 5
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 208000026935 allergic disease Diseases 0.000 description 5
- 230000007815 allergy Effects 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 230000003042 antagnostic effect Effects 0.000 description 5
- 102000005936 beta-Galactosidase Human genes 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
- 230000036952 cancer formation Effects 0.000 description 5
- 231100000504 carcinogenesis Toxicity 0.000 description 5
- 235000015872 dietary supplement Nutrition 0.000 description 5
- 235000013376 functional food Nutrition 0.000 description 5
- 238000009396 hybridization Methods 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 230000002519 immonomodulatory effect Effects 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 235000021129 infant diet Nutrition 0.000 description 5
- 229940072205 lactobacillus plantarum Drugs 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 150000002482 oligosaccharides Chemical class 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 206010009657 Clostridium difficile colitis Diseases 0.000 description 4
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 description 4
- 108010074328 Interferon-gamma Proteins 0.000 description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
- 241000186604 Lactobacillus reuteri Species 0.000 description 4
- 241001529936 Murinae Species 0.000 description 4
- 108010057466 NF-kappa B Proteins 0.000 description 4
- 102000003945 NF-kappa B Human genes 0.000 description 4
- 206010054094 Tumour necrosis Diseases 0.000 description 4
- 102000009270 Tumour necrosis factor alpha Human genes 0.000 description 4
- 108050000101 Tumour necrosis factor alpha Proteins 0.000 description 4
- 241000202221 Weissella Species 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 4
- 229940009289 bifidobacterium lactis Drugs 0.000 description 4
- 239000000090 biomarker Substances 0.000 description 4
- 229940077731 carbohydrate nutrients Drugs 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 230000003828 downregulation Effects 0.000 description 4
- 239000002158 endotoxin Substances 0.000 description 4
- 230000004890 epithelial barrier function Effects 0.000 description 4
- 210000002919 epithelial cell Anatomy 0.000 description 4
- 210000003527 eukaryotic cell Anatomy 0.000 description 4
- 235000021255 galacto-oligosaccharides Nutrition 0.000 description 4
- 150000003271 galactooligosaccharides Chemical class 0.000 description 4
- 230000009036 growth inhibition Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 4
- 229940001882 lactobacillus reuteri Drugs 0.000 description 4
- 235000013372 meat Nutrition 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 244000000010 microbial pathogen Species 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 210000003097 mucus Anatomy 0.000 description 4
- 238000010899 nucleation Methods 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000006152 selective media Substances 0.000 description 4
- 150000004666 short chain fatty acids Chemical class 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical class C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 241000590002 Helicobacter pylori Species 0.000 description 3
- 240000002129 Malva sylvestris Species 0.000 description 3
- 241000940612 Medina Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 241001138501 Salmonella enterica Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 235000021128 adult diet Nutrition 0.000 description 3
- 230000000172 allergic effect Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 239000012298 atmosphere Substances 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229960002433 cysteine Drugs 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000012091 fetal bovine serum Substances 0.000 description 3
- 210000004211 gastric acid Anatomy 0.000 description 3
- 229960001031 glucose Drugs 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 229940037467 helicobacter pylori Drugs 0.000 description 3
- 230000013632 homeostatic process Effects 0.000 description 3
- 238000010874 in vitro model Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 230000028709 inflammatory response Effects 0.000 description 3
- 229940115931 listeria monocytogenes Drugs 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 238000010197 meta-analysis Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000002438 mitochondrial effect Effects 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 230000001766 physiological effect Effects 0.000 description 3
- 230000003334 potential effect Effects 0.000 description 3
- 238000011321 prophylaxis Methods 0.000 description 3
- 235000019419 proteases Nutrition 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 229940115939 shigella sonnei Drugs 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 235000019722 synbiotics Nutrition 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 230000036642 wellbeing Effects 0.000 description 3
- ZFTFOHBYVDOAMH-XNOIKFDKSA-N (2r,3s,4s,5r)-5-[[(2r,3s,4s,5r)-5-[[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-2-(hydroxymethyl)oxolan-2-yl]oxymethyl]-2-(hydroxymethyl)oxolane-2,3,4-triol Chemical class O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(OC[C@@H]2[C@H]([C@H](O)[C@@](O)(CO)O2)O)O1 ZFTFOHBYVDOAMH-XNOIKFDKSA-N 0.000 description 2
- VLEIUWBSEKKKFX-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound OCC(N)(CO)CO.OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O VLEIUWBSEKKKFX-UHFFFAOYSA-N 0.000 description 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 2
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 108090000397 Caspase 3 Proteins 0.000 description 2
- 244000298479 Cichorium intybus Species 0.000 description 2
- 235000007542 Cichorium intybus Nutrition 0.000 description 2
- 241001398967 Colonia Species 0.000 description 2
- 102100030497 Cytochrome c Human genes 0.000 description 2
- 108010075031 Cytochromes c Proteins 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 206010012742 Diarrhoea infectious Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000520134 Enterococcus mundtii Species 0.000 description 2
- 241000345386 Fabia Species 0.000 description 2
- 108010040721 Flagellin Proteins 0.000 description 2
- 229920002670 Fructan Polymers 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 206010017943 Gastrointestinal conditions Diseases 0.000 description 2
