DK2769729T3 - Polypeptider og polynukleotider og anvendelser deraf som et lægemiddelmål til produktion af lægemidler og bioteknologiske produkter - Google Patents

Polypeptider og polynukleotider og anvendelser deraf som et lægemiddelmål til produktion af lægemidler og bioteknologiske produkter Download PDF

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DK2769729T3
DK2769729T3 DK14162019.5T DK14162019T DK2769729T3 DK 2769729 T3 DK2769729 T3 DK 2769729T3 DK 14162019 T DK14162019 T DK 14162019T DK 2769729 T3 DK2769729 T3 DK 2769729T3
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Prior art keywords
antibody
cancer
c10rf32
antibodies
seq
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DK14162019.5T
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English (en)
Inventor
Zurit Levine
Amir Toporik
Sergey Nemzer
Cynthia Koifman
Merav Beiman
Shira Walach
Tania Pergam
Dalit Milo
Anat Cohen-Dayag
Ofer Levy
Marina Bubis
Eve Montia
Yaron Kinar
Liat Dassa
Shirley Sameach-Greenwald
Avi Rosenberg
Galit Rotman
Amit Novik
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Compugen Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Claims (15)

1. Monokonalt eller polyklonalt antistof eller fragment deraf, der binder ektodomænet af C10RF32 eller dele eller varianter deraf og blokerer interaktionen mellem C10RF32 og dets modreceptor, hvor ektodomænet er valgt blandt polypeptiderne ifølge SEQ ID NO: 147, 148 og 299, og varianten deraf har mindst 80 % sekvensidentitet dermed, til anvendelse til terapi.
2. Monokonalt eller polyklonalt antistof eller fragment deraf, der binder ektodomænet af C10RF32 eller dele eller varianter deraf og blokerer interaktionen mellem C10RF32 og dets modreceptor, hvor ektodomænet er valgt blandt polypeptiderne ifølge SEQ ID NO: 147, 148 og 299, og varianten deraf har mindst 80 % sekvensidentitet dermed, til anvendelse til behandling af cancer.
3. Antistof eller fragment ifølge krav 2 til anvendelse til behandling af cancer, hvor canceren er valgt blandt lungecancer, ovariecancer, coloncancer, hæmatologiske maligniteter og bryst-, prostata-, milt-, nyre-, blære-, hoved- og hals-, uterus-, testikel-, ventrikel-, cervix-, lever-, knogle-, hud-, pankreas- eller hjernecancer.
4. Antistof eller antistoffragment ifølge krav 1 til anvendelse til terapi eller antistof eller antistoffragment ifølge krav 2 til anvendelse til behandling af cancer indeholdt i en farmaceutisk sammensætning.
5. Antistof eller antistoffragment ifølge krav 1 til anvendelse til terapi eller antistof eller antistoffragment ifølge krav 2 til anvendelse til behandling af cancer, hvor antistoffet eller antistoffragmentet er bundet til et enzym, et toksin, et terapeutisk middel eller et kemoterapeutisk middel.
6. Antistof eller antistoffragment ifølge krav 1 til anvendelse til terapi eller antistof eller antistoffragment ifølge krav 2 til anvendelse til behandling af cancer, hvor antistoffet eller antistoffragmentet er bundet til en radioisotop, en metalchelator, en fluorescerende forbindelse, en bioluminescerende forbindelse eller en kemiluminescerende forbindelse.
7. Antistof eller antistoffragment ifølge krav 1 til anvendelse til terapi eller antistof eller antistoffragment ifølge krav 2 til anvendelse til behandling af cancer, hvor antistoffet er et humant anti-C10RF32-antistof, og hvor antistoffet administreres sammen med mindst ét terapeutisk middel valgt fra gruppen, der består af et cytotoksisk middel, et radiotoksisk middel og et immunosuppressivt middel.
