PL3527199T3 - Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację - Google Patents

Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację

Info

Publication number
PL3527199T3
PL3527199T3 PL19167839.0T PL19167839T PL3527199T3 PL 3527199 T3 PL3527199 T3 PL 3527199T3 PL 19167839 T PL19167839 T PL 19167839T PL 3527199 T3 PL3527199 T3 PL 3527199T3
Authority
PL
Poland
Prior art keywords
corticosteroid
adrenergic
inhalation
beta
administration
Prior art date
Application number
PL19167839.0T
Other languages
English (en)
Inventor
Elisa MONARI
Anna Maria Cantarelli
Daniela Cocconi
Irene PASQUALI
Original Assignee
Chiesi Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47715987&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3527199(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farmaceutici S.P.A. filed Critical Chiesi Farmaceutici S.P.A.
Publication of PL3527199T3 publication Critical patent/PL3527199T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0003Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL19167839.0T 2012-01-25 2013-01-23 Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację PL3527199T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12152392 2012-01-25

Publications (1)

Publication Number Publication Date
PL3527199T3 true PL3527199T3 (pl) 2022-12-12

Family

ID=47715987

Family Applications (6)

Application Number Title Priority Date Filing Date
PL19167775.6T PL3527196T3 (pl) 2012-01-25 2013-01-23 Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację
PL19167839.0T PL3527199T3 (pl) 2012-01-25 2013-01-23 Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację
PL13704372T PL2806855T3 (pl) 2012-01-25 2013-01-23 Preparaty proszkowe, zawierające kortykosteroid i środek beta-adrenergiczny do podawania wziewnego
PL19167835.8T PL3527198T3 (pl) 2012-01-25 2013-01-23 Preparaty proszkowe zawierające kortykosteroid i środek beta-adrenergiczny do podawania wziewnego
PL18181331.2T PL3412277T3 (pl) 2012-01-25 2013-01-23 Preparaty proszkowe zawierające kortykosteroid i środek beta-adrenergiczny do podawania wziewnego
PL19167829.1T PL3527197T3 (pl) 2012-01-25 2013-01-23 Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL19167775.6T PL3527196T3 (pl) 2012-01-25 2013-01-23 Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację

Family Applications After (4)

Application Number Title Priority Date Filing Date
PL13704372T PL2806855T3 (pl) 2012-01-25 2013-01-23 Preparaty proszkowe, zawierające kortykosteroid i środek beta-adrenergiczny do podawania wziewnego
PL19167835.8T PL3527198T3 (pl) 2012-01-25 2013-01-23 Preparaty proszkowe zawierające kortykosteroid i środek beta-adrenergiczny do podawania wziewnego
PL18181331.2T PL3412277T3 (pl) 2012-01-25 2013-01-23 Preparaty proszkowe zawierające kortykosteroid i środek beta-adrenergiczny do podawania wziewnego
PL19167829.1T PL3527197T3 (pl) 2012-01-25 2013-01-23 Preparat suchego proszku zawierający kortykosteroid i środek beta-adrenergiczny do podawania przez inhalację

Country Status (37)

Country Link
US (3) US10028964B2 (pl)
EP (7) EP3527196B1 (pl)
JP (1) JP6104282B2 (pl)
KR (3) KR101895279B1 (pl)
CN (2) CN104080444B (pl)
AR (1) AR089805A1 (pl)
AU (1) AU2013211656B2 (pl)
BR (1) BR112014017481A8 (pl)
CA (1) CA2862548C (pl)
CL (1) CL2014001966A1 (pl)
CO (1) CO7010836A2 (pl)
CY (1) CY1120684T1 (pl)
DK (6) DK3527199T3 (pl)
EA (2) EA026267B1 (pl)
ES (6) ES2929807T3 (pl)
FI (2) FI3527198T3 (pl)
GE (1) GEP201706767B (pl)
HR (6) HRP20230147T1 (pl)
HU (6) HUE040525T2 (pl)
IL (1) IL233784A0 (pl)
LT (5) LT3412277T (pl)
MA (1) MA35859B1 (pl)
MX (2) MX368199B (pl)
MY (1) MY165888A (pl)
NZ (1) NZ627837A (pl)
PE (1) PE20141703A1 (pl)
PH (1) PH12014501565B1 (pl)
PL (6) PL3527196T3 (pl)
PT (6) PT3527196T (pl)
RS (5) RS63761B1 (pl)
SG (1) SG11201404350PA (pl)
SI (3) SI2806855T1 (pl)
TN (1) TN2014000322A1 (pl)
TW (1) TWI559940B (pl)
UA (1) UA115543C2 (pl)
WO (1) WO2013110632A1 (pl)
ZA (1) ZA201405464B (pl)

