DK2471954T3 - Susceptibility genetic variants associated with cardiovascular diseases - Google Patents

Susceptibility genetic variants associated with cardiovascular diseases Download PDF

Info

Publication number
DK2471954T3
DK2471954T3 DK11194162.1T DK11194162T DK2471954T3 DK 2471954 T3 DK2471954 T3 DK 2471954T3 DK 11194162 T DK11194162 T DK 11194162T DK 2471954 T3 DK2471954 T3 DK 2471954T3
Authority
DK
Denmark
Prior art keywords
risk
markers
allele
disease
marker
Prior art date
Application number
DK11194162.1T
Other languages
Danish (da)
English (en)
Inventor
Gudmar Thorleifsson
Anna Helgadottir
Andrei Manolescu
Original Assignee
Decode Genetics Ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Decode Genetics Ehf filed Critical Decode Genetics Ehf
Application granted granted Critical
Publication of DK2471954T3 publication Critical patent/DK2471954T3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK11194162.1T 2007-02-21 2008-02-21 Susceptibility genetic variants associated with cardiovascular diseases DK2471954T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IS8613 2007-02-21
IS8640 2007-04-30
IS8701 2007-12-21
EP08710293A EP2115172A1 (en) 2007-02-21 2008-02-21 Genetic susceptibility variants associated with cardiovascular disease

Publications (1)

Publication Number Publication Date
DK2471954T3 true DK2471954T3 (en) 2016-09-12

Family

ID=39432938

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11194162.1T DK2471954T3 (en) 2007-02-21 2008-02-21 Susceptibility genetic variants associated with cardiovascular diseases

Country Status (16)

