DK2806855T3 - Tørpulverformulering omfattende et kortikosteroid corticosteroid and a beta-adrenerg til indgivelse via inhalation - Google Patents
Tørpulverformulering omfattende et kortikosteroid corticosteroid and a beta-adrenerg til indgivelse via inhalation Download PDFInfo
- Publication number
- DK2806855T3 DK2806855T3 DK13704372.5T DK13704372T DK2806855T3 DK 2806855 T3 DK2806855 T3 DK 2806855T3 DK 13704372 T DK13704372 T DK 13704372T DK 2806855 T3 DK2806855 T3 DK 2806855T3
- Authority
- DK
- Denmark
- Prior art keywords
- particles
- microns
- fraction
- bdp
- diameter
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (12)
1. Tørpulverformulering til anvendelse i en tørpulverinhalator (DPI), omfattende: a) en fraktion af fine partikler fremstillet af en blanding af 90 til 99,5 vægtprocent partikler af alpha-lactose-monohydrat og 0,5 til 10 vægtprocent magnesi-umstearat, hvilken blanding har en massemediandiameter på mindre end 20 mi kron; b) en fraktion af grove partikler bestående af alpha-lactose-monohydrat med en massemediandiameter, der er lig med eller større end 175 mikron, hvor forholdet mellem de fine partikler og de grove partikler er mellem 2:98 og 20:80 vægtprocent; og c1) formoterolfumaratdihydrat i form af mikroniserede partikler; c2) beclomethasondipropionat (BDP) i form af mikroniserede partikler; hvor i) ikke mere end 10 % af BDP-partiklerne (d(v,0,1)) har en volumendiameter på mindre end 0,6 mikron; ii) ikke mere end 50 % af partiklerne (d(v,0,5)) har en volumendiameter på mellem 1,5 mikron og 2,0 mikron; og iii) mindst 90 % af partiklerne (d(v,0,9)) har en volumendiameter på mindre end 4,7 mikron, og hvor BDP-partiklerne endvidere er kendetegnet ved et partikelstørrelsesspænd, defineret som [d(v,0,9) - d(v,0,1)]/d(v,0,5), på mellem 1,2 og 2,2 og ved et specifikt overfladeareal på mellem 5,5 og 7,0 m2/g.
2. Formulering ifølge krav 1, hvor i) d(v,0,1) ligger mellem 0,8 og 1,0 mikron; ii) d(v,0,5) ligger mellem 1,6 og 1,9 mikron; iii) d(v,0,9) ligger mellem 3,0 og 4,0 mikron, og partikelstørrelsesspændet ligger mellem 1,3 og 2,1.
3. Formulering ifølge krav 1 eller 2, hvor det specifikke overfladeareal ligger mellem 5,9 og 6,8 m2/g.
4. Formulering ifølge et hvilket som helst af kravene 1 til 3, hvor ikke mere end 10 % af de mikroniserede formoterolfumaratdihydrat-partikler har en volumendiameter på mindre end 0,8 mikron; ii) ikke mere end 50 % af partiklerne har en volumendiameter på mindre end 1,7 mikron; og iii) mindst 90 % af partiklerne har en volumendiameter på mindre end 5,0 mikron.
5. Formulering ifølge et hvilket som helst af kravene 1 til 4, hvor forholdet mellem de fine partikler i fraktion a) og de grove partikler i fraktion b) er 10:90 vægtprocent.
6. Formulering ifølge et hvilket som helst af de foregående krav, hvor fraktionen affine partikler a) har en massemediandiameter, der er lig med eller lavere end 10 mikron.
7. Formulering ifølge et hvilket som helst af de foregående krav, hvor massediameteren af de grove partikler i fraktion b) ligger mellem 212 og 355 mikron.
