DK2462161T3 - Antistoffer der specifikt binder til A-beta-oligomerer og anvendelse deraf - Google Patents

Antistoffer der specifikt binder til A-beta-oligomerer og anvendelse deraf Download PDF

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DK2462161T3
DK2462161T3 DK10806238.1T DK10806238T DK2462161T3 DK 2462161 T3 DK2462161 T3 DK 2462161T3 DK 10806238 T DK10806238 T DK 10806238T DK 2462161 T3 DK2462161 T3 DK 2462161T3
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seq
amino acid
chain
acid sequence
antibody
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DK10806238.1T
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Tatsuki Yokoseki
Yasuhide Okamoto
Makoto Umeda
Naofumi Takamatsu
Toshiyuki Ito
Yukiho Imai
Shinobu Fujii
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Immunas Pharma Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
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  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (4)

1. Antistof, eller antigen-bindende fragment deraf, som genkender en isoleret A-beta-oligomer som et antigen, hvor antistoffet ikke binder til en A-beta-monomer og omfatter (a) en H-kæde med aminosyresekvensen ifølge SEQ ID NO: 1366 som CDR1, amino-syresekvensen ifølge SEQ ID NO: 1368 som CDR2, og aminosyresekvensen ifølge SEQ ID NO: 1370 som CDR3; og (b) en L-kæde med aminosyresekvensen ifølge SEQ ID NO: 1372 som CDR1, aminosyresekvensen ifølge SEQ ID NO: 1374 som CDR2, og aminosyresekvensen ifølge SEQ ID NO: 1376 som CDR3, til anvendelse ved en fremgangsmåde til at forebygge og/eller behandle af Alzheimer's syge.
2. Antistof eller antigen-bindende fragment til anvendelse ved en fremgangsmåde til at forebygge og/eller behandle Alzheimer's syge ifølge krav 1, hvor antistoffet eller det antigen-bindende fragment omfatter en H-kæde med aminosyresekvensen ifølge SEQ ID NO: 2630 som VH; og en L-kæde med aminosyresekvensen ifølge SEQ ID NO: 2632 som VL.
3. Antistof til anvendelse ved en fremgangsmåde til forebyggelse og/eller behandling af Alzheimer's syge ifølge ethvert af kravene 1 og 2, hvor antistoffet er et kimerisk antistof eller et humaniseret antistof.
4. Farmaceutisk sammensætning til anvendelse ved en fremgangsmåde til forebyggelse og/eller behandling af Alzheimer's syge, omfattende antistoffet eller det antigenbindende fragment ifølge ethvert af kravene 1 til 3 og et farmaceutisk acceptabelt bærestof.
DK10806238.1T 2009-08-06 2010-08-05 Antistoffer der specifikt binder til A-beta-oligomerer og anvendelse deraf DK2462161T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23179709P 2009-08-06 2009-08-06
US28253310P 2010-02-26 2010-02-26
PCT/JP2010/004925 WO2011016238A1 (en) 2009-08-06 2010-08-05 Antibodies that specifically bind to a beta oligomers and use thereof

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US (1) US8858949B2 (da)
EP (1) EP2462161B1 (da)
JP (1) JP5769316B2 (da)
CN (1) CN102574915B (da)
DK (1) DK2462161T3 (da)
ES (1) ES2624835T3 (da)
WO (1) WO2011016238A1 (da)

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EP2462161B1 (en) 2017-03-08
WO2011016238A1 (en) 2011-02-10

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