DK2814945T3 - Celle med reduceret ppgppase-aktivitet - Google Patents

Celle med reduceret ppgppase-aktivitet

Info

Publication number
DK2814945T3
DK2814945T3 DK13701624.2T DK13701624T DK2814945T3 DK 2814945 T3 DK2814945 T3 DK 2814945T3 DK 13701624 T DK13701624 T DK 13701624T DK 2814945 T3 DK2814945 T3 DK 2814945T3
Authority
DK
Denmark
Prior art keywords
cell
reduced
activity
ppgppase activity
reduced ppgppase
Prior art date
Application number
DK13701624.2T
Other languages
English (en)
Inventor
Frank Schneider
Caroline Gerth
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Application granted granted Critical
Publication of DK2814945T3 publication Critical patent/DK2814945T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/07—Diphosphoric monoester hydrolases (3.1.7)
    • C12Y301/07002—Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase (3.1.7.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Sustainable Development (AREA)
  • Animal Husbandry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Enzymes And Modification Thereof (AREA)
DK13701624.2T 2012-02-17 2013-01-28 Celle med reduceret ppgppase-aktivitet DK2814945T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12156052.8A EP2628792A1 (de) 2012-02-17 2012-02-17 Zelle mit verringerter ppGppase-Aktivität
PCT/EP2013/051529 WO2013120685A1 (en) 2012-02-17 2013-01-28 A cell with reduced ppgppase activity

Publications (1)

Publication Number Publication Date
DK2814945T3 true DK2814945T3 (da) 2017-11-13

Family

ID=47624064

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13701624.2T DK2814945T3 (da) 2012-02-17 2013-01-28 Celle med reduceret ppgppase-aktivitet

Country Status (10)