8. Formulering ifølge krav 1, bestående af: a) en fraktion affine partikler fremstillet af en blanding af 98 vægtprocent fine partikler af alpha-lactose-monohydrat og 2 vægtprocent magnesiumstearat, hvilken blanding har en massemediandiameter, der er lig med eller mindre end 6 mi kron; b) en fraktion af grove partikler fremstillet af alpha-lactose-monohydrat med en massediameter på mellem 212 og 355 mikron, og hvor forholdet mellem de fine partikler og de grove partikler er 10:90 vægtprocent; c1) formoterolfumaratdihydrat i form af mikroniserede partikler; c2) beclomethasondipropionat (BDP) i form af mikroniserede partikler; hvor i) ikke mere end 10 % af BDP-partiklerne (d(v,0,1)) har en volumendiameter på mindre end 0,7 mikron; ii) ikke mere end 50 % af partiklerne (d(v,0,5)) har en volumendiameter på mellem 1,6 mikron og 1,9 mikron; og iii) mindst 90 % af partiklerne (d(v,0,9)) har en volumendiameter på mindre end 4,0 mikron.
9. Formulering ifølge krav 8, hvor det specifikke overfladeareal af de mikroniserede partikler af BDP ligger mellem 5,9 og 6,8 m2/g.
10. Tørpulverinhalator, der er fyldt med tørpulverformuleringen ifølge et hvilket som helst af kravene 1 til 9.
11. Pulverformulering ifølge et hvilket som helst af kravene 1 til 9 til anvendelse ved forebyggelse og/eller behandling af en inflammatorisk eller obstruktiv luftvejssygdom.
12. Pulverformulering til anvendelse ifølge krav 11, hvor sygdommen er astma eller kronisk obstruktiv lungesygdom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12152392 | 2012-01-25 | ||
PCT/EP2013/051187 WO2013110632A1 (en) | 2012-01-25 | 2013-01-23 | Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2806855T3 true DK2806855T3 (da) | 2018-09-03 |
Family
ID=47715987
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19167775.6T DK3527196T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation |
DK13704372.5T DK2806855T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende et kortikosteroid corticosteroid and a beta-adrenerg til indgivelse via inhalation |
DK18181331.2T DK3412277T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende en corticosteroid og en beta-adrenergikum til indgivelse gennem inhalering |
DK19167829.1T DK3527197T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation |
DK19167839.0T DK3527199T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19167775.6T DK3527196T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18181331.2T DK3412277T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende en corticosteroid og en beta-adrenergikum til indgivelse gennem inhalering |
DK19167829.1T DK3527197T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation |
DK19167839.0T DK3527199T3 (da) | 2012-01-25 | 2013-01-23 | Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation |
Country Status (38)
Country | Link |
---|---|
US (3) | US10028964B2 (da) |
EP (7) | EP3527196B1 (da) |
JP (1) | JP6104282B2 (da) |
KR (3) | KR101560288B1 (da) |
CN (2) | CN105726548B (da) |
AR (1) | AR089805A1 (da) |
AU (1) | AU2013211656B2 (da) |
BR (1) | BR112014017481A8 (da) |
CA (1) | CA2862548C (da) |
CL (1) | CL2014001966A1 (da) |
CO (1) | CO7010836A2 (da) |
CY (1) | CY1120684T1 (da) |
DK (5) | DK3527196T3 (da) |
EA (2) | EA026267B1 (da) |
ES (5) | ES2929807T3 (da) |
FI (1) | FI3412277T3 (da) |
