DK2558081T3 - Reduktion af intraokulært tryk med intrakamerale bimatoprost-implantater - Google Patents
Reduktion af intraokulært tryk med intrakamerale bimatoprost-implantater Download PDFInfo
- Publication number
- DK2558081T3 DK2558081T3 DK11717096T DK11717096T DK2558081T3 DK 2558081 T3 DK2558081 T3 DK 2558081T3 DK 11717096 T DK11717096 T DK 11717096T DK 11717096 T DK11717096 T DK 11717096T DK 2558081 T3 DK2558081 T3 DK 2558081T3
- Authority
- DK
- Denmark
- Prior art keywords
- implant
- prostamide
- eye
- use according
- implants
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (13)
1. Prostamid til anvendelse i behandling af forhøjet intraokulært tryk (IOP) ved placering af et biologisk nedbrydeligt intraokulært implantat i et øje på en patient med behov for behandlingen; hvor: implantatet omfatter et prostamid i en mængde af 15-25 vægt-% af implantatets vægt, hvilket prostamid associeres med en biologisk nedbrydelig polymermatrix, der frigiver en mængde af prostamidet, der er effektiv til at forebygge eller reducere et symptom på forhøjet IOP; og implantatet placeres i en intrakameral placering i positionen for kl. 06.00 for at udvide udløbskanalerne i øjet, der udgår fra Schlemms kanal, og for derved at blande prostamidet grundigt over hele det forreste segment via konvektionsstrømmene.
2. Prostamid til anvendelse ifølge krav 1, hvor implantatet placeres i en intrakameral placering i postionen for kl. 06.00 for at udvide karrene i det episclerale og conjunctivale venøse plexus.
3. Prostamid til anvendelse ifølge krav 1, hvor implantatet placeres i positionen for kl. 06.00 i øjets forreste kammer.
4. Prostamid til anvendelse ifølge krav 1, hvor implantatet placeres i positionen for kl. 06.00 i øjets iridocorneale vinkel.
5. Prostamid til anvendelse ifølge krav 1, hvor implantatet placeres i øjet ved anvendelse af en enhed til indsætning af et okulært implantat, hvilken enhed omfatter: (a) en kanyle, der har en ydre væg, en proximal ende, en proximal åbningsende, en distal ende, en distal åbningsende og en lumen, der strækker sig gennem kanylen; (b) et okulært implantat, der er dimensioneret og struktureret til implantering i øjet, hvilket okulært implantat befinder sig i lumenen; og (c) en hætte, der har en lukket distal ende, der er i kontakt med kanylens ydre væg og dækker kanylens distale ende og distale åbningsende, hvilken hætte er struktureret til at tillade, at kanylens distale ende og diskale åbningsende passerer gennem hætten, når kanylen indføres i et øje.
6. Prostamid til anvendelse ifølge krav 1, hvor prostamidet er en forbindelse med formlen (I):
hvor de stiplede bindinger repræsenterer en enkelt eller dobbelt binding, der kan være i cis- eller transkonfiguration, A er en alkylen- eller alkenylenradikal, der har fra to til seks carbonatomer, hvilket radikal kan afbrydes af en eller flere oxidradikaler og substitueres med en eller flere hydroxy-, oxo-, alkyloxy- eller alkylcarboxygrupper, hvor alkylradikalen omfatter fra et til seks carbonatomer; B er en cycloalkylradikal, der har fra tre til syv carbonatomer, eller en arylradikal, der er udvalgt fra gruppen bestående af hydrocarbylaryl- og heteroarylradikaler, der har fra fire til ti carbonatomer, hvor heteroatomet er udvalgt fra gruppen bestående af nitrogen-, oxygen- og svovlatomer; X er - N(R4)2, hvor R4 uafhængigt er udvalgt fra gruppen bestående af hydrogen og lavere alkylradikaler, der har fra et til seks carbonatomer, Z er =0; én af Ri og R2 er =0, -OH eller en -0(C0)R6-gruppe, og den anden er -OH eller -0(C0)R6, eller R·, er =0 og R2 er H; hvor R6 er en mættet eller umættet acyklisk hydrocarbongruppe, der har fra 1 til omkring 20 carbonatomer, eller -(CH2)mR7, hvor m er 0-10, og R7 er en cycloalkylradikal, der har fra tre til syv carbonatomer, eller hydrocarbylaryl eller heteroaryl, som defineret ovenfor; eller et farmaceutisk acceptabelt salt deraf.
7. Prostamid til anvendelse ifølge krav 6, hvor prostamidet har følgende formel (II):
hvor y er O eller 1, x er O eller 1 og x+y ikke begge er 1, Y er en radikal, der er udvalgt fra gruppen bestående af alkyl, halo, nitro, amino, thiol, hydroxy, alkyloxy, alkylcarboxy og halosubstitueret alkyl, hvor alkylradikalen omfatter fra et til seks carbonatomer, n er O eller et heltal fra 1 til 3 og R2 er =0,-0H eller -0(C0)R6, og skraverede linjer indikerer .alpha-konfigurationen og faste trekanter indikerer .beta-konfigurationen.