Country Link
US (2) US9617597B2 (cg-RX-API-DMAC7.html)
EP (2) EP2115172A1 (cg-RX-API-DMAC7.html)
JP (1) JP5646179B2 (cg-RX-API-DMAC7.html)
KR (1) KR101571523B1 (cg-RX-API-DMAC7.html)
CN (1) CN101668865B (cg-RX-API-DMAC7.html)
AU (1) AU2008218542B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0807927A2 (cg-RX-API-DMAC7.html)
CA (1) CA2679581C (cg-RX-API-DMAC7.html)
DK (1) DK2471954T3 (cg-RX-API-DMAC7.html)
EA (1) EA022610B1 (cg-RX-API-DMAC7.html)
HU (1) HUE030996T2 (cg-RX-API-DMAC7.html)
IL (1) IL200453A (cg-RX-API-DMAC7.html)
MX (1) MX2009008878A (cg-RX-API-DMAC7.html)
NZ (1) NZ579445A (cg-RX-API-DMAC7.html)
SG (1) SG178811A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008102380A1 (cg-RX-API-DMAC7.html)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7883851B2 (en) 2007-05-02 2011-02-08 Board Of Regents, The University Of Texas System Common allele on chromosome 9 associated with coronary heart disease
JP5781767B2 (ja) 2008-01-18 2015-09-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 体液中における疾患または状態のシグネチャーを検出する方法
US20090221620A1 (en) * 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
ES2344396B1 (es) * 2009-02-24 2011-06-24 Fina Biotech Slu Marcadores geneticos del riesgo de sufrir reestenosis.
WO2010131268A1 (en) * 2009-05-11 2010-11-18 Decode Genetics Ehf Genetic variants for basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma
PT2264183T (pt) * 2009-06-09 2017-03-14 Gendiag Exe Sl Marcadores de risco para doença cardiovascular
AU2010260152A1 (en) * 2009-06-15 2012-02-02 Cardiodx, Inc. Determination of coronary artery disease risk.
WO2011159157A1 (en) * 2010-06-15 2011-12-22 Cellagenics B.V. Novel intergenic elements for enhancing gene expression
MX382244B (es) 2010-07-23 2025-03-13 Harvard College Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales
US20120040846A1 (en) 2010-07-23 2012-02-16 President And Fellows Of Harvard College Methods of Detecting Diseases or Conditions Using Phagocytic Cells
US20130184178A1 (en) 2010-07-23 2013-07-18 President And Fellows Of Harvard College Methods of Detecting Autoimmune or Immune-Related Diseases or Conditions
US20130210647A1 (en) 2010-07-23 2013-08-15 President And Fellows Of Harvard College Methods of Detecting Cardiovascular Diseases or Conditions
CA2806304A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
WO2012066582A1 (en) * 2010-11-18 2012-05-24 Decode Genetics Ehf Genetic risk factors of sick sinus syndrome
US20150044239A1 (en) * 2011-03-31 2015-02-12 Yale University Compositions and Methods for Diagnosing, Preventing and Treating Intracranial Aneurysms
US12077823B2 (en) 2011-08-05 2024-09-03 Genincode Plc Risk assessment for cardiovascular disease
DK2554679T3 (en) * 2011-08-05 2016-04-04 Gendiag Exe Sl Genetic markers for risk assessment for cardiovascular disease
WO2013032883A2 (en) * 2011-08-26 2013-03-07 Ottawa Heart Institute Research Corporation Methods of detecting and treating cardiovascular diseases
EP2861765B1 (en) 2012-06-15 2019-01-23 Progenity, Inc. Methods of detecting diseases or conditions
CA2876711A1 (en) 2012-06-15 2013-12-19 Harry Stylli Methods of detecting diseases or conditions using circulating diseased cells
MD707Z (ro) * 2013-01-18 2014-07-31 Институт Зоологии Академии Наук Молдовы Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric
EP4202441A3 (en) 2013-03-09 2023-07-26 Immunis.AI, Inc. Gene expression profile in macrophages for the diagnosis of cancer
EP3385717A3 (en) 2013-03-09 2018-10-24 Harry Stylli Methods of detecting prostate cancer
WO2014175287A1 (ja) * 2013-04-26 2014-10-30 国立大学法人 京都大学 脳動脈瘤の形成および/または増大の抑制若しくは縮小用医薬組成物
KR101602688B1 (ko) 2013-12-30 2016-03-11 가톨릭관동대학교산학협력단 microRNA-365 활성화제를 포함하는 혈관평활근세포 증식 또는 이동 억제용 약학적 조성물
CN104946731B (zh) * 2014-03-28 2019-12-20 中国中医科学院中药研究所 快速检测金银花的pcr试剂盒及检测方法
EP3191846A4 (en) 2014-09-11 2018-06-13 Harry Stylli Methods of detecting prostate cancer
US11143659B2 (en) 2015-01-27 2021-10-12 Arterez, Inc. Biomarkers of vascular disease
RU2627643C2 (ru) * 2015-08-18 2017-08-09 Государственное бюджетное учреждение "Академия наук Республики Саха(Якутия)" (ГБУ АН РС(Я) Способ прогнозирования риска субарахноидального кровоизлияния вследствие разрыва аневризмы сосудов головного мозга у лиц азиатской расы
