DK2582714T3 - Nye jnk-inhibitormolekyler - Google Patents
Nye jnk-inhibitormolekyler Download PDFInfo
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- DK2582714T3 DK2582714T3 DK11727401.9T DK11727401T DK2582714T3 DK 2582714 T3 DK2582714 T3 DK 2582714T3 DK 11727401 T DK11727401 T DK 11727401T DK 2582714 T3 DK2582714 T3 DK 2582714T3
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Claims (25)
1. JNK-inhibitor omfattende en hæmmende peptidsekvens ifølge den følgende generelle formel: X1-X2-X3-R-X4-X5-X6-L-X7-L-X8 (SEQ ID NR. 1), hvor XI er en aminosyre valgt blandt aminosyrer R, P og Q, hvor X2 er en aminosyre valgt blandt aminosyrer R, P og G, hvor X3 er en aminosyre valgt blandt aminosyrer K, R, k og r, hvor X4 er en aminosyre valgt blandt aminosyrer P og K, hvor X5 er en aminosyre valgt blandt aminosyrer T, a, s, q, k eller er manglende, hvor X6 er en aminosyre valgt blandt aminosyrer T, D og A, hvor X7 er en aminosyre valgt blandt aminosyrer N, n, r og K; og hvor X8 er en aminosyre valgt blandt F, f og w og hvor en aminosyrerest angivet med store bogstaver indikerer en L-aminosyrerest, mens en aminosyrerest angivet med små bogstaver indikerer en D-aminosyrerest, med betingelsen at mindst én af aminosyrerne valgt fra gruppen bestående af X3, X5, X7 og X8 er (en) D-aminosyre(r).
2. JNK-inhibitor ifølge krav 1, hvor den hæmmende peptidsekvens er valgt blandt en hvilken af SEQ ID nr. 3-20, 22-24 og 27.
3. JNK-inhibitor ifølge krav 1 eller 2, hvor JNK-inhibitoren omfatter en hæmmende peptidsekvens som deler mindst 80% sekvensidentitet med en sekvens valgt blandt en hvilken af SEQ ID nr. 3-20, 22-24 og 27.
4. JNK-inhibitor ifølge et hvilket som helst af de foregående krav, hvor JNK-inhibitoren omfatter SEQ ID nr. 8 eller en hæmmende peptidsekvens som deler mindst 80% sekvensidentitet med SEQ ID nr. 8.
5. JNK-inhibitor ifølge et hvilket som helst af de foregående krav, hvor JNK-inhibitoren omfatter en transportsekvens.
6. JNK-inhibitor ifølge krav 5, hvor den hæmmende peptidsekvens og transportsekvensen overlapper.
7. JNK-inhibitor ifølge krav 5 eller 6, hvor transportsekvensen omfatter en sekvens af skiftevise D- og L-aminosyrer ifølge et hvilket af SEQ ID nr. 28-30, eller en transportsekvens valgt blandt et hvilket som helst af SEQ ID nr. 31-170.
8. JNK-inhibitor ifølge et hvilket som helst af krav 5 eller 7, hvor transportsekvensen er anbragt direkte N-terminal eller direkte C-terminal af den hæmmende peptidsekvens.
9. JNK-inhibitor ifølge et hvilket som helst af krav 5-8, hvor JNK-inhibitoren omfatter a) en sekvens ifølge et hvilket af SEQ ID nr. 171-183, 185-187 eller 190 eller b) en sekvens som deler mindst 50% sekvensidentitet med mindst én af SEQ ID nr. 171-190, med betingelsen at sekvensen som deler sekvensidentitet med et hvilket af SEQ ID nr. 171-190: i) bibeholder L-arginin (R)-resten på position 4 i sekvensstrækningen svarende til SEQ ID nr. 1, ii) bibeholder de to L-leucin (L)-rester i sekvensstrækningen svarende til SEQ ID nr. 1, og iii) udviser mindst én D-aminosyre ved positioner X3, X5, X7 eller X8 i sekvensstrækningen svarende til SEQ ID nr. 1.
10. JNK-inhibitor ifølge krav 9, hvor JNK-inhibitoren omfatter a) en sekvens ifølge SEQ ID nr. 172 eller b) en sekvens som deler mindst 50% sekvensidentitet med SEQ ID nr. 172, med betingelsen at sekvensen som deler sekvensidentitet with SEQ ID nr. 172: i) bibeholder L-arginin (R)-resten på position 4 i sekvensstrækningen svarende til SEQ ID nr. 1, ii) bibeholder de to L-leucin (L)-rester i sekvensstrækningen svarende til SEQ ID nr. 1, og iii) udviser mindst én D-aminosyre ved positions X3, X5, X7 eller X8 i sekvensstrækningen svarende til SEQ ID nr. 1.