- 241000447437 Gerreidae Species 0.000 description 2
- 102000003964 Histone deacetylase Human genes 0.000 description 2
- 108090000353 Histone deacetylase Proteins 0.000 description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 2
- 241000617996 Human rotavirus Species 0.000 description 2
- 102100037850 Interferon gamma Human genes 0.000 description 2
- 102000008070 Interferon-gamma Human genes 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241001616242 Lactobacillus paracasei ATCC 334 Species 0.000 description 2
- 241000218587 Lactobacillus paracasei subsp. paracasei Species 0.000 description 2
- 240000005776 Lupinus angustifolius Species 0.000 description 2
- 235000010653 Lupinus angustifolius Nutrition 0.000 description 2
- 206010028116 Mucosal inflammation Diseases 0.000 description 2
- 108010076864 Nitric Oxide Synthase Type II Proteins 0.000 description 2
- 102000011779 Nitric Oxide Synthase Type II Human genes 0.000 description 2
- 241000605159 Nitrobacter Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 240000004713 Pisum sativum Species 0.000 description 2
- 235000010582 Pisum sativum Nutrition 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 241000702670 Rotavirus Species 0.000 description 2
- 241000235070 Saccharomyces Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 244000057717 Streptococcus lactis Species 0.000 description 2
- 235000014897 Streptococcus lactis Nutrition 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- VLSOAXRVHARBEQ-UHFFFAOYSA-N [4-fluoro-2-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=C(F)C=C1CO VLSOAXRVHARBEQ-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 235000020167 acidified milk Nutrition 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 102000005840 alpha-Galactosidase Human genes 0.000 description 2
- 108010030291 alpha-Galactosidase Proteins 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 210000004082 barrier epithelial cell Anatomy 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 229940004120 bifidobacterium infantis Drugs 0.000 description 2
- 230000001847 bifidogenic effect Effects 0.000 description 2
- 210000003445 biliary tract Anatomy 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 235000020299 breve Nutrition 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 230000025084 cell cycle arrest Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000004709 cell invasion Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000036755 cellular response Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000012627 chemopreventive agent Substances 0.000 description 2
- 229940124443 chemopreventive agent Drugs 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000007621 cluster analysis Methods 0.000 description 2
- 230000004736 colon carcinogenesis Effects 0.000 description 2
- 210000004922 colonic epithelial cell Anatomy 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 239000007799 cork Substances 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 235000014048 cultured milk product Nutrition 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000000741 diarrhetic effect Effects 0.000 description 2
- 235000013325 dietary fiber Nutrition 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003596 drug target Substances 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 229940032049 enterococcus faecalis Drugs 0.000 description 2
- 210000001842 enterocyte Anatomy 0.000 description 2
- 230000000369 enteropathogenic effect Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 244000078673 foodborn pathogen Species 0.000 description 2
- VPUGDVKSAQVFFS-UHFFFAOYSA-N hexabenzobenzene Natural products C1=C(C2=C34)C=CC3=CC=C(C=C3)C4=C4C3=CC=C(C=C3)C4=C2C3=C1 VPUGDVKSAQVFFS-UHFFFAOYSA-N 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 230000000260 hypercholesteremic effect Effects 0.000 description 2
- 230000000871 hypocholesterolemic effect Effects 0.000 description 2
- 208000009326 ileitis Diseases 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000000099 in vitro assay Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000012678 infectious agent Substances 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229960003130 interferon gamma Drugs 0.000 description 2
- 229940096397 interleukin-8 Drugs 0.000 description 2
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 2
- 230000021995 interleukin-8 production Effects 0.000 description 2
- 230000031891 intestinal absorption Effects 0.000 description 2
- 210000005026 intestinal epithelial barrier Anatomy 0.000 description 2
- 238000007737 ion beam deposition Methods 0.000 description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 description 2
- 229940004311 lactobacillus casei rhamnosus Drugs 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 2
- HSMJRIUFXFAZSY-UHFFFAOYSA-N methylenedinitramine Chemical compound [O-][N+](=O)NCN[N+]([O-])=O HSMJRIUFXFAZSY-UHFFFAOYSA-N 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 231100000219 mutagenic Toxicity 0.000 description 2
- 230000003505 mutagenic effect Effects 0.000 description 2
- 230000013370 mutualism Effects 0.000 description 2
- 230000001613 neoplastic effect Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 230000007918 pathogenicity Effects 0.000 description 2
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 2
- 229960002702 piroxicam Drugs 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 235000013580 sausages Nutrition 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 235000021391 short chain fatty acids Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- 235000014214 soft drink Nutrition 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 2
- 150000003952 β-lactams Chemical class 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- OGQHCUYSWDOIMP-UHFFFAOYSA-N 7-(diethylamino)-n-[2-[(2-iodoacetyl)amino]ethyl]-2-oxochromene-3-carboxamide Chemical compound C1=C(C(=O)NCCNC(=O)CI)C(=O)OC2=CC(N(CC)CC)=CC=C21 OGQHCUYSWDOIMP-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 108700042778 Antimicrobial Peptides Proteins 0.000 description 1
- 102000044503 Antimicrobial Peptides Human genes 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000606125 Bacteroides Species 0.000 description 1