8. Prostamid til anvendelse ifølge krav 7, hvor prostamidet omfatter bimatoprost, salte deraf og blandinger deraf.
9. Prostamid til anvendelse ifølge krav 8, hvor IOP reduceres med mindst 60 % fra baseline.
10. Prostamid til anvendelse ifølge krav 8, hvor IOP reduceres i et omfang, der er større end omfanget opnået med topisk bimatoprost.
11. Prostamid til anvendelse ifølge krav 10, hvor frigivelsen af prostamidet er effektiv i mindst to uger efter placeringen i øjet.
12. Prostamid til anvendelse ifølge et hvilket som helst af de foregående krav, hvor implantatets diameter er mindre end 500 pm.
13. Prostamid til anvendelse ifølge et hvilket som helst af kravene 1 til 11, hvor implantatet er dimensioneret til at passe til den iridocorneale vinkels anatomi i øjet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/761,765 US8673341B2 (en) | 2004-04-30 | 2010-04-16 | Intraocular pressure reduction with intracameral bimatoprost implants |
PCT/US2011/032393 WO2011130462A2 (en) | 2010-04-16 | 2011-04-14 | Intraocular pressure reduction with intracameral bimatoprost implants |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2558081T3 true DK2558081T3 (da) | 2015-03-02 |
Family
ID=44194969
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11717096T DK2558081T3 (da) | 2010-04-16 | 2011-04-14 | Reduktion af intraokulært tryk med intrakamerale bimatoprost-implantater |
DK16201104.3T DK3205333T3 (da) | 2010-04-16 | 2011-04-14 | Reduktion af intraokulært tryk med intracamerale prostamid-implantater |
DK14194703.6T DK2902018T3 (da) | 2010-04-16 | 2011-04-14 | Reduktion af intraokulært tryk med intracamerale bimatoprost-implantater |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16201104.3T DK3205333T3 (da) | 2010-04-16 | 2011-04-14 | Reduktion af intraokulært tryk med intracamerale prostamid-implantater |
DK14194703.6T DK2902018T3 (da) | 2010-04-16 | 2011-04-14 | Reduktion af intraokulært tryk med intracamerale bimatoprost-implantater |
Country Status (21)
Country | Link |
---|---|
US (2) | US8673341B2 (da) |
EP (5) | EP3456323A1 (da) |
JP (5) | JP5982360B2 (da) |
KR (2) | KR101915326B1 (da) |
CN (2) | CN111450041A (da) |
AU (1) | AU2011239642B2 (da) |
BR (1) | BR112012026535A2 (da) |
CA (2) | CA2796443C (da) |
CY (3) | CY1115912T1 (da) |
DK (3) | DK2558081T3 (da) |
ES (3) | ES2617285T3 (da) |
HU (2) | HUE033186T2 (da) |
IL (1) | IL222457A (da) |
MX (1) | MX2012012040A (da) |
PL (3) | PL2558081T3 (da) |
PT (3) | PT3205333T (da) |
RU (1) | RU2586298C2 (da) |
SG (2) | SG10201606415UA (da) |
SI (3) | SI2558081T1 (da) |
TR (1) | TR201820663T4 (da) |
WO (1) | WO2011130462A2 (da) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
EP1977724A1 (en) | 2001-04-07 | 2008-10-08 | Glaukos Corporation | System for treating ocular disorders |
US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
US9498457B2 (en) * | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
US20060182781A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Methods for treating ocular conditions with cyclic lipid contraining microparticles |
US8506515B2 (en) | 2006-11-10 | 2013-08-13 | Glaukos Corporation | Uveoscleral shunt and methods for implanting same |
US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
US8846073B2 (en) | 2006-12-19 | 2014-09-30 | Allergan, Inc. | Low temperature processes for making cyclic lipid implants for intraocular use |
US20170360609A9 (en) | 2007-09-24 | 2017-12-21 | Ivantis, Inc. | Methods and devices for increasing aqueous humor outflow |
CA2717441A1 (en) | 2008-03-05 | 2009-09-11 | Ivantis, Inc. | Methods and apparatus for treating glaucoma |
WO2010093945A2 (en) | 2009-02-13 | 2010-08-19 | Glaukos Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
US20100247606A1 (en) * | 2009-03-25 | 2010-09-30 | Allergan, Inc. | Intraocular sustained release drug delivery systems and methods for treating ocular conditions |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
WO2015073571A1 (en) * | 2013-11-15 | 2015-05-21 | Dose Medical Corporation | Ocular implants configured to store and release stable drug formulations |
JP5695035B2 (ja) | 2009-06-03 | 2015-04-01 | フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. | 前眼部薬物供給 |
CA2766131C (en) | 2009-07-09 | 2017-10-24 | Ivantis, Inc. | Single operator device for delivering an ocular implant |
CN102481404B (zh) | 2009-07-09 | 2014-03-05 | 伊万提斯公司 | 眼部植入物 |
KR102126007B1 (ko) | 2010-01-22 | 2020-06-24 | 알러간, 인코포레이티드 | 전방내 서방성 치료제 이식물 |
