BR112013019011A2 - inibição de il17 e ifn-gama para o tratamento de inflamação autoimune - Google Patents
inibição de il17 e ifn-gama para o tratamento de inflamação autoimuneInfo
- Publication number
- BR112013019011A2 BR112013019011A2 BR112013019011A BR112013019011A BR112013019011A2 BR 112013019011 A2 BR112013019011 A2 BR 112013019011A2 BR 112013019011 A BR112013019011 A BR 112013019011A BR 112013019011 A BR112013019011 A BR 112013019011A BR 112013019011 A2 BR112013019011 A2 BR 112013019011A2
- Authority
- BR
- Brazil
- Prior art keywords
- ifn
- treatment
- autoimmune inflammation
- gamma inhibition
- gamma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
inibição de il17 e ifn-gama para o tratamento de inflamação autoimune a presente invenção refere-se a compostos da fórmula geral (i) e ao sal ou solvato farmaceuticamente aceitável do mesmo como agentes anti-inflamatórios e imunomodulatórios.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161437061P | 2011-01-28 | 2011-01-28 | |
EP11152515 | 2011-01-28 | ||
EP11152515.0 | 2011-01-28 | ||
US61/437,061 | 2011-01-28 | ||
PCT/EP2012/051357 WO2012101261A1 (en) | 2011-01-28 | 2012-01-27 | Il17 and ifn-gamma inhibition for the treatment of autoimmune inflammation |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013019011A2 true BR112013019011A2 (pt) | 2017-07-11 |
BR112013019011B1 BR112013019011B1 (pt) | 2021-10-13 |
Family
ID=46577835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013019011-6A BR112013019011B1 (pt) | 2011-01-28 | 2012-01-27 | Inibidores de il17 e ifn-gama, e seu uso |
Country Status (23)
Country | Link |
---|---|
US (1) | US8592456B2 (pt) |
EP (1) | EP2668182B1 (pt) |
JP (1) | JP5969505B2 (pt) |
KR (1) | KR101875248B1 (pt) |
CN (1) | CN103476771B (pt) |
AR (1) | AR085040A1 (pt) |
AU (1) | AU2012210489B2 (pt) |
BR (1) | BR112013019011B1 (pt) |
CA (1) | CA2825684C (pt) |
DK (1) | DK2668182T3 (pt) |
EA (1) | EA027351B1 (pt) |
ES (1) | ES2664507T3 (pt) |
IL (1) | IL227626A0 (pt) |
MX (1) | MX353762B (pt) |
MY (1) | MY162397A (pt) |
PL (1) | PL2668182T3 (pt) |
PT (1) | PT2668182T (pt) |
RU (1) | RU2013139663A (pt) |
SG (1) | SG192176A1 (pt) |
TW (1) | TWI520955B (pt) |
UA (1) | UA113160C2 (pt) |
UY (1) | UY33884A (pt) |
WO (1) | WO2012101261A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX348726B (es) * | 2011-01-28 | 2017-06-26 | 4Sc Discovery Gmbh | Inhibición del il17 e ifn-gamma para el tratamiento de inflamación autoinmune. |
EP2738170B1 (en) * | 2011-07-29 | 2017-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
EP2809660B1 (en) | 2012-02-02 | 2016-01-20 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
SG11201407919WA (en) | 2012-05-31 | 2014-12-30 | Phenex Pharmaceuticals Ag | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma] |
JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
CN104978732A (zh) * | 2014-04-11 | 2015-10-14 | 中国船舶工业系统工程研究院 | 一种摄像机参数标定板 |
US10220076B2 (en) | 2014-05-15 | 2019-03-05 | Incube Labs, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising glucose regulating proteins |
RU2580301C1 (ru) * | 2015-04-21 | 2016-04-10 | Людмила Николаевна Хон | Способ лечения системной красной волчанки человека |
CN111433202A (zh) | 2017-09-06 | 2020-07-17 | 埃慕尼克股份公司 | 作为IL-17和IFN-γ抑制剂用于治疗自体免疫疾病和慢性炎症的1-(4-(异*唑-5-基)-1H-吡唑-1-基)-2-甲基丙-2-醇衍生物和相关化合物 |
CN110511213B (zh) * | 2018-05-22 | 2021-10-19 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
CN112341442B (zh) * | 2019-08-09 | 2021-10-22 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
CN112341519A (zh) * | 2019-08-09 | 2021-02-09 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
CN112341435B (zh) * | 2019-08-09 | 2021-10-22 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
WO2021027729A1 (zh) * | 2019-08-09 | 2021-02-18 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
WO2023281097A1 (en) | 2021-07-09 | 2023-01-12 | Immunic Ag | Methods for treating cancer |
WO2023198873A1 (en) | 2022-04-14 | 2023-10-19 | Immunic Ag | Deuterated rorgamma/rorgammat inverse agonists |
WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE172985T1 (de) * | 1993-02-09 | 1998-11-15 | Bayer Ag | Sulfonamidaminomethylenderivate als immunsuppressiva |
US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
EP0979226B1 (en) * | 1997-04-21 | 2005-11-09 | Sumitomo Pharmaceuticals Company, Limited | Isoxazole derivatives |
JP3237608B2 (ja) * | 1997-04-21 | 2001-12-10 | 住友製薬株式会社 | イソキサゾール誘導体 |