Country Link
US (2) US20150072382A1 (da)
EP (2) EP2628792A1 (da)
JP (1) JP2015508647A (da)
CN (1) CN104583388A (da)
DK (1) DK2814945T3 (da)
ES (1) ES2645997T3 (da)
MY (1) MY171544A (da)
PL (1) PL2814945T3 (da)
RU (1) RU2014137392A (da)
WO (1) WO2013120685A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015103497A1 (en) * 2014-01-02 2015-07-09 Trelys, Inc. Compositions and methods for biological production of amino acids in hydrogenotrophic microorganisms
JP2018516552A (ja) 2015-05-06 2018-06-28 トレリス， インコーポレイテッド メチオニンの生物学的産生のための組成物及び方法
US10858676B2 (en) * 2017-05-22 2020-12-08 Ajinomoto Co., Inc. Method for producing objective substance
CN109055289B (zh) * 2018-07-27 2020-10-27 浙江工业大学 一种高产l-甲硫氨酸的重组大肠杆菌及其应用
JP7491312B2 (ja) 2018-12-27 2024-05-28 味の素株式会社 腸内細菌科の細菌の発酵による塩基性ｌ－アミノ酸またはその塩の製造方法
KR102134418B1 (ko) * 2019-06-17 2020-07-16 씨제이제일제당 주식회사 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
JP7471395B2 (ja) * 2019-08-28 2024-04-19 黒竜江伊品生物科技有限公司 大腸菌に基づく組換え株ならびにその構築方法および使用
CN112266892B (zh) * 2020-10-21 2021-10-08 中国科学院天津工业生物技术研究所 AroG的突变体及其在产氨基酸基因工程菌中的应用
CN113088503B (zh) * 2021-04-27 2023-01-10 浙江工业大学 一种o-琥珀酰巯基转移酶突变体及其在l-甲硫氨酸合成中的应用
KR102688095B1 (ko) * 2021-04-28 2024-07-24 씨제이제일제당 주식회사 변이형 SpoT 단백질 및 이를 이용한 L-아미노산을 생산하는 방법
CN113337486B (zh) * 2021-05-31 2022-12-20 廊坊梅花生物技术开发有限公司 重组微生物及其制备方法和应用
CN114369562B (zh) * 2022-03-21 2022-05-31 中国农业科学院北京畜牧兽医研究所 一种提高5-氨基乙酰丙酸表达量的方法
KR102725668B1 (ko) * 2022-10-24 2024-11-05 대상 주식회사 피루베이트 인산화효소 2 신규 변이체 및 이를 이용한 l-방향족 아미노산의 생산 방법
WO2024090883A1 (ko) * 2022-10-24 2024-05-02 대상 주식회사 피루베이트 인산화효소 2 신규 변이체 및 이를 이용한 l-방향족 아미노산의 생산 방법
CN118360353B (zh) * 2024-05-09 2025-04-08 安徽农业大学 一种通过疮痂病链霉菌relA基因提高thaxtomin A产量的方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54105293A (en) 1978-02-01 1979-08-18 Ajinomoto Co Inc Preparation of l-proline by fermentation
US4371614A (en) 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
JPS5780398A (en) 1980-11-05 1982-05-19 Sanraku Inc Plasmid produced by genetic manipulation, coliform bacillus having the same and preparation of tryptophan with said bacillus
DE3584848D1 (de) 1984-04-04 1992-01-23 Ajinomoto Kk Zusammengesetztes transduzierbares plasmid.
WO1987001130A1 (en) 1985-08-15 1987-02-26 Stauffer Chemical Company Tryptophan producing microorganism
FR2665711B1 (fr) 1990-08-08 1993-08-13 Centre Nat Rech Scient Integron de corynebacterie, procede de transformation d'une corynebacterie par ledit integron et corynebacterie obtenue.
JP3023615B2 (ja) 1990-08-30 2000-03-21 協和醗酵工業株式会社 発酵法によるｌ―トリプトファンの製造法
DE69124939T2 (de) 1990-11-30 1997-10-02 Ajinomoto Kk Rekombinante DNS-Sequenzen kodierend für Enzyme frei von Feedback Inhibition, Plasmide diese Sequenzen enthaltend, transformierte Mikroorganismen nützlich für Produktion von aromatischen Aminosäuren, und deren Verfahren zur Herstellung durch Fermentation
DE4130867A1 (de) 1991-09-17 1993-03-18 Degussa Verfahren zur fermentativen herstellung von aminosaeuren
DE4232468A1 (de) 1992-09-28 1994-03-31 Consortium Elektrochem Ind Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung
DE69219775T3 (de) 1992-10-14 2004-08-05 Ajinomoto Co., Inc. Neuartiges L-threoninproduzierendes Mikrobakterium und eine Herstellungsmethode für L-Threonin
JP3369231B2 (ja) 1992-12-03 2003-01-20 協和醗酵工業株式会社 芳香族アミノ酸の製造法
FR2736066B1 (fr) 1995-06-30 1998-11-20 Ajinomoto Kk Procede d'amplification d'un gene par transposon artificiel, bacterie coryneforme obtenue par ce procede et procede de production d'un acide amine a l'aide de cette bacterie
JP4032441B2 (ja) 1995-08-30 2008-01-16 味の素株式会社 Ｌ−アミノ酸の製造方法
GB2304718B (en) 1995-09-05 2000-01-19 Degussa The production of tryptophan by the bacterium escherichia coli
DE19547361A1 (de) 1995-12-19 1997-06-26 Degussa Verfahren zur Herstellung von L-Aminosäuren durch Fermentation
US5939295A (en) 1996-03-29 1999-08-17 Archer Daniels Midland Company Production of tryptophan by microorganisms
US5939307A (en) 1996-07-30 1999-08-17 The Archer-Daniels-Midland Company Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
DE19949579C1 (de) 1999-10-14 2000-11-16 Consortium Elektrochem Ind Verfahren zur fermentativen Herstellung von L-Cystein oder L-Cystein-Derivaten
CN100554426C (zh) 2001-08-06 2009-10-28 德古萨股份公司 用遗传修饰的谷氨酸棒杆菌生产l-赖氨酸
CN100336901C (zh) 2001-08-06 2007-09-12 德古萨股份公司 生产化合物ⅱ的棒状细菌
DE10305774A1 (de) 2003-02-06 2004-08-26 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von L-Methionin
JP2005021154A (ja) * 2003-06-11 2005-01-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
KR100651220B1 (ko) 2004-06-29 2006-11-29 씨제이 주식회사 Ｌ-메씨오닌 생산 균주 및 상기 균주를 이용한ｌ-메씨오닌의 생산방법
PL1969130T3 (pl) 2006-01-04 2014-08-29 Evonik Degussa Gmbh Sposób wytwarzania metioniny i jej prekursorów lub sukcynylo homoseryny przy zastosowaniu mikroorganizmów
ES2575082T3 (es) 2007-04-11 2016-06-24 Cj Cheiljedang Corporation Composiciones y métodos de producción de metionina
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
US20110111458A1 (en) * 2008-03-18 2011-05-12 Kyowa Hakko Kirin Co., Ltd. Industrially useful microorganism
DE102008040352A1 (de) 2008-07-11 2010-01-14 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
DE102008063900A1 (de) * 2008-12-19 2010-06-24 Wacker Chemie Ag Verfahren zur fermentativen Herstellung von heterologen Proteinen mittels Escherichia coli

Also Published As

Publication number Publication date
EP2814945B9 (en) 2017-11-22
EP2814945B1 (en) 2017-08-02
US20170067066A1 (en) 2017-03-09
US20150072382A1 (en) 2015-03-12
ES2645997T3 (es) 2017-12-11
WO2013120685A1 (en) 2013-08-22
JP2015508647A (ja) 2015-03-23
RU2014137392A (ru) 2016-04-10
EP2814945A1 (en) 2014-12-24
EP2628792A1 (de) 2013-08-21
CN104583388A (zh) 2015-04-29
MY171544A (en) 2019-10-17
PL2814945T3 (pl) 2018-01-31

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