8. Antistof eller antistoffragment ifølge krav 1 til anvendelse til terapi eller antistof eller antistoffragment ifølge krav 2 til anvendelse til behandling af cancer, hvor antistoffet eller antistoffragmentet er konjugeret til en terapeutisk del valgt blandt et cytotoksin, et lægemiddel eller et radiotoksin, hvor cytotoksinet er valgt fra gruppen, der består af taxol, cytochalasin B, gramicidin D, ethidiumbromid, emetin, mitomycin, etoposid, tenoposid, vineristin, vinblastin, colchicin, doxorubicin, daunorubicin, dihydroxyanthracindion, mitoxantron, mithramycin, actinomycin D, 1-dehydrotestosteron, glueokortikoider, procain, tetracain, lidocain, propranolol, puromycin og analoger eller homologer dertil, antimetabolitter, alkylerende midler, anthracykliner, antibiotika, antimitotiske midler, duocarmyciner, calicheamiciner, maytansiner og auristatiner.
9. Antistof eller antistoffragment ifølge krav 8 til anvendelse til terapi eller til anvendelse til behandling af cancer, hvor antistoffet eller antistoffragmentet er konjugeret til et cytotoksin valgt fra gruppen, der består af methotrexat, 6-mercaptopurin, 6-thioguanin, cytarabin, 5-fluoruracildecarbazin, mechlorethamin, thioepachlorambucil, melphalan, carmustin (BSNU), lomustin (CCNU), cyclothosphamid, busulfan, dibrommannitol, streptozotocin, mitomycin C, cis-dichlordiaminplatin (II) (DDP, cisplatin), daunorubicin, doxorubicin, dactinomycin, bleomycin, mithramycin, anthramycin (AMC), vineristin og vinblastin.
10. Anvendelse af et polyklonalt eller monoklonalt antistof eller fragment deraf, der binder ektodomænet af C10RF32 eller dele eller varianter deraf, hvor ektodomænet er valgt blandt polypeptiderne ifølge SEQ ID NO: 147, 148 og 299, og varianterne deraf har mindst 80 % sekvensidentitet dermed, til diagnosticering af cancere, der har differentiel ekspression af C10RF32-antigenet, hvor modulering af B7-relateret immun-costimulering, der inddrager C10RF32-antigenet, er terapeutisk ønskelig.
11. Anvendelse ifølge krav 10, hvor cancerne er valgt blandt lungecancer, ovariecancer, coloncancer, hæmatologiske maligniteter og bryst-, prostata-, milt-, nyre-, blære-, hoved- og hals-, uterus-, testikel-, ventrikel-, cervix-, lever-, knogle-, hud-, pankreas- eller hjernecancer.
12. Antistof eller antistoffragment ifølge krav 3 til anvendelse til behandling af cancer eller anvendelse ifølge krav 11, hvor de hæmatologiske maligniteter er valgt fra gruppen, der består af akut lymfatisk leukæmi, kronisk lymfatisk leukæmi, akut myeloid leukæmi, kronisk myeloid leukæmi, multipelt myelom, Hodgkins lymfom og non-Hodgkins lymfom.
13. Antistof eller antistoffragment ifølge krav 3 til anvendelse til behandling af cancer eller anvendelse ifølge krav 11, hvor lungecanceren er valgt fra gruppen, der består af pianocellulært lungekarcinom, lungeadenokarcinom, karcinoid, småcellet lungecancer eller ikke-småcellet lungecancer.
14. Antistof eller antistoffragment ifølge krav 2 til anvendelse til behandling af cancer eller anvendelse ifølge krav 10, hvor canceren er ikke-metastatisk, invasiv eller metastatisk.
15. Antistof eller antistoffragment ifølge krav 1 til anvendelse til terapi eller antistof eller antistoffragment ifølge krav 2 til anvendelse til behandling af cancer eller anvendelse ifølge krav 10, hvor varianterne af ektodomænet har mindst 90 %, mindst 95, 96, 97, 98 eller 99 % sekvensidentitet med polypeptiderne ifølge SEQ ID NO: 147, 148 og 299.
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