JP2013526572A (ja) | 2010-05-17 | 2013-06-24 | アエリエ・ファーマシューティカルズ・インコーポレーテッド | 眼治療薬の送達のための薬物送達装置 |
US9668915B2 (en) | 2010-11-24 | 2017-06-06 | Dose Medical Corporation | Drug eluting ocular implant |
WO2012149287A1 (en) | 2011-04-29 | 2012-11-01 | Allergan, Inc. | Solvent cast film sustained release latanoprost implant |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
US8657776B2 (en) | 2011-06-14 | 2014-02-25 | Ivantis, Inc. | Ocular implants for delivery into the eye |
AU2012308317B2 (en) | 2011-09-14 | 2017-01-05 | Forsight Vision5, Inc. | Ocular insert apparatus and methods |
US8663150B2 (en) | 2011-12-19 | 2014-03-04 | Ivantis, Inc. | Delivering ocular implants into the eye |
CA2868341C (en) | 2012-03-26 | 2021-01-12 | Glaukos Corporation | System and method for delivering multiple ocular implants |
US9358156B2 (en) | 2012-04-18 | 2016-06-07 | Invantis, Inc. | Ocular implants for delivery into an anterior chamber of the eye |
WO2014066658A1 (en) * | 2012-10-26 | 2014-05-01 | Allergan, Inc. | Ketorolac-containing sustained release drug delivery systems |
WO2014066653A1 (en) * | 2012-10-26 | 2014-05-01 | Allergan, Inc. | Ketorolac-containing sustained release intraocular drug delivery systems |
HUE046128T2 (hu) | 2012-10-26 | 2020-02-28 | Forsight Vision5 Inc | Szemészeti rendszer gyógyszer szembe való késleltetett kibocsátására |
WO2014085450A1 (en) | 2012-11-28 | 2014-06-05 | Ivantis, Inc. | Apparatus for delivering ocular implants into an anterior chamber of the eye |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
JP6675298B2 (ja) * | 2013-03-15 | 2020-04-01 | アラーガン、インコーポレイテッドAllergan,Incorporated | プロスタミド含有眼内インプラント |
US20160022695A1 (en) * | 2013-03-27 | 2016-01-28 | Forsight Vision5, Inc. | Bimatoprost Ocular Silicone Inserts and Methods of Use Thereof |
JP6570513B2 (ja) | 2013-04-01 | 2019-09-04 | アラーガン、インコーポレイテッドAllergan,Incorporated | 持続的眼内放出のためのマイクロスフェア薬剤送達システム |
CN110302138B (zh) * | 2013-10-31 | 2022-09-30 | 阿勒根公司 | 含前列腺酰胺的眼内植入物及其使用方法 |
JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
WO2016011056A1 (en) | 2014-07-14 | 2016-01-21 | Ivantis, Inc. | Ocular implant delivery system and method |
US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
US20210228408A1 (en) * | 2015-07-23 | 2021-07-29 | Allergan, Inc. | Glaucoma Treatment Via Intracameral Ocular Implants |
ES2962607T3 (es) | 2015-08-14 | 2024-03-20 | Alcon Inc | Implante ocular con sensor de presión |
WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
WO2017062770A1 (en) | 2015-10-08 | 2017-04-13 | Silverberg Noah | Punctal plug and bioadhesives |
WO2017106517A1 (en) | 2015-12-15 | 2017-06-22 | Ivantis, Inc. | Ocular implant and delivery system |
AU2017252294B2 (en) | 2016-04-20 | 2021-12-02 | Dose Medical Corporation | Bioresorbable ocular drug delivery device |
CA3038075A1 (en) | 2016-09-23 | 2018-03-29 | Incept, Llc | Intracameral drug delivery depots |
USD841152S1 (en) | 2017-06-27 | 2019-02-19 | Monica S. Naylor | Eye drop container |
CN113893085B (zh) | 2017-10-06 | 2024-05-24 | 格劳科斯公司 | 用于递送多个眼部植入物的系统和方法 |
USD846738S1 (en) | 2017-10-27 | 2019-04-23 | Glaukos Corporation | Implant delivery apparatus |
EP3810082A1 (en) * | 2018-06-19 | 2021-04-28 | Cella Therapeutics, LLC | Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension |
EP3990042A4 (en) | 2019-06-27 | 2023-07-19 | Layerbio, Inc. | METHODS AND SYSTEMS FOR RELEASING EYE DEVICES |
DK3861985T3 (da) | 2020-02-06 | 2023-07-24 | Ocular Therapeutix Inc | Sammensætninger og fremgangsmåder til behandling af øjensygdomme |
JP2024503989A (ja) | 2021-01-11 | 2024-01-30 | アルコン インコーポレイティド | 粘弾性体送達のためのシステム及び方法 |
Family Cites Families (205)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT252264B (de) | 1965-03-17 | 1967-02-10 | Etapharm Chem Pharm Lab Ges M | Verfahren zur Herstellung eines reinen hochviskosen Hyaluronsäurepräparates |
US3393081A (en) * | 1966-12-06 | 1968-07-16 | Monsanto Co | Heat sealable moisture barrier coatings for polystyrene articles |
US3749776A (en) * | 1970-08-28 | 1973-07-31 | Allergan Pharma | Method for blocking prostaglandin activity |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
SE390255B (sv) * | 1974-02-18 | 1976-12-13 | N G Y Torphammar | Upprullningsanordning foretredesvis for ett sekerhetsbelte i ett fordon |
GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
US3966749A (en) * | 1975-02-10 | 1976-06-29 | Interx Research Corporation | Novel synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols, the pharmaceutically acceptable acid addition salts thereof and intermediate useful in the preparation thereof |