CN106811520A (zh) * 2016-08-17 2017-06-09 上海易瑞生物科技有限公司 一种心肌梗死易感基因检测分型试剂盒及其应用
RU2693997C2 (ru) * 2017-12-04 2019-07-08 Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) Способ определения степени предрасположенности к сердечно-сосудистым заболеваниям
CN108342472A (zh) * 2018-04-13 2018-07-31 东华大学 一种冠心病易感基因检测分型试剂盒
US10468141B1 (en) 2018-11-28 2019-11-05 Asia Genomics Pte. Ltd. Ancestry-specific genetic risk scores
JPWO2020121489A1 (ja) * 2018-12-13 2021-12-02 国立研究開発法人国立循環器病研究センター 脳梗塞発症リスク予測方法
CN109486940A (zh) * 2018-12-25 2019-03-19 北京北基医学检验实验室有限公司 一种扩增颅内动脉肿瘤相关基因的引物组及检测试剂盒
CN109628577A (zh) * 2019-01-07 2019-04-16 杭州艾迪康医学检验中心有限公司 检测冠状动脉硬化相关单核苷酸多态性位点的引物和方法
KR102158720B1 (ko) * 2019-04-03 2020-09-22 한림대학교 산학협력단 Lrrc3 유전자의 단일염기다형성을 포함하는 뇌동맥류 진단용 snp 마커
KR102158714B1 (ko) * 2019-04-03 2020-09-22 한림대학교 산학협력단 Tcf24 유전자의 단일염기다형성을 포함하는 뇌동맥류 진단용 snp 마커
US12100480B2 (en) 2019-08-27 2024-09-24 The Board Of Trustees Of The Leland Stanford Junior University Assessment of polygenic trait risk via trait components and applications thereof
RU2719914C1 (ru) * 2019-12-06 2020-04-23 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ прогнозирования исходов операций коронарного шунтирования
KR102366097B1 (ko) * 2021-05-03 2022-02-23 주식회사 바이오에이지 임상 및 유전변이 정보를 통합한 한국인 뇌혈관 질환 예측 방법 및 관련 검사추천방법
KR102344173B1 (ko) * 2021-05-03 2021-12-29 주식회사 바이오에이지 임상 및 유전변이 정보를 통합한 한국인 관상동맥 질환 예측 방법 및 관련 검사추천방법
CN113484453B (zh) * 2021-07-07 2022-08-09 天津中医药大学 一种缺血性脑卒中预警方法
CN114672548B (zh) * 2022-03-10 2024-04-19 华捷生物科技(青岛)有限公司 一种人类静脉血栓风险基因pai-1,thbd和proc基因多态性检测试剂盒及其制备方法和应用
US20250270643A1 (en) * 2022-04-19 2025-08-28 The Regents Of The University Of Michigan Determining risk of fibromuscular dysplasia and systems and methods of use thereof
CN116144743B (zh) * 2022-12-16 2024-10-22 东华大学 基于多重长pcr结合高通量测序同时实现多个同源序列snp分型的引物、试剂盒及方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
ATE202801T1 (de) * 1983-01-10 2001-07-15 Gen Probe Inc Verfahren zum nachweis, identifizieren und quantifizieren von organismen und viren
US5288611A (en) * 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE68927933T2 (de) 1988-09-02 1997-08-14 Dyax Corp Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
AU665190B2 (en) 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0564531T3 (da) 1990-12-03 1998-09-28 Genentech Inc Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber
JPH06504997A (ja) 1990-12-06 1994-06-09 アフィメトリックス, インコーポレイテッド 非常に大きい規模の固定化されたポリマーの合成
DK1279731T3 (da) 1991-03-01 2007-09-24 Dyax Corp Fremgangsmåde til udvikling af bindende miniproteiner
DK1471142T3 (da) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5858659A (en) * 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
CN1141398C (zh) * 2000-03-28 2004-03-10 陈高明 一种多基因扩增芯片及其制备方法
USH2191H1 (en) * 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
USH2220H1 (en) * 2001-08-10 2008-07-01 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20040267458A1 (en) * 2001-12-21 2004-12-30 Judson Richard S. Methods for obtaining and using haplotype data
AU2003290527A1 (en) 2002-10-17 2004-05-04 Decode Genetics Ehf. Susceptibility gene for myocardial infarction
CA2518956A1 (en) * 2003-03-10 2004-09-23 Applera Corporation Single nucleotide polymorphisms associated with stenosis, methods of detection and uses thereof
EP2386657B1 (en) * 2003-11-26 2014-01-08 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US20050191678A1 (en) * 2004-02-12 2005-09-01 Geneob Usa Inc. Genetic predictability for acquiring a disease or condition
JP2009521905A (ja) * 2004-03-05 2009-06-11 アプレラ コーポレイション 冠動脈心疾患に関連する遺伝的多型、その検出方法および使用
CA2566257A1 (en) * 2004-05-07 2005-11-24 Applera Corporation Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof
US20060004526A1 (en) * 2004-07-01 2006-01-05 Ambion, Inc. System and method for processing results of a complex genetic test
US20080131887A1 (en) * 2006-11-30 2008-06-05 Stephan Dietrich A Genetic Analysis Systems and Methods
US7883851B2 (en) * 2007-05-02 2011-02-08 Board Of Regents, The University Of Texas System Common allele on chromosome 9 associated with coronary heart disease

