DK2446900T3 - Fremgangsmåder til behandling af tilstande associeret med MASP-2-afhængig komplementaktivering - Google Patents
Fremgangsmåder til behandling af tilstande associeret med MASP-2-afhængig komplementaktivering Download PDFInfo
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- DK2446900T3 DK2446900T3 DK10184424.9T DK10184424T DK2446900T3 DK 2446900 T3 DK2446900 T3 DK 2446900T3 DK 10184424 T DK10184424 T DK 10184424T DK 2446900 T3 DK2446900 T3 DK 2446900T3
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Claims (13)
1. MASP-2-inhiberende anti-MASP-2-antistof eller fragment deraf, der specifikt binder til en del af SEQ ID N0:6 og selektivt inhiberer MASP-2-afhængig komplementaktivering uden i alt væsentligt at inhibere Clq-afhængig komplementaktivering til anvendelse i behandlingen af et individ, der lider af diabetisk angiopati.
2. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge krav 1, hvor det MASP-2-inhiberende antistof specifikt binder til et polypeptid omfattende SEQ ID NO:6.
3. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge et hvilket som helst af de foregående krav, hvor det MASP-2-inhiberende antistof specifikt binder til et polypeptid omfattende SEQ ID NO: 6 med en affinitet på mindst 10 gange større end det binder til et andet antigen i komplementsystemet.
4. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge et hvilket som helst af de foregående krav, hvor det MASP-2-inhiberende antistof binder til polypeptidet ved et sted inden for aminosyreresterne 1-176 af SEQ ID NO:6.
5. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge krav 1, hvor anti-MASP-2-antistoffet eller fragmentet deraf er monoklonalt.
6. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge et hvilket som helst af de foregående krav, hvor anti-MASP-2-antistoffet eller fragmentet deraf er rekombinant.
7. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge et hvilket som helst af de foregående krav, hvor anti-MASP-2-antistoffet eller fragmentet deraf har nedsat effektorfunktion.
8. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge et hvilket som helst af de foregående krav, hvor anti-MASP-2-antistoffet eller fragmentet deraf er kimært, humaniseret eller humant.
9. MASP-2-inhiberende antistof eller fragment til anvendelse ifølge et hvilket som helst af de foregående krav, hvor anti-MASP-2-antistoffet eller fragmentet deraf er fremstillet i et MASP-2-mangelfuldt transgent dyr.
10. Farmaceutisk sammensætning omfattende et MASP-2-inhiberende anti-MASP-2-antistof eller fragment deraf, der specifikt binder til en del af SEQ ID NO:6 og selektivt inhiberer MASP-2-afhængig komplementaktivering uden i alt væsentligt at inhibere Clq-afhængig komplementaktivering og en farmaceutisk acceptabel bærer til anvendelse i behandlingen af diabetisk angiopati.
11. Farmaceutisk sammensætning til anvendelse ifølge krav 10, hvor det MASP-2-inhiberende antistof er som fremsat i et hvilket som helst af kravene 2 til 9.
12. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 10 til 11, hvor sammensætningen er formuleret for til intraarteriel, intravenøs, intrakranial, intramuskulær, subkutan indgivelse eller indgivelse som inhalationsmiddel.
13. Farmaceutisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 10 til 12, hvor sammensætningen er formuleret til subkutan indgivelse.
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| US57884704P | 2004-06-10 | 2004-06-10 | |
| EP05765604.3A EP1753456B1 (en) | 2004-06-10 | 2005-06-09 | Methods for treating conditions associated with masp-2 dependent complement activation |
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| DK05765604.3T DK1753456T3 (da) | 2004-06-10 | 2005-06-09 | Fremgangsmåder til behandling af tilstande forbundet med masp-2-afhængig komplementaktivering |
| DK10183893.6T DK2465534T3 (da) | 2004-06-10 | 2005-06-09 | Fremgangsmåde til behandling af tilstande associeret med MASP-2-afhængig komplementaktivering |
| DK10184424.9T DK2446900T3 (da) | 2004-06-10 | 2005-06-09 | Fremgangsmåder til behandling af tilstande associeret med MASP-2-afhængig komplementaktivering |
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| DK05765604.3T DK1753456T3 (da) | 2004-06-10 | 2005-06-09 | Fremgangsmåder til behandling af tilstande forbundet med masp-2-afhængig komplementaktivering |
| DK10183893.6T DK2465534T3 (da) | 2004-06-10 | 2005-06-09 | Fremgangsmåde til behandling af tilstande associeret med MASP-2-afhængig komplementaktivering |
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| GB0412966D0 (en) * | 2004-06-10 | 2004-07-14 | Univ Leicester | Genetically modified non-human mammals and cells |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
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