US4014335A (en) * | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
US4052505A (en) | 1975-05-30 | 1977-10-04 | Alza Corporation | Ocular therapeutic system manufactured from copolymer |
US4144317A (en) * | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
US4057619A (en) | 1975-06-30 | 1977-11-08 | Alza Corporation | Ocular therapeutic system with selected membranes for administering ophthalmic drug |
US4063064A (en) | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
US4186184A (en) * | 1977-12-27 | 1980-01-29 | Alza Corporation | Selective administration of drug with ocular therapeutic system |
US4190642A (en) * | 1978-04-17 | 1980-02-26 | Alza Corporation | Ocular therapeutic system for dispensing a medication formulation |
US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4285957A (en) | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
US4303637A (en) | 1980-04-04 | 1981-12-01 | Alza Corporation | Medication indicated for ocular hypertension |
US4281654A (en) | 1980-04-07 | 1981-08-04 | Alza Corporation | Drug delivery system for controlled ocular therapy |
US4396625A (en) | 1980-05-13 | 1983-08-02 | Sumitomo Chemical Company, Limited | Treatment of glaucoma or ocular hypertension and ophthalmic composition |
US4425346A (en) * | 1980-08-01 | 1984-01-10 | Smith And Nephew Associated Companies Limited | Pharmaceutical compositions |
US4304765A (en) | 1980-10-14 | 1981-12-08 | Alza Corporation | Ocular insert housing steroid in two different therapeutic forms |
US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
JPS58126435U (ja) | 1982-02-19 | 1983-08-27 | オリンパス光学工業株式会社 | Ttlオ−トストロボ用絞り制御回路 |
US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
US4599353A (en) * | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
DE3220156C2 (de) * | 1982-05-28 | 1990-01-25 | Heida Houston Tex. Thurlow | Mit Metallgriffen, insbesondere Edelstahlgriffen, versehenes Koch- und Bratgeschirr mit Deckel |
US4649151A (en) | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
US5166331A (en) | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
US4478818A (en) | 1982-12-27 | 1984-10-23 | Alza Corporation | Ocular preparation housing steroid in two different therapeutic forms |
US4521210A (en) * | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
US4693885A (en) | 1984-07-18 | 1987-09-15 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
FR2577509B1 (fr) | 1985-02-21 | 1987-05-07 | Nirvana Espar Systems Sa | Mat de bateau a voile |
US4656186A (en) * | 1985-04-30 | 1987-04-07 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
US4668506A (en) * | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
FR2594438B1 (fr) * | 1986-02-14 | 1990-01-26 | Labaz Sanofi Nv | Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant |
US4959217A (en) | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
CA1311686C (en) | 1986-06-25 | 1992-12-22 | John Weldon Shell | Controlled release bioerodible drug delivery system |
US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
US5089509A (en) * | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
US4981871A (en) * | 1987-05-15 | 1991-01-01 | Abelson Mark B | Treatment of ocular hypertension with class I calcium channel blocking agents |
DE3734223A1 (de) | 1987-10-09 | 1989-04-20 | Boehringer Ingelheim Kg | Implantierbares, biologisch abbaubares wirkstofffreigabesystem |
US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
US4997652A (en) * | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
US4865846A (en) | 1988-06-03 | 1989-09-12 | Kaufman Herbert E | Drug delivery system |
US4968715A (en) | 1988-07-06 | 1990-11-06 | Health Research, Inc. | Use of purified hematoporphyrin trimers in photodynamic therapy |
US5190966A (en) * | 1988-07-06 | 1993-03-02 | Health Research, Inc. | Purified hematoporphyrin dimers and trimers useful in photodynamic therapy |
US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
US5093349A (en) * | 1988-07-20 | 1992-03-03 | Health Research Inc. | Photosensitizing agents |
US5198460A (en) | 1988-07-20 | 1993-03-30 | Health Research Inc. | Pyropheophorbides and their use in photodynamic therapy |
DE68929435T2 (de) | 1988-09-06 | 2003-07-17 | Pharmacia Ab | Prostaglandinderivate zur Behandlung des grünen Stars oder einer okularen Hypertension |