Also Published As

Publication number Publication date
JP2010518848A (ja) 2010-06-03
EP2115172A1 (en) 2009-11-11
WO2008102380A1 (en) 2008-08-28
BRPI0807927A2 (pt) 2014-06-24
JP5646179B2 (ja) 2014-12-24
IL200453A0 (en) 2010-04-29
US9617597B2 (en) 2017-04-11
EP2471954B1 (en) 2016-08-24
US20120208709A1 (en) 2012-08-16
EA022610B1 (ru) 2016-02-29
KR20090117896A (ko) 2009-11-13
IL200453A (en) 2014-12-31
KR101571523B1 (ko) 2015-11-24
NZ579445A (en) 2012-02-24
CN101668865B (zh) 2015-05-06
AU2008218542B2 (en) 2014-06-26
HUE030996T2 (en) 2017-06-28
AU2008218542A1 (en) 2008-08-28
MX2009008878A (es) 2009-08-28
CA2679581C (en) 2020-12-22
SG178811A1 (en) 2012-03-29
CN101668865A (zh) 2010-03-10
EP2471954A1 (en) 2012-07-04
US20100068705A1 (en) 2010-03-18
EA200970781A1 (ru) 2010-04-30
CA2679581A1 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
DK2471954T3 (en) Susceptibility genetic variants associated with cardiovascular diseases
CN101874120B (zh) 作为用于乳腺癌风险评估、诊断、预后和治疗的标记的chr2和chr16的遗传性变型
KR101582321B1 (ko) 심장성 부정맥의 위험 관리를 위한 유전적 마커
CN101238222B (zh) 作为2型糖尿病风险诊断标记物的tcf7l2基因的遗传变异体
CN101641451A (zh) chr8q24.21上的癌症易感性变体
KR20110036608A (ko) 유방암 위험도 평가를 위한 유전적 변이
CN101772578A (zh) 作为标记物用在乳腺癌风险评估、诊断、预后和治疗中的在CHR 5p12和10q26上的遗传变异体
KR102481305B1 (ko) 유전자에 기반한 염증성 장 질환의 진단
US20090305284A1 (en) Methods for Identifying Risk of Breast Cancer and Treatments Thereof
KR20110081807A (ko) 갑상선암의 위험도 평가를 위해 유용한 유전적 변이
AU2016325030A1 (en) Novel biomarkers and methods of treating cancer
WO2006022629A1 (en) Methods of identifying risk of type ii diabetes and treatments thereof
KR20090087486A (ko) 타입 2 당뇨병의 유전적 감수성 변이
CN101631876A (zh) 2型糖尿病的遗传易感性变体
CA2497597A1 (en) Methods for identifying subjects at risk of melanoma and treatments
TW202227102A (zh) 治療脂肪肝病之方法
WO2006022636A1 (en) Methods for identifying risk of type ii diabetes and treatments thereof
KR20170116009A (ko) 전립선암의 진단을 위한 신규한 rna-바이오마커 시그니처
IL179831A (en) In vitro method for detecting the presence of or predisposition to autism or to an autism spectrum disorder, and an in vitro method of selecting biologically active compounds on autism or autism spectrum disorders
WO2006022638A1 (en) Methods for identifying risk of type ii diabetes and treatments thereof
AU2017209307A1 (en) Compositions and methods for screening and identifying clinically aggressive prostate cancer
CN101622361A (zh) 用于心律不齐的风险管理的遗传标记物
KR100909709B1 (ko) 골밀도 및 골절 위험과 itga1 유전자 다형성과의연관성
EA048246B1 (ru) Способ лечения жировой болезни печени
CA2826522A1 (en) Genetic polymorphism in pnlpa3 associated with liver fibrosis methods of detection and uses thereof