- 241000741973 Bifidobacterium breve DSM 20213 = JCM 1192 Species 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 206010048832 Colon adenoma Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 101710146739 Enterotoxin Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- RTVRUWIBAVHRQX-PMEZUWKYSA-N Fucosyllactose Chemical class C([C@H]1O[C@@H]([C@H]([C@@H](O[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@@H]1O)O)OC)O[C@H]1OC[C@@H](O)[C@H](O)[C@@H]1O RTVRUWIBAVHRQX-PMEZUWKYSA-N 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 241000224467 Giardia intestinalis Species 0.000 description 1
- 238000002738 Giemsa staining Methods 0.000 description 1
- 238000003794 Gram staining Methods 0.000 description 1
- 241000588754 Klebsiella sp. Species 0.000 description 1
- 239000004201 L-cysteine Substances 0.000 description 1
- 235000013878 L-cysteine Nutrition 0.000 description 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 235000003418 Lactobacillus casei ATCC 334 Nutrition 0.000 description 1
- 235000008018 Lactobacillus casei BL23 Nutrition 0.000 description 1
- 240000004365 Lactobacillus casei BL23 Species 0.000 description 1
- 241000186840 Lactobacillus fermentum Species 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- 241000186610 Lactobacillus sp. Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 241001158958 Longacerus giraffa Species 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 244000070406 Malus silvestris Species 0.000 description 1
- 235000006770 Malva sylvestris Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- XRYVAQQLDYTHCL-UHFFFAOYSA-N Marini Chemical compound O1C=2C(CC(CC=C(C)C)C(C)=C)=C(O)C=C(O)C=2C(=O)CC1C1=CC=C(O)C=C1O XRYVAQQLDYTHCL-UHFFFAOYSA-N 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 229920000715 Mucilage Polymers 0.000 description 1
- 102100022365 NAD(P)H dehydrogenase [quinone] 1 Human genes 0.000 description 1
- 102000004459 Nitroreductase Human genes 0.000 description 1
- 108010026867 Oligo-1,6-Glucosidase Proteins 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 229920000294 Resistant starch Polymers 0.000 description 1
- 101100421708 Schistosoma mansoni SM20 gene Proteins 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 102100027918 Sucrase-isomaltase, intestinal Human genes 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 239000009466 Valverde Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- SHZGCJCMOBCMKK-SXUWKVJYSA-N alpha-L-fucose Chemical compound C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-SXUWKVJYSA-N 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- 108010027597 alpha-chymotrypsin Proteins 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000027697 autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency Diseases 0.000 description 1
- 108010066657 azoreductase Proteins 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000003352 cell adhesion assay Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 238000011281 clinical therapy Methods 0.000 description 1
- 239000007382 columbia agar Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 108700036934 congenital Sucrase-isomaltase deficiency Proteins 0.000 description 1
- 208000001970 congenital sucrase-isomaltase deficiency Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- QYIXCDOBOSTCEI-NWKZBHTNSA-N coprostanol Chemical compound C([C@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-NWKZBHTNSA-N 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007580 dry-mixing Methods 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 210000000105 enteric nervous system Anatomy 0.000 description 1
- 239000000147 enterotoxin Substances 0.000 description 1
- 231100000655 enterotoxin Toxicity 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000021001 fermented dairy product Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000021060 food property Nutrition 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000012224 gene deletion Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229940085435 giardia lamblia Drugs 0.000 description 1
- 229930182480 glucuronide Natural products 0.000 description 1
- 150000008134 glucuronides Chemical class 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 210000005205 gut mucosa Anatomy 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000007236 host immunity Effects 0.000 description 1
- 244000005702 human microbiome Species 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 108020001162 nitroreductase Proteins 0.000 description 1
- 102000042567 non-coding RNA Human genes 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 235000006180 nutrition needs Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000007112 pro inflammatory response Effects 0.000 description 1
- 231100000586 procarcinogen Toxicity 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000009696 proliferative response Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 108700022487 rRNA Genes Proteins 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 235000021254 resistant starch Nutrition 0.000 description 1
- 230000012423 response to bacterium Effects 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 239000007320 rich medium Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000007727 signaling mechanism Effects 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000020192 tolerance induction in gut-associated lymphoid tissue Effects 0.000 description 1
- 201000002516 toxic megacolon Diseases 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 239000000717 tumor promoter Substances 0.000 description 1
- 241001300301 uncultured bacterium Species 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/519—Breve
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pediatric Medicine (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
Claims (23)
- DK/EP 2848681 T31. Stamme af en probiotisk mikroorganisme isoleret fra fæces fra børn, der udelukkende er fodret med modermælk, kendetegnet ved, at den består af Lactobacillus paracasei HERO 7 med deponeringsnummer CNCM I-4034, deponeret den 2. juli 2008 hos CNCM National Collection of Microorganism Culture, Pasteur Institute 25, Rue du Docteur Roux, F-75724 Paris.
- 2. Mikroorganismestamme ifølge krav 1, kendetegnet ved, at den foreligger i form af en ren biologisk kultur.
- 3. Mikroorganismestamme ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at den er isoleret.
- 4. Stamme af en probiotisk mikroorganisme ifølge et hvilket som helst af de foregående krav, kendetegnet ved, at den foreligger i form af levedygtige celler.
