DK2520654T3 - Inhibitorer for serinproteaseaktivitet og disses anvendelse i fremgangsmåder og sammensætninger til behandling af bakterielle infektioner - Google Patents

Inhibitorer for serinproteaseaktivitet og disses anvendelse i fremgangsmåder og sammensætninger til behandling af bakterielle infektioner Download PDF

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DK2520654T3
DK2520654T3 DK12003146.3T DK12003146T DK2520654T3 DK 2520654 T3 DK2520654 T3 DK 2520654T3 DK 12003146 T DK12003146 T DK 12003146T DK 2520654 T3 DK2520654 T3 DK 2520654T3
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seq
aat
antitrypsin
serine protease
nucleic acid
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DK12003146.3T
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English (en)
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Leland Shapiro
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Univ Colorado Regents
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/473—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used alpha-Glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (10)

1. Farmaceutisk sammensætning omfattende en farmaceutisk acceptabel bærer, excipiens eller diluent og et fusionsprotein, hvor den farmaceutiske sammensætning er til anvendelse i en fremgangsmåde til behandling af et subjekt, som har behov for AAT terapi eller som har en bakteriel infektion, eller som har en mycobakteriel infektion, hvor fusionsproteinet omfatter mammalt alpha-1 antitrypsin (AAT) eller et peptidfragment deraf, hvor peptidfragmentet består af en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 1, SEQ ID NO: 16, SEQ ID NO: 56, SEQ ID NO:
57, SEQ ID NO: 58 og SEQ ID NO: 59, og en immunoglobulin-konstant region, hvor AAT peptidfragmentet inhiberer serinproteaseaktivitet.
2. Farmaceutisk sammensætning omfattende en farmaceutisk acceptabel bærer, excipiens eller diluent og en nukleinsyre, som koder for et fusionsprotein, hvor den farmaceutiske sammensætning er til anvendelse i en fremgangsmåde til behandling af et subjekt, som har behov for AAT terapi eller som har en bakteriel infektion eller som har en mycobakteriel infektion, hvor fusionsproteinet omfatter mammalt alpha-1 antitrypsin (AAT) eller et peptidfragment deraf, hvor peptidfragmentet består af en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 1, SEQ ID NO: 16, SEQ ID NO: 56, SEQ ID NO: 57, SEQ ID NO: 58 og SEQ ID NO:59, og en immunoglobulin-konstant region, hvor AAT peptidfragmentet inhiberer serinproteaseaktivitet.
3. Nukleinsyre, som koder for et fusionsprotein til anvendelse som et medikament, hvor nukleinsyren koder fusionsproteinet omfattende mammalt alpha-1 antitrypsin (AAT) eller et peptidfragment deraf, hvor peptidfragmentet består af en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 1, SEQ ID NO: 16, SEQ ID NO: 56, SEQ ID NO: 57, SEQ ID NO: 58 og SEQ ID NO: 59, og en immunoglobulin-konstant region, hvor AAT peptidfragmentet inhiberer serinproteaseaktivitet.
4. Farmaceutisk sammensætning til anvendelse ifølge krav 1 og 2, og nukleinsyren til anvendelse ifølge krav 3, hvor det mammale alpha-1 antitrypsin (AAT) omfatter naturligt forekommende mammalt alpha-1 antitrypsin (AAT).
5. Farmaceutisk sammensætning til anvendelse ifølge krav 1 og 2, og nukleinsyren til anvendelse ifølge krav 3, hvor den immunoglobulin-konstante region omfatter en human lgG1 konstant region.
6. Farmaceutisk sammensætning til anvendelse ifølge krav 5, og nukleinsyren til anvendelse ifølge krav 5, hvor den nævnte lgG1 konstante region er modificeret og hvor den modificerede lgG1 konstante region ikke binder Fc receptoren og/eller ikke initierer antistof-afhængige cellulære cytotoksicitetsreaktioner (ADCC).
7. Farmaceutisk sammensætning til anvendelse ifølge krav 1 og 2 og nukleinsyren til anvendelse ifølge krav 3, hvor den nævnte mammale alpha-1 antitrypsin (AAT) eller det nævnte peptidfragment deraf er fusioneret til amino-terminus eller carboxyl-terminus på en immunoglobulin-konstant region.
8. Farmaceutisk sammensætning til anvendelse ifølge krav 7, og nukleinsyren til anvendelse ifølge krav 7, hvor den nævnte immunoglobulin-konstante region omfatter Fc regionen.
9. Farmaceutisk sammensætning til anvendelse ifølge krav 8 og nukleinsyren til anvendelse ifølge krav 8, hvor Fc regionen af immunoglobulin er vildt-type Fc eller en mutant Fc.
10. Nukleinsyre til anvendelse ifølge ethvert af kravene 3 til 9, hvor nukleinsyren er til anvendelse ved en fremgangsmåde til behandling af et subjekt med behov for AAT terapi eller som har en bakteriel infektion eller som har en mycobakteriel infektion.
DK12003146.3T 2003-08-26 2004-08-26 Inhibitorer for serinproteaseaktivitet og disses anvendelse i fremgangsmåder og sammensætninger til behandling af bakterielle infektioner DK2520654T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49770303P 2003-08-26 2003-08-26
EP04801916A EP1660094A4 (en) 2003-08-26 2004-08-26 INHIBITORS OF SERINE PROTEASE ACTIVITY AND USES THEREOF IN METHODS AND PREPARATIONS FOR TREATING BACTERIAL INFECTIONS

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DK2520654T3 true DK2520654T3 (da) 2017-05-01

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US (8) US7850970B2 (da)
EP (3) EP3192872A1 (da)
JP (1) JP2007504144A (da)
CA (1) CA2536918A1 (da)
DK (1) DK2520654T3 (da)
ES (1) ES2622522T3 (da)
PL (1) PL2520654T3 (da)
WO (1) WO2005019434A2 (da)

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