US4935498A (en) * | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5457183A (en) | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
US5173504A (en) | 1989-04-21 | 1992-12-22 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
US5171741A (en) | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5028624A (en) | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
US5034413A (en) | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
US4932984A (en) * | 1989-07-27 | 1990-06-12 | The Dow Chemical Company | Process for reduction of chlorinated solvent emissions |
US5268178A (en) | 1989-09-25 | 1993-12-07 | The Board Of Regents, The University Of Texas System | Biodegradable antibiotic implants and methods of their use in treating and preventing infections |
US5503721A (en) | 1991-07-18 | 1996-04-02 | Hri Research, Inc. | Method for photoactivation |
US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
US5075115A (en) | 1990-04-02 | 1991-12-24 | Fmc Corporation | Process for polymerizing poly(lactic acid) |
US5232844A (en) | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
US5196460A (en) * | 1990-05-29 | 1993-03-23 | Repap Technologies Inc. | Rubber compositions containing high purity lignin derivatives |
US5100431A (en) * | 1990-09-27 | 1992-03-31 | Allergan, Inc. | Single stitch suture needle and method |
KR0185215B1 (ko) * | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
CA2055522A1 (en) | 1990-12-12 | 1992-06-13 | Masako Andoh | Microspheres for ophthalmic use |
US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
CA2111199C (en) * | 1991-06-21 | 2008-08-05 | Eyal Ron | Pharmaceutical formulations of osteogenic proteins |
US5356629A (en) | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
US5169638A (en) | 1991-10-23 | 1992-12-08 | E. R. Squibb & Sons, Inc. | Buoyant controlled release powder formulation |
US5543154A (en) | 1991-12-27 | 1996-08-06 | Merck & Co., Inc. | Controlled release nifedipine delivery device |
US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
IT1263116B (it) | 1992-04-09 | 1996-07-30 | Rotta Research Lab | Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico |
US5655832A (en) | 1992-04-16 | 1997-08-12 | Tir Technologies, Inc. | Multiple wavelength light processor |
US5244914A (en) | 1992-04-27 | 1993-09-14 | American Cyanamid Company | Stable porfimer sodium compositions and methods for their manufacture |
US5178635A (en) * | 1992-05-04 | 1993-01-12 | Allergan, Inc. | Method for determining amount of medication in an implantable device |
US6217869B1 (en) * | 1992-06-09 | 2001-04-17 | Neorx Corporation | Pretargeting methods and compounds |
US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5972991A (en) * | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US5922773A (en) | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
US5716981A (en) * | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
WO1995003807A1 (en) * | 1993-07-27 | 1995-02-09 | The University Of Sydney | Treatment of age-related macular degeneration |
US5504074A (en) * | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US6051576A (en) * | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
DE4403326C1 (de) | 1994-02-03 | 1995-06-22 | Hans Reinhard Prof Dr Koch | Intraokulare Linsenanordnung zur Astigmatismuskorrektur |
US5516522A (en) * | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
US5798349A (en) | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
US5466233A (en) | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6270492B1 (en) | 1994-09-09 | 2001-08-07 | Cardiofocus, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US5585401A (en) | 1994-12-09 | 1996-12-17 | The Reents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
US5612027A (en) | 1995-04-18 | 1997-03-18 | Galin; Miles A. | Controlled release of miotic and mydriatic drugs in the anterior chamber |
US5972326A (en) | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
US6369116B1 (en) * | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
AU706541B2 (en) | 1995-06-09 | 1999-06-17 | Euro-Celtique S.A. | Formulations and methods for providing prolonged local anesthesia |
US5906920A (en) * | 1995-08-29 | 1999-05-25 | The Salk Institute For Biological Studies | Methods for the detection of ligands for retinoid X receptors |
US5776699A (en) | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
US5958954A (en) | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5877207A (en) * | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US6066675A (en) * | 1996-09-13 | 2000-05-23 | The Regents Of The University Of California | Method for treatment of retinal diseases |