- 5. Stamme af en probiotisk mikroorganisme ifølge krav 1 til 3, kendetegnet ved, at den foreligger i form af ikke-levedygtige celler.
- 6. Præparat omfattende en stamme af en mikroorganisme ifølge et hvilket som helst af de foregående krav.
- 7. Præparat ifølge krav 6, kendetegnet ved, at det desuden omfatter et andet probiotisk materiale.
- 8. Præparat ifølge krav 6 til 7, kendetegnet ved, at det endvidere omfatter præbiotisk materiale.
- 9. Præparat ifølge et hvilket som helst af kravene 6 til 8, kendetegnet ved, at det endvidere omfatter en til dets indtagelse egnet bærer.
- 10. Præparat ifølge krav 9, kendetegnet ved, at bæreren er en farmaceutisk acceptabel bærer, såsom kapsler, tabletter eller pulver.
- 11. Præparat ifølge krav 9, kendetegnet ved, at bæreren er et levnedsmiddelprodukt. DK/EP 2848681 T3
- 12. Præparat ifølge krav 11, kendetegnet ved, at det nævnte levnedsmiddelprodukt er valgt fra gruppen, der består af mælk og af mælk afledte produkter, især fermenteret mælk og ost; kornsorter og afledte produkter, herunder brøddej; supper og produkter i dehydratiseret form; fermenterede kødprodukter; af frugt afledte produkter, safter og sodavand; levnedsmidler til særlige ernæringsanvendelser.
- 13. Stamme af en probiotisk mikroorganisme ifølge et hvilket som helst af kravene 1 til 5 eller præparat ifølge et hvilket som helst af kravene 6 til 12 til anvendelse i diæter.
- 14. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 13 til anvendelse i spædbørns-og/eller voksen- og/eller specialdiæter.
- 15. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 14 til anvendelse ved fremstillingen af modermælkserstatning.
- 16. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 15, kendetegnet ved, at mælkeerstatningen består affærdig børnemælk og/eller børnegrød og/eller børnemad.
- 17. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 13 til anvendelse ved fremstillingen af kosttilskud.
- 18. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 13 til anvendelse ved fremstillingen af særlige præparater til oral og/eller enteral ernæring.
- 19. Stamme ifølge krav 1 til 5 eller præparat ifølge et hvilket som helst af kravene 6 til 10 til anvendelse ved fremstillingen af et farmaceutisk produkt.
- 20. Stamme ifølge krav 1 til 5 eller præparat ifølge et hvilket som helst af kravene 6 til 10 til anvendelse ved stimulering af immunsystemet og/eller ved forebyggelse/behandling af astma og/eller ved forebyggelse/behandling af mavetarmlidelser og/eller ved eliminering/modulering af de vigtigste pathogener i fordøjelseskanalen og/eller ved forebyggelse/behandling af obesitet og dens følgesygdomme, herunder metabolisk syndrom og diabetes, og/eller ved de typiske aldersbetingede sygdomme.
- 21. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 6 til 10 til anvendelse ifølge krav 20, kendetegnet ved, at mavetarmlidelserne omfatter forandringer i tarmpassagen, DK/EP 2848681 T3 såsom forstoppelse, og forandringer i biotilgængeligheden af mineraler, infektioner og malabsorptionssyndromer.
- 22. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 6 til 10 til anvendelse ifølge krav 21, kendetegnet ved, at infektionerne omfatter maveinfektioner og mavetarminfek-tioner med akut eller kronisk diarré.
- 23. Stamme ifølge krav 1 til 5 eller præparat ifølge krav 6 til 10, til anvendelse ifølge krav 21, kendetegnet ved, at malabsorptionssyndromerne omfatter lidelser, der rammer tarmenes anatomi, såsom korttarmssyndrom, og lidelser, der rammer tarmenes fysiologi, såsom cystisk fibrose i pankreas, malabsorption af sukkerarter, især lactose, forandringer i lipidabsorption, levnedsmiddelallergier og colitis, såsom Crohn's sygdom og colitis ulcerosa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/ES2009/000130 WO2010103132A1 (es) | 2009-03-10 | 2009-03-10 | Aislamiento, identificación y caracterización de cepas con actividad probiótica a partir de heces de lactantes alimentados exclusivamente con leche materna |