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* Cited by examiner, † Cited by third party
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DK3527199T3 (da) * 2012-01-25 2022-10-24 Chiesi Farm Spa Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation
KR102275904B1 (ko) 2013-07-11 2021-07-13 키에시 파르마슈티시 엣스. 피. 에이. 흡입에 의한 투여를 위한 항콜린제, 코르티코스테로이드 및 베타-아드레날린성 약물을 포함하는 건조 분말 제제
UA118861C2 (uk) * 2013-12-06 2019-03-25 Оріон Корпорейшн Спосіб отримання сухих порошкових композицій для інгаляцій
JP6919093B2 (ja) 2014-10-08 2021-08-18 ザンボン ソシエタ ペル アチオニ 配合物の安定性を高めるために噴霧乾燥によって得られる少なくとも1種の乾燥粉末を含む組成物
CN109789107B (zh) * 2016-09-29 2021-12-03 广东东阳光药业有限公司 药物组合物
EP3621590B1 (en) * 2017-05-11 2021-09-01 Chiesi Farmaceutici S.p.A. A process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
EP3687500A1 (en) 2017-09-29 2020-08-05 Crititech, Inc. Glucocorticoid particles and their use
EP3833964B1 (en) 2018-08-07 2023-07-26 Norton (Waterford) Limited Application of raman spectroscopy for the manufacture of inhalation powders
JP7368065B2 (ja) 2018-10-30 2023-10-24 キエージィ ファーマチェウティチ エス.ペー.アー. 人工呼吸器を装着している患者に薬物を投与するための装置
KR102898819B1 (ko) 2019-09-24 2025-12-12 키에시 파르마슈티시 엣스. 피. 에이. 흡입용 건조 분말 제제를 위한 신규 담체 입자
US20240033222A1 (en) 2020-08-14 2024-02-01 Norton (Waterford) Limited An inhalable formulation of fluticasone propionate and albuterol sulfate
US20250050042A1 (en) * 2021-12-21 2025-02-13 Chiesi Farmaceutici S.P.A. Dry powder formulations filled in an inhaler with improved resistance to humidity

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CA2347856C (en) * 1998-11-13 2009-02-17 Jagotec Ag Dry powder for inhalation
IT1309592B1 (it) * 1999-03-05 2002-01-24 Chiesi Farma Spa Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
FI20002215A0 (fi) * 2000-10-06 2000-10-06 Orion Yhtymae Oyj Yhdistelmäpartikkelit
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JO3102B1 (ar) * 2004-03-17 2017-09-20 Chiesi Framaceutici S P A صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
EP1944018A1 (en) * 2007-01-10 2008-07-16 CHIESI FARMACEUTICI S.p.A. Micronised particles of low-dosage strength active agents for powder formulations for inhalation
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WO2010097188A1 (en) * 2009-02-25 2010-09-02 Chiesi Farmaceutici S.P.A. Inhalation particles comprising a salt of carmoterol and a corticosteroid
JP2012526726A (ja) * 2009-05-15 2012-11-01 株式会社新日本科学 薬物動態が改善された鼻腔内用薬学的組成物
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BR112012024059B1 (pt) * 2010-04-01 2021-06-01 Chiesi Farmaceutici S.P.A. Processo de preparo de um excipiente para composições farmacêuticas em pó para inalação, partículas carreadoras para uma formulação farmacêutica de pó seco, composição farmacêutica em forma de pó seco para inalação e inalador de pó seco
DK2560611T3 (en) 2010-04-21 2018-02-26 Chiesi Farm Spa Process for providing particles with reduced electrostatic charges
DK3527199T3 (da) * 2012-01-25 2022-10-24 Chiesi Farm Spa Tørpulverformulering omfattende et kortikosteroid og et beta-adrenergikum til indgivelse via inhalation
KR102275904B1 (ko) * 2013-07-11 2021-07-13 키에시 파르마슈티시 엣스. 피. 에이. 흡입에 의한 투여를 위한 항콜린제, 코르티코스테로이드 및 베타-아드레날린성 약물을 포함하는 건조 분말 제제

