AU6977096A - Ketomethylene group-containing cysteine and serine protease inhibitors - Google Patents
Ketomethylene group-containing cysteine and serine protease inhibitorsInfo
- Publication number
- AU6977096A AU6977096A AU69770/96A AU6977096A AU6977096A AU 6977096 A AU6977096 A AU 6977096A AU 69770/96 A AU69770/96 A AU 69770/96A AU 6977096 A AU6977096 A AU 6977096A AU 6977096 A AU6977096 A AU 6977096A
- Authority
- AU
- Australia
- Prior art keywords
- protease inhibitors
- serine protease
- containing cysteine
- ketomethylene group
- ketomethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 Ketomethylene group Chemical group 0.000 title 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 title 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title 1
- 235000018417 cysteine Nutrition 0.000 title 1
- 239000002852 cysteine proteinase inhibitor Substances 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US367895P | 1995-09-14 | 1995-09-14 | |
| US003678 | 1995-09-14 | ||
| US646513 | 1996-05-07 | ||
| US646071 | 1996-05-07 | ||
| US08/646,513 US5723580A (en) | 1995-09-14 | 1996-05-07 | Ketomethylene group-containing aldehyde cysteine and serine protease inhibitors |
| US08/646,071 US5827877A (en) | 1995-09-14 | 1996-05-07 | Ketomethylene group-containing cysteine and serine protease inhibitors |
| PCT/US1996/014719 WO1997010231A1 (en) | 1995-09-14 | 1996-09-13 | Ketomethylene group-containing cysteine and serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU6977096A true AU6977096A (en) | 1997-04-01 |
Family
ID=27357460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU69770/96A Abandoned AU6977096A (en) | 1995-09-14 | 1996-09-13 | Ketomethylene group-containing cysteine and serine protease inhibitors |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU6977096A (en) |
| WO (1) | WO1997010231A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291640B1 (en) | 1996-12-27 | 2001-09-18 | Boehringer Ingelheim Ltd. | Peptidomimetic inhibitors of the human cytomegalovirus protease |
| DE19818614A1 (en) | 1998-04-20 | 1999-10-21 | Basf Ag | New benzamide derivatives useful as cysteine protease inhibitors for treating neurodegenerative diseases, neuronal damage, stroke, cranial trauma, Alzheimer's disease, etc. |
| AU3511500A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| EP3192872A1 (en) | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| JP4777908B2 (en) | 2004-02-02 | 2011-09-21 | コア・ダイナミクス・リミテッド | Biological materials and methods and solutions for storage of biological materials |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2848232B2 (en) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | Aldehyde derivatives |
| US5498616A (en) * | 1994-11-04 | 1996-03-12 | Cephalon, Inc. | Cysteine protease and serine protease inhibitors |
| US5545640A (en) * | 1995-04-04 | 1996-08-13 | Bio-Mega/Boehringer Ingeleheim Research Inc. | Protease inhibiting succinic acid derivatives |
-
1996
- 1996-09-13 AU AU69770/96A patent/AU6977096A/en not_active Abandoned
- 1996-09-13 WO PCT/US1996/014719 patent/WO1997010231A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997010231A1 (en) | 1997-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU4236796A (en) | Cysteine protease and serine protease inhibitors | |
| AU5122196A (en) | Cysteine protease inhibitor | |
| AU3972697A (en) | Inhibitors of cysteine protease | |
| AU7127298A (en) | Serine protease inhibitors | |
| AU5481498A (en) | Benzamidoaldehydes and their use as cysteine protease inhibitors | |
| ZA964751B (en) | Reversible cysteine protease inhibitors | |
| ZA951573B (en) | Cysteine protease inhibitors | |
| ZA983629B (en) | Serine protease inhibitors | |
| EP1021199A4 (en) | PEPTIDE-CONTAINING $g(a)-KETOAMIDE CYSTEINE AND SERINE PROTEASE INHIBITORS | |
| HUP9901187A3 (en) | Serine protease inhibitors | |
| AU1795697A (en) | Serine protease inhibitors | |
| AU7179598A (en) | Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors | |
| EP0923535A4 (en) | Inhibitors of cysteine protease | |
| AU1877597A (en) | Serine protease inhibitors | |
| AU2577699A (en) | Human serine protease and serpin polypeptides | |
| HK1039276A1 (en) | Hydroxamate-containing cysteine and serine protease inhibitors | |
| AU9624398A (en) | Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors | |
| AU4672996A (en) | Serine protease inhibitors | |
| AU6977096A (en) | Ketomethylene group-containing cysteine and serine protease inhibitors | |
| AU7133898A (en) | Nanosized aspartyl protease inhibitors | |
| AU9300298A (en) | Protease inhibitors | |
| AU4169997A (en) | Thiomethylene group-containing aldehyde cysteine and serine protease inhibitors | |
| AU7252398A (en) | Protease inhibitors | |
| AU3042597A (en) | Serine protease inhibitors | |
| AU9536198A (en) | Furopyrrolidine derivatives and their use as serine protease inhibitors |