EP10750390.6A EP2407532B1 (en) | 2009-03-10 | 2010-03-09 | Isolation, identification and characterisation of strains with probiotic activity, from faeces of infants fed exclusively with breast milk |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2848681T3 true DK2848681T3 (da) | 2017-07-24 |
Family
ID=42727821
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14190638.8T DK2848681T3 (da) | 2009-03-10 | 2010-03-09 | Isolering, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra børn, der udelukkende er fodret med modermælk |
DK14190648.7T DK2848682T3 (da) | 2009-03-10 | 2010-03-09 | Isolation, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra børn, der udelukkende er fodret med modermælk |
DK10750390.6T DK2407532T3 (da) | 2009-03-10 | 2010-03-09 | Isolering, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra spædbørn, der udelukkende er fodret med modermælk |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14190648.7T DK2848682T3 (da) | 2009-03-10 | 2010-03-09 | Isolation, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra børn, der udelukkende er fodret med modermælk |
DK10750390.6T DK2407532T3 (da) | 2009-03-10 | 2010-03-09 | Isolering, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra spædbørn, der udelukkende er fodret med modermælk |
Country Status (8)
Country | Link |
---|---|
US (3) | US8637297B2 (da) |
EP (3) | EP2407532B1 (da) |
CN (3) | CN102421889B (da) |
DK (3) | DK2848681T3 (da) |
ES (3) | ES2636944T3 (da) |
PL (3) | PL2407532T3 (da) |
RU (1) | RU2551315C2 (da) |
WO (2) | WO2010103132A1 (da) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
EP2134835B1 (en) * | 2007-03-28 | 2014-10-15 | Alimentary Health Limited | Probiotic bifidobacterium strains |
NZ618935A (en) | 2010-08-04 | 2014-03-28 | Karma Medical Prod Co Ltd | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
BR112013022927A2 (pt) | 2011-03-09 | 2016-12-06 | Univ Minnesota | composição, métodos para substituir ou suplementar ou modificar uma microbiota do cólon de um sujeito, e para tratar um sujeito, e, uso de uma composição |
RU2453591C1 (ru) * | 2011-04-21 | 2012-06-20 | Общество с ограниченной ответственностью "Бифилюкс" | Штамм lactobacillus rhamnosus, используемый для получения продукции, содержащей лактобактерии |
KR101228035B1 (ko) * | 2011-06-29 | 2013-01-30 | 주식회사 쎌바이오텍 | 신규한 유산균 및 이를 포함하는 당뇨병 예방 및 치료용 조성물 |
WO2013176774A1 (en) | 2012-05-25 | 2013-11-28 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
CA2891618A1 (en) * | 2012-11-12 | 2014-05-15 | Compagnie Gervais Danone | Use of lactobacillus rhamnosus strain for reducing weight gain and/or insulin resistance |
ES2468040B1 (es) * | 2012-11-13 | 2014-12-26 | Instituto Nacional De Investigación Y Tecnología Agraria Y Alimentaria (Inia) | Microorganismo aislado de leche materna y de heces de un lactante, y su uso como probiótico |
CN102960599A (zh) * | 2012-11-19 | 2013-03-13 | 陕西科技大学 | 一种含益生元的双歧杆菌微胶囊的制备方法 |
ITRM20130174A1 (it) * | 2013-03-22 | 2014-09-23 | Eurospital S P A | Ceppo di lactobacillus e suo uso come probiotico |
CA2920461C (en) * | 2013-08-09 | 2023-01-03 | Ab-Biotics, S.A. | Probiotic for infantile excessive crying |
ITMI20131467A1 (it) | 2013-09-06 | 2015-03-07 | Sofar Spa | Uso di una composizione comprendente microrganismi per aumentare la produzione intestinale di acido butirrico, di acido folico o di niacina e/o per diminuire la produzione intestinale di acido succinico |
WO2015042683A1 (en) * | 2013-09-26 | 2015-04-02 | Hassan Firoozmand | Biopolymer compositions comprising a plurality of treated single-celled microorganisms |
WO2015146916A1 (ja) * | 2014-03-24 | 2015-10-01 | 大塚製薬株式会社 | 新規ラクトバチラス・パラカゼイ株 |
MA39710A (fr) | 2014-04-23 | 2015-10-29 | Sofar Spa | Composition topique destinée à être utilisée dans le traitement d'une maladie inflammatoire de l'intestin |
RU2605626C2 (ru) * | 2015-04-28 | 2016-12-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Кемеровский технологический институт пищевой промышленности (университет)" | Способ получения бактериального препарата с пробиотической активностью |