US5913884A (en) * | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
US6270749B1 (en) | 1996-12-11 | 2001-08-07 | Pharmacyclics, Inc. | Use of Texaphyrin in ocular diagnosis and therapy |
US6274614B1 (en) | 1997-02-11 | 2001-08-14 | Qlt Inc. | Methods, compositions and articles for reducing or preventing the effects of inflammation |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
JP2002511868A (ja) * | 1997-06-30 | 2002-04-16 | アラーガン・セイルズ・インコーポレイテッド | 増殖性硝子体網膜症を治療するためのカルシウム遮断薬 |
WO1999007418A2 (en) * | 1997-08-11 | 1999-02-18 | Allergan Sales, Inc. | Sterile bioerodible implant device with improved biocompatability and method |
US6306426B1 (en) * | 1997-08-11 | 2001-10-23 | Allergan Sales, Inc. | Implant device with a retinoid for improved biocompatibility |
FR2767699A1 (fr) * | 1997-08-28 | 1999-02-26 | Oreal | Composition filmogene epaissie |
US6207713B1 (en) * | 1997-09-17 | 2001-03-27 | Eric T. Fossel | Topical and oral delivery of arginine to cause beneficial effects |
US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
US6271220B1 (en) | 1998-03-11 | 2001-08-07 | Allergan Sales, Inc. | Anti-angiogenic agents |
EP1100366B1 (en) | 1998-07-09 | 2009-04-15 | Curelight Medical Ltd | Apparatus and method for efficient high energy photodynamic therapy of acne vulgaris and seborrhea |
WO2000030698A1 (en) | 1998-11-20 | 2000-06-02 | University Of Connecticut | Apparatus and method for control of tissue/implant interactions |
US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US6482854B1 (en) | 1999-03-25 | 2002-11-19 | Massachusetts Eye And Ear Infirmary | Glaucoma treatment |
US6290713B1 (en) | 1999-08-24 | 2001-09-18 | Thomas A. Russell | Flexible illuminators for phototherapy |
US6317616B1 (en) | 1999-09-15 | 2001-11-13 | Neil David Glossop | Method and system to facilitate image guided surgery |
KR100732262B1 (ko) * | 1999-10-21 | 2007-06-25 | 알콘, 인코퍼레이티드 | 약물 전달 장치 |
US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US6728918B1 (en) | 1999-11-01 | 2004-04-27 | Matsushita Electric Industrial Co., Ltd. | Relay transmission method and system, and device used thereof |
US6319273B1 (en) | 1999-12-16 | 2001-11-20 | Light Sciences Corporation | Illuminating device for treating eye disease |
US6395787B1 (en) * | 2000-02-08 | 2002-05-28 | Allergan Sales, Inc. | Ocular hypotensive lipids |
ES2311507T3 (es) * | 2000-02-10 | 2009-02-16 | MASSACHUSETTS EYE & EAR INFIRMARY | Terapia fotodinamica para tratamiento de afecciones oftalmicas. |
US7708711B2 (en) | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
US20040208910A1 (en) | 2000-04-26 | 2004-10-21 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of adrenergic agents |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
JP4927298B2 (ja) * | 2000-07-14 | 2012-05-09 | アラーガン、インコーポレイテッド | α−2−アドレナリンアゴニスト成分を含有する組成物 |
US6357568B1 (en) * | 2000-09-27 | 2002-03-19 | Shou Mao Chen | Structure for protecting a luggage shell |
AU2002248284A1 (en) | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
AU2002236495B2 (en) * | 2000-11-29 | 2006-05-11 | Allergan, Inc. | Intraocular implants for preventing transplant rejection in the eye |
US6595945B2 (en) | 2001-01-09 | 2003-07-22 | J. David Brown | Glaucoma treatment device and method |
US6713081B2 (en) * | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
JP2004536631A (ja) * | 2001-05-03 | 2004-12-09 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 移植可能な薬物送達デバイスおよびその使用 |
TWI298257B (en) * | 2001-05-31 | 2008-07-01 | Allergan Inc | Hypotensive lipid and timolol compositions and methods of using same |
US6713268B2 (en) | 2001-06-26 | 2004-03-30 | Allergan, Inc. | Methods of identifying ocular hypotensive compounds having reduced hyperpigmentation |
US20030220376A1 (en) | 2001-08-10 | 2003-11-27 | Pharmacia Corporation | Methods for treating carbonic anhydrase mediated disorders |
US7749528B2 (en) * | 2001-08-29 | 2010-07-06 | Ricardo Azevedo Pontes De Carvalho | Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues |
GB0122318D0 (en) | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
US20030225152A1 (en) | 2001-09-27 | 2003-12-04 | Andrews Steven W. | 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
WO2003092665A2 (en) | 2002-05-02 | 2003-11-13 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
