DK2516469T3 - ANTI-HER3-antistoffer og anvendelser deraf - Google Patents
ANTI-HER3-antistoffer og anvendelser deraf Download PDFInfo
- Publication number
- DK2516469T3 DK2516469T3 DK10798541.8T DK10798541T DK2516469T3 DK 2516469 T3 DK2516469 T3 DK 2516469T3 DK 10798541 T DK10798541 T DK 10798541T DK 2516469 T3 DK2516469 T3 DK 2516469T3
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- DK
- Denmark
- Prior art keywords
- ser
- leu
- val
- antibody
- gly
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (14)
1. Antistof der binder til humant HER3, kendetegnet ved at det tungkæde-variable domæne VH er SEQ ID NO:8; og det letkæde-variable domæne VL er SEQ ID NO:9, eller det letkæde-variable domæne VL er SEQ ID NO: 10, eller det letkæde-variable domæne VL er SEQ ID NO: 11.
2. Antistoffet ifølge krav 1, kendetegnet ved at det tungkæde-variable domæne VH er SEQ ID NO:8; og det letkæde-variable domæne VL er SEQ ID NO:9, eller det letkæde-variable domæne VL er SEQ ID NO: 11.
3. Antistoffet ifølge krav 1, kendetegnet ved at det tungkæde-variable domæne VH er SEQ ID NO:8; og det letkæde-variable domæne VL er SEQ ID NO: 10.
4. Antistoffet ifølge et hvilket som helst af kravene 1 til 3, kendetegnet ved at antistoffet er monoklonalt.
5. Antistoffet ifølge et hvilket som helst af kravene 1 til 4, kendetegnet ved at antistoffet er af IgGl-underklasse.
6. Antistoffet ifølge et hvilket som helst af kravene 1 til 5, kendetegnet ved at antistoffet er glycosyleret med en sukkerkæde ved Asn297 hvorved mængden af fucose i denne sukkerkæde er 65% eller derunder.
7. Antistoffet ifølge krav 6, hvorved mængden af fucose i denne sukkerkæde er mellem 5 og 65%.
8. Farmaceutisk sammensætning kendetegnet ved at omfatte et antistof ifølge et hvilket som helst af kravene 1 til 7.
9. Antistof ifølge et hvilket som helst af kravene 1 til 7 til anvendelse i behandlingen af cancer.
10. Anvendelse af et antistof ifølge et hvilket som helst af kravene 1 til 7 til fremstillingen af et medikament til behandlingen af cancer.
11. Nukleinsyre der koder for en tung- og letkæde af et antistof der binder til humant HER3, kendetegnet ved at antistoffet omfatter et variabelt domæne VH af SEQ ID NO:8; og et let kæde-variabelt domæne VL af SEQ ID NO:9, SEQ ID NO: 10, eller SEQ ID NO:ll.
12. Ekspressionsvektor kendetegnet ved at omfatte en nukleinsyre ifølge krav 11 til ekspression af antistoffet ifølge et hvilket som helst af kravene 1 til 7 i en prokaryot eller eukaryot værtscelle.
13. Prokaryot eller eukaryot værtscelle omfattende en vektor ifølge krav 12.
14. Fremgangsmåde til fremstillingen af et rekombinant antistof ifølge kravene 1 til 7, kendetegnet ved ekspression afen nukleinsyre ifølge krav 11 i en prokaryot eller eukaryot værtscelle og genvinde antistoffet fra cellen eller cellekultursupernatanten.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09015831 | 2009-12-22 | ||
| PCT/EP2010/070062 WO2011076683A1 (en) | 2009-12-22 | 2010-12-17 | Anti-her3 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2516469T3 true DK2516469T3 (da) | 2016-05-02 |
Family
ID=42126432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10798541.8T DK2516469T3 (da) | 2009-12-22 | 2010-12-17 | ANTI-HER3-antistoffer og anvendelser deraf |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US8859737B2 (da) |
| EP (1) | EP2516469B1 (da) |
| JP (2) | JP5680671B2 (da) |
| KR (2) | KR20140130751A (da) |
| CN (1) | CN102822201B (da) |
| AR (1) | AR079551A1 (da) |
| AU (1) | AU2010335282B2 (da) |
| BR (1) | BR112012015255A2 (da) |
| CA (1) | CA2782571C (da) |
| CL (1) | CL2012001649A1 (da) |
| CO (1) | CO6551674A2 (da) |
| CR (1) | CR20120284A (da) |
| CY (1) | CY1117563T1 (da) |
| DK (1) | DK2516469T3 (da) |
| EC (1) | ECSP12011995A (da) |
| ES (1) | ES2571226T3 (da) |
| HK (1) | HK1175183A1 (da) |
| HR (1) | HRP20160737T1 (da) |
| HU (1) | HUE029026T2 (da) |
| IL (1) | IL220162A (da) |
| MA (1) | MA33892B1 (da) |
| MX (1) | MX2012007340A (da) |
| MY (1) | MY161909A (da) |
| NZ (1) | NZ600262A (da) |
| PE (1) | PE20121616A1 (da) |
| PL (1) | PL2516469T3 (da) |
| RS (1) | RS54795B1 (da) |
| RU (1) | RU2560583C2 (da) |
| SG (1) | SG181894A1 (da) |
| SI (1) | SI2516469T1 (da) |
| TW (1) | TWI421092B (da) |
| UA (1) | UA107821C2 (da) |
| WO (1) | WO2011076683A1 (da) |
Families Citing this family (38)
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| AR075896A1 (es) | 2009-03-20 | 2011-05-04 | Genentech Inc | Anticuerpos anti-her (factor de crecimiento epidermico) |
| MX2011010166A (es) * | 2009-04-07 | 2011-10-11 | Roche Glycart Ag | Anticuerpos biespecificos anti-erbb-3/anti-c-met. |
| SI2516469T1 (sl) * | 2009-12-22 | 2016-05-31 | Roche Glycart Ag | Protitelesa proti her3 in uporabe le-teh |
| MX348739B (es) | 2010-03-10 | 2017-06-27 | F Hoffmann-La Roche Ag * | Metodo para purificar soluciones de inmunoglobulina. |
| ES2566602T3 (es) | 2010-04-09 | 2016-04-14 | Aveo Pharmaceuticals, Inc. | Anticuerpos anti-ErbB3 |
| JP6057896B2 (ja) | 2010-08-20 | 2017-01-11 | ノバルティス アーゲー | 上皮細胞増殖因子受容体３（ｈｅｒ３）に対する抗体 |
| ITRM20100577A1 (it) * | 2010-11-02 | 2012-05-03 | Takis Srl | Immunoterapia contro il recettore erbb-3 |
| US20120258073A1 (en) | 2011-02-10 | 2012-10-11 | Christian Gerdes | Immunotherapy |
| JP2014509593A (ja) | 2011-03-15 | 2014-04-21 | メリマック ファーマシューティカルズ インコーポレーティッド | ＥｒｂＢ経路阻害剤に対する耐性の克服 |
| BR112013027021A2 (pt) | 2011-04-19 | 2016-11-29 | Merrimack Pharmaceuticals Inc | anticorpos anti-igf-1r e anti-erbb3 monoespecíficos e biespecíficos |
| PL2748202T3 (pl) | 2011-08-23 | 2018-12-31 | Roche Glycart Ag | Dwuswoiste cząsteczki wiążące antygen |
| BR112014007382A2 (pt) | 2011-09-30 | 2017-04-04 | Regeneron Pharma | anticorpos anti-erbb3 e seus usos |
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