WO2016183577A1 (en) | 2015-05-14 | 2016-11-17 | Crestovo Llc | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
ES2909456T3 (es) | 2015-05-22 | 2022-05-06 | Univ Arizona State | Métodos para tratar el trastorno del espectro autista y síntomas asociados |
CN104894021B (zh) * | 2015-06-03 | 2018-02-09 | 宜兰食品工业股份有限公司 | 一种副干酪乳杆菌及其应用 |
CN105176822B (zh) * | 2015-10-23 | 2019-01-11 | 广州康泽医疗科技有限公司 | 一种人类肠道益生菌的优化分离方法 |
MA45288A (fr) | 2016-06-08 | 2019-04-17 | Sofar Spa | Nouvelle utilisation médicale de probiotiques |
US20170360848A1 (en) | 2016-06-15 | 2017-12-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
US10849936B2 (en) | 2016-07-01 | 2020-12-01 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
US20180036352A1 (en) | 2016-08-03 | 2018-02-08 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
US11213549B2 (en) | 2016-10-11 | 2022-01-04 | Finch Therapeutics Holdings Llc | Compositions and method for treating primary sclerosing cholangitis and related disorders |
US11026978B2 (en) | 2016-10-11 | 2021-06-08 | Finch Therapeutics Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
IT201600122724A1 (it) | 2016-12-02 | 2018-06-02 | Sofar Spa | Exopolysaccharides and uses thereof |
IT201600127498A1 (it) | 2016-12-16 | 2018-06-16 | Sofar Spa | Probiotici per uso nella diverticolosi e malattia diverticolare |
WO2018187464A1 (en) | 2017-04-05 | 2018-10-11 | Crestovo Holdings Llc | Compositions and methods for treating diverticulitis and related disorders |
US11433102B2 (en) | 2017-04-05 | 2022-09-06 | Finch Therapeutics Holdings Llc | Compositions and methods for treating Parkinson's disease (PD) and related disorders |
JP2020521760A (ja) | 2017-05-26 | 2020-07-27 | クレストヴォ・ホールディングス・エルエルシー | 糞便微生物ベースの治療剤を含む凍結乾燥組成物ならびにそれを製造および使用する方法 |
CN111328284A (zh) | 2017-08-07 | 2020-06-23 | 芬奇治疗公司 | 用于维持和恢复健康的肠道屏障的组合物和方法 |
WO2019136186A2 (en) * | 2018-01-03 | 2019-07-11 | Evolve Biosystems, Inc. | Method for determining dysbiosis in the intestinal microbiome |
TWI705136B (zh) * | 2018-01-05 | 2020-09-21 | 益福生醫股份有限公司 | 新穎乳酸菌及其應用 |
CN108315285A (zh) * | 2018-05-08 | 2018-07-24 | 西藏高原之宝牦牛乳业股份有限公司 | 一种副干酪乳杆菌及其制备方法 |
WO2020006663A1 (zh) * | 2018-07-02 | 2020-01-09 | 葡萄王生技股份有限公司 | 用于改善代谢症候群的新颖副干酪乳杆菌 gks6、其培养基、培养方法、用途、医药组合物及可食用组合物 |
US11166990B2 (en) | 2018-07-13 | 2021-11-09 | Finch Therapeutics Holdings Llc | Methods and compositions for treating ulcerative colitis |
CN109134628A (zh) * | 2018-09-26 | 2019-01-04 | 福建傲农生物科技集团股份有限公司 | 一种乳酸菌素plnE及其制备方法 |
US11911419B2 (en) | 2018-09-27 | 2024-02-27 | Finch Therapeutics Holdings Llc | Compositions and methods for treating epilepsy and related disorders |
CN109536415B (zh) * | 2018-12-26 | 2021-12-07 | 江西仁仁健康产业有限公司 | 一种鼠李糖乳杆菌及其应用 |
BR112021007249A2 (pt) | 2019-01-16 | 2021-08-10 | N.V. Nutricia | composições nutricionais |
US11865151B2 (en) * | 2019-02-14 | 2024-01-09 | Gutsybio Inc. | Live biotherapeutics for the treatment of carbohydrate disorders |
EP3718416B1 (en) | 2019-04-03 | 2024-05-29 | COREE S.r.l. | Production method to increase bioavailability of sugars from natural complex polysaccharides for human, animal and agricultural purposes |
KR102139687B1 (ko) * | 2019-05-03 | 2020-07-30 | 주식회사 메디오젠 | 가드네렐라 바기날리스 및 칸디다 알비칸스에 항균 효과를 갖는 질염 치료 또는 개선용 유산균 mg4288 |
JP7013419B2 (ja) * | 2019-08-07 | 2022-02-15 | 日清食品ホールディングス株式会社 | 炎症性サイトカインの産生誘導活性は低いが抗炎症性サイトカインの産生誘導活性が高いビフィズス菌 |
US11751597B2 (en) | 2019-11-05 | 2023-09-12 | Alfasigma S.P.A. | Compositions comprising bacterial strains for use in increasing the bioavailability of amino acids derived from proteins, and related food product methods and systems |
IT201900020422A1 (it) * | 2019-11-05 | 2021-05-05 | Sofar Spa | Composizioni comprendenti ceppi di batteri per uso per aumentare la biodisponibilità degli amminoacidi derivanti da proteine |
EP3725167A1 (en) * | 2019-11-11 | 2020-10-21 | COREE S.r.l. | Synergistic blends of probiotics expressing improved beneficial activity for human host favourably interacting with food, particularly baby food |
WO2021242057A1 (ko) * | 2020-05-28 | 2021-12-02 | 주식회사 바이오뱅크힐링 | 락토바실러스 속 균주, 및 그의 유래의 소포체 및 그의 항염증 및 항균 용도 |