ATE546143T1 (de) | 2002-08-29 | 2012-03-15 | Santen Pharmaceutical Co Ltd | Mittel zur behandlung von glaukom mit einem rho- kinase-hemmer und prostaglandinen |
ES2400852T3 (es) * | 2002-09-18 | 2013-04-12 | Allergan Inc. | Aparato para el aporte de implantes oculares |
US6899717B2 (en) * | 2002-09-18 | 2005-05-31 | Allergan, Inc. | Methods and apparatus for delivery of ocular implants |
DE60325511D1 (de) | 2002-11-06 | 2009-02-05 | Alza Corp | Depot-formulierungen mit verzögerter freisetzung |
JP2004196787A (ja) * | 2002-12-04 | 2004-07-15 | Santen Pharmaceut Co Ltd | 結膜下デポによるドラッグデリバリーシステム |
US20040137059A1 (en) | 2003-01-09 | 2004-07-15 | Thierry Nivaggioli | Biodegradable ocular implant |
US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
US7186744B2 (en) * | 2003-11-13 | 2007-03-06 | Allergan, Inc. | Prostamides for the treatment of glaucoma and related diseases |
EP1711186A4 (en) | 2004-02-04 | 2009-03-18 | Retmed Pty Ltd | SLOWLY RELEASED STEROID COMPOSITION |
US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US20050244471A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Estradiol derivative and estratopone containing sustained release intraocular implants and related methods |
US20050244478A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Anti-excititoxic sustained release intraocular implants and related methods |
US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
US20050244465A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Drug delivery systems and methods for treatment of an eye |
US20050244466A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Photodynamic therapy in conjunction with intraocular implants |
US8147865B2 (en) * | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US20050244462A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Devices and methods for treating a mammalian eye |
US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US7799336B2 (en) * | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
US20060182781A1 (en) | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Methods for treating ocular conditions with cyclic lipid contraining microparticles |
US20050244461A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Controlled release drug delivery systems and methods for treatment of an eye |
US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
US20050244458A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
US7589057B2 (en) | 2004-04-30 | 2009-09-15 | Allergan, Inc. | Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems |
US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
US7091231B2 (en) | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
NZ560691A (en) | 2005-03-10 | 2011-03-31 | Allergan Inc | Substituted gamma lactams as therapeutic agents |
US7427685B2 (en) * | 2005-12-06 | 2008-09-23 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
US7585895B2 (en) | 2005-12-06 | 2009-09-08 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
ZA200804496B (en) * | 2005-12-16 | 2009-09-30 | Alcon Inc | Control of intraocular pressure using ALK5 modulation agents |
WO2007084582A2 (en) | 2006-01-17 | 2007-07-26 | Forsight Labs, Llc | Drug delivery treatment device |
KR20140093764A (ko) * | 2006-02-09 | 2014-07-28 | 산텐 세이야꾸 가부시키가이샤 | 안정한 제제와 그 제조 및 사용 방법 |
US7592364B2 (en) | 2006-02-28 | 2009-09-22 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
US9039761B2 (en) * | 2006-08-04 | 2015-05-26 | Allergan, Inc. | Ocular implant delivery assemblies with distal caps |
US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
US8846073B2 (en) * | 2006-12-19 | 2014-09-30 | Allergan, Inc. | Low temperature processes for making cyclic lipid implants for intraocular use |
US7589213B2 (en) | 2007-04-27 | 2009-09-15 | Old David W | Therapeutic substituted lactams |
US8231892B2 (en) | 2007-05-24 | 2012-07-31 | Allergan, Inc. | Biodegradable drug delivery system |
US7947732B2 (en) | 2007-07-13 | 2011-05-24 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
US7740604B2 (en) | 2007-09-24 | 2010-06-22 | Ivantis, Inc. | Ocular implants for placement in schlemm's canal |
IL186598A0 (en) | 2007-10-11 | 2008-11-03 | Mohammad Abdulrazik | Composition and method for the treatment or prevention of glaucoma and ocular hypertension |
CA2705150C (en) | 2007-11-09 | 2016-06-14 | Allergan, Inc. | Substituted cyclopentanes having prostaglandin activity |
JP5524181B2 (ja) | 2008-04-24 | 2014-06-18 | アラーガン インコーポレイテッド | 治療剤としての置換ガンマラクタム |
