DK2544680T3 - Anvendelse af erbb3-hæmmere i behandlingen af triple-negativ brystcancer - Google Patents

Anvendelse af erbb3-hæmmere i behandlingen af triple-negativ brystcancer Download PDF

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DK2544680T3
DK2544680T3 DK11730112T DK11730112T DK2544680T3 DK 2544680 T3 DK2544680 T3 DK 2544680T3 DK 11730112 T DK11730112 T DK 11730112T DK 11730112 T DK11730112 T DK 11730112T DK 2544680 T3 DK2544680 T3 DK 2544680T3
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inhibitor
antibody
erbb3
seq
sequence
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Victor Moyo
Gabriela Garcia
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Merrimack Pharmaceuticals Inc
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Claims (15)

1. ErbB3-hæmmer til anvendelse i en fremgangsmåde til behandling af triple-negativ brystcancer, hvor hæmmeren er et anti-ErbB3-antistof.
2. Hæmmer til anvendelse ifølge krav 1, hvor anti-ErbB3-antistoffet omfatter, i aminoterminal til carboxyterminal orden, en Vh CDR1-sekvens som vist i SEQ ID NO: 3, en Vh CDR2-sekvens som vist i SEQ ID NO: 4 og en Vh CDR3-sekvens som vist i SEQ ID NO: 5, og i aminoterminal til carboxyterminal orden, en VL CDR1-sekvens som vist i SEQ ID NO: 6, en V|_ CDR2-sekvens som vist i SEQ ID NO: 7 og en VL CDR3-sekvens som vist i SEQ ID NO: 8.
3. Hæmmer til anvendelse ifølge krav 1, hvor anti-ErbB3-antistoffet er udvalgt fra: (a) et antistof omfattende en Vn-sekvens som vist i SEQ ID NO: 1 og en Vi_-sekvens som vist i SEQ ID NO: 2; (b) et antistof omfattende en VH-sekvens som vist i SEQ ID NO: 9 og en VL-sekvens som vist i SEQ ID NO: 10; (c) et antistof omfattende en VH-sekvens som vist i SEQ ID NO: 17 og en VL-sekvens som vist i SEQ ID NO: 18 og (d) et antistof omfattende en VH-sekvens som vist i SEQ ID NO: 25 og en VL-sekvens som vist i SEQ ID NO: 26.
4. Hæmmer til anvendelse ifølge et hvilket som helst af kravene 1 til 3, hvor den triple-negative brystcancertumor histopatologisk er kendetegnet ved at have: (i) en basal-lignende fænotype eller (ii) en anden fænotype end basal-lignende.
5. Hæmmer til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor fremgangsmåden endvidere omfatter administration af det mindst ene supplerende anticancermiddel.
6. Hæmmer til anvendelse ifølge krav 5, hvor det supplerende anticancermid-del ikke er en ErbB3-hæmmer.
7. Hæmmer til anvendelse ifølge krav 5 eller 6, hvor det mindst ene supplerende anticancermiddel er udvalgt fra platinbaserede kemoterapimidler, taxaner, tyrosinkinasehæmmere, anti-EGFR-antistoffer, anti-ErbB2-antistoffer, kombinationer deraf, EGFR-hæmmere og VEGF-hæmmere.
8. Hæmmer til anvendelse ifølge krav 7, hvor det mindst ene supplerende anticancermiddel er paclitaxel.
9. Hæmmer til anvendelse ifølge krav 7, hvor det mindst ene supplerende anticancermiddel er et anti-EGFR-antistof.
10. Hæmmer til anvendelse ifølge krav 9, hvor anti-EGFR-antistoffet er udvalgt fra cetuximab, matuzumab, panitumumab, nimotuzumab og mAb 806.
11. Hæmmer til anvendelse ifølge krav 7, hvor EGFR-hæmmeren er en lille molekylær hæmmer af EGFR-signalering udvalgt fra gefitinib, lapatinib, canerti-nib, pelitinib, erlotinib HCL, PKI-166, PD158780 og AG 1478.
12. Hæmmer til anvendelse ifølge krav 7, hvor VEGF-hæmmeren omfatter be-vacizumab.
13. Hæmmer til anvendelse ifølge et hvilket som helst af kravene 1 til 3, hvor den triple-negative brystcancertumor er en tumor, hvori tumorcellerne reagerer negativt på østrogen receptor (ER) og progesteronreceptor og giver et testresultat på 0, 1 +, eller 2+ ved anvendelse af et sem i kvantitativt immunhistokemisk assay ved anvendelse af et polyklonalt anti-HER2 primært antistof.
14. Hæmmer til anvendelse ifølge krav 13, hvor tumorcellerne er negative i FISH-test for HER2-genamplifikation.
15. Anvendelse af en ErbB3-hæmmer til fremstilling af et medikament til behandling af triple-negativ brystcancer, hvor hæmmeren er et ErbB3-antistof.
DK11730112T 2010-03-11 2011-03-11 Anvendelse af erbb3-hæmmere i behandlingen af triple-negativ brystcancer DK2544680T3 (da)

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US31289510P 2010-03-11 2010-03-11
PCT/US2011/028129 WO2011112953A2 (en) 2010-03-11 2011-03-11 Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers

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US (4) US8895001B2 (da)
EP (2) EP2859893A1 (da)
JP (2) JP2013522237A (da)
KR (1) KR101798679B1 (da)
CN (1) CN102858335B (da)
AU (1) AU2011224186C1 (da)
BR (1) BR112012022802A2 (da)
CA (1) CA2792327C (da)
DK (1) DK2544680T3 (da)
EA (1) EA201201186A1 (da)
ES (1) ES2535503T3 (da)
HK (1) HK1174254A1 (da)
IL (1) IL221693A (da)
MX (1) MX344355B (da)
NZ (1) NZ602084A (da)
PL (1) PL2544680T3 (da)
PT (1) PT2544680E (da)
SG (1) SG183532A1 (da)
UA (1) UA111149C2 (da)
WO (1) WO2011112953A2 (da)
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