KR102296286B1 (ko) * | 2020-06-16 | 2021-09-01 | 주식회사 바이오뱅크힐링 | 락토바실러스 람노서스 균주, 및 그의 유래의 소포체 및 그의 항염증 및 항균 용도 |
CN113817622B (zh) * | 2020-06-18 | 2023-05-26 | 青岛蔚蓝生物股份有限公司 | 一株具有减轻致癌物对人体细胞基因毒性作用的长双歧杆菌及其应用 |
CN111826312B (zh) * | 2020-07-10 | 2022-03-25 | 江南大学 | 一株可缓解苯并芘暴露的鼠李糖乳杆菌及其应用 |
CN111733110B (zh) * | 2020-07-17 | 2021-10-22 | 佛山市朗芯生物科技有限公司 | 副干酪乳杆菌及其在制备治疗溃疡性结肠炎药物中的应用 |
CN111944727B (zh) * | 2020-08-24 | 2021-12-03 | 汤臣倍健股份有限公司 | 一种短双歧杆菌207-1及其应用 |
CN113265351B (zh) * | 2021-05-11 | 2022-05-06 | 昆明理工大学 | 一株乳杆菌w8172及其应用 |
RU2766765C1 (ru) * | 2021-05-25 | 2022-03-15 | Федеральное государственное бюджетное учреждение "Детский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства" | Способ лечения функциональных заболеваний желудочно-кишечного тракта у детей |
CN113322216B (zh) * | 2021-07-30 | 2021-11-05 | 北京量化健康科技有限公司 | 一种副干酪乳杆菌b111h及其在代谢综合征中的应用 |
KR102562507B1 (ko) * | 2021-12-08 | 2023-08-02 | 한국식품연구원 | 항염증 효과가 뛰어난 신규한 락토바실러스 파라카제이 아종 톨러란스 WiKim0148 및 이의 용도 |
CN114113023B (zh) * | 2021-12-16 | 2024-04-26 | 郑州轻工业大学 | 基于单核增生李斯特菌来源的氮掺杂碳点的制备方法和应用 |
CN114292779A (zh) * | 2021-12-22 | 2022-04-08 | 清远西周生物医药科技有限公司 | 一种副干酪乳杆菌冻干粉、其应用及制备方法 |
CN114381411B (zh) * | 2022-03-23 | 2022-05-27 | 山东中科嘉亿生物工程有限公司 | 乳酸乳球菌jyll-60及其在制备提高免疫力的产品上的应用 |
CN115998777B (zh) * | 2022-10-18 | 2023-11-17 | 汤臣倍健股份有限公司 | 副干酪乳杆菌207-27的用途 |
CN116731891B (zh) * | 2022-12-07 | 2024-05-07 | 内蒙古科拓生物有限公司 | 一株短双歧杆菌b2798及其制备益生菌制剂的用途 |
CN116396905A (zh) * | 2023-04-08 | 2023-07-07 | 威凯海思(山东)生物工程有限公司 | 一种短双歧杆菌hc2953、菌剂及其应用 |
CN116855413B (zh) * | 2023-07-07 | 2024-02-09 | 镇江远森医药科技有限公司 | 利用鼠李糖乳杆菌YSs069制备调节人体微生态平衡的生物活性物质及其应用 |
KR102700400B1 (ko) * | 2023-11-24 | 2024-09-02 | (주)마이크로바이옴 | 항균 활성 및 프로바이오틱스 특성을 갖는 글루텐 분해능이 있는 락토바실러스 파라카제이 glu70 균주 및 이의 용도 |
CN117660253A (zh) * | 2023-12-10 | 2024-03-08 | 石河子大学 | 一种鼠李糖乳酪杆菌fmbl l23004 cnn、酸奶发酵剂、酸奶及其应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0768375T4 (da) * | 1992-07-06 | 2002-09-16 | Nestle Sa | Mælkesyrebakterier |
SK283008B6 (sk) * | 1997-08-21 | 2003-01-09 | New Zealand Dairy Board | Biologicky čistá kultúra Lactobacillus rhamnosus, kompozícia s jej obsahom a jej použitie |
EP1034788A1 (en) * | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactic acid bacteria strains capable of preventing diarrhea |
ES2238285T3 (es) * | 1999-05-07 | 2005-09-01 | Compagnie Gervais Danone | Uso de bacterias acidolacticas en la preparacion de leches fermentadas para el tratamiento de niveles inmunitarios reducidos. |
FI109602B (fi) * | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
EP1384483A1 (en) * | 2002-07-23 | 2004-01-28 | Nestec S.A. | Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function |
NZ546664A (en) * | 2003-10-24 | 2009-04-30 | Nutricia Nv | Synbiotic composition for infants |
ITMI20042189A1 (it) * | 2004-11-16 | 2005-02-16 | Anidral Srl | Composizione a base di batteri probiotici e suo uso nella prevenzione e-o nel trattamento di patologie e-o infezioni respiratorie e nel miglioramento della funzionalita' intestinale |
CN1259054C (zh) * | 2004-12-27 | 2006-06-14 | 孙文基 | 龙胆苦苷在制备抑制乙型肝炎病毒药物中的应用 |
US8377430B2 (en) * | 2005-04-13 | 2013-02-19 | Nestec S.A. | Infant formula with probiotics |
EP2269465A1 (en) * | 2006-05-03 | 2011-01-05 | Probiotical S.p.a. | Compositions comprising Bifidobacterium adolescentis |
CA2689862A1 (en) * | 2006-06-09 | 2007-12-13 | Nutravital Inc. | Probiotic compositions comprising propionibacterium and uses thereof |
US8066986B2 (en) * | 2007-02-01 | 2011-11-29 | Master Supplements, Inc. | Formulations including digestive enzymes and polysorbate surfactants that enhance the colonization of administered probiotics microoganisms |
EP1974743A1 (en) * | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics to Improve Gut Microbiota |
EP1997499A1 (en) * | 2007-05-31 | 2008-12-03 | Puleva Biotech, S.A. | Mammalian milk microorganisms, compositions containing them and their use for the treatment of mastitis |
-
2009
- 2009-03-10 WO PCT/ES2009/000130 patent/WO2010103132A1/es active Application Filing