GE (1) | GEP201706767B (da) |
HK (1) | HK1200021A1 (da) |
HR (5) | HRP20221431T1 (da) |
HU (5) | HUE061566T2 (da) |
IL (1) | IL233784A0 (da) |
LT (5) | LT3527199T (da) |
MA (1) | MA35859B1 (da) |
MX (2) | MX355729B (da) |
MY (1) | MY165888A (da) |
NZ (1) | NZ627837A (da) |
PE (1) | PE20141703A1 (da) |
PH (1) | PH12014501565B1 (da) |
PL (5) | PL2806855T3 (da) |
PT (5) | PT3527199T (da) |
RS (5) | RS57637B1 (da) |
SG (1) | SG11201404350PA (da) |
SI (2) | SI3412277T1 (da) |
TN (1) | TN2014000322A1 (da) |
TW (1) | TWI559940B (da) |
UA (1) | UA115543C2 (da) |
WO (1) | WO2013110632A1 (da) |
ZA (1) | ZA201405464B (da) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY165888A (en) * | 2012-01-25 | 2018-05-18 | Chiesi Farm Spa | Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation |
WO2015004243A1 (en) | 2013-07-11 | 2015-01-15 | Chiesi Farmaceutici S.P.A. | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
UA118861C2 (uk) * | 2013-12-06 | 2019-03-25 | Оріон Корпорейшн | Спосіб отримання сухих порошкових композицій для інгаляцій |
KR102462058B1 (ko) | 2014-10-08 | 2022-11-01 | 잠본쏘시에떼퍼아찌오니 | 제제의 안정성을 증가시키기 위해 분무 건조에 의해 수득된 1종 이상의 건조 분말을 포함하는 조성물 |
CN109789107B (zh) * | 2016-09-29 | 2021-12-03 | 广东东阳光药业有限公司 | 药物组合物 |
BR112019023378A2 (pt) * | 2017-05-11 | 2020-06-16 | Chiesi Farmaceutici S.P.A. | Processo para preparar uma formulação em pó para inalação para uso em um inalador de pó seco |
EP3687500A1 (en) * | 2017-09-29 | 2020-08-05 | Crititech, Inc. | Glucocorticoid particles and their use |
PT3833964T (pt) * | 2018-08-07 | 2023-08-17 | Norton Waterford Ltd | Aplicação de espetroscopia de raman para o fabrico de pós de inalação |
KR20210086614A (ko) | 2018-10-30 | 2021-07-08 | 치에시 파마슈티시 에스.피.아. | 기계 호흡중인 환자에게 약물을 투여하는 장치 |
CA3150240A1 (en) | 2019-09-24 | 2021-04-01 | Tomaso GUIDI | Dry powder formulation for a dry powder inhaler, with a combination of spheronised particles and coarse particles, and a dry powder inhaler comprising the formulation |
CN116615201A (zh) | 2020-08-14 | 2023-08-18 | 诺顿(沃特福特)有限公司 | 丙酸氟替卡松和硫酸沙丁胺醇的可吸入制剂 |
CN118414147A (zh) * | 2021-12-21 | 2024-07-30 | 凯西制药公司 | 填充在具有改善的耐湿性的吸入器中的干粉制剂 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
EP1283036B2 (de) * | 1998-11-13 | 2020-01-01 | Jagotec AG | Multidosis-Trockenpulverinhalator mit Pulverreservoir |
IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
GB0015043D0 (en) | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
FI20002215A0 (fi) * | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit |
PT1658872E (pt) | 2002-07-31 | 2011-05-12 | Chiesi Farma Spa | Inalador de p? |
JO3102B1 (ar) * | 2004-03-17 | 2017-09-20 | Chiesi Framaceutici S P A | صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
EP1944018A1 (en) * | 2007-01-10 | 2008-07-16 | CHIESI FARMACEUTICI S.p.A. | Micronised particles of low-dosage strength active agents for powder formulations for inhalation |
EP1982709A1 (en) | 2007-04-19 | 2008-10-22 | CHIESI FARMACEUTICI S.p.A. | Use of a composition comprising formoterol and beclomethasone dipropionate for the prevention or treatment of an acute condition of asthma |
WO2010097188A1 (en) * | 2009-02-25 | 2010-09-02 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a salt of carmoterol and a corticosteroid |
US9101539B2 (en) * | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