Also Published As

Publication number Publication date
LT3527197T (lt) 2022-11-25
HUE061566T2 (hu) 2023-07-28
HUE040525T2 (hu) 2019-03-28
PT2806855T (pt) 2018-09-28
ES2996893T3 (en) 2025-02-13
EA026267B1 (ru) 2017-03-31
PE20141703A1 (es) 2014-11-24
DK2806855T3 (en) 2018-09-03
EP3527196A1 (en) 2019-08-21
GEP201706767B (en) 2017-11-10
PL2806855T3 (pl) 2018-12-31
KR101895279B1 (ko) 2018-09-05
KR101560288B1 (ko) 2015-10-14
US20150164915A1 (en) 2015-06-18
AU2013211656B2 (en) 2017-07-13
RS63706B1 (sr) 2022-11-30
TN2014000322A1 (en) 2015-12-21
MY165888A (en) 2018-05-18
PH12014501565A1 (en) 2014-10-08
SI3412277T1 (sl) 2023-03-31
FI3412277T3 (fi) 2023-03-23
HUE060705T2 (hu) 2023-04-28
ZA201405464B (en) 2015-12-23
HRP20181550T1 (hr) 2018-11-30
CO7010836A2 (es) 2014-07-31
EA031566B1 (ru) 2019-01-31
FI3527198T3 (fi) 2024-12-13
JP6104282B2 (ja) 2017-03-29
US8778402B2 (en) 2014-07-15
EP3020394A1 (en) 2016-05-18
RS63952B1 (sr) 2023-02-28
MX355729B (es) 2018-04-27
HUE060402T2 (hu) 2023-02-28
HRP20221433T1 (hr) 2023-01-06
SG11201404350PA (en) 2014-08-28
AR089805A1 (es) 2014-09-17
ES2683254T3 (es) 2018-09-25
ES2928688T3 (es) 2022-11-22
MX368199B (es) 2019-09-24
HRP20241638T1 (hr) 2025-02-14
RS63761B1 (sr) 2022-12-30
EP3412277B1 (en) 2022-12-14
JP2015508416A (ja) 2015-03-19
KR20150089093A (ko) 2015-08-04
DK3412277T3 (da) 2023-02-20
PL3527196T3 (pl) 2022-11-21
PH12014501565B1 (en) 2014-10-08
PT3412277T (pt) 2023-02-14
RS63759B1 (sr) 2022-12-30
US10028964B2 (en) 2018-07-24
EP3527199B1 (en) 2022-09-07
MA35859B1 (fr) 2014-12-01
KR20140114374A (ko) 2014-09-26
LT3527196T (lt) 2022-11-25
CL2014001966A1 (es) 2014-11-14
CN105726548A (zh) 2016-07-06
EP3527198B1 (en) 2024-10-09
EA201491281A1 (ru) 2014-12-30
MX2014008631A (es) 2014-08-21
DK3527199T3 (da) 2022-10-24
PL3412277T3 (pl) 2023-06-19
DK3527196T3 (da) 2022-10-24
BR112014017481A2 (pt) 2017-06-13
KR101786586B1 (ko) 2017-10-18
CY1120684T1 (el) 2019-12-11
EP3527197B1 (en) 2022-09-07
KR20170116234A (ko) 2017-10-18
EP3527198A1 (en) 2019-08-21
PL3527198T3 (pl) 2025-01-27
SI2806855T1 (sl) 2018-11-30
AU2013211656A1 (en) 2014-07-24
SI3527198T1 (sl) 2025-03-31
HUE060421T2 (hu) 2023-02-28
PL3527197T3 (pl) 2022-11-21
CA2862548C (en) 2020-07-07
PT3527196T (pt) 2022-10-18
ES2929137T3 (es) 2022-11-25
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US20130189324A1 (en) 2013-07-25
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HK1200021A1 (en) 2015-07-31
DK3527198T3 (da) 2024-10-28
WO2013110632A1 (en) 2013-08-01
EP3527196B1 (en) 2022-09-07
EP2806855A1 (en) 2014-12-03
BR112014017481A8 (pt) 2021-06-15
UA115543C2 (uk) 2017-11-27
EP2806855B1 (en) 2018-07-11
RS57637B1 (sr) 2018-11-30
ES2938466T3 (es) 2023-04-11
CA2862548A1 (en) 2013-08-01
TWI559940B (en) 2016-12-01
IL233784A0 (en) 2014-09-30
EP3527199A1 (en) 2019-08-21
LT2806855T (lt) 2018-10-10
HUE069624T2 (hu) 2025-03-28
PT3527198T (pt) 2024-12-04
HRP20221431T1 (hr) 2023-01-06
US10946029B2 (en) 2021-03-16
LT3527199T (lt) 2022-12-12
EA201690187A1 (ru) 2016-05-31
HRP20230147T1 (hr) 2023-03-31
PT3527197T (pt) 2022-10-26
LT3412277T (lt) 2023-04-25
US20180296573A1 (en) 2018-10-18
PT3527199T (pt) 2022-11-08
EP3412277A1 (en) 2018-12-12
DK3527197T3 (da) 2022-10-24
HRP20221432T1 (hr) 2023-01-06
CN104080444B (zh) 2017-06-20
CN105726548B (zh) 2019-05-14
EP3527197A1 (en) 2019-08-21
CN104080444A (zh) 2014-10-01

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