DK2486048T4 - Fremgangsmåder til fremstilling af glycoproteiner i pattedyrecellekulturer ved anvendelse af glucocorticoider - Google Patents

Fremgangsmåder til fremstilling af glycoproteiner i pattedyrecellekulturer ved anvendelse af glucocorticoider Download PDF

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Publication number
DK2486048T4
DK2486048T4 DK10765714.0T DK10765714T DK2486048T4 DK 2486048 T4 DK2486048 T4 DK 2486048T4 DK 10765714 T DK10765714 T DK 10765714T DK 2486048 T4 DK2486048 T4 DK 2486048T4
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Prior art keywords
glucocorticoids
glycoproteins
procedures
preparation
cell cultures
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DK10765714.0T
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English (en)
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DK2486048T3 (da
Inventor
Ying Jing
Zhengjian Li
Yueming Qian
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK10765714.0T 2009-10-06 2010-10-06 Fremgangsmåder til fremstilling af glycoproteiner i pattedyrecellekulturer ved anvendelse af glucocorticoider DK2486048T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27834309P 2009-10-06 2009-10-06
US12/897,857 US9540426B2 (en) 2009-10-06 2010-10-05 Mammalian cell culture processes for protein production
PCT/US2010/051552 WO2011044180A1 (en) 2009-10-06 2010-10-06 Methods of production of glycoproteins in mammalian cell cultures using glucocorticoids

Publications (2)

Publication Number Publication Date
DK2486048T3 DK2486048T3 (da) 2017-02-27
DK2486048T4 true DK2486048T4 (da) 2020-03-30

Family

ID=43823459

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10765714.0T DK2486048T4 (da) 2009-10-06 2010-10-06 Fremgangsmåder til fremstilling af glycoproteiner i pattedyrecellekulturer ved anvendelse af glucocorticoider

Country Status (26)

Country Link
US (3) US9540426B2 (da)
EP (1) EP2486048B2 (da)
JP (1) JP2013506436A (da)
KR (1) KR20120100973A (da)
CN (1) CN102753572A (da)
AR (1) AR078544A1 (da)
AU (1) AU2010303590B2 (da)
BR (1) BR112012007854A2 (da)
CA (1) CA2777050C (da)
CO (1) CO6531436A2 (da)
CY (1) CY1118734T1 (da)
DK (1) DK2486048T4 (da)
EA (2) EA025604B1 (da)
ES (1) ES2613269T5 (da)
HR (1) HRP20170269T4 (da)
HU (1) HUE031867T2 (da)
IL (1) IL219124A (da)
LT (1) LT2486048T (da)
MX (1) MX2012003654A (da)
PL (1) PL2486048T5 (da)
PT (1) PT2486048T (da)
RS (1) RS55727B2 (da)
SI (2) SI2486048T1 (da)
SM (1) SMT201700116B (da)
TW (1) TW201118176A (da)
WO (1) WO2011044180A1 (da)

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Also Published As

Publication number Publication date
RS55727B2 (sr) 2020-09-30
CA2777050A1 (en) 2011-04-14
PL2486048T3 (pl) 2017-07-31
SI2486048T1 (sl) 2017-02-28
WO2011044180A1 (en) 2011-04-14
SMT201700116B (it) 2017-03-08
AU2010303590A1 (en) 2012-05-03
ES2613269T5 (es) 2020-08-03
US9540426B2 (en) 2017-01-10
IL219124A0 (en) 2012-06-28
ES2613269T3 (es) 2017-05-23
KR20120100973A (ko) 2012-09-12
PL2486048T5 (pl) 2020-07-13
AR078544A1 (es) 2011-11-16
IL219124A (en) 2017-10-31
PT2486048T (pt) 2017-02-06
CA2777050C (en) 2016-12-20
SI2486048T2 (sl) 2020-04-30
MX2012003654A (es) 2012-04-30
CO6531436A2 (es) 2012-09-28
US20110081679A1 (en) 2011-04-07
CN102753572A (zh) 2012-10-24
LT2486048T (lt) 2017-02-10
BR112012007854A2 (pt) 2016-11-22
HRP20170269T4 (hr) 2020-04-03
AU2010303590B2 (en) 2016-07-07
EA201490631A1 (ru) 2016-05-31
US20170129937A1 (en) 2017-05-11
RS55727B1 (sr) 2017-07-31
HUE031867T2 (en) 2017-09-28
US10030064B2 (en) 2018-07-24
US10059754B2 (en) 2018-08-28
DK2486048T3 (da) 2017-02-27
JP2013506436A (ja) 2013-02-28
EA028491B1 (ru) 2017-11-30
EA201270469A1 (ru) 2012-10-30
EP2486048B2 (en) 2019-12-25
CY1118734T1 (el) 2017-07-12
HRP20170269T1 (hr) 2017-04-07
EA025604B1 (ru) 2017-01-30
EP2486048B1 (en) 2016-11-23
US20170129936A1 (en) 2017-05-11
TW201118176A (en) 2011-06-01
EP2486048A1 (en) 2012-08-15

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