-
2010
- 2010-03-09 EP EP10750390.6A patent/EP2407532B1/en active Active
- 2010-03-09 ES ES14190648.7T patent/ES2636944T3/es active Active
- 2010-03-09 RU RU2011138363/10A patent/RU2551315C2/ru active
- 2010-03-09 EP EP14190638.8A patent/EP2848681B1/en not_active Not-in-force
- 2010-03-09 WO PCT/ES2010/000097 patent/WO2010103140A2/es active Application Filing
- 2010-03-09 PL PL10750390T patent/PL2407532T3/pl unknown
- 2010-03-09 DK DK14190638.8T patent/DK2848681T3/da active
- 2010-03-09 PL PL14190648T patent/PL2848682T3/pl unknown
- 2010-03-09 PL PL14190638T patent/PL2848681T3/pl unknown
- 2010-03-09 DK DK14190648.7T patent/DK2848682T3/da active
- 2010-03-09 US US13/255,842 patent/US8637297B2/en active Active
- 2010-03-09 CN CN201080020442.2A patent/CN102421889B/zh active Active
- 2010-03-09 ES ES14190638.8T patent/ES2632436T3/es active Active
- 2010-03-09 EP EP14190648.7A patent/EP2848682B1/en active Active
- 2010-03-09 CN CN201410478147.1A patent/CN104232545B/zh active Active
- 2010-03-09 ES ES10750390.6T patent/ES2532095T3/es active Active
- 2010-03-09 CN CN201410476564.2A patent/CN104232544B/zh not_active Expired - Fee Related
- 2010-03-09 DK DK10750390.6T patent/DK2407532T3/da active
-
2013
- 2013-03-15 US US13/841,135 patent/US20130280789A1/en not_active Abandoned
- 2013-03-15 US US13/841,604 patent/US20130280790A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2632436T3 (es) | 2017-09-13 |
CN104232545A (zh) | 2014-12-24 |
EP2407532A4 (en) | 2013-04-10 |
PL2848682T3 (pl) | 2017-12-29 |
DK2848682T3 (da) | 2017-09-11 |
CN104232544B (zh) | 2017-04-12 |
ES2636944T3 (es) | 2017-10-10 |
US20120076829A1 (en) | 2012-03-29 |
EP2848681A1 (en) | 2015-03-18 |
US8637297B2 (en) | 2014-01-28 |
WO2010103140A3 (es) | 2010-11-04 |
ES2532095T3 (es) | 2015-03-24 |
DK2407532T3 (da) | 2015-03-09 |
WO2010103132A1 (es) | 2010-09-16 |
RU2011138363A (ru) | 2013-04-20 |
US20130280789A1 (en) | 2013-10-24 |
RU2551315C2 (ru) | 2015-05-20 |
CN102421889A (zh) | 2012-04-18 |
EP2848682A1 (en) | 2015-03-18 |
EP2407532A2 (en) | 2012-01-18 |
PL2848681T4 (pl) | 2017-10-31 |
EP2407532B1 (en) | 2014-12-10 |
EP2848681B1 (en) | 2017-04-12 |
CN104232545B (zh) | 2017-11-21 |
WO2010103140A2 (es) | 2010-09-16 |
CN104232544A (zh) | 2014-12-24 |
EP2848682B1 (en) | 2017-05-31 |
PL2407532T3 (pl) | 2015-06-30 |
PL2848681T3 (pl) | 2017-10-31 |
US20130280790A1 (en) | 2013-10-24 |
CN102421889B (zh) | 2014-10-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2848681T3 (da) | Isolering, identifikation og karakterisering af stammer med probiotisk aktivitet fra fæces fra børn, der udelukkende er fodret med modermælk | |
Torres-Maravilla et al. | Identification of novel anti-inflammatory probiotic strains isolated from pulque | |
RU2567009C2 (ru) | ШТАММ Lactococcus lactis ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАССТРОЙСТВА ПИЩЕВАРЕНИЯ И ЕГО ПРИМЕНЕНИЕ | |
CA2893822C (en) | Strain of bifidobacterium animalis ssp. animalis | |
Ale et al. | Lactobacillus fermentum: Could EPS production ability be responsible for functional properties? | |
EP3018199B1 (en) | Composition containing bacterium belonging to genus lactobacillus | |
CA3223260A1 (en) | Probiotic composition for the treatment of increased intestinal permeability | |
EP2785878B1 (en) | Reuterin-producing lactobacillus brevis | |
EP2742125B1 (en) | New strain of l. bulgaricus capable of inhibiting the adhesion of h. pylori strains to epithelial cells | |
US20220395011A1 (en) | Synergistic blends of probiotics expressing improved beneficial activity for human host favourably interacting with food, particularly baby food | |
WO2013027087A1 (en) | A non-reuterin-producing lactobacillus reuteri strain for treating helicobacter pylori infection | |
WO2007023912A1 (ja) | 病原菌の細胞への付着阻害能を有するビフィズス菌、その処理物及びそれを含有する食品・医薬品組成物 | |
RU2708146C2 (ru) | Средство для улучшения состояния пищеварения | |
Mathipa | Pre-adaptation of selected probiotic strains to multiple stress factors: consequent effect on their stability and probiotic properties |