DK2668182T3 - Hæmning af IL17 og IFN-gamma til behandling af autoimmun inflammation - Google Patents
Hæmning af IL17 og IFN-gamma til behandling af autoimmun inflammationInfo
- Publication number
- DK2668182T3 DK2668182T3 DK12703013.8T DK12703013T DK2668182T3 DK 2668182 T3 DK2668182 T3 DK 2668182T3 DK 12703013 T DK12703013 T DK 12703013T DK 2668182 T3 DK2668182 T3 DK 2668182T3
- Authority
- DK
- Denmark
- Prior art keywords
- ifn
- gamma
- inhibition
- treat autoimmune
- autoimmune inflammation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437061P | 2011-01-28 | 2011-01-28 | |
| EP11152515 | 2011-01-28 | ||
| PCT/EP2012/051357 WO2012101261A1 (en) | 2011-01-28 | 2012-01-27 | Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2668182T3 true DK2668182T3 (da) | 2018-01-29 |
Family
ID=46577835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12703013.8T DK2668182T3 (da) | 2011-01-28 | 2012-01-27 | Hæmning af IL17 og IFN-gamma til behandling af autoimmun inflammation |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8592456B2 (he) |
| EP (1) | EP2668182B1 (he) |
| JP (1) | JP5969505B2 (he) |
| KR (1) | KR101875248B1 (he) |
| CN (1) | CN103476771B (he) |
| AR (1) | AR085040A1 (he) |
| AU (1) | AU2012210489B2 (he) |
| BR (1) | BR112013019011B1 (he) |
| CA (1) | CA2825684C (he) |
| DK (1) | DK2668182T3 (he) |
| EA (1) | EA027351B1 (he) |
| ES (1) | ES2664507T3 (he) |
| IL (1) | IL227626A0 (he) |
| MX (1) | MX353762B (he) |
| MY (1) | MY162397A (he) |
| PL (1) | PL2668182T3 (he) |
| PT (1) | PT2668182T (he) |
| RU (1) | RU2013139663A (he) |
| SG (1) | SG192176A1 (he) |
| TW (1) | TWI520955B (he) |
| UA (1) | UA113160C2 (he) |
| UY (1) | UY33884A (he) |
| WO (1) | WO2012101261A1 (he) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX348726B (es) * | 2011-01-28 | 2017-06-26 | 4Sc Discovery Gmbh | Inhibición del il17 e ifn-gamma para el tratamiento de inflamación autoinmune. |
| WO2013018695A1 (ja) * | 2011-07-29 | 2013-02-07 | 武田薬品工業株式会社 | 複素環化合物 |
| US9284283B2 (en) | 2012-02-02 | 2016-03-15 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating IL-17 |
| AU2013270036B2 (en) | 2012-05-31 | 2016-12-01 | Phenex Pharmaceuticals Ag | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR(gamma) |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| CN104978732A (zh) * | 2014-04-11 | 2015-10-14 | 中国船舶工业系统工程研究院 | 一种摄像机参数标定板 |
| JP2017521479A (ja) | 2014-05-15 | 2017-08-03 | ラニ セラピューティクス， エルエルシー | ポリペプチドおよび／またはタンパク質を含む固体塊の薬学的組成物およびそれを製造するための方法 |
| RU2580301C1 (ru) * | 2015-04-21 | 2016-04-10 | Людмила Николаевна Хон | Способ лечения системной красной волчанки человека |
| US11292788B2 (en) | 2017-09-06 | 2022-04-05 | Immunic Ag | IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation |
| WO2019223718A1 (zh) * | 2018-05-22 | 2019-11-28 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112341435B (zh) * | 2019-08-09 | 2021-10-22 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112341442B (zh) * | 2019-08-09 | 2021-10-22 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112341519A (zh) * | 2019-08-09 | 2021-02-09 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112341440B (zh) * | 2019-08-09 | 2022-05-31 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| WO2023281097A1 (en) | 2021-07-09 | 2023-01-12 | Immunic Ag | Methods for treating cancer |
| WO2023198873A1 (en) | 2022-04-14 | 2023-10-19 | Immunic Ag | Deuterated rorgamma/rorgammat inverse agonists |
| WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2124327T3 (es) * | 1993-02-09 | 1999-02-01 | Bayer Ag | Derivados de sulfonamida aminometileno como inmunosupresores. |
| EP0979226B1 (en) * | 1997-04-21 | 2005-11-09 | Sumitomo Pharmaceuticals Company, Limited | Isoxazole derivatives |
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
| JP3237608B2 (ja) * | 1997-04-21 | 2001-12-10 | 住友製薬株式会社 | イソキサゾール誘導体 |
| US20060089398A1 (en) * | 2003-03-19 | 2006-04-27 | Gang Liu | Isoxazole carboxamide derivatives as ghrelin receptor modulators |
