DK2450353T3 - Fremgangsmåde til fremstilling af en pyrimidinforbindelse - Google Patents

Fremgangsmåde til fremstilling af en pyrimidinforbindelse Download PDF

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Publication number
DK2450353T3
DK2450353T3 DK12000829.7T DK12000829T DK2450353T3 DK 2450353 T3 DK2450353 T3 DK 2450353T3 DK 12000829 T DK12000829 T DK 12000829T DK 2450353 T3 DK2450353 T3 DK 2450353T3
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DK
Denmark
Prior art keywords
compound
formula
solvent
added
pyridine
Prior art date
Application number
DK12000829.7T
Other languages
English (en)
Inventor
Shigeo Murai
Ryoji Koto
Hiroshi Yoshizawa
Takeshi Ohshima
Katsuyoshi Murakami
Takao Awazu
Hisayoshi Jonishi
Takayoshi Ando
Tadashi Nakamura
Norio Adachi
Akihiko Isogai
Original Assignee
Ishihara Sangyo Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha filed Critical Ishihara Sangyo Kaisha
Application granted granted Critical
Publication of DK2450353T3 publication Critical patent/DK2450353T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (2)

1. Fremgangsmåde, som omfatter at reagere forbindelsen med formlen (VI):
(hvor Y er alkyl, arylalkyl eller halogen, og p er et helt tal fra 0 til 3, forudsat at når p er mindst 2, kan flerheden af Y være den samme eller forskellig fra hinanden, og hver af R1 og R2 er methyl, methoxy eller ethoxy, og R1 og R2 kan være de samme eller forskellige fra hinanden), med en forbindelse repræsenteret af formlen (VII):
(hvor R3 er -CF3 eller -CON(R5)R6, R4 er halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkoxyalkyl, haloalkoxyalkyl eller -N(R7)R8, hver af R5 og R6 er et hydrogenatom, alkyl, haloalkyl, alkenyl, al-kynyl, alkoxy, haloalkoxy, alkoxyalkyl, haloalkoxyalkyl, cycloalkyl, halocy-cloalkyl, alkoxycarbonyl, haloalkoxycarbonyl, phenyl eller halophenyl, forudsat at når enten R5 eller R6 er et hydrogenatom, er det andet noget andet end et hydrogenatom, R5 og R6 kan danne en heterocyklisk ring sammen med det tilstødende nitrogenatom, og R5 og R6 kan være de samme eller forskellige fra hinanden, hver af R7 og R8 er et hydrogenatom eller alkyl, og R7 og R8 kan være de samme eller forskellige fra hinanden, n er et helt tal fra 0 til 2, forudsat at når n er 2, kan R4 være de samme eller forskellige fra hinanden, og m er 0 eller 1), i nærvær af kaliumcarbonat, for at fremstille en forbindelse repræsenteret af formlen (VIII):
(hvor R1, R2, R3, R4, n og m er som defineret ovenfor).
2. Fremgangsmåde ifølge krav 1, hvor kaliumcarbonatet anvendes som fint pulver.
DK12000829.7T 2008-04-18 2009-04-16 Fremgangsmåde til fremstilling af en pyrimidinforbindelse DK2450353T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008108898 2008-04-18
EP09732378.6A EP2264023B1 (en) 2008-04-18 2009-04-16 Method for producing pyrimidine compound

Publications (1)

Publication Number Publication Date
DK2450353T3 true DK2450353T3 (da) 2016-11-28

Family

ID=41199199

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12000829.7T DK2450353T3 (da) 2008-04-18 2009-04-16 Fremgangsmåde til fremstilling af en pyrimidinforbindelse

Country Status (11)

Country Link
US (1) US8440824B2 (da)
EP (2) EP2450353B1 (da)
JP (1) JP5468289B2 (da)
KR (1) KR101595140B1 (da)
CN (2) CN102007119B (da)
BR (1) BRPI0910595B1 (da)
DK (1) DK2450353T3 (da)
ES (2) ES2592281T3 (da)
HU (1) HUE031127T2 (da)
PL (2) PL2264023T3 (da)
WO (1) WO2009128512A1 (da)

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CN102993176A (zh) * 2012-11-02 2013-03-27 安徽丰乐农化有限责任公司 一种烟嘧磺隆的合成新工艺
CN105377911B (zh) * 2013-07-25 2017-05-24 昭和电工株式会社 组合物、固化性组合物、其制造方法及固化物
CN111004217A (zh) * 2019-12-30 2020-04-14 大连九信精细化工有限公司 一种啶嘧磺隆晶型及其制备方法
CN111116557A (zh) * 2019-12-30 2020-05-08 大连九信精细化工有限公司 一种啶嘧磺隆晶型及其制备方法
CN111423385B (zh) * 2020-05-22 2022-02-18 北京英力精化技术发展有限公司 4,6-二甲氧基-2-((苯氧基羰基)氨基)-嘧啶的精制方法
CN114539165A (zh) * 2022-02-21 2022-05-27 江苏瑞邦农化股份有限公司 一种甲基二磺隆的制备方法

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Also Published As

Publication number Publication date
JP2009275038A (ja) 2009-11-26
KR101595140B1 (ko) 2016-02-17
KR20110003339A (ko) 2011-01-11
WO2009128512A1 (ja) 2009-10-22
EP2264023A4 (en) 2011-08-24
EP2264023A1 (en) 2010-12-22
CN102007119A (zh) 2011-04-06
CN104151294B (zh) 2016-08-24
BRPI0910595B1 (pt) 2020-08-18
CN102007119B (zh) 2014-10-15
ES2592281T3 (es) 2016-11-29
EP2264023B1 (en) 2014-12-17
EP2450353A1 (en) 2012-05-09
PL2450353T3 (pl) 2017-02-28
EP2450353B1 (en) 2016-09-07
US8440824B2 (en) 2013-05-14
CN104151294A (zh) 2014-11-19
JP5468289B2 (ja) 2014-04-09
BRPI0910595A2 (pt) 2016-10-04
US20110021774A1 (en) 2011-01-27
HUE031127T2 (en) 2017-07-28
ES2527045T3 (es) 2015-01-19
PL2264023T3 (pl) 2015-05-29

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