US20060089398A1 (en) * | 2003-03-19 | 2006-04-27 | Gang Liu | Isoxazole carboxamide derivatives as ghrelin receptor modulators |
PL1725544T3 (pl) * | 2004-03-09 | 2009-10-30 | Boehringer Ingelheim Pharmaceuticals Inc | 3-[4-Heterocyklilo-1,2,3-triazol-1-ilo]-N-arylobenzamidy jako inhibitory wytwarzania cytokin, do leczenia przewlekłych chorób zapalnych |
TW200826936A (en) * | 2006-12-01 | 2008-07-01 | Merck Frosst Canada Ltd | Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
AU2009300317A1 (en) * | 2008-10-01 | 2010-04-08 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
AR076984A1 (es) * | 2009-06-08 | 2011-07-20 | Merck Serono Sa | Derivados de pirazol oxadiazol |
MX348726B (es) * | 2011-01-28 | 2017-06-26 | 4Sc Discovery Gmbh | Inhibición del il17 e ifn-gamma para el tratamiento de inflamación autoinmune. |
-
2012
- 2012-01-27 EP EP12703013.8A patent/EP2668182B1/en active Active
- 2012-01-27 CA CA2825684A patent/CA2825684C/en active Active
- 2012-01-27 KR KR1020137022372A patent/KR101875248B1/ko active IP Right Grant
- 2012-01-27 ES ES12703013.8T patent/ES2664507T3/es active Active
- 2012-01-27 JP JP2013550893A patent/JP5969505B2/ja active Active
- 2012-01-27 RU RU2013139663/04A patent/RU2013139663A/ru not_active Application Discontinuation
- 2012-01-27 MY MYPI2013002812A patent/MY162397A/en unknown
- 2012-01-27 CN CN201280010668.3A patent/CN103476771B/zh active Active
- 2012-01-27 UA UAA201310314A patent/UA113160C2/uk unknown
- 2012-01-27 MX MX2013008718A patent/MX353762B/es active IP Right Grant
- 2012-01-27 BR BR112013019011-6A patent/BR112013019011B1/pt active IP Right Grant
- 2012-01-27 AU AU2012210489A patent/AU2012210489B2/en active Active
- 2012-01-27 WO PCT/EP2012/051357 patent/WO2012101261A1/en active Application Filing
- 2012-01-27 PT PT127030138T patent/PT2668182T/pt unknown
- 2012-01-27 SG SG2013057237A patent/SG192176A1/en unknown
- 2012-01-27 US US13/360,050 patent/US8592456B2/en active Active
- 2012-01-27 PL PL12703013T patent/PL2668182T3/pl unknown
- 2012-01-27 EA EA201300862A patent/EA027351B1/ru not_active IP Right Cessation
- 2012-01-27 DK DK12703013.8T patent/DK2668182T3/da active
- 2012-01-30 TW TW101102962A patent/TWI520955B/zh active
- 2012-01-30 AR ARP120100297A patent/AR085040A1/es active IP Right Grant
- 2012-01-30 UY UY0001033884A patent/UY33884A/es not_active Application Discontinuation
-
2013
- 2013-09-10 IL IL227626A patent/IL227626A0/en active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013019011A2 (pt) | inibição de il17 e ifn-gama para o tratamento de inflamação autoimune | |
BR112013019256A2 (pt) | inibição de il-17 e ifn-gama para o tratamento de inflamação autoimune | |
CY1122266T1 (el) | Ενωσεις 3-αμινοκυκλοαλκυλιου ως ror-gamma-t αναστολεις και χρησεις αυτων | |
UY39630A (es) | Inhibidores de bromodominios | |
AU2012214029A8 (en) | Rorgammat inhibitors | |
BR112015032693A2 (pt) | inibidores de bromodomínio | |
MX2015011273A (es) | Uso de derivados de pirazolopirimidina para el tratamiento de trastornos relacio nados con la fosfoinositida 3-cinasa delta. | |
EA201690247A1 (ru) | Аминометилбиарильные производные-ингибиторы фактора d комплемента и их применения | |
EA201500926A1 (ru) | Фумараты как пролекарства и их применение при лечении различных заболеваний | |
IN2014MN02652A (pt) | ||
CO6940432A2 (es) | Compuestos de 1-arilcarbonilo-4-oxi-piperidina útiles para el tratamiento de enfermedades neurodegenerativas | |
WO2012173682A3 (en) | Compounds and methods for the treatment of isocitrate dehydrognase related diseases | |
MX349159B (es) | Derivados deuterados de ivacaftor. | |
IN2014MN00988A (pt) | ||
IN2014MN02657A (pt) | ||
UY35683A (es) | Polimorfo de inhibidores de tirosina quinasa de bazo (syk) | |
CR20130045A (es) | Compuestos terapéuticos | |
IL241264A0 (en) | Compounds and compositions for the treatment of parasitic diseases | |
PL2925757T3 (pl) | Związki i kompozycje do leczenia chorób pasożytniczych | |
CR20140134A (es) | Composiciones farmacéuticas | |
WO2012104823A3 (en) | Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases | |
BR112014004416A2 (pt) | composições e métodos para o tratamento de doenças neurodegenerativas | |
EA201270728A1 (ru) | Пуриновые соединения | |
EA201591177A1 (ru) | Трициклические соединения для ингибирования канала cftr | |
ES2722926T3 (es) | Combinación de levocabastina y furoato de fluticasona para el tratamiento de condiciones inflamatorias y/o alérgicas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/01/2012, OBSERVADAS AS CONDICOES LEGAIS. |