GB0914240D0 (en) * | 2009-08-14 | 2009-09-30 | Breath Ltd | Steroid solvates |
PL2482799T3 (pl) * | 2009-10-02 | 2014-11-28 | Chiesi Farm Spa | Farmaceutyczne formulacje aerozolowe formoterolu i dipropionianu beklometazonu |
BR112012024059B1 (pt) * | 2010-04-01 | 2021-06-01 | Chiesi Farmaceutici S.P.A. | Processo de preparo de um excipiente para composições farmacêuticas em pó para inalação, partículas carreadoras para uma formulação farmacêutica de pó seco, composição farmacêutica em forma de pó seco para inalação e inalador de pó seco |
KR101863523B1 (ko) | 2010-04-21 | 2018-05-31 | 키에시 파르마슈티시 엣스. 피. 에이. | 정전하가 감소된 입자를 제공하는 방법 |
MY165888A (en) * | 2012-01-25 | 2018-05-18 | Chiesi Farm Spa | Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation |
WO2015004243A1 (en) * | 2013-07-11 | 2015-01-15 | Chiesi Farmaceutici S.P.A. | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration by inhalation |
-
2013
- 2013-01-23 MY MYPI2014002176A patent/MY165888A/en unknown
- 2013-01-23 EP EP19167775.6A patent/EP3527196B1/en active Active
- 2013-01-23 UA UAA201408448A patent/UA115543C2/uk unknown
- 2013-01-23 DK DK19167775.6T patent/DK3527196T3/da active
- 2013-01-23 HU HUE18181331A patent/HUE061566T2/hu unknown
- 2013-01-23 ES ES19167839T patent/ES2929807T3/es active Active
- 2013-01-23 ES ES18181331T patent/ES2938466T3/es active Active
- 2013-01-23 PL PL13704372T patent/PL2806855T3/pl unknown
- 2013-01-23 RS RS20181038A patent/RS57637B1/sr unknown
- 2013-01-23 ES ES19167775T patent/ES2928688T3/es active Active
- 2013-01-23 EA EA201491281A patent/EA026267B1/ru unknown
- 2013-01-23 SI SI201332032T patent/SI3412277T1/sl unknown
- 2013-01-23 EP EP13704372.5A patent/EP2806855B1/en active Active
- 2013-01-23 EP EP15202117.6A patent/EP3020394A1/en not_active Withdrawn
- 2013-01-23 HU HUE13704372A patent/HUE040525T2/hu unknown
- 2013-01-23 PL PL19167839.0T patent/PL3527199T3/pl unknown
- 2013-01-23 FI FIEP18181331.2T patent/FI3412277T3/fi active
- 2013-01-23 PT PT191678390T patent/PT3527199T/pt unknown
- 2013-01-23 HU HUE19167775A patent/HUE060402T2/hu unknown
- 2013-01-23 JP JP2014553692A patent/JP6104282B2/ja active Active
- 2013-01-23 DK DK13704372.5T patent/DK2806855T3/da active
- 2013-01-23 HR HRP20221431TT patent/HRP20221431T1/hr unknown
- 2013-01-23 HU HUE19167839A patent/HUE060705T2/hu unknown
- 2013-01-23 LT LTEP19167839.0T patent/LT3527199T/lt unknown
- 2013-01-23 CN CN201610080909.1A patent/CN105726548B/zh active Active
- 2013-01-23 EP EP18181331.2A patent/EP3412277B1/en active Active
- 2013-01-23 HR HRP20230147TT patent/HRP20230147T1/hr unknown
- 2013-01-23 PL PL18181331.2T patent/PL3412277T3/pl unknown
- 2013-01-23 PL PL19167775.6T patent/PL3527196T3/pl unknown
- 2013-01-23 BR BR112014017481A patent/BR112014017481A8/pt not_active Application Discontinuation
- 2013-01-23 CA CA2862548A patent/CA2862548C/en active Active
- 2013-01-23 PL PL19167829.1T patent/PL3527197T3/pl unknown
- 2013-01-23 HU HUE19167829A patent/HUE060421T2/hu unknown
- 2013-01-23 ES ES13704372.5T patent/ES2683254T3/es active Active
- 2013-01-23 RS RS20221007A patent/RS63761B1/sr unknown
- 2013-01-23 KR KR1020147019763A patent/KR101560288B1/ko active IP Right Grant
- 2013-01-23 EP EP19167839.0A patent/EP3527199B1/en active Active
- 2013-01-23 HR HRP20221432TT patent/HRP20221432T1/hr unknown