| ATE432273T1 (de) * | 2004-03-09 | 2009-06-15 | Boehringer Ingelheim Pharma | 3-ä4-heterocyclyl-1,2,3-triazol-1-ylü-n- arylbenzamide als inhibitoren der cytokinenproduktion für die behandlung von chronischen entzündlichen erkrankungen |
| TW200826936A (en) * | 2006-12-01 | 2008-07-01 | Merck Frosst Canada Ltd | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| EP2350064A1 (en) * | 2008-10-01 | 2011-08-03 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| AR076984A1 (es) * | 2009-06-08 | 2011-07-20 | Merck Serono Sa | Derivados de pirazol oxadiazol |
| MX348726B (es) * | 2011-01-28 | 2017-06-26 | 4Sc Discovery Gmbh | Inhibición del il17 e ifn-gamma para el tratamiento de inflamación autoinmune. |
-
2012
- 2012-01-27 SG SG2013057237A patent/SG192176A1/en unknown
- 2012-01-27 KR KR1020137022372A patent/KR101875248B1/ko active IP Right Grant
- 2012-01-27 UA UAA201310314A patent/UA113160C2/uk unknown
- 2012-01-27 MY MYPI2013002812A patent/MY162397A/en unknown
- 2012-01-27 PL PL12703013T patent/PL2668182T3/pl unknown
- 2012-01-27 MX MX2013008718A patent/MX353762B/es active IP Right Grant
- 2012-01-27 US US13/360,050 patent/US8592456B2/en active Active
- 2012-01-27 JP JP2013550893A patent/JP5969505B2/ja active Active
- 2012-01-27 RU RU2013139663/04A patent/RU2013139663A/ru not_active Application Discontinuation
- 2012-01-27 CA CA2825684A patent/CA2825684C/en active Active
- 2012-01-27 BR BR112013019011-6A patent/BR112013019011B1/pt active IP Right Grant
- 2012-01-27 ES ES12703013.8T patent/ES2664507T3/es active Active
- 2012-01-27 EP EP12703013.8A patent/EP2668182B1/en active Active
- 2012-01-27 CN CN201280010668.3A patent/CN103476771B/zh active Active
- 2012-01-27 WO PCT/EP2012/051357 patent/WO2012101261A1/en active Application Filing
- 2012-01-27 DK DK12703013.8T patent/DK2668182T3/da active
- 2012-01-27 AU AU2012210489A patent/AU2012210489B2/en active Active
- 2012-01-27 EA EA201300862A patent/EA027351B1/ru not_active IP Right Cessation
- 2012-01-27 PT PT127030138T patent/PT2668182T/pt unknown
- 2012-01-30 TW TW101102962A patent/TWI520955B/zh active
- 2012-01-30 UY UY0001033884A patent/UY33884A/es not_active Application Discontinuation
- 2012-01-30 AR ARP120100297A patent/AR085040A1/es active IP Right Grant
-
2013
- 2013-09-10 IL IL227626A patent/IL227626A0/he active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2668182T3 (da) | Hæmning af IL17 og IFN-gamma til behandling af autoimmun inflammation | |
| DK2668183T3 (da) | Hæmning af IL17 og IFN-gamma til behandling af autoimmun inflammation | |
| PH12016500024A1 (en) | Bromodomain inhibitor | |
| WO2014179564A8 (en) | Thiazolopyrrolidine inhibitors of ror-gamma | |
| EA201300730A1 (ru) | Производные индазолилтриазола | |
| WO2014028600A3 (en) | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF | |
| EA201590534A1 (ru) | Новые бициклические производные | |
| WO2011153157A3 (en) | Benzoquinolone inhibitors of vmat2 | |
| AU2012214029A8 (en) | Rorgammat inhibitors | |
| MY181898A (en) | Heterocyclic compounds and uses thereof | |
| IN2014MN02652A (he) | ||
| IN2014MN02658A (he) | ||
| IN2014MN02657A (he) | ||
| DK3520805T3 (da) | Sammensætninger til behandling af myelofibrose | |
| EA201490567A1 (ru) | Новые бициклические производные дигидрохинолин-2-она | |
| WO2014153235A3 (en) | Arginine methyltransferase inhibitors and uses thereof | |
| WO2014153100A3 (en) | Arginine methyltransferase inhibitors and uses thereof | |
| WO2011113060A3 (en) | Antiviral compounds and methods of use thereof | |
| MX2017007607A (es) | Inhibidores de necrosis celular y metodos relacionados. | |
| AU2012213775A8 (en) | 7-azaindole derivatives | |
| EA201591360A1 (ru) | Азабензимидазолы в качестве ингибиторов изозимов фдэ4 для лечения цнс и других расстройств | |
| EA201490471A1 (ru) | Пиридазиноновые соединения и их применение в качестве ингибиторов daao | |
| EA201792021A1 (ru) | Ингибитор jak | |
| EA201500628A1 (ru) | Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов | |
| UA111098C2 (uk) | Проліки адреномедуліну на основі поліетиленгліколю і їх застосування |