EP2296621A1 (en) | 2008-05-20 | 2011-03-23 | Yale University | Biodegradable sustained-release polymeric microparticulates comprising a hydrophobic drug and determined for ophthalmic use |
US20100098772A1 (en) * | 2008-10-21 | 2010-04-22 | Allergan, Inc. | Drug delivery systems and methods for treating neovascularization |
US20100104654A1 (en) * | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
US9095506B2 (en) * | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
WO2010093945A2 (en) * | 2009-02-13 | 2010-08-19 | Glaukos Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
US20100247606A1 (en) * | 2009-03-25 | 2010-09-30 | Allergan, Inc. | Intraocular sustained release drug delivery systems and methods for treating ocular conditions |
KR102126007B1 (ko) | 2010-01-22 | 2020-06-24 | 알러간, 인코포레이티드 | 전방내 서방성 치료제 이식물 |
US20130071349A1 (en) * | 2010-03-02 | 2013-03-21 | Allergan, Inc. | Biodegradable polymers for lowering intraocular pressure |
-
2010
- 2010-04-16 US US12/761,765 patent/US8673341B2/en active Active
-
2011
- 2011-04-14 CN CN202010034408.6A patent/CN111450041A/zh active Pending
- 2011-04-14 HU HUE14194703A patent/HUE033186T2/en unknown
- 2011-04-14 ES ES14194703.6T patent/ES2617285T3/es active Active
- 2011-04-14 SI SI201130419T patent/SI2558081T1/sl unknown
- 2011-04-14 MX MX2012012040A patent/MX2012012040A/es active IP Right Grant
- 2011-04-14 EP EP18187001.5A patent/EP3456323A1/en not_active Withdrawn
- 2011-04-14 DK DK11717096T patent/DK2558081T3/da active
- 2011-04-14 CA CA2796443A patent/CA2796443C/en active Active
- 2011-04-14 SI SI201131645T patent/SI3205333T1/sl unknown
- 2011-04-14 KR KR1020127029910A patent/KR101915326B1/ko active IP Right Grant
- 2011-04-14 PL PL11717096T patent/PL2558081T3/pl unknown
- 2011-04-14 SI SI201131120A patent/SI2902018T1/sl unknown
- 2011-04-14 DK DK16201104.3T patent/DK3205333T3/da active
- 2011-04-14 SG SG10201606415UA patent/SG10201606415UA/en unknown
- 2011-04-14 HU HUE16201104A patent/HUE040529T2/hu unknown
- 2011-04-14 KR KR1020187030085A patent/KR102252437B1/ko active IP Right Grant
- 2011-04-14 PT PT16201104T patent/PT3205333T/pt unknown
- 2011-04-14 JP JP2013505123A patent/JP5982360B2/ja active Active
- 2011-04-14 TR TR2018/20663T patent/TR201820663T4/tr unknown
- 2011-04-14 ES ES11717096.9T patent/ES2528117T3/es active Active
- 2011-04-14 PL PL14194703T patent/PL2902018T3/pl unknown
- 2011-04-14 AU AU2011239642A patent/AU2011239642B2/en active Active
- 2011-04-14 WO PCT/US2011/032393 patent/WO2011130462A2/en active Application Filing
- 2011-04-14 EP EP14194703.6A patent/EP2902018B1/en active Active
- 2011-04-14 RU RU2012147550/15A patent/RU2586298C2/ru active
- 2011-04-14 PL PL16201104T patent/PL3205333T3/pl unknown
- 2011-04-14 DK DK14194703.6T patent/DK2902018T3/da active
- 2011-04-14 CA CA3010374A patent/CA3010374A1/en not_active Abandoned
- 2011-04-14 ES ES16201104T patent/ES2707801T3/es active Active
- 2011-04-14 EP EP23202362.2A patent/EP4316594A3/en active Pending
- 2011-04-14 SG SG2012077079A patent/SG184905A1/en unknown
- 2011-04-14 CN CN201180027636.XA patent/CN103002884B/zh active Active
- 2011-04-14 BR BR112012026535A patent/BR112012026535A2/pt not_active Application Discontinuation
- 2011-04-14 PT PT117170969T patent/PT2558081E/pt unknown
- 2011-04-14 PT PT141947036T patent/PT2902018T/pt unknown
- 2011-04-14 EP EP11717096.9A patent/EP2558081B1/en active Active
- 2011-04-14 EP EP16201104.3A patent/EP3205333B1/en active Active
-
2012
- 2012-10-15 IL IL222457A patent/IL222457A/en active IP Right Grant
-
2014
- 2014-03-07 US US14/201,194 patent/US20140316009A1/en not_active Abandoned
-
2015
- 2015-01-21 CY CY20151100056T patent/CY1115912T1/el unknown
-
2016
- 2016-06-03 JP JP2016111665A patent/JP6416154B2/ja active Active
-
2017
- 2017-02-24 CY CY20171100261T patent/CY1120299T1/el unknown
-
2018
- 2018-10-03 JP JP2018188114A patent/JP6683787B2/ja active Active
- 2018-12-27 CY CY181101399T patent/CY1121064T1/el unknown
-
2020
- 2020-03-26 JP JP2020055435A patent/JP6946503B2/ja active Active
-
2021
- 2021-09-15 JP JP2021150124A patent/JP2022000441A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2558081T3 (da) | Reduktion af intraokulært tryk med intrakamerale bimatoprost-implantater | |
US10278919B2 (en) | Intracameral sustained release therapeutic agent implants | |
US20230026451A1 (en) | Intraocular pressure reduction with intracameral bimatoprost implants | |
AU2018366214A1 (en) | Sustained-release implants for lowering intraocular pressure with extended duration of effect |