11. JNK-inhibitor ifølge krav 10, hvor JNK-inhibitoren består af en sekvens ifølge SEQ ID nr. 172.
12. Fremgangsmåde til at immunisere et ikke-menneskeligt dyr på ikke-terapeutisk vis med en JNK-inhibitor ifølge et hvilket som helst af krav 1-11, hvilken fremgangsmåde omfatter det følgende trin: - at bringe et ikke-menneskeligt dyr egnet til antistofproduktion i kontakt med en JNK-inhibitor på ikke-terapeutisk vis ifølge et hvilket som helst af krav 1-11.
13. Fremgangsmåde til at immunisere et ikke-menneskeligt dyr på ikke-terapeutisk vis ifølge krav 12, hvor det ikke-menneskelige dyr er et ikke-menneskeligt pattedyr.
14. Fremgangsmåde til at immunisere et ikke-menneskeligt dyr på ikke-terapeutisk vis ifølge krav 13, hvor det ikke-menneskelige dyr er valgt blandt ged, mus, rotte og kanin.
15. Fremgangsmåde til at fremstille et antistof som genkender en JNK-inhibitor ifølge et hvilket som helst af krav 1-11, hvilken fremgangsmåde omfatter trinnet: - at isolere fra et ikke-menneskeligt dyr egnet til antistofproduktion, som tidligere er sat i kontakt med en JNK-inhibitor på ikke-terapeutisk vis ifølge et hvilket som helst af krav 1-11, et antistof som genkender JNK-inhibitoren.
16. Fremgangsmåde til at fremstille et antistof ifølge krav 15, hvor det ikke-menneskelige dyr er et ikke-menneskeligt pattedyr.
17. Fremgangsmåde til at fremstille et antistof ifølge krav 16, hvor det ikke-menneskelige dyr er valgt blandt ged, mus, rotte og kanin.
18. Fremgangsmåde til at isolere en celle som fremstiller et antistof, som genkender en JNK-inhibitor ifølge et hvilket som helst af krav 1-11, hvilken fremgangsmåde omfatter trinnet: - at isolere fra et ikke-menneskeligt dyr egnet til antistofproduktion, som tidligere er sat i kontakt med en JNK-inhibitor på ikke-terapeutisk vis ifølge et hvilket som helst af krav 1-11, en celle som fremstiller antistoffet, som genkender JNK-inhibitoren.
19. Fremgangsmåde til at isolere en celle ifølge krav 18, hvor det ikke-menneskelige dyr er et ikke-menneskeligt pattedyr.
20. Fremgangsmåde til at isolere en celle ifølge krav 19, hvor det ikke-menneskelige dyr er valgt blandt ged, mus, rotte og kanin.
21. Fremgangsmåde til at isolere en celle ifølge et hvilket som helst af krav 18 - 20, hvor cellen som fremstiller antistoffet er immortaliseret.
22. Fremgangsmåde til at fremstille et antistof som specifikt genkender en JNK-inhi-bitor ifølge et hvilket som helst af krav 1-11, hvilken fremgangsmåde omfatter trinnet: at isolere et antistof som specifikt genkender en JNK-inhibitor ifølge et hvilket som helst af krav 1-11, fra cellekultursupernatanten fra en celle som fremstiller antistoffet.
23. Fremgangsmåde til at fremstille et antistof ifølge krav 22, hvor cellen som fremstiller antistoffet er immortaliseret.
24. Antistof, som kan fremstilles med en hvilken som helst af fremgangsmåderne ifølge et hvilket som helst af krav 15 - 17 eller 22 - 23, hvor antistoffet genkender mindst ét peptid valgt blandt et hvilket som helst af SEQ ID nr. 1, 3-20, 22-24 og 27, men som ikke genkender det i alt væsentligt samme peptid med L-aminosyrer i stedet for D-aminosyrerne.
25. Celle som kan fremstilles med fremgangsmåden ifølge et hvilket som helst af krav 18-21, hvor cellen fremstiller et antistof ifølge krav 24.
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PCT/EP2010/003729 WO2011160653A1 (en) | 2010-06-21 | 2010-06-21 | Novel jnk inhibitor molecules |
PCT/EP2011/003074 WO2011160827A2 (en) | 2010-06-21 | 2011-06-21 | Novel jnk inhibitor molecules |
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US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
US9150618B2 (en) | 2010-10-14 | 2015-10-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
WO2013091670A1 (en) * | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
CN105307670A (zh) | 2013-06-26 | 2016-02-03 | 埃克西金炎症有限公司 | Jnk信号转导途径的细胞渗透肽抑制剂用于治疗多种疾病的新用途 |
WO2014206426A1 (en) * | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2015197097A1 (en) * | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
EP3160989A2 (en) * | 2014-06-26 | 2017-05-03 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
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