- 2013-01-23 DK DK18181331.2T patent/DK3412277T3/da active
- 2013-01-23 LT LTEP13704372.5T patent/LT2806855T/lt unknown
- 2013-01-23 US US14/417,484 patent/US10028964B2/en active Active
- 2013-01-23 NZ NZ627837A patent/NZ627837A/en unknown
- 2013-01-23 WO PCT/EP2013/051187 patent/WO2013110632A1/en active Application Filing
- 2013-01-23 HR HRP20221433TT patent/HRP20221433T1/hr unknown
- 2013-01-23 RS RS20230066A patent/RS63952B1/sr unknown
- 2013-01-23 ES ES19167829T patent/ES2929137T3/es active Active
- 2013-01-23 EP EP19167835.8A patent/EP3527198A1/en active Pending
- 2013-01-23 LT LTEP19167829.1T patent/LT3527197T/lt unknown
- 2013-01-23 DK DK19167829.1T patent/DK3527197T3/da active
- 2013-01-23 DK DK19167839.0T patent/DK3527199T3/da active
- 2013-01-23 PT PT137043725T patent/PT2806855T/pt unknown
- 2013-01-23 EP EP19167829.1A patent/EP3527197B1/en active Active
- 2013-01-23 AU AU2013211656A patent/AU2013211656B2/en active Active
- 2013-01-23 PT PT191677756T patent/PT3527196T/pt unknown
- 2013-01-23 GE GEAP201313532A patent/GEP201706767B/en unknown
- 2013-01-23 MX MX2014008631A patent/MX355729B/es active IP Right Grant
- 2013-01-23 RS RS20221033A patent/RS63759B1/sr unknown
- 2013-01-23 PT PT181813312T patent/PT3412277T/pt unknown
- 2013-01-23 PE PE2014001166A patent/PE20141703A1/es active IP Right Grant
- 2013-01-23 MX MX2016001311A patent/MX368199B/es unknown
- 2013-01-23 RS RS20220971A patent/RS63706B1/sr unknown
- 2013-01-23 KR KR1020157019169A patent/KR101786586B1/ko active IP Right Grant
- 2013-01-23 SG SG11201404350PA patent/SG11201404350PA/en unknown
- 2013-01-23 PT PT191678291T patent/PT3527197T/pt unknown
- 2013-01-23 CN CN201380006645.XA patent/CN104080444B/zh active Active
- 2013-01-23 LT LTEP18181331.2T patent/LT3412277T/lt unknown
- 2013-01-23 KR KR1020177027831A patent/KR101895279B1/ko active IP Right Grant
- 2013-01-23 LT LTEP19167775.6T patent/LT3527196T/lt unknown
- 2013-01-23 EA EA201690187A patent/EA031566B1/ru unknown
- 2013-01-23 SI SI201331186T patent/SI2806855T1/sl unknown
- 2013-01-24 US US13/748,882 patent/US8778402B2/en active Active
- 2013-01-24 TW TW102102606A patent/TWI559940B/zh active
- 2013-01-24 AR ARP130100225A patent/AR089805A1/es not_active Application Discontinuation
-
2014
- 2014-07-07 PH PH12014501565A patent/PH12014501565B1/en unknown
- 2014-07-11 MA MA37200A patent/MA35859B1/fr unknown
- 2014-07-24 IL IL233784A patent/IL233784A0/en active IP Right Grant
- 2014-07-24 CL CL2014001966A patent/CL2014001966A1/es unknown
- 2014-07-24 TN TNP2014000322A patent/TN2014000322A1/fr unknown
- 2014-07-24 CO CO14161092A patent/CO7010836A2/es unknown
- 2014-07-24 ZA ZA2014/05464A patent/ZA201405464B/en unknown
-
2015
- 2015-01-15 HK HK15100459.7A patent/HK1200021A1/xx unknown
-
2018
- 2018-06-22 US US16/015,666 patent/US10946029B2/en active Active
- 2018-09-11 CY CY181100948T patent/CY1120684T1/el unknown
- 2018-09-28 HR HRP20181550TT patent/HRP20181550T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10946029B2 (en) | Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation | |
DK3019153T3 (da) | Tørpulverformulering omfattende et antikolinergikum, et corticosteroid og et beta-adrenergikum til indgivelse ved inhalation | |
AU2016356858B2 (en) | A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic |